CAS/Crk coupling serves as a 'molecular switch' for induction of cell migration

Journal of Cell Biology

Volumn 140, Issue 4, 1998, Pages 961-972

  Klemke, Richard L ^a   Leng, Jie ^a   Molander, Rachel ^a   Brooks, Peter C ^a   Vuori, Kristiina ^b   Cheresh, David A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYTOKINE; GUANOSINE TRIPHOSPHATASE; INSULIN;

ANIMAL CELL; ARTICLE; CANCER INVASION; CELL MEMBRANE; CELL MIGRATION; EMBRYO; HUMAN; HUMAN CELL; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; TUMOR CELL;

ANIMALS; CELL MEMBRANE; CELL MOVEMENT; COS CELLS; CRK-ASSOCIATED SUBSTRATE PROTEIN; EXTRACELLULAR MATRIX; GENE EXPRESSION; GTP-BINDING PROTEINS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MEMBRANE PROTEINS; NEOPLASM METASTASIS; PANCREAS; PANCREATIC NEOPLASMS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CRK; RABBITS; RAC GTP-BINDING PROTEINS; RAS PROTEINS; RETINOBLASTOMA-LIKE PROTEIN P130; SRC HOMOLOGY DOMAINS; TUMOR CELLS, CULTURED; TYROSINE;

ANIMALIA;

EID: 0032559562     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.140.4.961     Document Type: Article

References (43)

