Brain-derived neurotrophic factor

Growth Factors

Volumn 22, Issue 3, 2004, Pages 123-131

  Binder, Devin K ^a   Scharfman, Helen E ^b,c  

^a UCSF Medical Center at Parnassus   (United States)

^b HELEN HAYES HOSPITAL   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; LITHIUM;

BRAIN DEVELOPMENT; BRAIN DISEASE; BRAIN FUNCTION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CHRONIC PAIN; DEGENERATIVE DISEASE; DRUG MECHANISM; EPILEPSY; EVIDENCE BASED MEDICINE; HIPPOCAMPUS; HUMAN; MENTAL DISEASE; NEOCORTEX; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PURIFICATION; SENSITIZATION; SHORT SURVEY; SYNAPTIC TRANSMISSION; TREATMENT PLANNING;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; EPILEPSY; EXCITATORY POSTSYNAPTIC POTENTIALS; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; LEARNING; MEMORY; MODELS, BIOLOGICAL; NEOCORTEX; NEURODEGENERATIVE DISEASES; NEURONAL PLASTICITY; NEURONS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 5744233877     PISSN: 08977194     EISSN: None     Source Type: Journal    
DOI: 10.1080/08977190410001723308     Document Type: Short Survey

References (168)

1. Acheson, A., et al. (1995) "A BDNF autocrine loop in adult sensory neurons prevents cell death", Nature 374, 450-453.
2. Alderson, R.F., et al. (2000) "Truncated TrkB mediates the endocytosis and release of BDNF and neurotrophin-4/5 by rat astrocytes and schwann cells in vitro", Brain Res. 871, 210-222.
3. Alonso, M., et al. (2002) "BDNF-triggered events in the rat hippocampus are required for both short- and long-term memory formation", Hippocampus 12, 551-560.
4. Altar, C.A. (1999) "Neurotrophins and depression", Trends Pharmacol. Sci. 20, 59-61.
5. Altar, C.A. and DiStefano, P.S. (1998) "Neurotrophin trafficking by anterograde transport", Trends Neurosci. 21, 433-437.
6. Altar, C.A., et al. (1997) "Anterograde transport of brain-derived neurotrophic factor and its role in the brain", Nature 389, 856-860.
7. Altar, C.A., et al. (2003) "Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain", Biol. Psychiatry 54, 703-709.
8. Barbacid, M. (1994) "The Trk family of neurotrophin receptors", J. Neurobiol. 25, 1386-1403.
9. Barde, Y.A., Edgar, D. and Thoenen, H. (1982) "Purification of a new neurotrophic factor from mammalian brain", EMBO J. 1, 549-553.
10. Barnabe-Heider, F. and Miller, F.D. (2003) "Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways", J. Neurosci. 23, 5149-5160.
11. Benraiss, A., et al. (2001) "Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain" , J. Neurosci. 21, 6718-6731.
12. Biffo, S., et al. (1995) "Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development", Development 121, 2461-2470.
13. Binder, D.K., Routbort, M.J. and McNamara, J.O. (1999a) "Immunohistochemical evidence of seizure-induced activation of trk receptors in the mossy fiber pathway of adult rat hippocampus", J. Neurosci. 19, 4616-4626.
14. Binder, D.K., et al. (1999b) "Selective inhibition of kindling development by intraventricular administration of TrkB receptor body", J. Neurosci. 19, 1424-1436.
15. Binder, D.K., et al. (2001) "BDNF and epilepsy: too much of a good thing?", Trends Neurosci. 24, 47-53.
16. Black, I.B. (1999) "Trophic regulation of synaptic plasticity", J. Neurobiol. 41, 108-118.
17. Bramham, C.R., et al. (1996) "Unilateral LTP triggers bilateral increases in hippocampal neurotrophin and trk receptor mRNA expression in behaving rats: evidence for interhemispheric communication", J. Comp. Neurol. 368, 371-382.
18. Bregola, G., et al. (2000) "Different patterns of induction of fibroblast growth factor-2 and brain-derived neurotrophic factor messenger RNAs during kindling epileptogenesis, and development of a herpes simplex vector for fibroblast growth factor-2 gene transfer in vivo", Epilepsia 41(Suppl. 6), S122-S126.
19. Burbach, G.J., et al. (2004) "Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice", J. Neurosci. 24, 2421-2430.
20. Cabelli, R.J., Hohn, A. and Shatz, C.J. (1995) "Inhibition of ocular dominance column formation by infusion of NT-4/5 or BDNF", Science 267, 1662-1666.
