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Volumn 111, Issue 18, 2014, Pages

Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression

Author keywords

Cdc7 Dbf4 kinase; DNA helicase; MCM2 7

Indexed keywords

CHECKPOINT KINASE RAD3; CYCLIN DEPENDENT KINASE; HELICASE; MINICHROMOSOME MAINTENANCE PROTEIN 4;

EID: 84899846910     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1404063111     Document Type: Article
Times cited : (51)

References (39)
  • 1
    • 33846330909 scopus 로고    scopus 로고
    • CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast
    • Tanaka S, et al. (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445(7125):328-332.
    • (2007) Nature , vol.445 , Issue.7125 , pp. 328-332
    • Tanaka, S.1
  • 2
    • 33846328709 scopus 로고    scopus 로고
    • Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast
    • Zegerman P, Diffley JF (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445(7125):281-285.
    • (2007) Nature , vol.445 , Issue.7125 , pp. 281-285
    • Zegerman, P.1    Diffley, J.F.2
  • 3
    • 73849129578 scopus 로고    scopus 로고
    • The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4
    • Sheu YJ, Stillman B (2010) The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature 463(7277):113-117.
    • (2010) Nature , vol.463 , Issue.7277 , pp. 113-117
    • Sheu, Y.J.1    Stillman, B.2
  • 4
    • 33645717628 scopus 로고    scopus 로고
    • GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks
    • Gambus A, et al. (2006) GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol 8(4):358-366.
    • (2006) Nat Cell Biol , vol.8 , Issue.4 , pp. 358-366
    • Gambus, A.1
  • 5
    • 33745925880 scopus 로고    scopus 로고
    • Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DN A replication fork helicase
    • Moyer SE, Lewis PW, Botchan MR (2006) Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DN A replication fork helicase. Proc Natl Acad Sci USA 103(27):10236-10241.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.27 , pp. 10236-10241
    • Moyer, S.E.1    Lewis, P.W.2    Botchan, M.R.3
  • 6
    • 32444450705 scopus 로고    scopus 로고
    • Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication
    • Pacek M, Tutter AV, Kubota Y, Takisawa H, Walter JC (2006) Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. Mol Cell 21(4):581-587.
    • (2006) Mol Cell , vol.21 , Issue.4 , pp. 581-587
    • Pacek, M.1    Tutter, A.V.2    Kubota, Y.3    Takisawa, H.4    Walter, J.C.5
  • 7
    • 0043092109 scopus 로고    scopus 로고
    • Identification of MCM4 as a target of the DNA replication block checkpoint system
    • Ishimi Y, Komamura-Kohno Y, Kwon HJ, Yamada K, Nakanishi M (2003) Identification of MCM4 as a target of the DNA replication block checkpoint system. J Biol Chem 278(27):24644-24650.
    • (2003) J Biol Chem , vol.278 , Issue.27 , pp. 24644-24650
    • Ishimi, Y.1    Komamura-Kohno, Y.2    Kwon, H.J.3    Yamada, K.4    Nakanishi, M.5
  • 8
    • 34249947699 scopus 로고    scopus 로고
    • ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    • Matsuoka S, et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316(5828):1160-1166.
    • (2007) Science , vol.316 , Issue.5828 , pp. 1160-1166
    • Matsuoka, S.1
  • 9
    • 84858053395 scopus 로고    scopus 로고
    • Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases
    • De Piccoli G, et al. ( 2012) Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases. Mol Cell 45(5):696-704.
    • (2012) Mol Cell , vol.45 , Issue.5 , pp. 696-704
    • De Piccoli, G.1
  • 10
    • 84865188025 scopus 로고    scopus 로고
    • Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex
    • Ilves I, Tamberg N, Botchan MR (2012) Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex. Proc Natl Acad Sci USA 109(33):13163-13170.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.33 , pp. 13163-13170
    • Ilves, I.1    Tamberg, N.2    Botchan, M.R.3
  • 11
    • 77957149919 scopus 로고    scopus 로고
    • Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation
    • Zegerman P, Diffley JF (2010) Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. Nature 467(7314):474-478.
    • (2010) Nature , vol.467 , Issue.7314 , pp. 474-478
    • Zegerman, P.1    Diffley, J.F.2
  • 12
    • 77957144885 scopus 로고    scopus 로고
    • Damage-induced phosphorylation of Sld3 is important to block late origin firing
    • Lopez-Mosqueda J, et al. (2010) Damage-induced phosphorylation of Sld3 is important to block late origin firing. Nature 467(7314):479-483.
    • (2010) Nature , vol.467 , Issue.7314 , pp. 479-483
