Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production

Journal of Biological Chemistry

Volumn 288, Issue 7, 2013, Pages 4878-4890

  Kearney, Conor J ^a   Sheridan, Clare ^a   Cullen, Sean P ^a   Tynan, Graham A ^a   Logue, Susan E ^a   Afonina, Inna S ^a   Vucic, Domagoj ^b   Lavelle, Ed C ^a   Martin, Seamus J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINES; CYTOKINE PRODUCTION; CYTOKINES; INHIBITOR OF APOPTOSIS PROTEINS; PROINFLAMMATORY CYTOKINES; TUMOR NECROSIS FACTORS;

CHEMOTHERAPY;

CELL DEATH;

CXCL1 CHEMOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INHIBITOR OF APOPTOSIS PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PEPTIDES AND PROTEINS; PROTEIN CIAP 1; PROTEIN CIAP 2; PROTEIN INHIBITOR; PROTEIN RIPK1; RANTES; SMALL MOLECULE INHIBITOR OF APOPTOSIS PROTEIN ANTAGONIST; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REGULATORY MECHANISM;

ANIMALS; APOPTOSIS; CHEMOKINES; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; HELA CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; INHIBITOR OF APOPTOSIS PROTEINS; LIGANDS; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; RECEPTORS, TUMOR NECROSIS FACTOR; RNA INTERFERENCE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84874087182     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.422410     Document Type: Article

References (34)

