-
1
-
-
84873830397
-
Cardiovascular science: opportunities for translating research into improved care
-
Braunwald E. 2013. Cardiovascular science: opportunities for translating research into improved care. J. Clin. Invest. 123:6-10. http://dx.doi.org/10.1172/JCI67541.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 6-10
-
-
Braunwald, E.1
-
2
-
-
84873855851
-
Genetic mutations and mechanisms in dilated cardiomyopathy
-
McNally EM, Golbus JR, Puckelwartz MJ. 2013. Genetic mutations and mechanisms in dilated cardiomyopathy. J. Clin. Invest. 123:19-26. http://dx.doi.org/10.1172/JCI62862.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 19-26
-
-
McNally, E.M.1
Golbus, J.R.2
Puckelwartz, M.J.3
-
3
-
-
78649631986
-
Clinical and genetic issues in dilated cardiomyopathy: a review for genetics professionals
-
Hershberger RE, Morales A, Siegfried JD. 2010. Clinical and genetic issues in dilated cardiomyopathy: a review for genetics professionals. Genet. Med. 12:655-667. http://dx.doi.org/10.1097/GIM.0b013e3181f2481f.
-
(2010)
Genet. Med.
, vol.12
, pp. 655-667
-
-
Hershberger, R.E.1
Morales, A.2
Siegfried, J.D.3
-
4
-
-
77249109399
-
Dilated cardiomyopathy
-
Jefferies JL, Towbin JA. 2010. Dilated cardiomyopathy. Lancet 375:752-762. http://dx.doi.org/10.1016/S0140-6736(09)62023-7.
-
(2010)
Lancet
, vol.375
, pp. 752-762
-
-
Jefferies, J.L.1
Towbin, J.A.2
-
5
-
-
0042161933
-
Sizing up the heart: development redux in disease
-
Olson EN, Schneider MD. 2003. Sizing up the heart: development redux in disease. Genes Dev. 17:1937-1956. http://dx.doi.org/10.1101/gad.1110103.
-
(2003)
Genes Dev.
, vol.17
, pp. 1937-1956
-
-
Olson, E.N.1
Schneider, M.D.2
-
6
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA. 1996. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15:6541.
-
(1996)
EMBO J.
, vol.15
, pp. 6541
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
7
-
-
12644301164
-
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
-
Alessi DR, Deak M, Casamayor A, Barry Caudwell F, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D. 1997. 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr. Biol. 7:776-789. http://dx.doi.org/10.1016/S0960-9822(06)00336-8.
-
(1997)
Curr. Biol.
, vol.7
, pp. 776-789
-
-
Alessi, D.R.1
Deak, M.2
Casamayor, A.3
Barry Caudwell, F.4
Morrice, N.5
Norman, D.G.6
Gaffney, P.7
Reese, C.B.8
MacDougall, C.N.9
Harbison, D.10
-
8
-
-
2342565881
-
Advances in protein kinase B signalling: AKTion on multiple fronts
-
Brazil D, Yang Z, Hemmings B. 2004. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem. Sci. 29:233-242. http://dx.doi.org/10.1016/j.tibs.2004.03.006.
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 233-242
-
-
Brazil, D.1
Yang, Z.2
Hemmings, B.3
-
9
-
-
77957326627
-
PKB/Akt signaling in heart development and disease
-
Chang Z, Xiao Q, Feng Q, Yang Z. 2010. PKB/Akt signaling in heart development and disease. Front. Biosci. 2:1485-1491. http://dx.doi.org/10.2741/E207.
-
(2010)
Front. Biosci.
, vol.2
, pp. 1485-1491
-
-
Chang, Z.1
Xiao, Q.2
Feng, Q.3
Yang, Z.4
-
10
-
-
1342342993
-
PDK1, the master regulator of AGC kinase signal transduction
-
Mora AKD, van Aalten DM, Alessi DR. 2004. PDK1, the master regulator of AGC kinase signal transduction. Semin. Cell Dev. Biol. 15:161-170. http://dx.doi.org/10.1016/j.semcdb.2003.12.022.
-
(2004)
Semin. Cell Dev. Biol.
, vol.15
, pp. 161-170
-
-
Mora, A.K.D.1
van Aalten, D.M.2
Alessi, D.R.3
-
11
-
-
68149096799
-
The pharmacology of mTOR inhibition
-
Guertin DA, Sabatini DM. 2009. The pharmacology of mTOR inhibition. Sci. Signal. 2:24. http://dx.doi.org/10.1126/scisignal.267pe24.