1. Bar-Sagi, D., D. Rotin, A. Batzer, V. Mandiyan, and J. Schlessinger. 1993. SH3 domains direct cellular localization of signaling molecules. Cell. 74:83-91.
2. Birge, B., J. Fajardo, B. Mayer, and H. Hanafusa. 1992. Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitro. J. Biol. Chem. 267:10588-10595.
3. Brooks, P.C., R.L. Klemke, S. Schön, J.M. Lewis, M.A. Schwartz, and D.A. Cheresh. 1997. Insulin-like growth factor receptor cooperates with integrin αvβ5 to promote tumor cell dissemination in vivo. J. Clin. Invest. 99:1390-1398.
4. Cary, L.A., J.F. Chang, and J. Guan. 1996. Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J. Cell Sci. 109:1787-1794.
5. Chen, P., H. Xie, M. Sekar, K. Gupta, and A. Wells. 1994. Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required but mitosen-activated protein kinase is not sufficient for induced cell movement. J. Cell Biol. 127:847-857.
6. Clark, R.A.F., M.G. Tonnesen, J. Gailit, and D.A. Cheresh. 1996. Transient functional expression of αvβ3 on vascular cells during wound repair. Am. J. Pathol. 148:1407-1421.
7. Feller, S., R. Ren, H. Hanafusa, and D. Baltimore. 1994a. SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl. Trends Biochem. Sci. 19:453-458.
8. Feller, S., B. Knudsen, and H. Hanafusa. 1994b. C-Abl kinase regulates the protein binding activity of c-Crk. EMBO (Eur. Mol. Biol. Organ.) J. 13:2341-2351.
9. Feller, S., B. Knudsen, and H. Hanafusa. 1995. Cellular proteins binding to the first Src homology 3 (SH3) domain of the proto-oncogene product c-Crk indicate Crk-specific signaling pathways. Oncogene. 10:1465-1473.
10. Garton, A., A. Flint, N. Tonks. 1996. Identification of p130CAS as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. Mol. Cell. Biol. 271:6408-6418.
11. Gilmore, A.P., and L.H. Romer. 1996. Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol. Biol. Cell. 7:1209-1224.
12. Greulich, H., and H. Hanafusa. 1996. A role for Ras in v-Crk transformation. Cell Growth Diff. 7:1443-1451.
13. Hanks, S.K., and T.R. Polte. 1997. Signaling through focal adhesion kinase. BioEssays. 19:137-145.
14. Harte, M.T., J.D. Hildebrand, M.R. Burnham, A.H. Bouton, and J.T. Parsons. 1996. p130CAS, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase. J. Biol. Chem. 271:13649-13655.
15. Hasegawa, H., E. Kiyokawa, S. Tanaka, K. Nagashima, N. Gotoh, M. Shibuya, T. Kurata, and M. Matsuda. 1996. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol. Cell Biol. 16:1770-1776.
16. Hotchin, N.A., and A. Hall. 1995. The assembly of integrin complexes requires both extracellular matrix and intracellular rho/rac GTPases. J. Cell Biol. 131: 1857-1865.
17. Huttenlocher, A., M. Ginsberg, and A. Horwitz. 1996. Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity. J. Cell Biol. 134:1551-1562.
18. Ilic, D., Y. Furuat, S. Kanazawa, N. Takeda, K. Sobue, N. Nakatsuji, S. Nomura, J. Fujimoto, M. Okada, T. Yamamoio, and S. Aizawa. 1995. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature. 377:539-544.
19. Klemke, R., M. Yebra, E.M. Bayna, and D. A. Cheresh. 1994. Receptor tyrosine kinase signaling required for integrin αvβ5-directed cell motility but not adhesion on vitronectin. J. Cell Biol. 127:859-866.
20. Klemke, R., S. Cai, A. Giannini, P. Gallagher, P. de Laneroile, and D. Cheresh. 1997. Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol. 137:481-492.
21. Matsuda, M., and T. Kurata. 1996. Emerging components of the Crk oncogene product: the first identified adaptor protein. Cell. Signalling. 8:335-340.
22. Matsuda, M., S. Nagata, S. Tanaka, K. Nagashima, and T. Kurata. 1993. Structural requirement of CRK SH2 region for binding to phosphotyrosine-containing proteins. J. Biol. Chem. 268:4441-4446.
23. Matsuda, Mi., Y. Hashimoto, K. Muroya, H. Hasegawa, T. Kurata, S. Tanaka, S. Nakamura, and S. Hattori. 1994. CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of ras in PC12 cells. Mol. Cell. Biol. 14:5495-5500.
24. Mayer, B.J., H. Hirai, and R. Sakai. 1995. Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases. Curr. Biol. 5:296-305.
25. Michiels, F., G.G.M. Habets, J.C. Stam, R. A. van der Kammen, and J.G. Collard. 1995. A role for Rac in Tiam1-induced membrane ruffline and invasion Nature. 375:338-340.
26. Minden, A., A. Lin, F. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-jun transcriptional activity by the small GTPases Rac and Cdc42HS. Cell. 81:1147-1157.
27. Nakamoto, T., R. Sakai, H. Honda, S. Ogawa, H. Ueno, T. Suzuki, S. Aizawa, Y. Yazaki, and H. Hirai. 1997. Requirements for localization of p130CAS to focal adhesions. Mol. Cell. Biol. 17:3884-3887.
28. Nip, J., H. Shibata, D. Loskutoff, D. Cheresh, and P. Brodt. 1992. Human melanoma cells derived from lymphatic metastasis use integrin αvβ3 to adhere to lymph node vitronectin. J. Clin. Invest. 90:1406-1413.
29. Nojima, Y., N. Morino, T. Mimura, K. Hamasaki, H. Furuya, R. Sakai, T. Sato, K. Tachibana, C. Morimoto, Y. Yazaki, and H. Hirai. 1995. Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. J. Biol. Chem. 270:15398-15402.
30. Palecek, S., J. Loftus, M. Ginsberg, D. Lauffenburger, and A. Horwitz. 1997. Integrin-ligand binding properties govern speed through cell-substratum adhesiveness. Nature. 385:537-540.
31. Parsons, T. 1996. Integrin-mediated signaling: regulation by protein tyrosine kinases and small GTP-binding proteins. Curr. Opin. Cell Biol. 8:146-152.
32. Ridley, A.J., H.F. Paterson, C.L. Johnston, D. Diekmann, and A. Hall. 1992. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 70:401-410.
33. c-src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line. J. Cell Biol. 131:761-773.
34. Rodriguez-Viciana, P., P.H. Warne, A. Khwaja, B.M. Marte, D. Pappin, P. Das, M.D. Waterfield, A. Ridley, and J. Downward. 1997. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell. 89:457-467.
35. Sakai, R., A. Iwamatsu, N. Hirano, S. Ogawa, T. Tanaka, H. Mano, Y. Yazaki, and H. Hirai. 1994. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO (Eur. Mol. Biol. Organ.) J. 13:3748-3756.
36. Schlaepfer, D., M. Broome, and T. Hunter. 1997. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130 CAS and Nck adaptor proteins. Mol. Cell. Biol. 17:1702-1713.
37. Schumacher, C., B. Knudsen, T. Ohuchi, P. Di Fiore, R. Glassman, and H. Hanafusa. 1995. The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps 15 and Eps 15R. J. Biol. Chem. 270(25):15341-15347.
38. Schwartz, M., M. Schaller, and M. Ginsberg. 1995. Integrins: emerging paradigms of signal transduction. Annu. Rev. Cell Dev. Biol. 11:549-599.
39. Takaishi, K., A. Kiluchi, S. Kuroda, K. Kotani, T. Sasaki, and Y. Takai. 1993. Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility. Mol. Cell. Biol. 13:72-79.
40. Tanaka, S., S. Hattori, T. Kurata, K. Nagashima, Y. Fukui, S. Nakamura, and M. Matsuda. 1993. Both the SH2 and SH3 domains of human Crk protein are required for neuronal differentiation of PC12 cells. Mol. Cell. Biol. 13:4409-4415.
41. Vuori, K., and E. Ruoslahti. 1995. Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to the extracellular matrix. J. Biol. Chem. 270:22259-22262.
42. Vuori, K. H. Hirai, S. Aizawa, and E. Ruoslahti. 1996. Induction of p130Cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol. Cell. Biol. 16:2606-2613.
43. Yatohgo, T., M. Izumi, H. Kashiwagi, and M. Hiyashi. 1988. Novel purification of vitronectin from human plasma by heparin affinity chromatography. Cell Struct. Funct. 13:281-292.