Role of microtubules and MAPs during neuritogenesis

Intracellular Mechanisms for Neuritogenesis

Volumn , Issue , 2007, Pages 57-88

  Chilton, John K ^a   Gordon Weeks, Phillip R ^b  

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84900199580     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-68561-8_3     Document Type: Chapter

References (226)

1. Ahmad, F. J., Echeverri, C. J., Vallee, R. B., and Baas, P. W., 1998, Cytoplasmic dynein and dynactin are required for the transport of microtubules into the axon, J. Cell Biol. 140:391-401.
2. Akhmanova, A., and Hoogenraad, C. C., 2005, Microtubule plus-end-tracking proteins: Mechanisms and functions, Curr. Opin. Cell Biol. 17:47-54.
3. Akhmanova, A., Hoogenraad, C. C., Drabek, K., Stepanova, T., Dortland, B., Verkerk, T., et al., 2001, Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts, Cell 104:923-935.
4. Akhmanova, A., Mausset-Bonnefont, A. L., Van Cappellen, W., Keijzer, N., Hoogenraad, C. C., Stepanova, T., et al., 2005, The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis, Genes Dev. 19:2501-2515.
5. Amos, L. A., 2004, Microtubule structure and its stabilisation, Org. Biomol. Chem. 2:2153-2160.
6. Amos, L. A., and Schlieper, D., 2005, Microtubules and maps, Adv. Protein Chem. 71:257-298.
7. Arnal, I., Heichette, C., Diamantopoulos, G. S., and Chretien, D., 2004, CLIP-170/tubulin-curved oligomers coassemble at microtubule ends and promote rescues, Curr. Biol. 14:2086-2095.
8. Askham, J. M., Moncur, P., Markham, A. F., and Morrison, E. E., 2000, Regulation and function of the interaction between the APC tumour suppressor protein and EB1, Oncogene 19:1950-1958.
9. Askham, J. M., Vaughan, K. T., Goodson, H. V., and Morrison, E. E., 2002, Evidence that an interaction between EB1 and p150 (Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. Mol. Biol. Cell 13:3627-3645.
10. Baas, P. W., 1998, The role of motor proteins in establishing the microtubule arrays of axons and dendrites, J. Chem. Neuroanat. 14:175-180.
11. Baas, P. W., 2002, Microtubule transport in the axon, Int. Rev. Cytol. 212:41-62.
12. Baas, P. W., White, L. A., and Heidemann, S. R., 1987, Microtubule polarity reversal accompanies regrowth of amputated neuritis, Proc. Natl. Acad. Sci. USA 84:5272-5276.
13. Baas, P. W., Deitch, J. S., Black, M. M., and Banker, G. A., 1988, Polarity orientation of microtubules in hippocampal neurons: Uniformity in the axon and nonuniformity in the dendrite, Proc. Natl. Acad. Sci. USA 85:8335-8339.
14. Baas, P. W., Pienkowski, T. P., and Kosik, K. S., 1991, Processes induced by tau expression in Sf9 cells have an axon-like microtubule organization, J. Cell Biol. 115:1333-1344.
15. Bamburg, J. R., Bray, D., and Chapman, K., 1986, Assembly of microtubules at the tip of growing axons, Nature 321:788-790.
16. Barth, A. I., Siemers, K. A., and Nelson, W. J., 2002, Dissecting interactions between EB1, microtubules and APC in cortical clusters at the plasma membrane, J. Cell Sci. 115:1583-1590.
17. Bellugi, U., Lichtenberger, L., Mills, D., Galaburda, A., and Korenberg, J. R., 1999, Bridging cognition, the brain and molecular genetics: Evidence from Williams syndrome, Trends Neurosci. 22:197-207.
18. Bentley, D., and Toroian-Raymond, A., 1986, Disoriented pathfinding by pioneer neurone growth cones deprived of filopodia by cytochalasin treatment, Nature 323:712-715.
19. Berrueta, L., Kraeft, S. K., Tirnauer, J. S., Schuyler, S. C., Chen, L. B., Hill, D. E., et al., 1998, The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules, Proc. Natl. Acad. Sci. USA 95:10596-10601.
20. Bilbe, G., Delabie, J., Bruggen, J., Richener, H., Asselbergs, F. A., Cerletti, N., et al., 1992, Restin: A novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease, EMBO J. 11:2103-2113.
21. Billingsley, M. L., and Kincaid, R. L., 1997, Regulated phosphorylation and dephosphorylation of tau protein: Effects on microtubule interaction, intracellular trafficking and neurodegeneration, Biochem. J. 323:577-591.
22. Binder, L. I., Frankfurter, A., and Rebhun, L. I., 1985, The distribution of tau in the mammalian central nervous system, J. Cell Biol. 101:1371-1378.
23. Bouquet, C., Soares, S., Von Boxberg, Y., Ravaille-Veron, M., Propst, F., and Nothias, F., 2004, Microtubule-associated protein 1B controls directionality of growth cone migration and axonal branching in regeneration of adult dorsal root ganglia neurons, J. Neurosci. 24:7204-7213.
24. Bradke, F., and Dotti, C. G., 2000, Establishment of neuronal polarity: Lessons from cultured hippocampal neurons, Curr. Opin. Neurobiol. 10:574-581.
25. Brandt, R., and Leschik, J., 2004, Functional interactions of tau and their relevance for Alzheimer's disease, Curr. Alzheimer Res. 1:255-269.
26. Brandt, R., Leger, J., and Lee, G., 1995, Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain, J. Cell Biol. 131:1327-1340.
27. Bruckenstein, D. A., and Higgins, D., 1988, Morphological differentiation of embryonic rat sympathetic neurons in tissue culture. I. Conditions under which neurons form axons but not dendrites, Dev. Biol. 128:324-336.