21. Cabelli, R.J., et al. (1997) "Blockade of endogenous ligands of trkB inhibits formation of ocular dominance columns", Neuron 19, 63-76.
22. Casaccia-Bonnefil, E, et al. (1996) "Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75", Nature 383, 716-719.
23. Castrén, E., et al. (1992) "Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex", Proc. Natl Acad. Sci. USA 89, 9444-9448.
24. Castrén, E., et al. (1993) "The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus", Neuroreport 4, 895-898.
25. Castrén, E., Thoenen, H. and Lindholm, D. (1995) "Brain-derived neurotrophic factor messenger RNA is expressed in the septum, hypothalamus and in adrenergic brain stem nuclei of adult rat brain and is increased by osmotic stimulation in the paraventricular nucleus", Neuroscience 64, 71-80.
26. Castrén, E., et al. (1998) "Regulation of brain-derived neurotrophic factor mRNA levels in hippocampus by neuronal activity",Prog. Brain Res. 117, 57-64.
27. Chao, M.V. and Hempstead, B.L. (1995) "p75 and Trk: a two-receptor system", Trends Neurosci. 18, 321-326.
28. Chao, M.V. and Bothwell, M. (2002) "Neurotrophins: to cleave or not to cleave", Neuron 33, 9-12.
29. Chen, B., et al. (2001) "Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication" , Biol. Psychiatry 50, 260-265.
30. Chen, W.G., et al. (2003) "Depression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2", Science 302, 885-889.
31. Chmielnicki, E., et al. (2004) "Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone", J. Neurosci. 24, 2133-2142.
32. Climent, E. (2000) "Astrocytes in culture express the full-length Trk-B receptor and respond to brain derived neurotrophic factor by changing intracellular calcium levels: effect of ethanol exposure in rats", Neurosci. Lett. 288, 53-56.
33. Conner, J.M., et al. (1997) "Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport", J. Neurosci. 17, 2295-2313.
34. Cotman, C.W. and Berchtold, N.C. (2002) "Exercise: a behavioral intervention to enhance brain health and plasticity", Trends Neurosci. 25, 295-301.
35. Croll, S.D., et al. (1999) "Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex", Neuroscience 93, 1491-1506.
36. Dechant, G. and Barde, Y.A. (2002) "The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system", Nat. Neurosci. 5, 1131-1136.
37. Dias, B.G., et al. (2003) "Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain", Neuropharmacology 45, 553-563.
38. Drake, C.T., Milner, T.A. and Patterson, S.L. (1999) "Ultrastructural localization of full-length trkB immunoreactivity in rat hippocampus suggests multiple roles in modulating activity-dependent synaptic plasticity", J. Neurosci. 19, 8009-8026.
39. Egan, M.F., et al. (2003) "The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function", Cell 112, 257-269.
40. Eide, F.F., et al. (1996) "Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling", J. Neurosci. 16, 3123-3129.
41. Ernfors, P., et al. (1991) "Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis", Neuron 7, 165-176.
42. Esposito, D., et al. (2001) "The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factor", J. Biol. Chem. 276, 32687-32695.
43. Farhadi, H.F., et al. (2000) "Neurotrophin-3 sorts to the constitutive secretory pathway of hippocampal neurons and is diverted to the regulated secretory pathway by coexpression with brain-derived neurotrophic factor", J. Neurosci. 20, 4059-4068.
44. Fawcett, J.P., et al. (1997) "Detection of brain-derived neurotrophic factor in a vesicular fraction of brain synaptosomes", J. Biol. Chem. 272, 8837-8840.
45. Fawcett, J.P., et al. (1998) "Functional evidence that BDNF is an anterograde neuronal trophic factor in the CNS", J. Neurosci. 18, 2808-2821.
46. Fawcett, J.P., et al. (2000) "Evidence that brain-derived neurotrophic factor from presynaptic nerve terminals regulates the phenotype of calbindin-containing neurons in the lateral septum", J. Neurosci. 20, 274-282.
47. Ferrer, I., et al. (1999) "BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies", J. Neuropathol. Exp. Neurol. 58, 729-739.
48. Figurov, A., et al. (1996) "Regulation of synaptic responses to high-frequency stimulation and UP by neurotrophins in the hippocampus", Nature 381, 706-709.
