Filopodia and actin arcs guide the assembly and transport of two populations of microtubules with unique dynamic parameters in neuronal growth cones

Journal of Cell Biology

Volumn 158, Issue 1, 2002, Pages 139-152

  Schaefer, Andrew W ^a   Kabir, Nurul ^a   Forscher, Paul ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Actin; Axon outgrowth; Dynamics; Growth cone; Microtubules

Indexed keywords

ACTIN; F ACTIN; POLYMER;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; DYNAMICS; FILOPODIUM; FLUORESCENCE MICROSCOPY; GROWTH CONE; MICROTUBULE; NERVE CELL GROWTH; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN TRANSPORT;

ACTINS; ANIMALS; APLYSIA; GROWTH CONES; IMMUNOHISTOCHEMISTRY; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MICROTUBULES; NEURONS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PSEUDOPODIA; TIME FACTORS;

ANIMALIA;

EID: 0037043343     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200203038     Document Type: Article

References (46)

1. Microtubule transport in the axon
2. Disoriented pathfinding by pioneer neurone growth cones deprived of filopodia by cytochalasin treatment
3. Mechanical tension produced by nerve cells in tissue culture
4. An analysis of an axonal gradient of phosphorylated MAP 1B in cultured rat sensory neutons
5. Actin filament bundles are required for microtubule reorientation during growth cone turning to avoid an inhibitory guidance cue
6. Dynamic microtubule ends are required for growth cone turning to avoid an inhibitory guidance cue
7. A sensory role for neuronal growth cone filopodia
8. Kinetics and thermodynamics of phalloidin binding to actin filaments from three divergent species
9. Axon branching requires interactions between dynamic microtubules and actin filaments
10. Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone
11. Cytoplasmic actin filaments move particles on the surface of a neuronal growth cone
12. Cyclic AMP induces changes in distribution and transport of organelles within growth cones of Aplysia bag cell neurons
13. Novel form of growth cone motility involving site-directed actin filament assembly
14. Filopodial calcium transients promote substrate-dependent growth cone turning
15. Evidence for microtubule capture by filopodial actin filaments in growth cones
16. Behaviour and structure of the leading lamella in moving fibroblasts. I. Occurrence and centripetal movement of arc-shaped microfilament bundles beneath the dorsal cell surface
17. Protein kinase C activation promotes microtubule advance in neuronal growth cones by increasing average microtubule growth lifetimes
18. Motor-cargo interactions: The key to transport specificity
19. Microtubule targeting of substrate contacts promotes their relaxation and dissociation
20. Beyond self-assembly: From microtubules to morphogenesis
21. Direct evidence that growth cones pull
22. Differences in the organization of actin in the growth cones compared with the neurites of cultured neurons from chick embryos
23. Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarity
24. Cytoskeletal remodeling during growth cone-target interactions
25. Growth cone advance is inversely proportional to retrograde F-actin flow
26. Cytoskeletal reorganization underlying growth cone motility
27. Myosin drives retrograde F-actin flow in neuronal growth cones
28. Growth of neurites without filopodial or lamellipodial activity in the presence of cytochalasin B
29. Dynamic instability of microtubule growth
30. Accumulation of actin in subsets of pioneer growth cone filopodia in response to neural and epithelial guidance cues in situ
31. Microtubule stability decreases axon elongation but not axoplasm production
32. Polymerizing microtubules activate site-directed F-actin assembly in nerve growth cones
33. Microtubule behavior during guidance of pioneer neuron growth cones in situ
34. Dual-wavelength fluorescent speckle microscopy reveals coupling of microtubule and actin movements in migrating cells
35. The lamellipodium: Where motility begins
36. Signal transduction underlying growth cone guidance by diffusible factors
37. The Ig superfamily cell adhesion molecule, apCAM, mediates growth cone steering by substrate-cytoskeletal coupling
38. Substrate-cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidance
39. Improved procedures for electron microscopic visualization of the cytoskeleton of cultured cells
40. The role of microtubules in growth cone turning at substrate boundaries
41. The role of microtubule dynamics in growth cone motility and axonal growth
42. Actomyosin-based retrograde flow of microtubules in the lamella of migrating epithelial cells influences microtubule dynamic instability and turnover and is associated with microtubule breakage and treadmilling
43. How microtubules get fluorescent speckles
44. Fluorescent speckle microscopy, a method to visualize the dynamics of protein assemblies in living cells
45. Microtubule reorganization is obligatory for growth cone turning
46. Myosin V orientates the mitotic spindle in yaest