28. Brugg, B., Reddy, D., and Matus, A., 1993, Attenuation of microtubule-associated protein 1B expression by antisense oligodeoxynucleotides inhibits initiation of neurite outgrowth, Neuroscience 52:489-496.
29. Bu, W., and Su, L. K., 2003, Characterization of functional domains of human EB1 family proteins, J. Biol. Chem. 278:49721-49731.
30. Buck, K. B., and Zheng, J. Q., 2002, Growth cone turning induced by direct local modification of microtubule dynamics, J. Neurosci. 22:9358-9367.
31. Caceres, A., and Kosik, K. S., 1990, Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons, Nature 343:461-463.
32. Caceres, A., Potrebic, S., and Kosik, K. S., 1991, The effect of tau antisense oligonucleotides on neurite formation of cultured cerebellar macroneurons, J. Neurosci. 11:1515-1523.
33. Cahana, A., Escamez, T., Nowakowski, R. S., Hayes, N. L., Giacobini, M., Von Holst, A., et al., 2001, Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization, Proc. Natl. Acad. Sci. USA 98:6429-6434.
34. Carvalho, P., Tirnauer, J. S., and Pellman, D., 2003, Surfing on microtubule ends, Trends Cell Biol. 13:229-237.
35. Caspi, M., Atlas, R., Kantor, A., Sapir, T., and Reiner, O., 2000, Interaction between LIS1 and doublecortin, two lissencephaly gene products, Hum. Mol. Genet. 9:2205-2213.
36. Cassimeris, L., Pryer, N. K., and Salmon, E. D., 1988, Real-time observations of microtubule dynamic instability in living cells, J. Cell Biol. 107:2223-2231.
37. Challacombe, J. F., Snow, D. M., and Letourneau, P. C., 1997, Dynamic microtubule ends are required for growth cone turning to avoid an inhibitory guidance cue, J. Neurosci. 17:3085-3095.
38. Chen, J., Kanai, Y., Cowan, N. J., and Hirokawa, N., 1992, Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons, Nature 360:674-677.
39. Chien, C. B., Rosenthal, D. E., Harris, W. A., and Holt, C. E., 1993, Navigational errors made by growth cones without filopodia in the embryonic Xenopus brain, Neuron 11:237-251.
40. Choi, J. H., Bertram, P. G., Drenan, R., Carvalho, J., Zhou, H. H., and Zheng, X. F., 2002, The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase, EMBO Rep. 3:988-994.
41. Chrétien, D., Fuller, S. D., and Karsenti, E., 1995, Structure of growing microtubule ends: Two-dimensional sheets close into tubes at variable rates, J. Cell Biol. 129:1311-1328.
42. Ciani, L., and Salinas, P. C., 2005, WNTs in the vertebrate nervous system: From patterning to neuronal connectivity, Nat. Rev. Neurosci. 6:351-362.
43. Coquelle, F. M., Caspi, M., Cordelieres, F. P., Dompierre, J. P., Dujardin, D. L., Koifman, C., et al., 2002, LIS1, CLIP-170's key to the dynein/dynactin pathway, Mol. Cell Biol. 22:3089-3102.
44. Craig, A. M., and Banker, G., 1994, Neuronal polarity, Annu. Rev. Neurosci. 17:267-310.
45. Dawson, H. N., Ferreira, A., Eyster, M. V., Ghoshal, N., Binder, L. I., and Vitek, M. P., 2001, Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice, J. Cell Sci. 114:1179-1187.
46. De Zeeuw, C. I., Hoogenraad, C. C., Goedknegt, E., Hertzberg, E., Neubauer, A., Grosveld, F., et al., 1997, CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies, Neuron 19:1187-1199.
47. Deka, J., Kuhlmann, J., and Muller, O., 1998, A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau, Eur. J. Biochem. 253:591-597.
48. Del Rio, J. A., Gonzalez-Billault, C., Urena, J. M., Jimenez, E. M., Barallobre, M. J., Pascual, M., et al., 2004, MAP1B is required for Netrin 1 signaling in neuronal migration and axonal guidance, Curr. Biol. 14:840-850.
49. Dent, E. W., and Gertler, F. B., 2003, Cytoskeletal dynamics and transport in growth cone motility and axon guidance, Neuron 40:209-227.
50. Dent, E. W., and Kalil, K., 2001, Axon branching requires interactions between dynamic microtubules and actin filaments, J. Neurosci. 21:9757-9769.
51. Dent, E. W., Callaway, J. L., Szebenyi, G., Baas, P. W., and Kalil, K., 1999, Reorganization and movement of microtubules in axonal growth cones and developing interstitial branches, J. Neurosci. 19:8894-8908.
52. Des Portes, V., Pinard, J. M., Billuart, P., Vinet, M. C., Koulakoff, A., Carrie, A., et al., 1998, A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome, Cell 92:51-61.
53. Diamantopoulos, G. S., Perez, F., Goodson, H. V., Batelier, G., Melki, R., Kreis, T. E., and Rickard, J. E., 1999, Dynamic localization of CLIP-170 to microtubule plus ends is coupled to microtubule assembly, J. Cell Biol. 144:99-112.
54. Di Tella, M., Feiguin, F., Morfini, G., and Caceres, A., 1994, Microfilament-associated growth cone component depends upon Tau for its intracellular localization, Cell Motil. Cytoskeleton 29:117-130.
55. Di Tella, M. C., Feiguin, F., Carri, N., Kosik, K. S., and Caceres, A., 1996, MAP-1B/TAU functional redundancy during laminin-enhanced axonal growth, J. Cell Sci. 109:467-477.
56. Dotti, C. G., and Banker, G. A., 1987, Experimentally induced alteration in the polarity of developing neurons, Nature 330:254-256.