49. Frade, J.M., Rodriguez-Tebar, A. and Barde, Y.A. (1996) "Induction of cell death by endogenous nerve growth factor through its p75 receptor", Nature 383, 166-168.
50. Frerking, M., Malenka, R.C. and Nicoll, R.A. (1998) "Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus", J. Neurophysiol. 80, 3383-3386.
51. Frisen, J., et al. (1993) "Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems", Proc. Natl Acad. Sci. USA 90, 4971-4975.
52. Fryer, R.H., Kaplan, D.R. and Kromer, L.F. (1997) "Truncated trkB receptors on nonneuronal cells inhibit BDNF-induced neurite outgrowth in vitro", Exp. Neurol. 148, 616-627.
53. Fukuoka, T., et al. (2001) "Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model", J. Neurosci. 21, 4891-4900.
54. Gall, C.M. and Isackson, P.J. (1989) "Limbic seizures increase neuronal production of messenger RNA for nerve growth factor", Science 245, 758-761.
55. Gall, C., et al. (1991) "Seizures and the regulation of neurotrophic factor and neuropeptide gene expression in brain", Epilepsy Res. Suppl. 4, 225-245.
56. Gall, C.M., et al. (1997) "Seizures and the regulation of neurotrophic factor expression: associations with structural plasticity in epilepsy", Adv. Neurol. 72, 9-24.
57. Ginty, D.D. and Segal, R.A. (2002) "Retrograde neurotrophin signaling: Trk-ing along the axon", Curr. Opin. Neurobiol. 12, 268-274.
58. Goggi, J., et al. (2003) "The control of [125I]BDNF release from striatal rat brain slices", Brain Res. 967, 201-209.
59. Green, E. and Craddock, N. (2003) "Brain-derived neurotrophic factor as a potential risk locus for bipolar disorder: evidence, limitations, and implications", Curr. Psychiatry Rep. 5, 469-476.
60. Griesbeck, O., et al. (1999) "Are there differences between the secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity", Microsc. Res. Tech. 45, 262-275.
61. Gustafsson, E., Lindvall, O. and Kokaia, Z. (2003) "Intraventricular infusion of TrkB-Fc fusion protein promotes ischemia-induced neurogenesis in adult rat dentate gyrus", Stroke 34, 2710-2715.
62. Haapasalo, A., et al. (2001) "Truncated trkB.T1 is dominant negative inhibitor of trkB. TK + -mediated cell survival", Biochem. Biophys. Res. Commun. 280, 1352-1358.
63. Haapasalo, A., et al. (2002) "Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRKB isoforms", J. Biol. Chem. 277, 43160-43167.
64. Hall, J., Thomas, K.L. and Everitt, B.J. (2000) "Rapid and selective induction of BDNF expression in the hippocampus during contextual learning", Nat. Neurosci. 3, 533-535.
65. Hallbook, F., Ibanez, C.F. and Persson, H. (1991) "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary", Neuron 6, 845-858.
66. Hashimoto, R., et al. (2002) "Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity", Neuropharmacology 43, 1173-1179.
67. Hong, C.J., et al. (2003) "Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior", Neuropsychobiology 48, 186-189.
68. Horch, H.W. and Katz, L.C. (2002) "BDNF release from single cells elicits local dendritic growth in nearby neurons", Nat. Neurosci. 5, 1177-1184.
69. Howells, D.W., et al. (2000) "Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra", Exp. Neurol. 166, 127-135.
70. Huang, E.J. and Reichardt, L.F. (2001) "Neurotrophins: roles in neuronal development and function", Annu. Rev. Neurosci. 24, 677-736.
71. Ip, N.Y., et al. (1992) "Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity", Proc. Natl Acad. Sci. USA 89, 3060-3064.
72. Isackson, P.J., et al. (1991) "BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF", Neuron 6, 937-948.
73. Ishibashi, H., et al. (2002) "Tool-use learning induces BDNF expression in a selective portion of monkey anterior parietal cortex", Brain Res. Mol. Brain Res. 102, 110-112.
74. Ito, H., et al. (2003) "Neurotrophins facilitate neuronal differentiation of cultured neural stem cells via induction of mRNA expression of basic helix-loop-helix transcription factors Mash1 and Math1", J. Neurosci. Res. 71, 648-658.
75. Jankowsky, J.L. and Patterson, P.H. (2001) "The role of cytokines and growth factors in seizures and their sequelae", Prog. Neurobiol. 63, 125-149.
