Proteasome inhibition induces DNA damage and reorganizes nuclear architecture and protein synthesis machinery in sensory ganglion neurons

Cellular and Molecular Life Sciences

Volumn 71, Issue 10, 2014, Pages 1961-1975

  Palanca, Ana ^a   Casafont, Iñigo ^a   Berciano, María T ^a   Lafarga, Miguel ^a  

^a UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

BDNF; Bortezomib; Chromatolysis; DNA damage; Nuclear architecture; Nuclear shape; Peripheral neuropathies; Proteasome inhibitors; Sensory ganglia neurons

Indexed keywords

BORTEZOMIB; BRAIN DERIVED NEUROTROPHIC FACTOR; PROTEASOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL NUCLEUS; CELL POLARITY; CELL SHAPE; CELL STRESS; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; LOW DRUG DOSE; MALE; NEUROTOXICITY; NONHUMAN; PERIPHERAL NEUROPATHY; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SENSORY GANGLION; SENSORY NERVE CELL; UPREGULATION;

ANIMALIA; RATTUS;

ANIMALS; ANTINEOPLASTIC AGENTS; BORONIC ACIDS; CELL NUCLEUS; DNA DAMAGE; DNA REPAIR; GANGLIA, SENSORY; GENE EXPRESSION; MALE; MICROSCOPY, CONFOCAL; NISSL BODIES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 84900295538     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-013-1474-2     Document Type: Article

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