메뉴 건너뛰기




Volumn , Issue , 2010, Pages 137-170

Vitronectin-binding integrins in cancer

Author keywords

cell adhesion; cell migration; extracellular matrix; Key word: Angiogenesis; metastasis

Indexed keywords


EID: 84900083790     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-0814-8_7     Document Type: Chapter
Times cited : (4)

References (183)
  • 1
    • 16844381981 scopus 로고    scopus 로고
    • Threedimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin
    • Adair BD, Xiong JP, Maddock C, Goodman SL, Arnaout MA, Yeager M (2005) Threedimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin. J Cell Biol 168:1109-1118
    • (2005) J Cell Biol , vol.168 , pp. 1109-1118
    • Adair, B.D.1    Xiong, J.P.2    Maddock, C.3    Goodman, S.L.4    Arnaout, M.A.5    Yeager, M.6
  • 2
    • 0036007394 scopus 로고    scopus 로고
    • Association between alphavbeta6 integrin expression, elevated p42/44 kDa MAPK, and plasminogen-dependent matrix degradation in ovarian cancer
    • Ahmed N, Pansino F, Baker M, Rice G, Quinn M (2002) Association between alphavbeta6 integrin expression, elevated p42/44 kDa MAPK, and plasminogen-dependent matrix degradation in ovarian cancer. J Cell Biochem 84:675-686
    • (2002) J Cell Biochem , vol.84 , pp. 675-686
    • Ahmed, N.1    Pansino, F.2    Baker, M.3    Rice, G.4    Quinn, M.5
  • 3
    • 0034695929 scopus 로고    scopus 로고
    • Tissue transglutaminase is an integrinbinding adhesion coreceptor for fibronectin
    • Akimov SS, Krylov D, Fleischman LF, Belkin AM (2000) Tissue transglutaminase is an integrinbinding adhesion coreceptor for fibronectin. J Cell Biol 148:825-838
    • (2000) J Cell Biol , vol.148 , pp. 825-838
    • Akimov, S.S.1    Krylov, D.2    Fleischman, L.F.3    Belkin, A.M.4
  • 4
    • 0038724937 scopus 로고    scopus 로고
    • Role of Raf in vascular protection from distinct apoptotic stimuli
    • Alavi A, Hood JD, Frausto R, Stupack DG, Cheresh DA (2003) Role of Raf in vascular protection from distinct apoptotic stimuli. Science 301:94-96
    • (2003) Science , vol.301 , pp. 94-96
    • Alavi, A.1    Hood, J.D.2    Frausto, R.3    Stupack, D.G.4    Cheresh, D.A.5
  • 6
    • 0035809182 scopus 로고    scopus 로고
    • Matrix attachment regulates Fas-induced apoptosis in endothelial cells: A role for c-flip and implications for anoikis
    • Aoudjit F, Vuori K (2001) Matrix attachment regulates Fas-induced apoptosis in endothelial cells: A role for c-flip and implications for anoikis. J Cell Biol 152:633-643
    • (2001) J Cell Biol , vol.152 , pp. 633-643
    • Aoudjit, F.1    Vuori, K.2
  • 7
    • 0032535999 scopus 로고    scopus 로고
    • Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
    • Arap W, Pasqualini R, Ruoslahti E (1998) Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 279:377-380
    • (1998) Science , vol.279 , pp. 377-380
    • Arap, W.1    Pasqualini, R.2    Ruoslahti, E.3
  • 9
    • 0035957050 scopus 로고    scopus 로고
    • Solution structures and integrin binding activities of an RGD peptide with two isomers
    • Assa-Munt N, Jia X, Laakkonen P, Ruoslahti E (2001) Solution structures and integrin binding activities of an RGD peptide with two isomers. Biochemistry 40:2373-2378
    • (2001) Biochemistry , vol.40 , pp. 2373-2378
    • Assa-Munt, N.1    Jia, X.2    Laakkonen, P.3    Ruoslahti, E.4
  • 10
    • 0025988323 scopus 로고
    • Differences in laminin fragment interactions of normal and transformed endothelial cells
    • Aumailley M, Timpl R, Risau W (1991) Differences in laminin fragment interactions of normal and transformed endothelial cells. Exp Cell Res 196:177-183
    • (1991) Exp Cell Res , vol.196 , pp. 177-183
    • Aumailley, M.1    Timpl, R.2    Risau, W.3
  • 12
    • 0032568608 scopus 로고    scopus 로고
    • CYR61, a product of a growth factorinducible immediate early gene, promotes angiogenesis and tumor growth
    • Babic AM, Kireeva ML, Kolesnikova TV, Lau LF (1998) CYR61, a product of a growth factorinducible immediate early gene, promotes angiogenesis and tumor growth. Proc Natl Acad Sci U S A 95:6355-6360
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6355-6360
    • Babic, A.M.1    Kireeva, M.L.2    Kolesnikova, T.V.3    Lau, L.F.4
  • 14
    • 14944348752 scopus 로고    scopus 로고
    • Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition Defines a novel prognostic indicator of aggressive colon carcinoma
    • Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM (2005) Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition Defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest 115:339-347
    • (2005) J Clin Invest , vol.115 , pp. 339-347
    • Bates, R.C.1    Bellovin, D.I.2    Brown, C.3    Maynard, E.4    Wu, B.5    Kawakatsu, H.6    Sheppard, D.7    Oettgen, P.8    Mercurio, A.M.9
  • 15
    • 0034704174 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain
    • Borges E, Jan Y, Ruoslahti E (2000) Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain. J Biol Chem 275:39867-39873
    • (2000) J Biol Chem , vol.275 , pp. 39867-39873
    • Borges, E.1    Jan, Y.2    Ruoslahti, E.3
  • 16
    • 2442620150 scopus 로고    scopus 로고
    • Template assembled cyclopeptides as multimeric system for integrin targeting and endocytosis
    • Boturyn D, Coll JL, Garanger E, Favrot MC, Dumy P (2004) Template assembled cyclopeptides as multimeric system for integrin targeting and endocytosis. J Am Chem Soc 126:5730-5739
    • (2004) J Am Chem Soc , vol.126 , pp. 5730-5739
    • Boturyn, D.1    Coll, J.L.2    Garanger, E.3    Favrot, M.C.4    Dumy, P.5
  • 19
    • 0028362876 scopus 로고
    • Requirement of vascular integrin alpha v beta 3 for angiogenesis
    • Brooks PC, Clark RA, Cheresh DA (1994) Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 264:569-571
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 20
    • 0030901145 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo
    • Brooks PC, Klemke RL, Schon S, Lewis JM, Schwartz MA, Cheresh DA (1997) Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. J Clin Invest 99:1390-1398
    • (1997) J Clin Invest , vol.99 , pp. 1390-1398
    • Brooks, P.C.1    Klemke, R.L.2    Schon, S.3    Lewis, J.M.4    Schwartz, M.A.5    Cheresh, D.A.6
  • 21
    • 0010712792 scopus 로고    scopus 로고
    • Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
    • Brooks PC, Silletti S, von Schalscha TL, Friedlander M, Cheresh DA (1998) Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Cell 92:391-400
    • (1998) Cell , vol.92 , pp. 391-400
    • Brooks, P.C.1    Silletti, S.2    Von Schalscha, T.L.3    Friedlander, M.4    Cheresh, D.A.5
  • 24
    • 0036346347 scopus 로고    scopus 로고
    • Enhanced fibroblast contraction of 3D collagen lattices and integrin expression by TGF-beta1 and -beta3: Mechanoregulatory growth factors?
