Enhanced fibroblast contraction of 3D collagen lattices and integrin expression by TGF-β1 and -β3: Mechanoregulatory growth factors?

Experimental Cell Research

Volumn 274, Issue 2, 2002, Pages 310-322

  Brown, Robert A ^a   Sethi, Kamaljit K ^a   Gwanmesia, Ivo ^a   Raemdonck, David ^a   Eastwood, Mark ^b   Mudera, Vivek ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF WESTMINSTER   (United Kingdom)

Author keywords

Collagen lattices; Culture force monitor; Cytomechanics; Fibronectin; Force generation; Human dermal fibroblasts; Integrins; Transforming growth factor ; Vitronectin

Indexed keywords

COLLAGEN; FIBRONECTIN RECEPTOR; INTEGRIN; INTEGRIN RECEPTOR; ISOPROTEIN; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA3; VITRONECTIN RECEPTOR;

ARTICLE; CELL ADHESION; CELL KINETICS; CELL STIMULATION; CONTROLLED STUDY; FIBROBLAST; FORCE; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SCALE UP;

EID: 0036346347     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5471     Document Type: Article

References (62)

1. Neutralising antibody to TGF-β1 and TGF-β2 reduces cutaneous scarring in rodents
2. Transforming Growth Factor type beta: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
3. TGF-β: Activity and efficacy in animal models of wound healing
4. Cell adhesion protein receptors as targets for TGFβ action
5. Regulation of mRNA for Type 1 plasminogen activator inhibitor, fibronectin and Type I procollagen by Transforming growth factor-beta
6. Transcriptional and post-transcriptional regulation of 72kDa gelatinase/type IV collagenase by transforming growth factor-beta1 in human fibroblasts. Comparison with collagenase and TIMP gene expression
7. Neutralisation of TGF-β1 and TGF-β2 by exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring
8. TGF-β3 stimulates and regulates collagen synthesis through TGF-β1 dependent and independent mechanisms
9. Extracellular matrix deposition by primary human lung fibro-blasts in response to TGF-β1 and TGF-β3
10. Myofibroblast transformation with trasforming growth factor-beta 1 and -beta 3 in cutaneous foetal excisional wounds
11. TGF-β-1 induces alpha smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
12. Induction of alpha-smooth muscle actin expression and myofibroblast transformation in cultured corneal keratocytes
13. Myofibroblasts differentiate from fibroblasts when plated at low density
14. Modulation of fibroblastic cytoskeletal features during pathological situations: The role of extracellular matrix and cytokines
15. Fibroblast traction as a mechanism for morphogenesis
16. Intgrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness
17. Collagen substrata for studies on cell behaviour
18. Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro
19. Transforming growth factor beta stimulates collagen matrix contractionby fibroblsts: Implications for wound healing
20. Tensional homeostasis in dermal fibroblasts: Mechanical responses to mechanical loading in three-dimensional substrates
21. Ultrastructural changes during contraction of collagen lattices by ocular fibroblasts
22. Differences in the regulation of fibroblast contraction of floating versus stressed collagen matrices
23. Release of mechanical tension triggers apoptosis of human fibroblasts in a model of regressing granulation tissue
24. Measurement of mechanical forces generated by skin fibroblasts embedded in a 3D collagen gel
25. Isometric contraction by fibroblasts and endothelial cells in tissue culture: A quantitative study
26. A culture force monitor for measurement of contraction forces generated by dermal fibroblast cultures: Evidence for cell-matrix mechanical signaling
27. Quantitative analysis of collagen gel contractile forces generated by dermal fibroblasts and their relationship to cell morphology
28. Balanced mechanical forces and microtubule contribution to fibroblast contraction
29. Cell locomotion forces versus cell contraction forces for collagen lattice contraction: An in vitro model of wound contraction
30. The biochemistry, structure and macromolecular organisation of collagen in Dupuytren's disease
31. A monoclonal antibody against a smooth muscle actin: A new probe for smooth muscle differentiation
32. Mechanisms of myofibroblast activity and phenotypic modulation
33. Production and use of skin cell cultures in therapeutic situation
34. Novel method for stereo imaging in light microscopy at high magnifications
35. Probing the phalloidin binding site actin
36. Fibroblast contraction occurs on release of tension in attached collagen lattices: Dependency on an organized actin cytoskeleton and serum
37. Review: Fibroblasts, myofibroblasts and wound contraction
38. Phenytoin reduces the contraction of Recessive Dystrophic Epidermolysis Bullosa fibroblast populated collagen gels
39. Changes in keratinocyte adhesion during terminal differentiation: Reduction in fibronectin binding precedes α5β1 integrin loss from the cell surface
40. Stimulation of protracted connective tissue repair in normal mice by TGFβ-1
41. Collagen gel contraction induced by retinal pigment epithelial cells and choroidalfibroblasts involves the protein kinase C pathway
42. TGF-β-1 induces the expression of type-I-collagen and SPARC, and enhances contraction of collagen gels, by fibroblasts from young and aged donors
43. Activation & suppression of fibroblast activity
44. Effect of precise mechanical loading on fibroblast populated collagen lattices: Morphological changes
45. Regulation of LPA-promoted myofibroblast contraction: Role of myosin light chain kinase and phosphatase
46. Increased myosin light chain phosphorylation is not required for growth factor stimulation of collagen matrix contraction
47. Angiotensin II and alpha (v) beta(3) integrin expression in rat neonatal cardiac fibroblasts
48. The compliance of collagen gels regulates transforming growth factor-β induction of α-smooth muscle actin in fibroblasts
49. Molecular responses of human dermal fibroblasts to dual cues: Contact guidance and mechanical load
50. Lysophosphatidic acid synthesis and release
51. Regulation of fibroblast-mediated collagen gel contraction by PDGF, IL-1-alpha and TGF-β-1
52. Induction of beta-1 integrin synthesis by recombinant PDGF-AB correlates with an enhanced migratory response of human dermal fibroblasts to various extracellular matrix proteins
53. Role of growth factors in scar contraction: An in vitro analysis
54. Growth factor effects on the expression of collagenase and TIMP-1 in peridontal ligament cells
55. Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations
56. Transforming growth factor beta regulated collagen gel contraction by increasing alpha 2 beta 1 integrin expression in osteogenic cells
57. Are stress fibres contractile?
58. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
59. Stress relaxation of contracted collagen gels: Disruption of actin filament bundles, release of cell surface fibronectin, and down regulation of DNA and protein synthesis
60. Transforming growth factor β stimuolates fibroblasts-collagen matrix contraction by different mechanisms in mechanically loaded and unloaded matrices