57. Drubin, D. G., and Kirschner, M. W., 1986, Tau protein function in living cells, J. Cell Biol. 103:2739-2746.
58. Edelmann, W., Zervas, M., Costello, P., Roback, L., Fischer, I., Hammarback, J. A., et al., 1996, Neuronal abnormalities in microtubule- associated protein 1B mutant mice, Proc. Natl. Acad. Sci. USA 93:1270-1275.
59. Erck, C., Peris, L., Andrieux, A., Meissirel, C., Gruber, A. D., Vernet, M., et al., 2005, A vital role of tubulin-tyrosine-ligase for neuronal organization, Proc. Natl. Acad. Sci. USA 102:7853-7858.
60. Esmaeli-Azad, B., McCarty, J. H., and Feinstein, S. C., 1994, Sense and antisense transfection analysis of tau function: Tau influences net microtubule assembly, neurite outgrowth and neuritic stability, J. Cell Sci. 107:869-879.
61. Etienne-Manneville, S., and Hall, A., 2003, Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity, Nature 421:753-756.
62. Etienne-Manneville, S., Manneville, J. B., Nicholls, S., Ferenczi, M. A., and Hall, A., 2005, Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization, J. Cell Biol. 170:895-901.
63. Faulkner, N. E., Dujardin, D. L., Tai, C. Y., Vaughan, K. T., O'Connell, C. B., Wang, Y., et al., 2000, A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function, Nat. Cell Biol. 2:784-791.
64. Ferreira, A., Busciglio, J., and Caceres, A., 1989, Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: Evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau, Brain Res. Dev. Brain Res. 49:215-228.
65. Folker, E. S., Baker, B. M., and Goodson, H. V., 2005, Interactions between CLIP-170, Tubulin, and Microtubules: Implications for the Mechanism of CLIP-170 Plus-End Tracking Behavior, Mol. Biol. Cell 16:5373-5384.
66. Francis, F., Koulakoff, A., Boucher, D., Chafey, P., Schaar, B., Vinet, M. C., et al., 1999, Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons, Neuron 23:247-256.
67. Friocourt, G., Chafey, P., Billuart, P., Koulakoff, A., Vinet, M. C., Schaar, B. T., et al., 2001, Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system, Mol. Cell. Neurosci. 18:307-319.
68. Friocourt, G., Koulakoff, A., Chafey, P., Boucher, D., Fauchereau, F., Chelly, J., et al., 2003, Doublecortin functions at the extremities of growing neuronal processes, Cereb. Cortex 13:620-626.
69. Fukata, M., Watanabe, T., Noritake, J., Nakagawa, M., Yamaga, M., Kuroda, S., et al., 2002, Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170, Cell 109:873-885.
70. Gill, S. R., Schroer, T. A., Szilak, I., Steuer, E. R., Sheetz, M. P., and Cleveland, D. W., 1991, Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein, J. Cell Biol. 115:1639-1650.
71. Gleeson, J. G., Allen, K. M., Fox, J. W., Lamperti, E. D., Berkovic, S., Scheffer, I., et al., 1998, Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein, Cell 92:63-72.
72. Gleeson, J. G., Lin, P. T., Flanagan, L. A., and Walsh, C. A., 1999, Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons, Neuron 23:257-271.
73. Gleeson, J. G., Luo, R. F., Grant, P. E., Guerrini, R., Huttenlocher, P. R., Berg, M. J., et al., 2000, Genetic and neuroradiological heterogeneity of double cortex syndrome, Ann. Neurol. 47:265-269.
74. Gonzalez-Billault, C., and Avila, J., 2000, Molecular genetic approaches to microtubuleassociated protein function, Histol. Histopathol. 15:1177-1183.
75. Gonzalez-Billault, C., Avila, J., Caceres, A., 2001, Evidence for the role of MAPIB in axon formation. Mol. Biol. Cell 12:2087-2098.
76. Gonzalez-Billault, C., Demandt, E., Wandosell, F., Torres, M., Bonaldo, P., Stoykova, A., et al., 2000, Perinatal lethality of microtubule-associated protein 1B-deficient mice expressing alternative isoforms of the protein at low levels, Mol. Cell. Neurosci. 16:408-421.
77. Gonzalez-Billault, C., Owen, R., Gordon-Weeks, P. R., and Avila, J., 2002, Microtubuleassociated protein 1B is involved in the initial stages of axonogenesis in peripheral nervous system cultured neurons, Brain Res. 943:56-67.
78. Gonzalez-Billault, C., Jimenez-Mateos, E. M., Caceres, A., Diaz-Nido, J., Wandosell, F., and Avila, J., 2004, Microtubule-associated protein 1B function during normal development, regeneration, and pathological conditions in the nervous system, J. Neurobiol. 58:48-59.
79. Goode, B. L., Denis, P. E., Panda, D., Radeke, M. J., Miller, H. P., Wilson, L., and Feinstein, S. C., 1997, Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly, Mol. Biol. Cell 8:353-365.
80. Goodson, H. V., Skube, S. B., Stalder, R., Valetti, C., Kreis, T. E., Morrison, E. E., et al., 2003, CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms, Cell Motil. Cytoskeleton 55:156-173.
81. Goold, R. G., Owen, R., and Gordon-Weeks, P. R., 1999, Glycogen synthase kinase 3β phosphorylation of microtubule-associated protein 1B regulates the stability of microtubules in growth cones, J. Cell Sci. 112:3373-3384.
82. Gordon-Weeks, P. R., 2004, Microtubules and growth cone function, J. Neurobiol. 58:70-83.
83. Gordon-Weeks, P. R., 2005, Neuronal Growth Cones, Cambridge University Press, Cambridge.
84. Gordon-Weeks, P. R., and Fischer, I., 2000, MAP1B expression and microtubule stability in growing and regenerating axons, Microsc. Res. Tech. 48:63-74.