    • Brown RA, Sethi KK, Gwanmesia I, Raemdonck D, Eastwood M, Mudera V (2002) Enhanced fibroblast contraction of 3D collagen lattices and integrin expression by TGF-beta1 and -beta3: Mechanoregulatory growth factors?. Exp Cell Res 274:310-322
    • (2002) Exp Cell Res , vol.274 , pp. 310-322
    • Brown, R.A.1    Sethi, K.K.2    Gwanmesia, I.3    Raemdonck, D.4    Eastwood, M.5    Mudera, V.6
  • 25
    • 0041924982 scopus 로고    scopus 로고
    • A novel role for FAK as a protease-Targeting adaptor protein: Regulation by p42 ERK and Src
    • Carragher NO, Westhoff MA, Fincham VJ, Schaller MD, Frame MC (2003) A novel role for FAK as a protease-Targeting adaptor protein: Regulation by p42 ERK and Src. Curr Biol 13:1442-1450
    • (2003) Curr Biol , vol.13 , pp. 1442-1450
    • Carragher, N.O.1    Westhoff, M.A.2    Fincham, V.J.3    Schaller, M.D.4    Frame, M.C.5
  • 27
    • 13944278751 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-Targeted drug delivery
    • Chen X, Plasencia C, Hou Y, Neamati N (2005) Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-Targeted drug delivery. J Med Chem 48:1098-1106
    • (2005) J Med Chem , vol.48 , pp. 1098-1106
    • Chen, X.1    Plasencia, C.2    Hou, Y.3    Neamati, N.4
  • 28
    • 0005306564 scopus 로고
    • Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor
    • Cheresh DA (1987) Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proc Natl Acad Sci U S A 84:6471-6475
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 6471-6475
    • Cheresh, D.A.1
  • 29
    • 0025753662 scopus 로고
    • Structure, function and biological properties of integrin alpha v beta 3 on human melanoma cells
    • Cheresh DA (1991) Structure, function and biological properties of integrin alpha v beta 3 on human melanoma cells. Cancer Metastasis Rev 10:3-10
    • (1991) Cancer Metastasis Rev , vol.10 , pp. 3-10
    • Cheresh, D.A.1
  • 30
    • 0023601045 scopus 로고
    • An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in an Divalent cationdependent functional complex with the disialoganglioside GD2
    • Cheresh DA, Pytela R, Pierschbacher MD, Klier FG, Ruoslahti E, Reisfeld RA (1987) An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in an Divalent cationdependent functional complex with the disialoganglioside GD2. J Cell Biol 105:1163-1173
    • (1987) J Cell Biol , vol.105 , pp. 1163-1173
    • Cheresh, D.A.1    Pytela, R.2    Pierschbacher, M.D.3    Klier, F.G.4    Ruoslahti, E.5    Reisfeld, R.A.6
  • 31
    • 0024509915 scopus 로고
    • A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells
    • Cheresh DA, Smith JW, Cooper HM, Quaranta V (1989) A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells. Cell 57:59-69
    • (1989) Cell , vol.57 , pp. 59-69
    • Cheresh, D.A.1    Smith, J.W.2    Cooper, H.M.3    Quaranta, V.4
  • 32
    • 0023612102 scopus 로고
    • Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor
    • Cheresh DA, Spiro RC (1987) Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor. J Biol Chem 262:17703-17711
    • (1987) J Biol Chem , vol.262 , pp. 17703-17711
    • Cheresh, D.A.1    Spiro, R.C.2
  • 34
    • 0035941075 scopus 로고    scopus 로고
    • Taking cell-matrix adhesions to the third dimension
    • Cukierman E, Pankov R, Stevens DR, Yamada KM (2001) Taking cell-matrix adhesions to the third dimension. Science 294:1708-1712
    • (2001) Science , vol.294 , pp. 1708-1712
    • Cukierman, E.1    Pankov, R.2    Stevens, D.R.3    Yamada, K.M.4
  • 38
    • 0023116942 scopus 로고
    • A cell surface receptor complex for collagen type I recognizes the Arg-Gly-Asp sequence
    • Dedhar S, Ruoslahti E, Pierschbacher MD (1987) A cell surface receptor complex for collagen type I recognizes the Arg-Gly-Asp sequence. J Cell Biol 104:585-593
    • (1987) J Cell Biol , vol.104 , pp. 585-593
    • Dedhar, S.1    Ruoslahti, E.2    Pierschbacher, M.D.3
  • 40
    • 4344672352 scopus 로고    scopus 로고
    • Prointegrin maturation follows rapid trafficking and processing of mt1-mmp in furin-negative colon carcinoma lovo cells
    • Deryugina EI, Ratnikov BI, Yu Q, Baciu PC, Rozanov DV, Strongin AY (2004) Prointegrin maturation follows rapid trafficking and processing of MT1-MMP in Furin-Negative Colon Carcinoma LoVo Cells. Traffic 5:627-641
    • (2004) Traffic , vol.5 , pp. 627-641
    • Deryugina, E.I.1    Ratnikov, B.I.2    Yu, Q.3    Baciu, P.C.4    Rozanov, D.V.5    Strongin, A.Y.6
  • 41
    • 0141994778 scopus 로고    scopus 로고
    • The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged
    • Ding Q, Stewart J Jr, Olman MA, Klobe MR, Gladson CL (2003) The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged. J Biol Chem 278:39882-39891
    • (2003) J Biol Chem , vol.278 , pp. 39882-39891
    • Ding, Q.1    Stewart Jr., J.2    Olman, M.A.3    Klobe, M.R.4    Gladson, C.L.5
  • 42
    • 0029909686 scopus 로고    scopus 로고
    • Identification of a sequence within the integrin beta6 subunit cytoplasmic domain that is required to support the specific effect of alphavbeta6 on proliferation in three-dimensional culture
    • Dixit RB, Chen A, Chen J, Sheppard D (1996) Identification of a sequence within the integrin beta6 subunit cytoplasmic domain that is required to support the specific effect of alphavbeta6 on proliferation in three-dimensional culture. J Biol Chem 271:25976-25980
    • (1996) J Biol Chem , vol.271 , pp. 25976-25980
    • Dixit, R.B.1    Chen, A.2    Chen, J.3    Sheppard, D.4
  • 43
    • 38949197102 scopus 로고    scopus 로고
    • T-cell activation through immunological synapses and kinapses
    • Dustin ML (2008) T-cell activation through immunological synapses and kinapses. Immunol Rev 221:77-89
    • (2008) Immunol Rev , vol.221 , pp. 77-89
    • Dustin, M.L.1
  • 44
    • 0033121275 scopus 로고    scopus 로고
    • The role of alphav integrins during angiogenesis: Insights into potential mechanisms of action and clinical development
    • Eliceiri BP, Cheresh DA (1999) The role of alphav integrins during angiogenesis: Insights into potential mechanisms of action and clinical development. J Clin Invest 103:1227-1230
    • (1999) J Clin Invest , vol.103 , pp. 1227-1230
    • Eliceiri, B.P.1    Cheresh, D.A.2
  • 45
    • 0032498640 scopus 로고    scopus 로고
    • Integrin alphavbeta3 requirement for sustained mitogen-Activated protein kinase activity during angiogenesis