76. Jovanovic, J.N., et al. (2004) "Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability", J. Neurosci. 24, 522-530.
77. Kafitz, K.W., et al. (1999) "Neurotrophin-evoked rapid excitation through TrkB receptors", Nature 401, 918-921.
78. Kang, H. and Schuman, E.M. (1995) "Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus", Science 267, 1658-1662.
79. Kang, H., et al. (1997) "Neurotrophins and time: different roles for TrkB signaling in hippocampal long-term potentiation", Neuron 19, 653-664.
80. Katoh-Semba, R., et al. (2002) "Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus", FASEB J. 16, 1328-1330.
81. Kernie, S.G., Liebl, D.J. and Parada, L.F. (2000) "BDNF regulates eating behavior and locomotor activity in mice", EMBO J. 19, 1290-1300.
82. Kerr, B.J., et al. (1999) "Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord", J. Neurosci. 19, 5138-5148.
83. Kohara, K., et al. (2001) "Activity-dependent transfer of brain-derived neurotrophic factor to postsynaptic neurons", Science 291, 2419-2423.
84. Kokaia, M., et al. (1995) "Suppressed epileptogenesis in BDNF mutant mice", Exp. Neurol. 133, 215-224.
85. Korte, M., et al. (1995) "Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor", Proc. Natl Acad. Sci. USA 92, 8856-8860.
86. Korte, M., et al. (1996) "Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice", Proc. Natl Acad. Sci. USA 93, 12547-12552.
87. Lahteinen, S., et al. (2002) "Decreased BDNF signalling in transgenic mice reduces epileptogenesis", Eur. J. Neurosci. 15, 721-734.
88. Larsson, E., et al. (2002) "Suppression of insult-induced neurogenesis in adult rat brain by brain-derived neurotrophic factor", Exp. Neurol. 177, 1-8.
89. Lauterborn, J.C., et al. (1996) "Differential effects of protein synthesis inhibition on the activity-dependent expression of BDNF transcripts: evidence for immediate-early gene responses from specific promoters", J. Neurosci. 16, 7428-7436.
90. Lee, F.S., et al. (2001a) "The uniqueness of being a neurotrophin receptor", Curr. Opin. Neurobiol. 11, 281-286.
91. Lee, R., et al. (2001b) "Regulation of cell survival by secreted proneurotrophins", Science 294, 1945-1948.
92. Lee, J., Duan, W. and Mattson, M.P. (2002) "Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice", J. Neurochem. 82, 1367-1375.
93. Levi-Montalcini, R. and Hamburger, V. (1951) "Selective growth-stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo", J. Exp. Zool. 116, 321-361.
94. Lindholm, D., et al. (1994) "Activity-dependent and hormonal regulation of neurotrophin mRNA levels in the brain - implications for neuronal plasticity", J. Neurobiol. 25, 1362-1372.
95. Lindvall, O., et al. (1994) "Neurotrophins and brain insults", Trends Neurosci. 17, 490-496.
96. Linnarsson, S., Bjorklund, A. and Ernfors, P. (1997) "Learning deficit in BDNF mutant mice", Eur. J. Neurosci. 9, 2581-2587.
97. Lohof, A.M., Ip, N.Y. and Poo, M.M. (1993) "Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF", Nature 363, 350-353.
98. Luikart, B.W., et al. (2003) "In vivo role of truncated trkb receptors during sensory ganglion neurogenesis", Neuroscience 117, 847-858.
99. Lyons, W.E., et al. (1999) "Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities", Proc. Natl Acad. Sci. USA 96, 15239-15244.
100. Maisonpierre, P.C., et al. (1990) "Neurotrophin-3: a neurotrophic factor related to NGF and BDNF", Science 247, 1446-1451.
101. Malcangio, M. and Lessmann, V. (2003) "A common thread for pain and memory synapses? Brain-derived neurotrophic factor and trkB receptors", Trends Pharmacol. Sci. 24, 116-121.
102. Mamounas, L.A., et al. (1995) "Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain", J. Neurosci. 15, 7929-7939.
103. Marty, S., et al. (1996) "GABAergic stimulation regulates the phenotype of hippocampal interneurons through the regulation of brain-derived neurotrophic factor", Neuron 16, 565-570.
104. Mathern, G.W., et al. (1997) "Granule cell mRNA levels for BDNF, NGF, and NT-3 correlate with neuron losses or supragranular mossy fiber sprouting in the chronically damaged and epileptic human hippocampus", Mol. Chem. Neuropathol. 30, 53-76.