85. Gordon-Weeks, P. R., Mansfield, S. G., and Curran, I., 1989, Direct visualisation of the soluble pool of tubulin in the neuronal growth cone: Immunofluorescence studies following taxol polymerization, Brain Res. Dev. Brain Res. 49:305-310.
86. Graham, M. E., Ruma-Haynes, P., Capes-Davis, A. G., Dunn, J. M., Tan, T. C., Valova, V. A., et al., 2004, Multisite phosphorylation of doublecortin by cyclin-dependent kinase 5, Biochem. J. 381:471-481.
87. Gregory, S. L., and Brown, N. H., 1998, kakapo, a gene required for adhesion between and within cell layers in Drosophila, encodes a large cytoskeletal linker protein related to plectin and dystrophin, J. Cell Biol. 143:1271-1282.
88. Griparic, L., and Keller, T. C., 1998, Identification and expression of two novel CLIP-170/Restin isoforms expressed predominantly in muscle, Biochim. Biophys. Acta 1405:35-46.
89. Griparic, L., and Keller, T. C., III, 1999, Differential usage of two 5' splice sites in a complex exon generates additional protein sequence complexity in chicken CLIP-170 isoforms, Biochim. Biophys. Acta 1449:119-124.
90. Griparic, L., Volosky, J. M., and Keller, T. C., III, 1998, Cloning and expression of chicken CLIP-170 and restin isoforms, Gene 206:195-208.
91. Groden, J., Thliveris, A., Samowitz, W., Carlson, M., Gelbert, L., Albertsen, H., et al., 1991, Identification and characterization of the familial adenomatous polyposis coli gene, Cell 66:589-600.
92. Guan, K. L., and Rao, Y., 2003, Signalling mechanisms mediating neuronal responses to guidance cues, Nat. Rev. Neurosci. 4:941-956.
93. Gustke, N., Trinczek, B., Biernat, J., Mandelkow, E. M., and Mandelkow, E., 1994, Domains of tau protein and interactions with microtubules, Biochemistry 33:9511-9522.
94. Hahn, C. M., Kleinholz, H., Koester, M. P., Grieser, S., Thelen, K., and Pollerberg, G. E., 2005, Role of cyclin-dependent kinase 5 and its activator P35 in local axon and growth cone stabilization, Neuroscience 134:449-465.
95. Hall, A. C., Lucas, F. R., and Salinas, P. C., 2000, Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling, Cell 100:525-535.
96. Hall, A. C., Brennan, A., Goold, R. G., Cleverley, K., Lucas, F. R., Gordon-Weeks, P. R. et al., 2002, Valproate regulates GSK-3-mediated axonal remodelling and synapsin I clustering in developing neurons, Mol. Cell. Neurosc. 20:257-270.
97. Hammarback, J. A., Obar, R. A., Hughes, S. M., and Vallee, R. B., 1991, MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain, Neuron 7:129-139.
98. Hanemaaijer, R., and Ginzburg, I., 1991, Involvement of mature tau isoforms in the stabilization of neurites in PC12 cells, J. Neurosci. Res. 30:163-171.
99. Hanley, J. G., Koulen, P., Bedford, F., Gordon-Weeks, P. R., and Moss, S. J., 1999, The protein MAP-1B links GABA (C) receptors to the cytoskeleton at retinal synapses, Nature 397:66-69.
100. Harada, A., Oguchi, K., Okabe, S., Kuno, J., Terada, S., Ohshima, T., et al., 1994, Altered microtubule organization in small-calibre axons of mice lacking tau protein, Nature 369:488-491.
101. Harte, P. J., and Kankel, D. R., 1982, Genetic analysis of mutations at the Glued locus and interacting loci in Drosophila melanogaster, Genetics 101:477-501.
102. Hattori, M., Adachi, H., Tsujimoto, M., Arai, H., and Inoue, K., 1994, Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected], Nature 370:216-218.
103. Hayashi, I., and Ikura, M., 2003, Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1(EB1), J. Biol. Chem. 278:36430-36434.
104. Hayashi, I., Wilde, A., Mal, T. K., and Ikura, M. 2005, Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex, Mol. Cell 19:449-460.
105. Hayden, J. H., Bowser, S. S., and Rieder, C. L., 1990, Kinetochores capture astral microtubules during chromosome attachment to the mitotic spindle: Direct visualization in live newt lung cells, J. Cell Biol. 111:1039-1045.
106. He, Y., Francis, F., Myers, K. A., Yu, W., Black, M. M., and Baas, P. W., 2005, Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments, J. Cell Biol. 168:697-703.
107. Heidemann, S. R., Landers, J. M., and Hamborg, M. A., 1981, Polarity orientation of axonal microtubules, J. Cell Biol. 91:61-665.
108. Holzbaur, E. L., Hammarback, J. A., Paschal, B. M., Kravit, N. G., Pfister, K. K., and Vallee, R. B., 1991, Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued, Nature 351:579-583.
109. Honnappa, S., John, C. M., Kostrewa, D., Winkler, F. K., and Steinmetz, M. O., 2005, Structural insights into the EB1-APC interaction, EMBO J. 24:261-269.
110. Hoogenraad, C. C., Akhmanova, A., Grosveld, F., De Zeeuw, C. I., and Galjart, N., 2000, Functional analysis of CLIP-115 and its binding to microtubules, J. Cell Sci. 113:2285-2297.
111. Hoogenraad, C. C., Koekkoek, B., Akhmanova, A., Krugers, H., Dortland, B., Miedema, M., et al., 2002, Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice, Nat. Genet. 32:116-127.
112. Hoogenraad, C. C., Akhmanova, A., Galjart, N., and De Zeeuw, C. I., 2004, LIMK1 and CLIP-115: Linking cytoskeletal defects to Williams syndrome, Bioessays 26:141-150.