    • Eliceiri BP, Klemke R, Stromblad S, Cheresh DA (1998) Integrin alphavbeta3 requirement for sustained mitogen-Activated protein kinase activity during angiogenesis. J Cell Biol 140:1255-1263
    • (1998) J Cell Biol , vol.140 , pp. 1255-1263
    • Eliceiri, B.P.1    Klemke, R.2    Stromblad, S.3    Cheresh, D.A.4
  • 48
    • 0029669969 scopus 로고    scopus 로고
    • Role of beta3 integrins in melanoma cell adhesion to activated platelets under flow
    • Felding-Habermann B, Habermann R, Saldivar E, Ruggeri ZM (1996) Role of beta3 integrins in melanoma cell adhesion to activated platelets under flow. J Biol Chem 271:5892-5900
    • (1996) J Biol Chem , vol.271 , pp. 5892-5900
    • Felding-Habermann, B.1    Habermann, R.2    Saldivar, E.3    Ruggeri, Z.M.4
  • 49
  • 50
    • 0028678048 scopus 로고
    • A structural basis for bidirectional integrin signalling
    • Filardo EJ, Cheresh DA (1994) A structural basis for bidirectional integrin signalling. Princess Takamatsu Symp 24:106-117
    • (1994) Princess Takamatsu Symp , vol.24 , pp. 106-117
    • Filardo, E.J.1    Cheresh, D.A.2
  • 51
    • 0029998296 scopus 로고    scopus 로고
    • Regulation of cell migration by the integrin beta subunit ectodomain
    • Filardo EJ, Deming SL, Cheresh DA (1996) Regulation of cell migration by the integrin beta subunit ectodomain. J Cell Sci 109(Pt 6):1615-1622
    • (1996) J Cell Sci , vol.109 , Issue.PART 6 , pp. 1615-1622
    • Filardo, E.J.1    Deming, S.L.2    Cheresh, D.A.3
  • 52
    • 0023607232 scopus 로고
    • Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alphasubunits and platelet glycoprotein IIb
    • Fitzgerald LA, Poncz M, Steiner B, Rall SC Jr, Bennett JS, Phillips DR (1987) Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alphasubunits and platelet glycoprotein IIb. Biochemistry 26:8158-8165
    • (1987) Biochemistry , vol.26 , pp. 8158-8165
    • Fitzgerald, L.A.1    Poncz, M.2    Steiner, B.3    Rall Jr., S.C.4    Bennett, J.S.5    Phillips, D.R.6
  • 53
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1:27-31
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 55
    • 0029929675 scopus 로고    scopus 로고
    • Migration of brain tumor cells on extracellular matrix proteins in vitro correlates with tumor type and grade and involves alphaV and beta1 integrins
    • Friedlander DR, Zagzag D, Shiff B, Cohen H, Allen JC, Kelly PJ, Grumet M (1996) Migration of brain tumor cells on extracellular matrix proteins in vitro correlates with tumor type and grade and involves alphaV and beta1 integrins. Cancer Res 56:1939-1947
    • (1996) Cancer Res , vol.56 , pp. 1939-1947
    • Friedlander, D.R.1    Zagzag, D.2    Shiff, B.3    Cohen, H.4    Allen, J.C.5    Kelly, P.J.6    Grumet, M.7
  • 56
    • 40549115658 scopus 로고    scopus 로고
    • Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta
    • Galliher-Beckley AJ, Schiemann WP (2008) Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta. Carcinogenesis 29: 244-251
    • (2008) Carcinogenesis , vol.29 , pp. 244-251
    • Galliher-Beckley, A.J.1    Schiemann, W.P.2
  • 58
    • 1342281679 scopus 로고    scopus 로고
    • Physical association of uPAR with the alphaV integrin on the surface of human NK cells
    • Gellert GC, Goldfarb RH, Kitson RP (2004) Physical association of uPAR with the alphaV integrin on the surface of human NK cells. Biochem Biophys Res Commun 315:1025-1032
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 1025-1032
    • Gellert, G.C.1    Goldfarb, R.H.2    Kitson, R.P.3
  • 60
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: Glioblastoma stem cells and the vascular niche
    • Gilbertson RJ, Rich JN (2007) Making a tumour's bed: Glioblastoma stem cells and the vascular niche. Nat Rev Cancer 7:733-736
    • (2007) Nat Rev Cancer , vol.7 , pp. 733-736
    • Gilbertson, R.J.1    Rich, J.N.2
  • 62
    • 0026334978 scopus 로고
    • Glioblastoma expression of vitronectin and the alpha v beta 3 integrin Adhesion mechanism for transformed glial cells
    • Gladson CL, Cheresh DA (1991) Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells. J Clin Invest 88 1924-1932
    • (1991) J Clin Invest , vol.88 , pp. 1924-1932
    • Gladson, C.L.1    Cheresh, D.A.2
  • 63
    • 0034618121 scopus 로고    scopus 로고
    • Restructuring of focal adhesion plaques by PI 3-kinase. Regulation by PtdIns 3, 4, 5)-p(3) binding to alpha-Actinin
    • Greenwood JA, Theibert AB, Prestwich GD, Murphy-Ullrich JE (2000) Restructuring of focal adhesion plaques by PI 3-kinase. Regulation by PtdIns (3, 4, 5)-p(3) binding to alpha-Actinin. J Cell Biol 150:627-642
    • (2000) J Cell Biol , vol.150 , pp. 627-642
    • Greenwood, J.A.1    Theibert, A.B.2    Prestwich, G.D.3    Murphy-Ullrich, J.E.4
  • 65
    • 0027102818 scopus 로고
    • Conformation/activity studies of rationally designed potent anti-Adhesive RGD peptides
    • Gurrath M, Muller G, Kessler H, Aumailley M, Timpl R (1992) Conformation/activity studies of rationally designed potent anti-Adhesive RGD peptides. Eur J Biochem 210:911-921
    • (1992) Eur J Biochem , vol.210 , pp. 911-921
    • Gurrath, M.1    Muller, G.2    Kessler, H.3    Aumailley, M.4    Timpl, R.5
  • 70
    • 35148840122 scopus 로고    scopus 로고
    • Design and chemical synthesis of integrin ligands
    • Heckmann D, Kessler H (2007) Design and chemical synthesis of integrin ligands. Meth Enzymol 426:463-503
    • (2007) Meth Enzymol , vol.426 , pp. 463-503
    • Heckmann, D.1    Kessler, H.2
  • 72
    • 4644302286 scopus 로고    scopus 로고
    • Novel RGD lipopeptides for the targeting of liposomes to integrin-expressing endothelial and melanoma cells
    • Holig P, Bach M, Volkel T, Nahde T, Hoffmann S, Muller R, Kontermann RE (2004) Novel RGD lipopeptides for the targeting of liposomes to integrin-expressing endothelial and melanoma cells. Protein Eng Des Sel 17:433-441
    • (2004) Protein Eng Des Sel , vol.17 , pp. 433-441
    • Holig, P.1    Bach, M.2    Volkel, T.3    Nahde, T.4    Hoffmann, S.5    Muller, R.6    Kontermann, R.E.7
  • 75
    • 0023666065 scopus 로고
    • Integrins: A family of cell surface receptors
    • Hynes RO (1987) Integrins: A family of cell surface receptors. Cell 48:549-554
    • (1987) Cell , vol.48 , pp. 549-554
    • Hynes, R.O.1
  • 76