1. O'Riordan, M. X., Bauler, L. D., and Scott., F. L., and Duckett, C. S. (2008) Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation. Dev. Cell 15, 497-508
2. Gyrd-Hansen, M., and Meier, P. (2010) IAPs: from caspase inhibitors to modulators of NF-KB, inflammation and cancer. Nat. Rev. Cancer 10, 561-574
3. Silke, J., and Brink, R. (2010) Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs. Cell Death Differ. 17, 35-45
4. Bertrand, M. J., Doiron, K., Labbé, K., Korneluk, R. G., and Barker., P. A., and Saleh, M. (2009) Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity 30, 789-801
5. Vince, J. E., and Wong., W. W., Gentle, I., Lawlor, K. E., Allam, R., O'Reilly, L., Mason, K., Gross, O., Ma, S., Guarda, G., Anderton, H., Castillo, R., Häcker, G., Silke, J., and Tschopp, J. (2012) Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity 36, 215-227
6. Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W. W., and Fiil., B. K., Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C, Ruland, J., Bekker-Jensen, S., Mailand, N., Kaufmann, T., Strasser, A., Walczak, H., Silke, J., Jost, P. J., and Gyrd-Hansen, M. (2012) The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity. Mol. Cell 46, 746-758
7. Feldmann, M. (2008) Many cytokines are very useful therapeutic targets in disease. J. Clin. Invest. 118, 3533-3536
8. Brennan, F. M., and McInnes, I. B. (2008) Evidence that cytokines play a role in rheumatoid arthritis. J. Clin. Invest. 118, 3537-3545
9. Ashkenazi, A., and Dixit, V. M. (1998) Death receptors: signaling and modulation. Science 281, 1305-1308
10. Wang, L., Du, F., and Wang, X. (2008) TNF-α induces two distinct caspase-8 activation pathways. Cell 133, 693-703
11. Van Antwerp, D. J., Martin, S. J., and Verma., I. M., and Green, D. R. (1998) Inhibition of TNF-induced apoptosis by NF-KB. Trends Cell Biol. 8, 107-111
12. Beg, A. A., Sha, W. C, Bronson, R. T., Ghosh, S., and Baltimore, D. (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-KB. Nature 376, 167-170
13. Van Antwerp, D. J., Martin, S. J., Kafri, T., and Green., D. R., and Verma, I. M. (1996) Suppression of TNF-α-induced apoptosis by NF-KB. Science 274, 787-789
14. Beg, A. A., and Baltimore, D. (1996) An essential role for NF-KB in preventing TNF-α-induced cell death. Science 274, 782-784
15. Wang, C. Y., and Mayo., M. W., and Baldwin, A. S. Jr. (1996) TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-KB. Science 274, 784-787
16. Varfolomeev, E., and Blankenship., J. W., Wayson, S. M., Fedorova, A. V., Kayagaki, N., Garg, P., Zobel, K., Dynek, J. N., and Elliott., L. O., Wallweber, H. J., Flygare, J. A., Fairbrother, W. J., Deshayes, K., Dixit, V. M., and Vucic, D. (2007) IAP antagonists induce autoubiquitination of c-IAPs, NF-KB activation, and TNFa-dependent apoptosis. Cell 131, 669-681
17. Vince, J. E., and Wong., W. W., Khan, N., Feltham, R., Chau, D., and Ahmed., A. U., Benetatos, CA., Chunduru, S. K., and Condon., S. M., McKinlay, M., Brink, R., Leverkus, M., Tergaonkar, V., Schneider, P., Callus, B. A., Koentgen, F., Vaux, D. L., and Silke, J. (2007) IAP antagonists target cIAP1 to induce TNFa-dependent apoptosis. Cell 131, 682-693
18. Gaither, A., Porter, D., Yao, Y., Borawski, J., Yang, G., Donovan, J., Sage, D., Slisz, J., Tran, M., Straub, C, Ramsey, T., Iourgenko, V., Huang, A., Chen, Y., Schlegel, R., Labow, M., Fawell, S., Sellers, W. R., and Zawel, L. (2007) A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-a signaling. Cancer Res. 67, 11493-11498
19. Petersen, S. L., Wang, L., Yalcin-Chin, A., Li, L., Peyton, M., Minna, J., Harran, P., and Wang, X. (2007) Autocrine TNFa signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 12, 445-456
20. Varfolomeev, E., Goncharov, T., Fedorova, A. V., Dynek, J. N, Zobel, K., Deshayes, K., Fairbrother, W.J., and Vucic, D. (2008) c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-ΚB activation. J. Biol. Chem. 283, 24295-24299
21. Bertrand, M. J., Milutinovic, S., Dickson, K. M., Ho, W. C, Boudreault, A., Durkin, J., Gillard, J. W., Jaquith, J. B., Morris, S. J., and Barker, P. A. (2008) cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 30, 689-700
22. Dynek, J. N, Goncharov, T., Dueber, E. C, Fedorova, A. V., Izrael-Tomasevic, A., Phu, L., Helgason, E., Fairbrother, W. J., Deshayes, K., Kirk-patrick, D. S., and Vucic, D. (2010) c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 29, 4198-4209
23. Tenev, T., Bianchi, K., Darding, M., Broemer, M., Langlais, C, Wallberg, F., Zachariou, A., Lopez, J., MacFarlane, M., Cain, K., and Meier, P. (2011) The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol. Cell 43, 432-448
24. Feoktistova, M., Geserick, P., Kellert, B., Dimitrova, D. P., Langlais, C, Hupe, M., Cain, K., MacFarlane, M., Häcker, G., and Leverkus, M. (2011) cIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 43, 449-463
25. Moulin, M., Anderton, H., Voss, A. K., Thomas, T., and Wong., W. W., Bankovacki, A., Feltham, R., Chau, D., and Cook., W. D., Silke, J., and Vaux, D. L. (2012) IAPs limit activation of RIP kinases by TNF receptor 1 during development. EMBO J. 31, 1679-1691
26. Basak, S., Kim, H, and Kearns., J. D., Tergaonkar, V., O'Dea, E., Werner, S. L., Benedict, C. A., Ware, C F., Ghosh, G., Verma, I. M., and Hoffmann, A. (2007) A fourth IkappaB protein within the NF-kappaB signaling module. Cell 128, 369-381
27. Vucic, D., and Dixit., V. M., and Wertz, I. E. (2011) Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. Nat. Rev. Mol. Cell Biol. 12, 439-452
28. Scheinecker, C, Redlich, K., and Smolen, J. S. (2008) Cytokines as therapeutic targets: advances and limitations. Immunity 28, 440-444
29. Taylor, P. C, and Feldmann, M. (2009) Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis. Nat. Rev. Rheumatol. 5, 578-582
30. Zarnegar, B. J., Wang, Y., Mahoney, D. J., and Dempsey., P. W., Cheung, H. H, He, J., Shiba, T., Yang, X., Yeh, W. C, Mak, T. W., Korneluk, R. G., and Cheng, G. (2008) Noncanonical NF-KB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat. Immunol. 9, 1371-1388
31. Mantovani, A., Allavena, P., Sica, A., and Balkwill, F. (2008) Cancer-related inflammation. Nature 454, 436-444
32. Zhang, D. W., Shao, J., Lin, J., Zhang, N., and Lu., B. J., Lin, S. C, Dong, M. Q., and Han, J. (2009) RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325, 332-336
33. Green, D. R., Oberst, A., Dillon, C. P., Weinlich, R., and Salvesen, G. S. (2011) RIPK-dependent necrosis and its regulation by caspases: A mystery in five acts. Mol. Cell 44, 9-16
34. Duprez, L., Takahashi, N., Van Hauwermeiren, F., Vandendriessche, B., Goossens, V., Vanden Berghe, T., Declercq, W., Libert, C, Cauwels, A., and Vandenabeele, P. (2011) RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome. Immunity 35, 908-918