113. Horesh, D., Sapir, T., Francis, F., Wolf, S. G., Caspi, M., Elbaum, M., et al., 1999, Doublecortin, a stabilizer of microtubules, Hum. Mol. Genet. 8:1599-1610.
114. Horio, T., and Hotani, H., 1986, Visualization of the dynamic instability of individual microtubules by dark-field microscopy, Nature 321:605-607.
115. Howard, J., and Hyman, A. A., 2003, Dynamics and mechanics of the microtubule plus end, Nature 422:753-758.
116. Inoue, Y. H., Do Carmo, A. M., Shiraki, M., Deak, P., Yamaguchi, M., Nishimoto, Y., et al., 2000, Orbit, a novel microtubule-associated protein essential for mitosis in Drosophila melanogaster, J. Cell Biol. 149:153-166.
117. Jacobson, M., 1991, Developmental Neurobiology, Plenum, New York.
118. Jimbo, T., Kawasaki, Y., Koyama, R., Sato, R., Takada, S., Haraguchi, K., et al., 2002, Identification of a link between the tumour suppressor APC and the kinesin superfamily, Nat. Cell Biol. 4:323-327.
119. Jimenez-Mateos, E. M., Wandosell, F., Reiner, O., Avila, J., and Gonzalez-Billault, C., 2005a, Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1, Biochem. J. 389:333-341.
120. Jimenez-Mateos, E. M., Paglini, G., Gonzalez-Billault, C., Caceres, A., and Avila, J., 2005b, End binding protein-1 (EB1) complements microtubule-associated protein-1B during axonogenesis, J. Neurosci. Res. 80:350-359.
121. Juwana, J. P., Henderikx, P., Mischo, A., Wadle, A., Fadle, N., Gerlach, K., et al., 1999, EB/RP gene family encodes tubulin binding proteins, Int. J. Cancer 81:275-284.
122. Kalil, K., and Dent, E. W., 2005, Touch and go: Guidance cues signal to the growth cone cytoskeleton, Curr. Opin. Neurobiol. 15:521-526.
123. Kanai, Y., Takemura, R., Oshima, T., Mori, H., Ihara, Y., Yanagisawa, M., et al., 1989, Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA, J. Cell Biol. 109:1173-1184.
124. Kato, M., and Dobyns, W. B., 2003, Lissencephaly and the molecular basis of neuronal migration, Hum. Mol. Genet. 12:R89-R96.
125. Kawakami, S., Muramoto, K., Ichikawa, M., and Kuroda, Y., 2003, Localization of microtubule-associated protein (MAP) 1B in the postsynaptic densities of the rat cerebral cortex, Cell Mol. Neurobiol. 23:887-894.
126. Keith, C. H., 1990, Neurite elongation is blocked if microtubule polymerization is inhibited in PC12 cells, Cell Motil. Cytoskeleton 17:95-105.
127. Kim, M. H., Cierpicki, T., Derewenda, U., Krowarsch, D., Feng, Y., Devedjiev, Y., et al., 2003, The DCX-domain tandems of doublecortin and doublecortin-like kinase, Nat. Struct. Mol. Biol. 10:324-333.
128. Kirschner, M. W., and Mitchison, T., 1986a, Beyond self-assembly: From microtubules to morphogenesis, Cell 45:329-342.
129. Kirschner, M. W., and Mitchison, T., 1986b, Microtubule dynamics, Nature 324:621.
130. Knops, J., Kosik, K. S., Lee, G., Pardee, J. D., Cohen, G. L., and McConlogue, L., 1991, Overexpression of tau in a non-neuronal cell induces long cellular processes, J. Cell Biol. 114:725-732.
131. Kodama, A., Karakesisoglou, I., Wong, E., Vaezi, A., and Fuchs, E., 2003, ACF7: An essential integrator of microtubule dynamics, Cell 115:343-354.
132. Komarova, Y. A., Akhmanova, A. S., Kojima, S., Galjart, N., and Borisy, G. G., 2002, Cytoplasmic linker proteins promote microtubule rescue in vivo, J. Cell Biol. 159:589-599.
133. Komarova, Y., Lansbergen, G., Galjart, N., Grosveld, F., Borisy, G. G., and Akhmanova, A., 2005, EB1 and EB3 Control CLIP Dissociation from the Ends of Growing Microtubules, Mol. Biol. Cell 16:5334-5345.
134. Kosik, K. S., and Finch, E. A., 1987, MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: An immunocytochemical study of cultured rat cerebrum, J. Neurosci. 7:3142-3153.
135. La Monte, B. H., Wallace, K. E., Holloway, B. A., Shelly, S. S., Ascano, J., Tokito, M., et al., 2002, Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration, Neuron 34:715-727.
136. Langkopf, A., Hammarback, J. A., Muller, R., Vallee, R. B., and Garner, C. C., 1992, Microtubule-associated proteins 1A and LC2. Two proteins encoded in one messenger RNA, J. Biol. Chem. 267:16561-16566.
137. Lansbergen, G., Komarova, Y., Modesti, M., Wyman, C., Hoogenraad, C. C., Goodson, H. V., et al., 2004, Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization, J. Cell Biol. 166:1003-1014.
138. Le Clerc, N., Baas, P. W., Garner, C. C., and Kosik, K. S., 1996, Juvenile and mature MAP2 isoforms induce distinct patterns of process outgrowth, Mol. Biol. Cell 7:443-455.
139. Lee, G., and Brandt, R., 1992, Microtubule-bundling studies revisited: Is there a role for MAPs? Trends Cell Biol. 2:286-289.
140. Lee, G., and Rook, S. L., 1992, Expression of tau protein in non-neuronal cells: Microtubule binding and stabilization, J. Cell Sci. 102:227-237.