105. McAllister, A.K., Katz, L.C. and Lo, D.C. (1997) "Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth", Neuron 18, 767-778.
106. Merlio, J.P., et al. (1993) "Increased production of the trkB protein tyrosine kinase receptor after brain insults", Neuron 10, 151-164.
107. Metsis, M., et al. (1993) "Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation", Proc. Natl Acad. Sci. USA 90, 8802-8806.
108. Miller, F.D. and Kaplan, D.R. (2001) "On Trk for retrograde signaling", Neuron 32, 767-770.
109. Minichiello, L., et al. (1999) "Essential role for TrkB receptors in hippocampus-mediated learning", Neuron 24, 401-414.
110. Mowla, S.J., et al. (1999) "Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons", J. Neurosci. 19, 2069-2080.
111. Mowla, S.J., et al. (2001) "Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor", J. Biol. Chem. 276, 12660-12666.
112. Murer, M.G., Yan, Q. and Raisman-Vozari, R. (2001) "Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease", Prog. Neurobiol. 63, 71-124.
113. Murphy, D.D., Cole, N.B. and Segal, M. (1998) "Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons", Proc. Natl Acad. Sci. USA 95, 11412-11417.
114. Nakata, K., et al. (2003) "Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder" , Neurosci. Lett. 337, 17-20.
115. Neeper, S.A., et al. (1995) "Exercise and brain neurotrophins", Nature 373, 109.
116. Neves-Pereira, M., et al. (2002) "The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study", Am. J. Hum. Genet. 71, 651-655.
117. Nibuya, M., Morinobu, S. and Duman, R.S. (1995) "Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments", J. Neurosci. 15, 7539-7547.
118. Nibuya, M., Nestler, E.J. and Duman, R.S. (1996) "Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus", J. Neurosci. 16, 2365-2372.
119. Patapoutian, A. and Reichardt, L.F. (2001) "Trk receptors: mediators of neurotrophin action", Curr. Opin. Neurobiol. 11, 272-280.
120. Patterson, S.L., et al. (1992) "Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs", Neuron 9, 1081-1088.
121. Patterson, S.L., et al. (1996) "Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice", Neuron 16, 1137-1145.
122. Pencea, V., et al. (2001) "Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus", J. Neurosci. 21, 6706-6717.
123. Pezet, S., et al. (2002) "Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn", Mol. Cell. Neurosci. 21, 684-695.
124. Phillips, H.S., et al. (1991) "BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease", Neuron 7, 695-702.
125. Poo, M.M. (2001) "Neurotrophins as synaptic modulators", Nat. Rev. Neurosci. 2, 24-32.
126. Reibel, S., et al. (2000) "Brain-derived neurotrophic factor delays hippocampal kindling in the rat", Neuroscience 100, 777-788.
127. Rios, M., et al. (2001) "Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity", Mol. Endocrinol. 15, 1748-1757.
128. Rivera, C., et al. (2002) "BDNF-induced TrkB activation down-regulates the K + -Cl - cotransporter KCC2 and impairs neuronal Cl - extrusion", J. Cell Biol. 159, 747-752.
129. Roback, J.D., et al. (1995) "BDNF-activated signal transduction in rat cortical glial cells", Eur. J. Neurosci. 7, 849-862.
130. Rocamora, N., et al. (1996) "Upregulation of BDNF mRNA expression in the barrel cortex of adult mice after sensory stimulation", J. Neurosci. 16, 4411-4419.
131. Rose, C.R., et al. (2003) "Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells", Nature 426, 74-78.
132. Roux, P.P., et al. (1999) "p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure", J. Neurosci. 19, 6887-6896.
133. Russo-Neustadt, A., Beard, R.C. and Cotman, C.W. (1999) "Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression", Neuropsychopharmacology 21, 679-682.
134. Saarelainen, T., et al. (2000a) "Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia", Mol. Cell Neurosci. 16, 87-96.
135. Saarelainen, T., et al. (2000b) "Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons have impaired long-term spatial memory but normal hippocampal LTP", Synapse 38, 102-104.
136. Scharfman, H.E. (1997) "Hyperexcitability in combined entorhinal/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor", J. Neurophysiol. 78, 1082-1095.
137. Scharfman, H.E., Goodman, J.H. and Sollas, A.L. (1999) "Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus", J. Neurosci. 19, 5619-5631.
138. Scharfman, H.E., et al. (2002) "Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor", Exp. Neurol. 174, 201-214.
