Redistribution of flexibility in stabilizing antibody fragment mutants follows le châtelier's principle

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Li, Tong ^a   Tracka, Malgorzata B ^b   Uddin, Shahid ^b   Casas Finet, Jose ^b   Jacobs, Donald J ^c   Livesay, Dennis R ^a  

^a University of North Carolina at Charlotte   (United States)

^b MEDIMMUNE   (United States)

^c UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOZYME; ANTIGEN; IMMUNOGLOBULIN FRAGMENT; LYMPHOTOXIN BETA RECEPTOR; MUTANT PROTEIN;

ARTICLE; ENTHALPY; ENTROPY; EQUILIBRIUM CONSTANT; MOLECULAR DYNAMICS; MUTATION; POINT MUTATION; PRESSURE; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; TEMPERATURE; THERMODYNAMICS; WILD TYPE; ALGORITHM; CHEMISTRY; GENETICS; HYDROGEN BOND; PLIABILITY; PROTEIN DATABASE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; THEORETICAL MODEL; TRANSITION TEMPERATURE;

ALGORITHMS; ANTIGENS; DATABASES, PROTEIN; ENTROPY; HYDROGEN BONDING; IMMUNOGLOBULIN FRAGMENTS; LYMPHOTOXIN BETA RECEPTOR; MODELS, THEORETICAL; MOLECULAR DYNAMICS SIMULATION; MUTANT PROTEINS; MUTATION; PLIABILITY; PROTEIN STABILITY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TRANSITION TEMPERATURE;

EID: 84899890103     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092870     Document Type: Article

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