-
(2009)
Sci. Signal.
, vol.2
, pp. 24
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
12
-
-
63749105226
-
mTOR and the control of whole body metabolism
-
Polak P, Hall M. 2009. mTOR and the control of whole body metabolism. Curr. Opin. Cell Biol. 21:209-218. http://dx.doi.org/10.1016/j.ceb.2009.01.024.
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 209-218
-
-
Polak, P.1
Hall, M.2
-
13
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov D, Guertin D, Ali S, Sabatini D. 2005. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101. http://dx.doi.org/10.1126/science.1106148.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.1
Guertin, D.2
Ali, S.3
Sabatini, D.4
-
14
-
-
0034176579
-
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
-
Williams MR, Arthur JSC, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR. 2000. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr. Biol. 10:439-448. http://dx.doi.org/10.1016/S0960-9822(00)00441-3.
-
(2000)
Curr. Biol.
, vol.10
, pp. 439-448
-
-
Williams, M.R.1
Arthur, J.S.C.2
Balendran, A.3
van der Kaay, J.4
Poli, V.5
Cohen, P.6
Alessi, D.R.7
-
15
-
-
33751348056
-
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC [alpha], but not S6K1
-
Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM. 2006. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC [alpha], but not S6K1. Dev. Cell 11:859-871. http://dx.doi.org/10.1016/j.devcel.2006.10.007.
-
(2006)
Dev. Cell
, vol.11
, pp. 859-871
-
-
Guertin, D.A.1
Stevens, D.M.2
Thoreen, C.C.3
Burds, A.A.4
Kalaany, N.Y.5
Moffat, J.6
Brown, M.7
Fitzgerald, K.J.8
Sabatini, D.M.9
-
16
-
-
33749076673
-
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
-
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B. 2006. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127:125-137. http://dx.doi.org/10.1016/j.cell.2006.08.033.
-
(2006)
Cell
, vol.127
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
Soto, N.4
Wei, S.5
Jung, S.Y.6
Huang, Q.7
Qin, J.8
Su, B.9
-
17
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN. 2002. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10:457-468. http://dx.doi.org/10.1016/S1097-2765(02)00636-6.
-
(2002)
Mol. Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
18
-
-
77955290360
-
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice
-
Zhang D, Contu R, Latronico MVG, Zhang J, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, Sonenberg N, Condorelli G. 2010. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J. Clin. Invest. 120:2805-2816. http://dx.doi.org/10.1172/JCI43008.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2805-2816
-
-
Zhang, D.1
Contu, R.2
Latronico, M.V.G.3
Zhang, J.4
Rizzi, R.5
Catalucci, D.6
Miyamoto, S.7
Huang, K.8
Ceci, M.9
Gu, Y.10
Dalton, N.D.11
Peterson, K.L.12
Guan, K.L.13
Brown, J.H.14
Chen, J.15
Sonenberg, N.16
Condorelli, G.17
-
19
-
-
79955615939
-
IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation
-
Xie X, Zhang D, Zhao B, Lu M-K, You M, Condorelli G, Wang C-Y, Guan K-L. 2011. IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc. Natl. Acad. Sci. U. S. A. 108:6474-6479. http://dx.doi.org/10.1073/pnas.1016132108.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 6474-6479
-
-
Xie, X.1
Zhang, D.2
Zhao, B.3
Lu, M.-K.4
You, M.5
Condorelli, G.6
Wang, C.-Y.7
Guan, K.-L.8
-
20
-
-
84055213694
-
S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt
-
Di R, Wu X, Chang Z, Zhao X, Feng Q, Lu S, Luan Q, Hemmings B, Li X, Yang Z. 2012. S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt. Biochem. J. 441: 199-207. http://dx.doi.org/10.1042/BJ20110033.
-
(2012)
Biochem. J.
, vol.441
, pp. 199-207
-
-
Di, R.1
Wu, X.2
Chang, Z.3
Zhao, X.4
Feng, Q.5
Lu, S.6
Luan, Q.7
Hemmings, B.8
Li, X.9
Yang, Z.10
-
21
-
-
48549089459
-
Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice
-
He W, Peng Y, Zhang W, Lv N, Tang J, Chen C, Zhang C, Gao S, Chen H, Zhi G. 2008. Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology 135:610-620. http://dx.doi.org/10.1053/j.gastro.2008.05.032.