    • 0032725055 scopus 로고    scopus 로고
    • Insights and questions arising from studies of a mouse model of Glanzmann thrombasthenia
    • Hynes RO, Hodivala-Dilke KM (1999) Insights and questions arising from studies of a mouse model of Glanzmann thrombasthenia. Thromb Haemost 82:481-485
    • (1999) Thromb Haemost , vol.82 , pp. 481-485
    • Hynes, R.O.1    Hodivala-Dilke, K.M.2
  • 77
    • 52949128349 scopus 로고    scopus 로고
    • Therapeutic application of noncytotoxic molecular targeted therapy in gliomas: Growth factor receptors and angiogenesis inhibitors
    • Idbaih A, Ducray F, Sierra Del Rio M, Hoang-Xuan K, Delattre JY (2008) Therapeutic application of noncytotoxic molecular targeted therapy in gliomas: Growth factor receptors and angiogenesis inhibitors. Oncologist 13:978-992
    • (2008) Oncologist , vol.13 , pp. 978-992
    • Idbaih, A.1    Ducray, F.2    Sierra Del Rio, M.3    Hoang-Xuan, K.4    Delattre, J.Y.5
  • 78
    • 0037112468 scopus 로고    scopus 로고
    • Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology
    • Ingber DE (2002) Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology. Circ Res 91:877-887
    • (2002) Circ Res , vol.91 , pp. 877-887
    • Ingber, D.E.1
  • 79
    • 0028899991 scopus 로고
    • Characterization of selected strongly and weakly invasive sublines of a primary human melanoma cell line and isolation of subtractive cDNA clones
    • Jacob K, Bosserhoff AK, Wach F, Knuchel R, Klein EC, Hein R, Buettner R (1995) Characterization of selected strongly and weakly invasive sublines of a primary human melanoma cell line and isolation of subtractive cDNA clones. Int J Cancer 60:668-675
    • (1995) Int J Cancer , vol.60 , pp. 668-675
    • Jacob, K.1    Bosserhoff, A.K.2    Wach, F.3    Knuchel, R.4    Klein, E.C.5    Hein, R.6    Buettner, R.7
  • 81
    • 0242668787 scopus 로고    scopus 로고
    • Expression of alphav integrin family in gastric carcinomas: Increased alphavbeta6 is associated with lymph node metastasis
    • Kawashima A, Tsugawa S, Boku A, Kobayashi M, Minamoto T, Nakanishi I, Oda Y (2003) Expression of alphav integrin family in gastric carcinomas: Increased alphavbeta6 is associated with lymph node metastasis. Pathol Res Pract 199:57-64
    • (2003) Pathol Res Pract , vol.199 , pp. 57-64
    • Kawashima, A.1    Tsugawa, S.2    Boku, A.3    Kobayashi, M.4    Minamoto, T.5    Nakanishi, I.6    Oda, Y.7
  • 82
    • 9644275599 scopus 로고    scopus 로고
    • Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: Therapeutic strategy for herpetic stromal keratitis
    • Kim B, Tang Q, Biswas PS, Xu J, Schiffelers RM, Xie FY, Ansari AM, Scaria PV, Woodle MC, Lu P, Rouse BT (2004) Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: Therapeutic strategy for herpetic stromal keratitis. Am J Pathol 165:2177-2185
    • (2004) Am J Pathol , vol.165 , pp. 2177-2185
    • Kim, B.1    Tang, Q.2    Biswas, P.S.3    Xu, J.4    Schiffelers, R.M.5    Xie, F.Y.6    Ansari, A.M.7    Scaria, P.V.8    Woodle, M.C.9    Lu, P.10    Rouse, B.T.11
  • 85
    • 0028043735 scopus 로고
    • Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin
    • Klemke RL, Yebra M, Bayna EM, Cheresh DA (1994) Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol 127:859-866
    • (1994) J Cell Biol , vol.127 , pp. 859-866
    • Klemke, R.L.1    Yebra, M.2    Bayna, E.M.3    Cheresh, D.A.4
  • 86
    • 0027976103 scopus 로고
    • Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library
    • Koivunen E, Wang B, Ruoslahti E (1994) Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library. J Cell Biol 124:373-380
    • (1994) J Cell Biol , vol.124 , pp. 373-380
    • Koivunen, E.1    Wang, B.2    Ruoslahti, E.3
  • 88
    • 0031048045 scopus 로고    scopus 로고
    • Molecular determinants of arg-gly-Asp ligand specificity for beta3 integrins
    • Kunicki TJ, Annis DS, Felding-Habermann B (1997) Molecular determinants of arg-gly-Asp ligand specificity for beta3 integrins. J Biol Chem 272:4103-4107
    • (1997) J Biol Chem , vol.272 , pp. 4103-4107
    • Kunicki, T.J.1    Annis, D.S.2    Felding-Habermann, B.3
  • 89
    • 0035983879 scopus 로고    scopus 로고
    • Involvement of integrin alphavbeta3 in the pathogenesis of human immunodeficiency virus type 1 infection in monocytes
    • Lafrenie RM, Lee SF, Hewlett IK, Yamada KM, Dhawan S (2002) Involvement of integrin alphavbeta3 in the pathogenesis of human immunodeficiency virus type 1 infection in monocytes. Virology 297:31-8
    • (2002) Virology , vol.297 , pp. 31-8
    • Lafrenie, R.M.1    Lee, S.F.2    Hewlett, I.K.3    Yamada, K.M.4    Dhawan, S.5
  • 90
    • 33748328139 scopus 로고    scopus 로고
    • The matrix reorganized: Extracellular matrix remodeling and integrin signaling
    • Larsen M, Artym VV, Green JA, Yamada KM (2006) The matrix reorganized: Extracellular matrix remodeling and integrin signaling. Curr Opin Cell Biol 18:463-471
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 463-471
    • Larsen, M.1    Artym, V.V.2    Green, J.A.3    Yamada, K.M.4
  • 91
    • 0026764576 scopus 로고
    • Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen
    • Leavesley DI, Ferguson GD, Wayner EA, Cheresh DA (1992) Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen. J Cell Biol 117:1101-1107
    • (1992) J Cell Biol , vol.117 , pp. 1101-1107
    • Leavesley, D.I.1    Ferguson, G.D.2    Wayner, E.A.3    Cheresh, D.A.4
  • 92
    • 0033610807 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp 125(FAK) and pp60(src
    • Lebrun P, Mothe-Satney I, Delahaye L, Van Obberghen E, Baron V (1998) Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp 125(FAK) and pp60(src). J Biol Chem 273:32244-32253
    • (1998) J Biol Chem , vol.273 , pp. 32244-32253
    • Lebrun, P.1    Mothe-Satney, I.2    Delahaye, L.3    Van Obberghen, E.4    Baron, V.5
  • 93
    • 0029759727 scopus 로고    scopus 로고
    • Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation
    • Lewis JM, Cheresh DA, Schwartz MA (1996) Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. J Cell Biol 134:1323-1332
    • (1996) J Cell Biol , vol.134 , pp. 1323-1332
    • Lewis, J.M.1    Cheresh, D.A.2    Schwartz, M.A.3
  • 94
    • 0031912083 scopus 로고    scopus 로고
    • Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase
    • Li E, Stupack D, Klemke R, Cheresh DA, Nemerow GR (1998) Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase. J Virol 72:2055-2061
    • (1998) J Virol , vol.72 , pp. 2055-2061
    • Li, E.1    Stupack, D.2    Klemke, R.3    Cheresh, D.A.4    Nemerow, G.R.5
  • 95
    • 0032418834 scopus 로고    scopus 로고
    • A series of function blocking antibodies against the alpha v beta 3 integrin bind allosteric to the ligand binding site and induce ligand dissociation
    • Lin EC, Carron CP, Meyer DM, Smith JW (1998) A series of function blocking antibodies against the alpha v beta 3 integrin bind allosteric to the ligand binding site and induce ligand dissociation. Cell Adhes Commun 6:451-464
    • (1998) Cell Adhes Commun , vol.6 , pp. 451-464
    • Lin, E.C.1    Carron, C.P.2    Meyer, D.M.3    Smith, J.W.4
  • 97
    • 13544270759 scopus 로고    scopus 로고
    • DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells
    • Ling Y, Maile LA, Badley-Clarke J, Clemmons DR (2005) DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells. J Biol Chem 280:3151-3158
    • (2005) J Biol Chem , vol.280 , pp. 3151-3158
    • Ling, Y.1    Maile, L.A.2    Badley-Clarke, J.3    Clemmons, D.R.4
  • 99
    • 0035570242 scopus 로고    scopus 로고
    • Antisense to integrin alpha v inhibits growth and induces apoptosis in medulloblastoma cells
    • MacDonald TJ, Ladisch S (2001) Antisense to integrin alpha v inhibits growth and induces apoptosis in medulloblastoma cells. Anticancer Res 21:3785-3791
    • (2001) Anticancer Res , vol.21 , pp. 3785-3791
    • MacDonald, T.J.1    Ladisch, S.2
  • 102
    • 23944483491 scopus 로고    scopus 로고
    • EGF receptor activity is essential for adhesion-induced stress fiber formation and cofilin phosphorylation
    • Marcoux N, Vuori K (2005) EGF receptor activity is essential for adhesion-induced stress fiber formation and cofilin phosphorylation. Cell Signal 17:1449-1455
    • (2005) Cell Signal , vol.17 , pp. 1449-1455
    • Marcoux, N.1    Vuori, K.2
  • 103
    • 0031691062 scopus 로고    scopus 로고
    • Interactions of soluble recombinant integrin alphav beta5 with human adenoviruses
    • Mathias P, Galleno M, Nemerow GR (1998) Interactions of soluble recombinant integrin alphav beta5 with human adenoviruses. J Virol 72:8669-8675
    • (1998) J Virol , vol.72 , pp. 8669-8675
    • Mathias, P.1    Galleno, M.2    Nemerow, G.R.3
  • 104
    • 0035958902 scopus 로고    scopus 로고
    • A signaling pathway from the alpha5beta1 and alpha v)beta3 integrins that elevates bcl-2 transcription
    • Matter ML, Ruoslahti E (2001) A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription. J Biol Chem 276:27757-27763
    • (2001) J Biol Chem , vol.276 , pp. 27757-27763
    • Matter, M.L.1    Ruoslahti, E.2
  • 105
    • 18144404647 scopus 로고    scopus 로고
    • Expression of alpha V-Associated integrin beta subunits in epithelial ovarian cancer and its relation to prognosis in patients treated with platinum-based regimens
    • Maubant S, Cruet-Hennequart S, Dutoit S, Denoux Y, Crouet H, Henry-Amar M, Gauduchon P (2005) Expression of alpha V-Associated integrin beta subunits in epithelial ovarian cancer and its relation to prognosis in patients treated with platinum-based regimens. J Mol Histol 36:119-129
    • (2005) J Mol Histol , vol.36 , pp. 119-129
    • Maubant, S.1    Cruet-Hennequart, S.2    Dutoit, S.3    Denoux, Y.4    Crouet, H.5    Henry-Amar, M.6    Gauduchon, P.7
  • 106
    • 34548680519 scopus 로고    scopus 로고
    • Prostate cancer specific integrin alphavbeta3 modulates bone metastatic growth and tissue remodeling
    • McCabe NP, De S, Vasanji A, Brainard J, Byzova TV (2007) Prostate cancer specific integrin alphavbeta3 modulates bone metastatic growth and tissue remodeling. Oncogene 26:6238-6243
    • (2007) Oncogene , vol.26 , pp. 6238-6243
    • McCabe, N.P.1    De S Vasanji, A.2    Brainard, J.3    Byzova, T.V.4
  • 108
    • 0031594140 scopus 로고    scopus 로고
    • Expression of alphav integrins and vitronectin receptor identity in breast cancer cells
    • Meyer T, Marshall JF, Hart IR (1998) Expression of alphav integrins and vitronectin receptor identity in breast cancer cells. Br J Cancer 77:530-536
    • (1998) Br J Cancer , vol.77 , pp. 530-536
    • Meyer, T.1    Marshall, J.F.2    Hart, I.R.3
  • 109
    • 33748286819 scopus 로고    scopus 로고
    • Integrin-regulated FAK-Src signaling in normal and cancer cells
    • Mitra SK, Schlaepfer DD (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18:516-523
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 516-523
    • Mitra, S.K.1    Schlaepfer, D.D.2
  • 110
    • 17444394015 scopus 로고    scopus 로고
    • The expression of integrin alpha(v)beta6 promotes the epithelial cell morphology and suppresses invasive behavior in transformed oral keratinocytes
    • Mogi S, Dang D, Van Waes C, Ellis D, Atakilit A, Ramos DM (2005) The expression of integrin alpha(v)beta6 promotes the epithelial cell morphology and suppresses invasive behavior in transformed oral keratinocytes. Anticancer Res 25:751-755
    • (2005) Anticancer Res , vol.25 , pp. 751-755
    • Mogi, S.1    Dang, D.2    Van Waes, C.3    Ellis, D.4    Atakilit, A.5    Ramos, D.M.6
  • 114
    • 0028711918 scopus 로고
    • Pharmacophore refinement of gpIIb/IIIa antagonists based on comparative studies of antiadhesive cyclic and acyclic RGD peptides
    • Muller G, Gurrath M, Kessler H (1994) Pharmacophore refinement of gpIIb/IIIa antagonists based on comparative studies of antiadhesive cyclic and acyclic RGD peptides. J Comput Aided Mol Des 8:709-730
    • (1994) J Comput Aided Mol Des , vol.8 , pp. 709-730
    • Muller, G.1    Gurrath, M.2    Kessler, H.3
  • 118
  • 119
    • 0026451947 scopus 로고
    • Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin
    • Nip J, Shibata H, Loskutoff DJ, Cheresh DA, Brodt P (1992) Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin. J Clin Invest 90:1406-1413
    • (1992) J Clin Invest , vol.90 , pp. 1406-1413
    • Nip, J.1    Shibata, H.2    Loskutoff, D.J.3    Cheresh, D.A.4    Brodt, P.5
  • 120
    • 0033618460 scopus 로고    scopus 로고
    • Mechanisms and consequences of affinity modulation of integrin alpha V)beta 3) detected with a novel patch-engineered monovalent ligand