    • Lopez-Mosqueda, J.1
  • 13
    • 78149462002 scopus 로고    scopus 로고
    • Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7
    • Randell JC, et al. (2010) Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7. Mol Cell 40(3):353-363.
    • (2010) Mol Cell , vol.40 , Issue.3 , pp. 353-363
    • Randell, J.C.1
  • 14
    • 84871740379 scopus 로고    scopus 로고
    • Coordinated control of replication and transcription by a SAPK protects genomic integrity
    • Duch A, et al. (2013) Coordinated control of replication and transcription by a SAPK protects genomic integrity. Nature 493(7430):116-119.
    • (2013) Nature , vol.493 , Issue.7430 , pp. 116-119
    • Duch, A.1
  • 15
    • 33749075373 scopus 로고    scopus 로고
    • Cdc7-Dbf4 phosphorylates MCM proteins via a docking sitemediated mechanism to promote S phase progression
    • Sheu YJ, Stillman B (2006) Cdc7-Dbf4 phosphorylates MCM proteins via a docking sitemediated mechanism to promote S phase progression. Mol Cell 24(1):101-113.
    • (2006) Mol Cell , vol.24 , Issue.1 , pp. 101-113
    • Sheu, Y.J.1    Stillman, B.2
  • 16
    • 48249129062 scopus 로고    scopus 로고
    • Interplay between S-cyclin-dependent kinase and Dbf4-dependent kinase in controlling DNA replication through phosphorylation of yeast Mcm4 N-terminal domain
    • Devault A, Gueydon E, Schwob E (2008) Interplay between S-cyclin-dependent kinase and Dbf4-dependent kinase in controlling DNA replication through phosphorylation of yeast Mcm4 N-terminal domain. Mol Biol Cell 19(5):2267-2277.
    • (2008) Mol Biol Cell , vol.19 , Issue.5 , pp. 2267-2277
    • Devault, A.1    Gueydon, E.2    Schwob, E.3
  • 17
    • 33751578231 scopus 로고    scopus 로고
    • New vectors for simplified construction of BrdUIncorporating strains of Saccharomyces cerevisiae
    • Viggiani CJ, Aparicio OM (20 06) New vectors for simplified construction of BrdUIncorporating strains of Saccharomyces cerevisiae. Yeast 23(14- 15):1045-1051.
    • (2006) Yeast , vol.23 , Issue.14-15 , pp. 1045-1051
    • Viggiani, C.J.1    Aparicio, O.M.2
  • 18
    • 40649111377 scopus 로고    scopus 로고
    • A chemical method for fast and sensitive detection of DNA synthesis in vivo
    • Salic A, Mitchison TJ (2008) A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci USA 105(7):2415-2420.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.7 , pp. 2415-2420
    • Salic, A.1    Mitchison, T.J.2
  • 20
    • 34548789595 scopus 로고    scopus 로고
    • Replication in hydroxyurea: It?s a matter of time
    • Alvino GM, et al. (2007) Replication in hydroxyurea: It?s a matter of time. Mol Cell Biol 27(18):6396-6406.
    • (2007) Mol Cell Biol , vol.27 , Issue.18 , pp. 6396-6406
    • Alvino, G.M.1
  • 21
    • 84865547058 scopus 로고    scopus 로고
    • Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing
    • Bianco JN, et al. (2012) Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing. Methods 57(2):149-157.
    • (2012) Methods , vol.57 , Issue.2 , pp. 149-157
    • Bianco, J.N.1
  • 22
    • 0032562610 scopus 로고    scopus 로고
    • Formation of a preinitiation complex by S-phase cyclin CDKdependent loading of Cdc45p onto chromatin
    • Zou L, Stillman B (1998) Formation of a preinitiation complex by S-phase cyclin CDKdependent loading of Cdc45p onto chromatin. Science 280(5363):593-596.
    • (1998) Science , vol.280 , Issue.5363 , pp. 593-596
    • Zou, L.1    Stillman, B.2
  • 23
    • 0032497529 scopus 로고    scopus 로고
    • A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
    • Santocanale C, Diffley JF (1998) A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 395(6702):615-618.
    • (1998) Nature , vol.395 , Issue.6702 , pp. 615-618
    • Santocanale, C.1    Diffley, J.F.2
  • 24
    • 0035796505 scopus 로고    scopus 로고
    • The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage
    • Zhao X, Chabes A, Domkin V, Thelander L, Rothstein R (2001) The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage. EMBO J 20(13):3544-3553.
    • (2001) EMBO J , vol.20 , Issue.13 , pp. 3544-3553
    • Zhao, X.1    Chabes, A.2    Domkin, V.3    Thelander, L.4    Rothstein, R.5
  • 25
    • 0027605113 scopus 로고
    • DNA damage and cell cycle regulation of ribonucleotide reductase
    • Elledge SJ, Zhou Z, Allen JB, Navas TA (1993) DNA damage and cell cycle regulation of ribonucleotide reductase. BioEssays 15(5):333-339.
    • (1993) BioEssays , vol.15 , Issue.5 , pp. 333-339
    • Elledge, S.J.1    Zhou, Z.2    Allen, J.B.3    Navas, T.A.4
  • 26
    • 29144486147 scopus 로고    scopus 로고
    • Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations
    • Cobb JA, et al. (2005) Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations. Genes Dev 19(24):3055-3069.
    • (2005) Genes Dev , vol.19 , Issue.24 , pp. 3055-3069
    • Cobb, J.A.1
  • 27
    • 0033570894 scopus 로고    scopus 로고
    • Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphory lation of the lagging strand DNA polymerase
    • Pellicioli A, et al. (1999) Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphory lation of the lagging strand DNA polymerase. EMBO J 18(22):6561-6572.
    • (1999) EMBO J , vol.18 , Issue.22 , pp. 6561-6572
    • Pellicioli, A.1
  • 28
    • 80052498192 scopus 로고    scopus 로고
    • Phosphorylation ofMcm2 modulates Mcm2-7 activity and affects the cell?s response to DNA damage
    • Stead BE, Brandl CJ, Davey MJ (2011) Phosphorylation ofMcm2 modulates Mcm2-7 activity and affects the cell?s response to DNA damage. Nucleic Acids Res 39(16):6998-7008.
    • (2011) Nucleic Acids Res , vol.39 , Issue.16 , pp. 6998-7008
    • Stead, B.E.1    Brandl, C.J.2    Davey, M.J.3
  • 30
    • 84873044090 scopus 로고    scopus 로고
    • Location, location, location: It?s all in the timing for replication origins
    • Aparicio OM (2013) Location, location, location: It?s all in the timing for replication origins. Genes Dev 27(2):117-128.
    • (2013) Genes Dev , vol.27 , Issue.2 , pp. 117-128
    • Aparicio, O.M.1
  • 31
    • 77952986553 scopus 로고    scopus 로고
    • Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs
    • Mok J, et al. (2010) Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci Signal 3(109):ra12.
    • (2010) Sci Signal , vol.3 , Issue.109
    • Mok, J.1
  • 32
    • 0035860801 scopus 로고    scopus 로고
    • Phosphorylation of Mcm4 at specific sites by cyclin-dependent kinase leads to loss of Mcm4,6, 7 helicase activity
    • Ishimi Y, Komamura-Kohno Y (2001) Phosphorylation of Mcm4 at specific sites by cyclin-dependent kinase leads to loss of Mcm4,6, 7 helicase activity. J Biol Chem 276(37):34428-34433.
    • (2001) J Biol Chem , vol.276 , Issue.37 , pp. 34428-34433
    • Ishimi, Y.1    Komamura-Kohno, Y.2
  • 33
    • 84857060479 scopus 로고    scopus 로고
    • DNTP pools determine fork progression and origin usage under replication stress
    • Poli J, et al. (2012) dNTP pools determine fork progression and origin usage under replication stress. EMBO J 31(4):883-894.
    • (2012) EMBO J , vol.31 , Issue.4 , pp. 883-894
    • Poli, J.1
  • 34
    • 24044552287 scopus 로고    scopus 로고
    • Mrc1 and Tof1 pr omote replication fork progression and recovery independently of Rad53
    • Tourriè re H, Versini G, Cordón-Preciado V, Alabert C, Pasero P (2005) Mrc1 and Tof1 pr omote replication fork progression and recovery independently of Rad53. Mol Cell 19(5):699-706.
    • (2005) Mol Cell , vol.19 , Issue.5 , pp. 699-706
    • Tourrière, H.1    Versini, G.2    Cordón-Preciado, V.3    Alabert, C.4    Pasero, P.5
  • 35
    • 0042865938 scopus 로고    scopus 로고
    • S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex
    • Katou Y, et al. (2003) S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424(6952):1078-1083.
    • (2003) Nature , vol.424 , Issue.6952 , pp. 1078-1083
    • Katou, Y.1
  • 36
    • 0035735472 scopus 로고    scopus 로고
    • Mrc1 transduces signals of DNA replication stress to activate Rad53
    • Alcasabas AA, et al. (2001) Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat Cell Biol 3(11):958-965.
    • (2001) Nat Cell Biol , vol.3 , Issue.11 , pp. 958-965
    • Alcasabas, A.A.1
  • 37
    • 53149135030 scopus 로고    scopus 로고
    • Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint
    • Lou H, et al. (2008) Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint. Mol Cell 32(1):106-117.
    • (2008) Mol Cell , vol.32 , Issue.1 , pp. 106-117
    • Lou, H.1
  • 38
    • 0033215306 scopus 로고    scopus 로고
    • Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway
    • Weinreich M, Stillman B (1999) Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. EMBO J 18(19):5334-5346.
    • (1999) EMBO J , vol.18 , Issue.19 , pp. 5334-5346
    • Weinreich, M.1    Stillman, B.2
  • 39
    • 79953759105 scopus 로고    scopus 로고
    • Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerasee
    • Puddu F, Piergiovanni G, Plevani P, Muzi-Falconi M (2011) Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase e. PLoS Genet 7(3):e1002022.
    • (2011) PLoS Genet , vol.7 , Issue.3
    • Puddu, F.1    Piergiovanni, G.2    Plevani, P.3    Muzi-Falconi, M.4


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