-
(2008)
Gastroenterology
, vol.135
, pp. 610-620
-
-
He, W.1
Peng, Y.2
Zhang, W.3
Lv, N.4
Tang, J.5
Chen, C.6
Zhang, C.7
Gao, S.8
Chen, H.9
Zhi, G.10
-
22
-
-
0042357084
-
Protein kinase Bα/Akt 1 regulates placental development and fetal growth
-
Yang Z, Tschopp O, Hemmings-Mieszczak M, Feng J, Brodbeck D, Perentes E, Hemmings B. 2003. Protein kinase Bα/Akt 1 regulates placental development and fetal growth. J. Biol. Chem. 278:32124-32131. http://dx.doi.org/10.1074/jbc. M302847200.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32124-32131
-
-
Yang, Z.1
Tschopp, O.2
Hemmings-Mieszczak, M.3
Feng, J.4
Brodbeck, D.5
Perentes, E.6
Hemmings, B.7
-
23
-
-
77954372263
-
PDK1 regulates vascular remodeling and promotes epithelialmesenchymal transition in cardiac development
-
Feng Q, Di R, Tao F, Chang Z, Lu S, Fan W, Shan C, Li X, Yang Z. 2010. PDK1 regulates vascular remodeling and promotes epithelialmesenchymal transition in cardiac development. Mol. Cell. Biol. 30:3711-3721. http://dx.doi.org/10.1128/MCB.00420-10.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 3711-3721
-
-
Feng, Q.1
Di, R.2
Tao, F.3
Chang, Z.4
Lu, S.5
Fan, W.6
Shan, C.7
Li, X.8
Yang, Z.9
-
24
-
-
0141737071
-
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia
-
Mora A, Davies A, Bertrand L, Sharif I, Budas G, Jovanovi S, Mouton V, Kahn C, Lucocq J, Gray G, Jovanović A, Alessi D. 2003. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J. 22: 4666-4676. http://dx.doi.org/10.1093/emboj/cdg469.
-
(2003)
EMBO J.
, vol.22
, pp. 4666-4676
-
-
Mora, A.1
Davies, A.2
Bertrand, L.3
Sharif, I.4
Budas, G.5
Jovanovi, S.6
Mouton, V.7
Kahn, C.8
Lucocq, J.9
Gray, G.10
Jovanović, A.11
Alessi, D.12
-
25
-
-
33748950810
-
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
-
Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA. 2006. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev. Cell 11:583-589. http://dx.doi.org/10.1016/j.devcel.2006.08.013.
-
(2006)
Dev. Cell
, vol.11
, pp. 583-589
-
-
Shiota, C.1
Woo, J.T.2
Lindner, J.3
Shelton, K.D.4
Magnuson, M.A.5
-
26
-
-
27944493875
-
Dosage-dependent effects of Akt1/protein kinase Bα(PKBα) and Akt3/PKBγ on thymus, skin, and cardiovascular and nervous system development in mice
-
Yang Z, Tschopp O, Di-Poi N, Bruder E, Baudry A, Dummler B, Wahli W, Hemmings B. 2005. Dosage-dependent effects of Akt1/protein kinase Bα(PKBα) and Akt3/PKBγ on thymus, skin, and cardiovascular and nervous system development in mice. Mol. Cell. Biol. 25:10407-10418. http://dx.doi.org/10.1128/MCB.25.23.10407-10418.2005.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 10407-10418
-
-
Yang, Z.1
Tschopp, O.2
Di-Poi, N.3
Bruder, E.4
Baudry, A.5
Dummler, B.6
Wahli, W.7
Hemmings, B.8
-
27
-
-
77957889287
-
Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation
-
Chang Z, Zhang Q, Feng Q, Xu J, Teng T, Luan Q, Shan C, Hu Y, Hemmings BA, Gao X, Yang Z. 2010. Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation. Dev. Biol. 347:384-391. http://dx.doi.org/10.1016/j.ydbio.2010.08.033.
-
(2010)
Dev. Biol.
, vol.347
, pp. 384-391
-
-
Chang, Z.1
Zhang, Q.2
Feng, Q.3
Xu, J.4
Teng, T.5
Luan, Q.6
Shan, C.7
Hu, Y.8
Hemmings, B.A.9
Gao, X.10
Yang, Z.11
-
28
-
-
54849426651
-
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy
-
Bentzinger CF, Romanino K, Cloetta D, Lin S, Mascarenhas JB, Oliveri F, Xia J, Casanova E, Costa CF, Brink M, Zorzato F, Hall MN, Ruegg MA. 2008. Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab. 8:411-424. http://dx.doi.org/10.1016/j.cmet.2008.10.002.
-
(2008)
Cell Metab.