141. Lee, H., Engel, U., Rusch, J., Scherrer, S., Sheard, K., and Van Vactor, D., 2004, The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance, Neuron 42:913-926.
142. Lein, P., Johnson, M., Guo, X., Rueger, D., and Higgins, D., 1995, Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons, Neuron 15:597-605.
143. Lein, P., Guo, X., Hedges, A. M., Rueger, D., Johnson, M., and Higgins, D., 1996, The effects of extracellular matrix and osteogenic protein-1 on the morphological differentiation of rat sympathetic neurons, Int. J. Dev. Neurosci. 14:203-215.
144. Lemos, C. L., Sampaio, P., Maiato, H., Costa, M., Omel'yanchuk, L. V., Liberal, V., and Sunkel, C. E., 2000, Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization, EMBO J. 19:3668-3682.
145. Li, S., Finley, J., Liu, Z. J., Qiu, S. H., Chen, H., Luan, C. H., et al., 2002, Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain, J. Biol. Chem. 277:48596-48601.
146. Ligon, L. A., Shelly, S. S., Tokito, M., and Holzbaur, E. L., 2003, The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization, Mol. Biol. Cell 14:1405-1417.
147. Liu, C. W., Lee, G., and Jay, D. G., 1999, Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons, Cell Motil. Cytoskeleton 43:232-242.
148. Liu, J. J., Ding, J., Kowal, A. S., Nardine, T., Allen, E., Delcroix, J. D., et al., 2003, BPAG1n4 is essential for retrograde axonal transport in sensory neurons, J. Cell Biol. 163:223-229.
149. Lucas, F. R., and Salinas, P. C., 1997, WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons, Dev. Biol. 192:31-44.
150. Lucas, F. R., Goold, R. G., Gordon-Weeks, P. R., and Salinas, P. C., 1998, Inhibition of GSK-3β leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium, J. Cell Sci. 111:1351-1361.
151. Ma, Y., Shakiryanova, D., Vardya, I., and Popov, S. V., 2004, Quantitative analysis of microtubule transport in growing nerve processes, Curr. Biol. 14:725-730.
152. Mack, T. G., Koester, M. P., and Pollerberg, G. E., 2000, The microtubule-associated protein MAP1B is involved in local stabilization of turning growth cones, Mol. Cell. Neurosci. 15:51-65.
153. Mandell, J. W., and Banker, G. A., 1996, A spatial gradient of tau protein phosphorylation in nascent axons, J. Neurosci. 16:5727-5740.
154. Mann, S. S., and Hammarback, J. A., 1994, Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B, J. Biol. Chem. 269:11492-11497.
155. Meixner, A., Haverkamp, S., Wassle, H., Fuhrer, S., Thalhammer, J., Kropf, N., et al., 2000, MAP1B is required for axon guidance and is involved in the development of the central and peripheral nervous system, J. Cell Biol. 151:1169-1178.
156. Mimori-Kiyosue, Y., Shiina, N., and Tsukita, S., 2000a, Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells, J. Cell Biol. 148:505-518.
157. Mimori-Kiyosue, Y., Shiina, N., and Tsukita, S., 2000b, The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules, Curr. Biol. 10:865-868.
158. Mimori-Kiyosue, Y., Grigoriev, I., Lansbergen, G., Sasaki, H., Matsui, C., Severin, F., et al., 2005, CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex, J. Cell Biol. 168:141-153.
159. Mitchison, T., and Kirschner, M. W., 1984a, Microtubule assembly nucleated by isolated centromeres, Nature 312:232-237.
160. Mitchison, T., and Kirschner, M. W., 1984b, Dynamic instability of microtubule growth, Nature 312:237-242.
161. Moores, C. A., Perderiset, M., Francis, F., Chelly, J., Houdusse, A., and Milligan, R. A., 2004, Mechanism of microtubule stabilization by doublecortin, Mol. Cell 14:833-839.
162. Morrison, E. E., Wardleworth, B. N., Askham, J. M., Markham, A. F., and Meredith, D. M., 1998, EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle, Oncogene 17:3471-3477.
163. Morrison, E. E., Moncur, P. M., and Askham, J. M., 2002, EB1 identifies sites of microtubule polymerisation during neurite development, Brain Res. Mol. Brain Res. 98:145-152.
164. Munch, C., Sedlmeier, R., Meyer, T., Homberg, V., Sperfeld, A. D., Kurt, A., et al., 2004, Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS, Neurology 63:724-726.
165. Munch, C., Rosenbohm, A., Sperfeld, A. D., Uttner, I., Reske, S., Krause, B. J., et al., 2005, Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD, Ann. Neurol. 58:777-780.
166. Munemitsu, S., Souza, B., Muller, O., Albert, I., Rubinfeld, B., and Polakis, P., 1994, The APC gene product associates with microtubules in vivo and promotes their assembly in vitro, Cancer Res. 54:3676-3681.
167. Nakagawa, H., Koyama, K., Murata, Y., Morito, M., Akiyama, T., and Nakamura, Y., 2000, EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue, Oncogene 19:210-216.
168. Nakamura, M., Zhou, X. Z., and Lu, K. P., 2001, Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization, Curr. Biol. 11:1062-1067.
169. Nathke, I. S., 2004, The adenomatous polyposis coli protein: The Achilles heel of the gut epithelium, Annu. Rev. Cell Dev. Biol. 20:337-366.
170. Noble, M., Lewis, S. A., and Cowan, J., 1989, The microtubule binding domain of the microtubule-associated protein MAP-1B contains a repeated sequence motif unrelated to that of MAP-2 and tau, J. Cell Biol. 109:3367-3376.
171. Noiges, R., Eichinger, R., Kutschera, W., Fischer, I., Nemeth, Z., Wiche, G., et al., 2002, Microtubule-associated protein 1A (MAP1A) and MAP1B: Light chains determine distinct functional properties, J. Neurosci. 22:2106-2114.
