Purkinje cell degeneration in pcd mice reveals large scale chromatin reorganization and gene silencing linked to defective DNA repair

Journal of Biological Chemistry

Volumn 286, Issue 32, 2011, Pages 28287-28302

  Baltanás, Fernando C ^a   Casafont, Iñigo ^b   Lafarga, Vanesa ^c   Weruaga, Eduardo ^a   Alonso, José R ^a,d   Berciano, María T ^b   Lafarga, Miguel ^b  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b UNIVERSITY OF CANTABRIA   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^d UNIVERSIDAD DE TARAPACÁ   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIA-TELANGIECTASIA MUTATED; CODING GENES; DNA DAMAGE RESPONSE; DNA DAMAGES; DNA REPAIR; EXPRESSION LEVELS; GENE SILENCING; GENE TRANSCRIPTIONS; HISTONE MODIFICATION; HISTONE VARIANTS; IMMUNOCYTOCHEMISTRY; IN-SITU; IN-SITU HYBRIDIZATION; KEY FACTORS; NEURODEGENERATION; NEURODEGENERATIVE DISORDERS; NUCLEAR ARCHITECTURE; PROGRESSIVE ACCUMULATION; PURKINJE CELLS; TELOMERES; TRANSCRIPTION ASSAYS; TRIMETHYLATION; TWO-COMPONENT;

CELL DEATH; GENES; GENETIC ENGINEERING; MAMMALS; MICROCOMPUTERS; NEURODEGENERATIVE DISEASES; NEURONS; PHOSPHORYLATION; TRANSCRIPTION;

DNA;

ATM PROTEIN; DNA; HISTONE H2AX; HISTONE H4; HISTONE H4K20; NUCLEAR PROTEIN; PROTEIN 53BP1; PROTEIN NNA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA TELANGIECTASIA; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EPIGENETICS; FEMALE; GENE EXPRESSION REGULATION; GENE MUTATION; GENE SILENCING; GENETIC TRANSCRIPTION; HETEROCHROMATIN; HISTONE METHYLATION; HISTONE MODIFICATION; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; LOSS OF FUNCTION MUTATION; MALE; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN VARIANT; PURKINJE CELL; TELOMERE;

ANIMALS; CELL CYCLE PROTEINS; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; GENE SILENCING; GTP-BINDING PROTEINS; HISTONES; MALE; MICE; MICE, MUTANT STRAINS; NEURODEGENERATIVE DISEASES; PROTEIN-SERINE-THREONINE KINASES; PURKINJE CELLS; SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA; MUS;

EID: 80051516014     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.246041     Document Type: Article

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