, vol.8
, pp. 411-424
-
-
Bentzinger, C.F.1
Romanino, K.2
Cloetta, D.3
Lin, S.4
Mascarenhas, J.B.5
Oliveri, F.6
Xia, J.7
Casanova, E.8
Costa, C.F.9
Brink, M.10
Zorzato, F.11
Hall, M.N.12
Ruegg, M.A.13
-
29
-
-
67649867447
-
mTOR complex 2 in adipose tissue negatively controls whole-body growth
-
Cybulski N, Polak P, Auwerx J, Ruegg MA, Hall MN. 2009. mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proc. Natl. Acad. Sci. U. S. A. 106:9902-9907. http://dx.doi.org/10.1073/pnas.0811321106.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 9902-9907
-
-
Cybulski, N.1
Polak, P.2
Auwerx, J.3
Ruegg, M.A.4
Hall, M.N.5
-
30
-
-
77955488179
-
Sin1-mTORC2 SUppresses rag and il7r gene expression through Akt2 in B cells
-
Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B. 2010. Sin1-mTORC2 SUppresses rag and il7r gene expression through Akt2 in B cells. Mol. Cell 3:433-443. http://dx.doi.org/10.1016/j.molcel.2010.07.031.
-
(2010)
Mol. Cell
, vol.3
, pp. 433-443
-
-
Lazorchak, A.S.1
Liu, D.2
Facchinetti, V.3
Di Lorenzo, A.4
Sessa, W.C.5
Schatz, D.G.6
Su, B.7
-
31
-
-
44449171291
-
Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress
-
Oudit GY, Kassiri Z, Zhou J, Liu QC, Liu PP, Backx PH, Dawood F, Crackower MA, Scholey JW, Penninger JM. 2008. Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovasc. Res. 78:505-514. http://dx.doi.org/10.1093/cvr/cvn041.
-
(2008)
Cardiovasc. Res.
, vol.78
, pp. 505-514
-
-
Oudit, G.Y.1
Kassiri, Z.2
Zhou, J.3
Liu, Q.C.4
Liu, P.P.5
Backx, P.H.6
Dawood, F.7
Crackower, M.A.8
Scholey, J.W.9
Penninger, J.M.10
-
32
-
-
58149280238
-
Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury
-
Ruan H, Li J, Ren S, Gao J, Li G, Kim R, Wu H, Wang Y. 2009. Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury. J. Mol. Cell. Cardiol. 46:193-200. http://dx.doi.org/10.1016/j.yjmcc.2008.10.021.
-
(2009)
J. Mol. Cell. Cardiol.
, vol.46
, pp. 193-200
-
-
Ruan, H.1
Li, J.2
Ren, S.3
Gao, J.4
Li, G.5
Kim, R.6
Wu, H.7
Wang, Y.8
-
33
-
-
0032475861
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
-
Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW. 1998. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95:29-39. http://dx.doi.org/10.1016/S0092-8674(00)81780-8.
-
(1998)
Cell
, vol.95
, pp. 29-39
-
-
Stambolic, V.1
Suzuki, A.2
de la Pompa, J.L.3
Brothers, G.M.4
Mirtsos, C.5
Sasaki, T.6
Ruland, J.7
Penninger, J.M.8
Siderovski, D.P.9
Mak, T.W.10
-
34
-
-
77949666259
-
Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction
-
Keyes KT, Xu J, Long B, Zhang C, Hu Z, Ye Y. 2010. Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction. Am. J. Physiol. Heart Circ. Physiol. 298: H1198-H1208. http://dx.doi.org/10.1152/ajpheart.00915.2009.
-
(2010)
Am. J. Physiol. Heart Circ. Physiol.
, vol.298
-
-
Keyes, K.T.1
Xu, J.2
Long, B.3
Zhang, C.4
Hu, Z.5
Ye, Y.6
-
35
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. 2005. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098. http://dx.doi.org/10.1126/science.1106148.
-
(2005)
Science
, vol.307
, pp. 1098
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
36
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM. 2006. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell 22:159-168. http://dx.doi.org/10.1016/j.molcel.2006.03.029.