    • Pampori N, Hato T, Stupack DG, Aidoudi S, Cheresh DA, Nemerow GR, Shattil SJ (1999) Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand. J Biol Chem 274:21609-21616
    • (1999) J Biol Chem , vol.274 , pp. 21609-21616
    • Pampori, N.1    Hato, T.2    Stupack, D.G.3    Aidoudi, S.4    Cheresh, D.A.5    Nemerow, G.R.6    Shattil, S.J.7
  • 122
    • 0029120428 scopus 로고
    • A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins
    • Pasqualini R, Koivunen E, Ruoslahti E (1995) A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins. J Cell Biol 130:1189-1196
    • (1995) J Cell Biol , vol.130 , pp. 1189-1196
    • Pasqualini, R.1    Koivunen, E.2    Ruoslahti, E.3
  • 124
    • 45149106656 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces alphavbeta3 integrin expression in human lung fibroblasts via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway
    • Pechkovsky DV, Scaffidi AK, Hackett TL, Ballard J, Shaheen F, Thompson PJ, Thannickal VJ, Knight DA (2008) Transforming growth factor beta1 induces alphavbeta3 integrin expression in human lung fibroblasts via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway. J Biol Chem 283:12898-12908
    • (2008) J Biol Chem , vol.283 , pp. 12898-12908
    • Pechkovsky, D.V.1    Scaffidi, A.K.2    Hackett, T.L.3    Ballard, J.4    Shaheen, F.5    Thompson, P.J.6    Thannickal, V.J.7    Knight, D.A.8
  • 125
    • 0034677760 scopus 로고    scopus 로고
    • New functions for non-collagenous domains of human collagen type IV Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo
    • Petitclerc E, Boutaud A, Prestayko A, Xu J, Sado Y, Ninomiya Y, Sarras MP Jr, Hudson BG, Brooks PC (2000) New functions for non-collagenous domains of human collagen type IV. Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo. J Biol Chem 275:8051-8061
    • (2000) J Biol Chem , vol.275 , pp. 8051-8061
    • Petitclerc, E.1    Boutaud, A.2    Prestayko, A.3    Xu, J.4    Sado, Y.5    Ninomiya, Y.6    Sarras Jr., M.P.7    Hudson, B.G.8    Brooks, P.C.9
  • 126
    • 0036180132 scopus 로고    scopus 로고
    • Interactions of integrins with their partner proteins in leukocyte membranes
    • Petty HR, Worth RG, Todd RF III (2002) Interactions of integrins with their partner proteins in leukocyte membranes. Immunol Res 25:75-95
    • (2002) Immunol Res , vol.25 , pp. 75-95
    • Petty, H.R.1    Worth, R.G.2    Todd III, R.F.3
  • 127
    • 0027997413 scopus 로고
    • Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins
    • Pfaff M, Tangemann K, Muller B, Gurrath M, Muller G, Kessler H, Timpl R, Engel J (1994) Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins. J Biol Chem. 269:20233-20238
    • (1994) J Biol Chem , vol.269 , pp. 20233-20238
    • Pfaff, M.1    Tangemann, K.2    Muller, B.3    Gurrath, M.4    Muller, G.5    Kessler, H.6    Timpl, R.7    Engel, J.8
  • 129
    • 0001511468 scopus 로고
    • Variants of the cell recognition site of fibronectin that retain attachment-promoting activity
    • Pierschbacher MD, Ruoslahti E (1984) Variants of the cell recognition site of fibronectin that retain attachment-promoting activity. Proc Natl Acad Sci U S A 81:5985-5988
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 5985-5988
    • Pierschbacher, M.D.1    Ruoslahti, E.2
  • 130
    • 0022000778 scopus 로고
    • Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
    • Pytela R, Pierschbacher MD, Ruoslahti E (1985) Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor. Cell 40:191-198
    • (1985) Cell , vol.40 , pp. 191-198
    • Pytela, R.1    Pierschbacher, M.D.2    Ruoslahti, E.3
  • 131
    • 51449124031 scopus 로고    scopus 로고
    • Cilengitide: An integrin-Targeting arginineglycine-Aspartic acid peptide with promising activity for glioblastoma multiforme
    • Reardon DA, Nabors LB, Stupp R, Mikkelsen T (2008) Cilengitide: An integrin-Targeting arginineglycine-Aspartic acid peptide with promising activity for glioblastoma multiforme. Expert Opin Investig Drugs 17:1225-1235
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 1225-1235
    • Reardon, D.A.1    Nabors, L.B.2    Stupp, R.3    Mikkelsen, T.4
  • 134
    • 27544459331 scopus 로고    scopus 로고
    • In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation
    • Riemenschneider MJ, Mueller W, Betensky RA, Mohapatra G, Louis DN (2005) In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation. Am J Pathol 167:1379-1387
    • (2005) Am J Pathol , vol.167 , pp. 1379-1387
    • Riemenschneider, M.J.1    Mueller, W.2    Betensky, R.A.3    Mohapatra, G.4    Louis, D.N.5
  • 135
    • 0042424548 scopus 로고    scopus 로고
    • Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells
    • Rolli M, Fransvea E, Pilch J, Saven A, Felding-Habermann B (2003) Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells. Proc Natl Acad Sci U S A 100:9482-9487
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 9482-9487
    • Rolli, M.1    Fransvea, E.2    Pilch, J.3    Saven, A.4    Felding-Habermann, B.5
  • 136
    • 0034744723 scopus 로고    scopus 로고
    • Vascular integrin beta 3 and its relation to pulmonary metastasis of colorectal carcinoma
    • Sato T, Konishi K, Kimura H, Maeda K, Yabushita K, Tsuji M, Miwa A (2001) Vascular integrin beta 3 and its relation to pulmonary metastasis of colorectal carcinoma. Anticancer Res 21:643-647
    • (2001) Anticancer Res , vol.21 , pp. 643-647
    • Sato, T.1    Konishi, K.2    Kimura, H.3    Maeda, K.4    Yabushita, K.5    Tsuji, M.6    Miwa, A.7
  • 141
    • 0030464110 scopus 로고    scopus 로고
    • Signal transduction from the extracellular matrix-A role for the focal adhesion protein-Tyrosine kinase FAK
    • Schlaepfer DD, Hunter T (1996) Signal transduction from the extracellular matrix-A role for the focal adhesion protein-Tyrosine kinase FAK. Cell Struct Funct 21:445-450
    • (1996) Cell Struct Funct , vol.21 , pp. 445-450
    • Schlaepfer, D.D.1    Hunter, T.2
  • 142
    • 0030814976 scopus 로고    scopus 로고
    • Alphavbeta3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF
    • Schneller M, Vuori K, Ruoslahti E (1997) Alphavbeta3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF. Embo J 16:5600-5607
    • (1997) Embo J , vol.16 , pp. 5600-5607
    • Schneller, M.1    Vuori, K.2    Ruoslahti, E.3
  • 143
    • 0028179351 scopus 로고
    • Alpha v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion
    • Schwartz MA, Denninghoff K (1994) Alpha v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion. J Biol Chem 269:11133-11137
    • (1994) J Biol Chem , vol.269 , pp. 11133-11137
    • Schwartz, M.A.1    Denninghoff, K.2
  • 145
    • 0023039225 scopus 로고
    • A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines
    • Senger DR, Perruzzi CA, Feder J, Dvorak HF (1986) A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res 46:5629-5632
    • (1986) Cancer Res , vol.46 , pp. 5629-5632
    • Senger, D.R.1    Perruzzi, C.A.2    Feder, J.3    Dvorak, H.F.4
  • 146
    • 23744451167 scopus 로고    scopus 로고
    • Integrins and src: Dynamic duo of adhesion signaling
    • Shattil SJ (2005) Integrins and src: Dynamic duo of adhesion signaling. Trends Cell Biol 15:399-403
    • (2005) Trends Cell Biol , vol.15 , pp. 399-403
    • Shattil, S.J.1
  • 147
    • 0028156863 scopus 로고
    • Immunohistological examination of the relationship between metastatic potential and expression of adhesion molecules and selectins on melanoma cells
    • Si Z, Hersey P (1994) Immunohistological examination of the relationship between metastatic potential and expression of adhesion molecules and 'selectins' on melanoma cells. Pathology 26:6-15
    • (1994) Pathology , vol.26 , pp. 6-15
    • Si, Z.1    Hersey, P.2
  • 148
    • 27744579762 scopus 로고    scopus 로고
    • Quantitative analysis of integrin expression in effusions using flow cytometric immunophenotyping
    • Sigstad E, Dong HP, Nielsen S, Berner A, Davidson B, Risberg B (2005) Quantitative analysis of integrin expression in effusions using flow cytometric immunophenotyping. Diagn Cytopathol 33:325-331
    • (2005) Diagn Cytopathol , vol.33 , pp. 325-331
    • Sigstad, E.1    Dong, H.P.2    Nielsen, S.3    Berner, A.4    Davidson, B.5    Risberg, B.6
  • 149
    • 0033815099 scopus 로고    scopus 로고
    • Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51
    • Sims MA, Field SD, Barnes MR, Shaikh N, Ellington K, Murphy KE, Spurr N, Campbell DA (2000) Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51. Cytogenet Cell Genet 89:268-271
    • (2000) Cytogenet Cell Genet , vol.89 , pp. 268-271
    • Sims, M.A.1    Field, S.D.2    Barnes, M.R.3    Shaikh, N.4    Ellington, K.5    Murphy, K.E.6    Spurr, N.7    Campbell, D.A.8
  • 150
    • 0031862889 scopus 로고    scopus 로고
    • Detection of tumor angiogenesis in vivo by alphaVbeta3-Targeted magnetic resonance imaging
    • Sipkins DA, Cheresh DA, Kazemi MR, Nevin LM, Bednarski MD, Li KC (1998) Detection of tumor angiogenesis in vivo by alphaVbeta3-Targeted magnetic resonance imaging. Nat Med 4:623-626
    • (1998) Nat Med , vol.4 , pp. 623-626
    • Sipkins, D.A.1    Cheresh, D.A.2    Kazemi, M.R.3    Nevin, L.M.4    Bednarski, M.D.5    Li, K.C.6
  • 151
    • 0026043761 scopus 로고
    • Labeling of integrin alpha v beta 3 with 58Co(III). Evidence of metal ion coordination sphere involvement in ligand binding
    • Smith JW, Cheresh DA (1991) Labeling of integrin alpha v beta 3 with 58Co(III). Evidence of metal ion coordination sphere involvement in ligand binding. J Biol Chem 266:11429-11432
    • (1991) J Biol Chem , vol.266 , pp. 11429-11432
    • Smith, J.W.1    Cheresh, D.A.2
  • 152
    • 36049006185 scopus 로고    scopus 로고
    • Cell integrins: Commonly used receptors for diverse viral pathogens
    • Stewart PL, Nemerow GR (2007) Cell integrins: Commonly used receptors for diverse viral pathogens. Trends Microbiol 15:500-507
    • (2007) Trends Microbiol , vol.15 , pp. 500-507
    • Stewart, P.L.1    Nemerow, G.R.2
  • 154
    • 0030038229 scopus 로고    scopus 로고
    • Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis
    • Stromblad S, Becker JC, Yebra M, Brooks PC, Cheresh DA (1996) Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis. J Clin Invest 98:426-433
    • (1996) J Clin Invest , vol.98 , pp. 426-433
    • Stromblad, S.1    Becker, J.C.2    Yebra, M.3    Brooks, P.C.4    Cheresh, D.A.5
  • 156
    • 35748965583 scopus 로고    scopus 로고
    • The biology of integrins
    • Williston Park
    • Stupack DG (2007) The biology of integrins. Oncology (Williston Park) 21:6-12
    • (2007) Oncology , vol.21 , pp. 6-12
    • Stupack, D.G.1
  • 159
    • 34748884398 scopus 로고    scopus 로고
    • Chemoradiotherapy in malignant glioma: Standard of care and future directions
    • Stupp R, Hegi ME, Gilbert MR, Chakravarti A (2007) Chemoradiotherapy in malignant glioma: Standard of care and future directions. J Clin Oncol 25:4127-4136
    • (2007) J Clin Oncol , vol.25 , pp. 4127-4136
    • Stupp, R.1    Hegi, M.E.2    Gilbert, M.R.3    Chakravarti, A.4
  • 160
    • 3442894138 scopus 로고    scopus 로고
    • Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1
    • Subramanian G, Schwarz RE, Higgins L, McEnroe G, Chakravarty S, Dugar S, Reiss M (2004) Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1. Cancer Res 64:5200-5211
    • (2004) Cancer Res , vol.64 , pp. 5200-5211
    • Subramanian, G.1    Schwarz, R.E.2    Higgins, L.3    McEnroe, G.4    Chakravarty, S.5    Dugar, S.6    Reiss, M.7
  • 162
    • 0030856555 scopus 로고    scopus 로고
    • Changing ligand specificities of alphavbeta1 and alphavbeta3 integrins by swapping a short diverse sequence of the beta subunit
    • Takagi J, Kamata T, Meredith J, Puzon-McLaughlin W, Takada Y (1997) Changing ligand specificities of alphavbeta1 and alphavbeta3 integrins by swapping a short diverse sequence of the beta subunit. J Biol Chem 272:19794-19800
    • (1997) J Biol Chem , vol.272 , pp. 19794-19800
    • Takagi, J.1    Kamata, T.2    Meredith, J.3    Puzon-McLaughlin, W.4    Takada, Y.5
  • 163
    • 0036697001 scopus 로고    scopus 로고
    • Integrin activation and structural rearrangement
    • Takagi J, Springer TA (2002) Integrin activation and structural rearrangement. Immunol Rev 186:141-163
    • (2002) Immunol Rev , vol.186 , pp. 141-163
    • Takagi, J.1    Springer, T.A.2
  • 165
    • 16344380043 scopus 로고    scopus 로고
    • The relationship between bone metastasis from human breast cancer and integrin alpha(v)beta3 expression
    • Takayama S, Ishii S, Ikeda T, Masamura S, Doi M, Kitajima M (2005) The relationship between bone metastasis from human breast cancer and integrin alpha(v)beta3 expression. Anticancer Res 25:79-83