172. Owen, R., and Gordon-Weeks, P. R., 2003, Inhibition of glycogen synthase kinase 3β in sensory neurons in culture alters actin filament and microtubule dynamics in growth cones, Mol. Cell. Neurosci. 23:626-637.
173. Perez, F., Diamantopoulos, G. S., Stalder, R., and Kreis, T. E., 1999, CLIP-170 highlights growing microtubule ends in vivo, Cell 96:517-527.
174. Pierre, P., Scheel, J., Rickard, J. E., and Kreis, T. E., 1992, CLIP-170 links endocytic vesicles to microtubules, Cell 70:887-900.
175. Pierre, P., Pepperkok, R., and Kreis, T. E., 1994, Molecular characterization of two functional domains of CLIP-170 in vivo, J. Cell Sci. 107:1909-1920.
176. Powell, S. K., Rivas, R. J., Rodriguez-Boulan, E., and Hatten, M. E., 1997, Development of polarity in cerebellar granule neurons, J. Neurobiol. 32:223-236.
177. Preuss, U., Biernat, J., Mandelkow, E. M., and Mandelkow, E., 1997, The 'jaws' model of tau-microtubule interaction examined in CHO cells, J. Cell Sci. 110:789-800.
178. Prokop, A., Uhler, J., Roote, J., and Bate, M., 1998, The kakapo mutation affects terminal arborization and central dendritic sprouting of Drosophila motorneurons, J. Cell Biol. 143:1283-1294.
179. Reiner, O., Carrozzo, R., Shen, Y., Wehnert, M., Faustinella, F., Dobyns, W. B., et al., 1993, Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats, Nature 364:717-721.
180. Renner, C., Pfitzenmeier, J. P., Gerlach, K., Held, G., Ohnesorge, S., Sahin, U., et al., 1997, RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells, J. Immunol. 159:1276-1283.
181. Rickard, J. E., and Kreis, T. E., 1990, Identification of a novel nucleotide-sensitive microtubule-binding protein in HeLa cells, J. Cell Biol. 110:1623-1633.
182. Roberts, A., 1988, The early development of neurons in Xenopus embryos revelaed by transmitter immunocytochemistry for serotonin, GABA and glycine, in: Developmental Neurobiology of the Frog, E. D. Pollack, and H. D. Bibb, eds., Alan R. Liss, New York, pp. 191-205.
183. Roper, K., Gregory, S. L., and Brown, N. H., 2002, The 'spectraplakins': Cytoskeletal giants with characteristics of both spectrin and plakin families, J. Cell Sci. 115:4215-4225.
184. Sammak, P. J., and Borisy, G. G., 1988, Direct observation of microtubule dynamics in living cells, Nature 332:724-726.
185. Sapir, T., Elbaum, M., and Reiner, O., 1997, Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit, EMBO J. 16:6977-6984.
186. Sapir, T., Cahana, A., Seger, R., Nekhai, S., and Reiner, O., 1999, LIS1 is a microtubuleassociated phosphoprotein, Eur. J. Biochem. 265:181-188.
187. Schaar, B. T., Kinoshita, K., and McConnell, S. K., 2004, Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons, Neuron 41:203-213.
188. Schafer, D. A., Gill, S. R., Cooper, J. A., Heuser, J. E., and Schroer, T. A., 1994, Ultrastructural analysis of the dynactin complex: An actin-related protein is a component of a filament that resembles F-actin, J. Cell Biol. 126:403-412.
189. Schaefer, A. W., Kabir, N., and Forscher, P., 2002, Filopodia and actin arcs guide the assembly and transport of two populations of microtubules with unique dynamic parameters in neuronal growth cones, J. Cell Biol. 158:139-152.
190. Scheel, J., Pierre, P., Rickard, J. E., Diamantopoulos, G. S., Valetti, C., Van Der Goot, F. G., et al., 1999, Purification and analysis of authentic CLIP-170 and recombinant fragments, J. Biol. Chem. 274:25883-25891.
191. Shea, T. B., Beermann, M. L., Nixon, R. A., and Fischer, I. 1992, Microtubule-associated protein tau is required for axonal neurite elaboration by neuroblastoma cells, J. Neurosci. Res. 32:363-374.
192. Shi, S. H., Cheng, T., Jan, L. Y., and Jan, Y. N., 2004, APC and GSK-3β are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity, Curr. Biol. 14:2025-2032.
193. Shimomura, A., Kohu, K., Akiyama, T., and Senda, T., 2005, Subcellular localization of the tumor suppressor protein APC in developing cultured neurons, Neurosci. Lett. 375:81-86.
194. Slep, K. C., Rogers, S. L., Elliott, S. L., Ohkura, H., Kolodziej, P. A., and Vale, R. D., 2005, Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end, J. Cell Biol. 168:587-598.
195. Smith, D. S., Niethammer, M., Ayala, R., Zhou, Y., Gambello, M. J., Wynshaw-Boris, A., and Tsai, L. H., 2000, Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1, Nat. Cell Biol. 2:767-775.
196. Stepanova, T., Slemmer, J., Hoogenraad, C. C., Lansbergen, G., Dortland, B., De Zeeuw, C. I., et al., 2003, Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein), J. Neurosci. 23:2655-2664.
197. Su, L. K., and Qi, Y., 2001, Characterization of human MAPRE genes and their proteins, Genomics 71:142-149.
198. Su, L. K., Burrell, M., Hill, D. E., Gyuris, J., Brent, R., Wiltshire, R. et al., 1995, APC binds to the novel protein EB1, Cancer Res. 55:2972-2977.
199. Subramanian, A., Prokop, A., Yamamoto, M., Sugimura, K., Uemura, T., Betschinger, J., et al., 2003, Shortstop recruits EB1/APC1 and promotes microtubule assembly at the muscle-tendon junction, Curr. Biol. 13:1086-1095.
