Thermodynamic stability and flexibility characteristics of antibody fragment complexes

Protein and Peptide Letters

Volumn 21, Issue 8, 2014, Pages 752-765

  Li, Tong ^a   Verma, Deeptak ^a   Tracka, Malgorzata B ^b   Casas Finet, Jose ^b   Livesay, Dennis R ^a   Jacobs, Donald J ^b,c  

^a Department of Bioinformatics and Genomics ^*  (United States)

^b MEDIMMUNE   (United States)

^c UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

Author keywords

And quantitative stability flexibility relationships; Antibody structure; Computational biology; Distance constraint model; Free energy landscape

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2 ANTIBODY; FERRITIN ANTIBODY; FLUORESCEIN ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN LIGHT CHAIN; P24 HIV 1 ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; VASCULOTROPIN ANTIBODY; IMMUNOGLOBULIN FRAGMENT;

ANTIBODY FRAGMENT COMPLEX; ANTIGEN BINDING; ARTICLE; COMPLEX FORMATION; FRAGMENT ANTIGEN BINDING; MINIMAL DISTANCE CONSTRAINT MODEL; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; QUANTITATIVE STABILITY FLEXIBILITY RELATIONSHIP; STATISTICAL MODEL; THERMODYNAMICS; BIOLOGY; BIOMECHANICS; CHEMICAL STRUCTURE; CHEMISTRY; HEAT; HUMAN; METABOLISM; MOLECULAR WEIGHT; PROCEDURES; PROTEIN TERTIARY STRUCTURE;

BIOMECHANICAL PHENOMENA; COMPUTATIONAL BIOLOGY; HOT TEMPERATURE; HUMANS; IMMUNOGLOBULIN FRAGMENTS; MODELS, MOLECULAR; MOLECULAR WEIGHT; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; THERMODYNAMICS;

EID: 84903704327     PISSN: 09298665     EISSN: 18755305     Source Type: Journal    
DOI: 10.2174/09298665113209990051     Document Type: Article

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