    • (2005) Anticancer Res , vol.25 , pp. 79-83
    • Takayama, S.1    Ishii, S.2    Ikeda, T.3    Masamura, S.4    Doi, M.5    Kitajima, M.6
  • 166
    • 0022448122 scopus 로고
    • Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin
    • Tamkun JW, DeSimone DW, Fonda D, Patel RS, Buck C, Horwitz AF, Hynes RO (1986) Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell 46:271-82
    • (1986) Cell , vol.46 , pp. 271-82
    • Tamkun, J.W.1    DeSimone, D.W.2    Fonda, D.3    Patel, R.S.4    Buck, C.5    Horwitz, A.F.6    Hynes, R.O.7
  • 167
    • 33644827912 scopus 로고    scopus 로고
    • RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature
    • Temming K, Schiffelers RM, Molema G, Kok RJ (2005) RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature. Drug Resist Updat 8:381-402
    • (2005) Drug Resist Updat , vol.8 , pp. 381-402
    • Temming, K.1    Schiffelers, R.M.2    Molema, G.3    Kok, R.J.4
  • 169
    • 0029686918 scopus 로고    scopus 로고
    • Tumor angiogenesis and the role of vascular cell integrin alphavbeta3
    • Varner JA, Cheresh DA (1996). Tumor angiogenesis and the role of vascular cell integrin alphavbeta3. Important Adv Oncol 69-87
    • (1996) Important Adv Oncol , pp. 69-87
    • Varner, J.A.1    Cheresh, D.A.2
  • 170
    • 0037437150 scopus 로고    scopus 로고
    • RPTP-Alpha acts as a transducer of mechanical force on alphav/beta3-integrin-cytoskeleton linkages
    • von Wichert G, Jiang G, Kostic A, De Vos K, Sap J, Sheetz MP (2003) RPTP-Alpha acts as a transducer of mechanical force on alphav/beta3-integrin- cytoskeleton linkages. J Cell Biol 161:143-153
    • (2003) J Cell Biol , vol.161 , pp. 143-153
    • Von Wichert, G.1    Jiang, G.2    Kostic, A.3    De Vos, K.4    Sap, J.5    Sheetz, M.P.6
  • 171
    • 33746563570 scopus 로고    scopus 로고
    • Integrin-mediated transcriptional activation of inhibitor of apoptosis proteins protects smooth muscle cells against apoptosis induced by degraded collagen
    • von Wnuck Lipinski K, Keul P, Ferri N, Lucke S, Heusch G, Fischer JW, Levkau B (2006) Integrin-mediated transcriptional activation of inhibitor of apoptosis proteins protects smooth muscle cells against apoptosis induced by degraded collagen. Circ Res 98:1490-1497
    • (2006) Circ Res , vol.98 , pp. 1490-1497
    • Von Wnuck Lipinski, K.1    Keul, P.2    Ferri, N.3    Lucke, S.4    Heusch, G.5    Fischer, J.W.6    Levkau, B.7
  • 172
    • 18844442068 scopus 로고    scopus 로고
    • Integrin alphavbeta3 is a coreceptor for human cytomegalovirus
    • Wang X, Huang DY, Huong SM, Huang ES (2005) Integrin alphavbeta3 is a coreceptor for human cytomegalovirus. Nat Med 11:515-521
    • (2005) Nat Med , vol.11 , pp. 515-521
    • Wang, X.1    Huang, D.Y.2    Huong, S.M.3    Huang, E.S.4
  • 173
    • 0025895086 scopus 로고
    • Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface
    • Wayner EA, Orlando RA, Cheresh DA (1991) Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface. J Cell Biol 113:919-929
    • (1991) J Cell Biol , vol.113 , pp. 919-929
    • Wayner, E.A.1    Orlando, R.A.2    Cheresh, D.A.3
  • 175
    • 0027166647 scopus 로고
    • Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment
    • Wickham TJ, Mathias P, Cheresh DA, Nemerow GR (1993) Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 73:309-319
    • (1993) Cell , vol.73 , pp. 309-319
    • Wickham, T.J.1    Mathias, P.2    Cheresh, D.A.3    Nemerow, G.R.4
  • 177
    • 0037023363 scopus 로고    scopus 로고
    • Crystal structure of the extracellular segment of integrin alpha vbeta3 in complex with an arg-gly-Asp ligand
    • Xiong JP, Stehle T, Zhang R, Joachimiak A, Frech M, Goodman SL, Arnaout MA (2002) Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science 296:151-155
    • (2002) Science , vol.296 , pp. 151-155
    • Xiong, J.P.1    Stehle, T.2    Zhang, R.3    Joachimiak, A.4    Frech, M.5    Goodman, S.L.6    Arnaout, M.A.7
  • 178
    • 0029847191 scopus 로고    scopus 로고
    • Requirement of receptor-bound urokinase-Type plasminogen activator for integrin alphavbeta5-directed cell migration
    • Yebra M, Parry GC, Stromblad S, Mackman N, Rosenberg S, Mueller BM, Cheresh DA (1996) Requirement of receptor-bound urokinase-Type plasminogen activator for integrin alphavbeta5-directed cell migration. J Biol Chem 271:29393-29399
    • (1996) J Biol Chem , vol.271 , pp. 29393-29399
    • Yebra, M.1    Parry, G.C.2    Stromblad, S.3    Mackman, N.4    Rosenberg, S.5    Mueller, B.M.6    Cheresh, D.A.7
  • 179
    • 0036668842 scopus 로고    scopus 로고
    • TGFbeta1 -mediated epithelial to mesenchymal transition is accompanied by invasion in the SiHa cell line
    • Yi JY, Hur KC, Lee E, Jin YJ, Arteaga CL, Son YS (2002) TGFbeta1 -mediated epithelial to mesenchymal transition is accompanied by invasion in the SiHa cell line. Eur J Cell Biol 81:457-468
    • (2002) Eur J Cell Biol , vol.81 , pp. 457-468
    • Yi, J.Y.1    Hur, K.C.2    Lee, E.3    Jin, Y.J.4    Arteaga, C.L.5    Son, Y.S.6
  • 180
    • 0024778752 scopus 로고
    • Beta 3 subunit of vitronectin receptor is present in osteoclast adhesion structures and not in other monocyte-macrophage derived cells
    • Zambonin Zallone A, Teti A, Gaboli M, Marchisio PC (1989) Beta 3 subunit of vitronectin receptor is present in osteoclast adhesion structures and not in other monocyte-macrophage derived cells. Connect Tissue Res 20:143-149
    • (1989) Connect Tissue Res , vol.20 , pp. 143-149
    • Zambonin Zallone, A.1    Teti, A.2    Gaboli, M.3    Marchisio, P.C.4
  • 182
    • 14844317695 scopus 로고    scopus 로고
    • Unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal
    • Zhao H, Ross FP, Teitelbaum SL (2005) Unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal. Mol Endocrinol 19:771-780
    • (2005) Mol Endocrinol , vol.19 , pp. 771-780
    • Zhao, H.1    Ross, F.P.2    Teitelbaum, S.L.3
  • 183
    • 34249685565 scopus 로고    scopus 로고
    • Tests of the extension and deadbolt models of integrin activation
    • Zhu J, Boylan B, Luo BH, Newman PJ, Springer TA (2007) Tests of the extension and deadbolt models of integrin activation. J Biol Chem 282:11914-11920
    • (2007) J Biol Chem , vol.282 , pp. 11914-11920
    • Zhu, J.1    Boylan, B.2    Luo, B.H.3    Newman, P.J.4    Springer, T.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.