139. Scharfman, H.E., et al. (2003) "Hippocampal excitability increases during the estrous cycle in the rat: a potential role for brain-derived neurotrophic factor", J. Neurosci. 23, 11641-11652.
140. Schinder, A.F. and Poo, M. (2000) "The neurotrophin hypothesis for synaptic plasticity", Trends Neurosci. 23, 639-645.
141. Segal, R.A. (2003) "Selectivity in neurotrophin signaling: theme and variations", Annu. Rev. Neurosci. 26, 299-330.
142. Shieh, P.B. and Ghosh, A. (1999) "Molecular mechanisms underlying activity-dependent regulation of BDNF expression", J. Neurobiol. 41, 127-134.
143. Shieh, P.B., et al. (1998) "Identification of a signaling pathway involved in calcium regulation of BDNF expression" , Neuron 20, 727-740.
144. Simonato, M., et al. (2002) "Dendritic targeting of mRNAs for plasticity genes in experimental models of temporal lobe epilepsy", Epilepsia 43(Suppl. 5), 153-158.
145. Sklar, P, et al. (2002) "Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor", Mol. Psychiatry 7, 579-593.
146. Smith, M.A., et al. (1995) "Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus", J. Neurosci. 15, 1768-1777.
147. Spires, T.L., et al. (2004) "Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism", J. Neurosci. 24, 2270-2276.
148. Takahashi, M., et al. (1999) "Patients with temporal lobe epilepsy show an increase in brain-derived neurotrophic factor protein and its correlation with neuropeptide Y", Brain Res. 818, 579-582.
149. Tanaka, T., Saito, H. and Matsuki, N. (1997) "Inhibition of GABAA synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus", J. Neurosci. 17, 2959-2966.
150. Tao, X., et al. (1998) "Ca2+influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism", Neuron 20, 709-726.
151. Tao, X., et al. (2002) "A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF", Neuron 33, 383-395.
152. Thakker-Varia, S., et al. (2001) "Rab3A is required for brain-derived neurotrophic factor-induced synaptic plasticity: transcriptional analysis at the population and single-cell levels", J. Neurosci. 21, 6782-6790.
153. Thompson, S.W., et al. (1999) "Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord", Proc. Natl Acad sci. USA 96, 7714-7718.
154. Timmusk, T., et al. (1993) "Multiple promoters direct tissue-specific expression of the rat BDNF gene", Neuron 10, 475-489.
155. Tolwani, R.J., et al. (2002) "BDNF overexpression increases dendrite complexity in hippocampal dentate gyrus", Neuroscience 114, 795-805.
156. Tsai, S.J. (2004) "Is mania caused by overactivity of central brain-derived neurotrophic factor?", Med. Hypotheses 62, 19-22.
157. Tyler, W.J., Perrett, S.P. and Pozzo-Miller, L.D. (2002) "The role of neurotrophins in neurotransmitter release", Neuroscientist 8, 524-531.
158. Wardle, R.A. and Poo, M.M. (2003) "Brain-derived neurotrophic factor modulation of GABAergic synapses by postsynaptic regulation of chloride transport", J. Neurosci. 23, 8722-8732.
159. Xu, B., et al. (2000) "The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB", J. Neurosci. 20, 6888-6897.
160. Xu, B., et al. (2003) "Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor", Nat. Neurosci. 6, 736-742.
161. Yacoubian, T.A. and Lo, D.C. (2000) "Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth", Nat. Neurosci. 3, 342-349.
162. Yamada, K. and Nabeshima, T. (2003) "Brain-derived neurotrophic factor/TrkB signaling in memory processes", J. Pharmacol. Sci. 91, 267-270.
163. Yan, Q., et al. (1997a) "Immunocytochemical localization of trkB in the central nervous system of the rat", J. Comp. Neurol. 378, 135-157.
164. Yan, Q., et al. (1997b) "Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system" , Neuroscience 78, 431-448.
165. Zaccaro, M.C., et al. (2001) "p75 Co-receptors regulate ligand-dependent and ligand-independent Trk receptor activation, in part by altering Trk docking subdomains", J. Biol. Chem. 276, 31023-31029.
166. Zigova, T., et al. (1998) "Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb", Mol. Cell Neurosci. 11, 234-245.
167. Zuccato, C., et al. (2001) "Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease" , Science 293, 493-498.
168. Zuccato, C., et al. (2003) "Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes", Nat. Genet. 35, 76-83.