200. Takahashi, M., Yasutake, K., and Tomizawa, K., 1999, Lithium inhibits neurite growth and tau protein kinase I/glycogen synthase kinase-3β- dependent phosphorylation of juvenile tau in cultured hippocampal neurons, J. Neurochem. 73:2073-2083.
201. Takei, Y., Kondo, S., Harada, A., Inomata, S., Noda, T., and Hirokawa, N., 1997, Delayed development of nervous system in mice homozygous for disrupted microtubule-associated protein 1B (MAP1B) gene, J. Cell Biol. 137:1615-1626.
202. Takei, Y., Teng, J., Harada, A., and Hirokawa, N., 2000, Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes, J. Cell Biol. 150:989-1000.
203. Takemura, R., Okabe, S., Umeyama, T., Kanai, Y., Cowan, N. J., and Hirokawa, N., 1992, Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B, MAP2 or tau, J. Cell Sci. 103:953-964.
204. Tanaka, E., and Kirschner, M. W., 1995, The role of microtubules in growth cone turning at substrate boundaries, J. Cell Biol. 128:127-137.
205. Tanaka, E., Ho, T., and Kirschner, M. W., 1995, The role of microtubule dynamics in growth cone motility and axonal growth, J. Cell Biol. 128:139-155.
206. Tanaka, T., Serneo, F. F., Tseng, H. C., Kulkarni, A. B., Tsai, L. H., and Gleeson, J. G., 2004, Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration, Neuron 41:215-227.
207. Teichman-Weinberg, A., Littauer, U. Z., and Ginzburg, I., 1988, The inhibition of neurite outgrowth in PC12 cells by tubulin antisense oligodeoxyribonucleotides, Gene 72:297-307.
208. Teng, J., Takei, Y., Harada, A., Nakata, T., Chen, J., and Hirokawa, N., 2001, Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization, J. Cell Biol. 155:65-76.
209. Tint, I., Slaughter, T., Fischer, I., and Black, M. M., 1998, Acute inactivation of tau has no effect on dynamics of microtubules in growing axons of cultured sympathetic neurons, J. Neurosci. 18:8660-8673.
210. Tirnauer, J. S. and Bierer, B. E., 2000, EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability, J. Cell Biol. 149:761-766.
211. Tirnauer, J. S., Grego, S., Salmon, E. D., and Mitchison, T. J., 2002, EB1-microtubule interactions in Xenopus egg extracts: Role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules, Mol. Biol. Cell 13:3614-3626.
212. Togel, M., Wiche, G., and Propst, F., 1998, Novel features of the light chain of microtubule-associated protein MAP1B: Microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain, J. Cell Biol. 143:695-707.
213. Trivedi, N., Marsh, P., Goold, R. G., Wood-Kaczmar, A., and Gordon-Weeks, P. R., 2005, Glycogen synthase kinase-3β phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons, J. Cell Sci. 118:993-1005.
214. Vale, R. D., 2003, The molecular motor toolbox for intracellular transport, Cell 112:467-480.
215. Vandecandelaere, A., Pedrotti, B., Utton, M. A., Calvert, R. A., and Bayley, P. M., 1996, Differences in the regulation of microtubule dynamics by microtubule-associated proteins MAP1B and MAP2, Cell Motil. Cytoskeleton 35:134-146.
216. Vaughan, K. T., Tynan, S. H., Faulkner, N. E., Echeverri, C. J., and Vallee, R. B., 1999, Colocalization of cytoplasmic dynein with dynactin and CLIP-170 at microtubule distal ends, J. Cell Sci. 112:1437-1447.
217. Vaughan, P. S., Miura, P., Henderson, M., Byrne, B., and Vaughan, K. T., 2002, A role for regulated binding of p150 (Glued) to microtubule plus ends in organelle transport, J. Cell Biol. 158:305-319.
218. Watanabe, T., Wang, S., Noritake, J., Sato, K., Fukata, M., Takefuji, M., et al., 2004, Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration, Dev. Cell 7:871-883.
219. Wen, Y., Eng, C. H., Schmoranzer, J., Cabrera-Poch, N., Morris, E. J., Chen, M., et al., 2004, EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration, Nat. Cell Biol. 6:820-830.
220. Wiggin, G. R., Fawcett, J. P., and Pawson, T., 2005, Polarity proteins in axon specification and synaptogenesis, Dev. Cell 8:803-816.
221. Williamson, T. W., Gordon-Weeks, P. R., Schachner, M., and Taylor, J., 1996, Microtubule reorganization is obligatory for growth cone turning, Proc. Natl. Acad. Sci. USA 93:15221-15226.
222. Wu, X. S., Tsan, G. L., and Hammer, J. A., III, 2005, Melanophilin and myosin Va track the microtubule plus end on EB1, J. Cell Biol. 171:201-207.
223. Zauner, W., Kratz, J., Staunton, J., Feick, P., and Wiche, G., 1992, Identification of two distinct microtubule binding domains on recombinant rat MAP 1B, Eur. J. Cell Biol. 57:66-74.
224. Zhou, F. Q., Waterman-Storer, C. M., and Cohan, C. S., 2002, Focal loss of actin bundles causes microtubule redistribution and growth cone turning, J. Cell Biol. 157:839-849.
225. Zhou, F. Q., Zhou, J., Dedhar, S., Wu, Y. H., and Snider, W. D., 2004, NGF-induced axon growth is mediated by localized inactivation of GSK-3β and functions of the microtubule plus end binding protein APC, Neuron 42:897-912.
226. Zumbrunn, J., Kinoshita, K., Hyman, A. A., and Nathke, I. S., 2001, Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation, Curr. Biol. 11:44-49..