-
(2006)
Mol. Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
38
-
-
4644359805
-
Identification of a PKB/Akthydrophobic motif Ser-473 kinase asDNA-dependentprotein kinase
-
Feng J, Park J, Cron P, Hess D, Hemmings BA. 2004. Identification of a PKB/Akthydrophobic motif Ser-473 kinase asDNA-dependentprotein kinase. J. Biol. Chem. 279:41189. http://dx.doi.org/10.1074/jbc. M406731200.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 41189
-
-
Feng, J.1
Park, J.2
Cron, P.3
Hess, D.4
Hemmings, B.A.5
-
39
-
-
33748278519
-
Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure
-
White DE, Coutu P, Shi Y-F, Tardif J-C, Nattel S, St Arnaud R, Dedhar S, Muller WJ. 2006. Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. Genes Dev. 20:2355-2360. http://dx.doi.org/10.1101/gad.1458906.
-
(2006)
Genes Dev.
, vol.20
, pp. 2355-2360
-
-
White, D.E.1
Coutu, P.2
Shi, Y.-F.3
Tardif, J.-C.4
Nattel, S.5
St Arnaud, R.6
Dedhar, S.7
Muller, W.J.8
-
40
-
-
84872354779
-
Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth
-
Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G. 2013. Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS One 8:e54221. http://dx.doi.org/10.1371/journal.pone.0054221.
-
(2013)
PLoS One
, vol.8
-
-
Zhu, Y.1
Pires, K.M.2
Whitehead, K.J.3
Olsen, C.D.4
Wayment, B.5
Zhang, Y.C.6
Bugger, H.7
Ilkun, O.8
Litwin, S.E.9
Thomas, G.10
-
41
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, Thomas G. 2004. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431:200-205. http://dx.doi.org/10.1038/nature02866.
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
Fumagalli, S.7
Allegrini, P.R.8
Kozma, S.C.9
Auwerx, J.10
Thomas, G.11
-
42
-
-
79251517382
-
Regulation of cancer cell metabolism
-
Cairns RA, Harris IS, Mak TW. 2011. Regulation of cancer cell metabolism. Nat. Rev. Cancer 11:85-95. http://dx.doi.org/10.1038/nrc2981.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 85-95
-
-
Cairns, R.A.1
Harris, I.S.2
Mak, T.W.3
-
43
-
-
0035814747
-
Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure
-
Haq S, Choukroun G, Lim H, Tymitz KM, del Monte F, Gwathmey J, Grazette L, Michael A, Hajjar R, Force T, Molkentin JD. 2001. Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure. Circulation 103:670-677. http://dx.doi.org/10.1161/01.CIR.103.5.670.
-
(2001)
Circulation
, vol.103
, pp. 670-677
-
-
Haq, S.1
Choukroun, G.2
Lim, H.3
Tymitz, K.M.4
del Monte, F.5
Gwathmey, J.6
Grazette, L.7
Michael, A.8
Hajjar, R.9
Force, T.10
Molkentin, J.D.11
-
44
-
-
23644442091
-
PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury
-
Nagoshi T, Matsui T, Aoyama T, Leri A, Anversa P, Li L, Ogawa W, del Monte F, Gwathmey JK, Grazette L, Hemmings B, Kass DA, Champion HC, Rosenzweig A. 2005. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J. Clin. Invest. 115:2128-2138. http://dx.doi.org/10.1172/JCI23073.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2128-2138
-
-
Nagoshi, T.1
Matsui, T.2
Aoyama, T.3
Leri, A.4
Anversa, P.5
Li, L.6
Ogawa, W.7
del Monte, F.8
Gwathmey, J.K.9
Grazette, L.10
Hemmings, B.11
Kass, D.A.12
Champion, H.C.13
Rosenzweig, A.14
-
45
-
-
66649111290
-
PDK1 coordinates survival pathways and β-adrenergic response in the heart
-
Ito K, Akazawa H, Tamagawa M, Furukawa K, Ogawa W, Yasuda N, Kudo Y, Liao C, Yamamoto R, Sato T. 2009. PDK1 coordinates survival pathways and β-adrenergic response in the heart. Proc. Natl. Acad. Sci. U. S. A. 106:8689. http://dx.doi.org/10.1073/pnas.0900064106.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 8689
-
-
Ito, K.1
Akazawa, H.2
Tamagawa, M.3
Furukawa, K.4
Ogawa, W.5
Yasuda, N.6
Kudo, Y.7
Liao, C.8
Yamamoto, R.9
Sato, T.10
-
46
-
-
0141737071
-
Deficiency of P.D.K1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia.
-
Alfonso Mora AMD, Luc Bertrand IS, Grant RB. 2003. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J. 22:4666-4676. http://dx.doi.org/10.1093/emboj/cdg469.
-
(2003)
EMBO J.
, vol.22
, pp. 4666-4676
-
-
Alfonso Mora, A.M.D.1
Luc Bertrand, I.S.2
Grant, R.B.3
|