Phosphorylation of Mcm4 at Specific Sites by Cyclin-dependent Kinase Leads to Loss of Mcm4,6,7 Helicase Activity

Journal of Biological Chemistry

Volumn 276, Issue 37, 2001, Pages 34428-34433

  Ishimi, Yukio ^a   Komamura Kohno, Yuki ^a  

^a MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBODIES; CELLS; DNA; ENZYMES; MUTAGENESIS;

EUKARYOTES;

PROTEINS;

CYCLIN A; CYCLIN DEPENDENT KINASE; HELICASE; MCM4 PROTEIN; MCM6 PROTEIN; MCM7 PROTEIN; PHOSPHOTHREONINE; UNCLASSIFIED DRUG; CDC54 PROTEIN, S CEREVISIAE; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE 2; DNA BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; COMPLEX FORMATION; DNA REPLICATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; AMINO ACID SEQUENCE; CELL CYCLE G2 PHASE; DRUG ANTAGONISM; METABOLISM; MITOSIS; MOLECULAR GENETICS; PHOSPHORYLATION; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION;

EUKARYOTA;

AMINO ACID SEQUENCE; CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; CYCLIN A; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASES; DNA HELICASES; DNA REPLICATION; DNA-BINDING PROTEINS; G2 PHASE; MITOSIS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035860801     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104480200     Document Type: Article

References (56)

1. Blow, J. J., and Laskey, R. A. (1988) Nature 332, 546-548
2. Kubota, Y., Mimura, S., Nishimoto, S., Takisawa, H., and Nojima, H. (1995) Cell 81, 601-609
3. Chong, J. P., Mahbubani, H. M., Khoo, C. Y., and Blow, J. J. (1995) Nature 375, 418-421
4. Madine, M. A., Khoo, C. Y., Mills, A. D., and Laskey, R. A. (1995) Nature 375, 421-424
5. Maiorano, D., Moreau, J., and Mechali, M. (2000) Nature 404, 622-628
6. Nishitani, H., Lygerou, Z., Nishimoto, T., and Nurse, P. (2000) Nature 404, 625-628
7. Tada, S., Li, A., Maiorano, D., Mechali, M., and Blow, J. J. (2001) Nat. Cell Biol. 3, 107-113
8. Hua, X. H., and Newport, J. (1998) J. Cell Biol. 140, 271-281
9. Kelly, T. J., and Brown, G. W. (2000) Annu. Rev. Biochem. 69, 829-880
10. Takisawa, H., Mimura, S., and Kubota, Y. (2001) Curr. Opin. Cell Biol. 12, 690-696
11. Kearsey, S. E., Montgomery, S., Labib, K., and Lindner, K. (2000) EMBO J. 19, 1681-1690
12. Méndez, J., and Stillman, B. (2000) Mol. Cell. Biol. 20, 8602-8612
13. Nishitani, H., and Nurse, P. (1995) Cell 83, 397-405
14. Jallepalli, P. V., and Kelly, T. J. (1996) Genes Dev. 10, 541-552
15. Piatti, S., Bohm, T., Cocker, J. H., Diffley, J. F., and Nasmyth, K. (1996) Genes Dev. 10, 1516-1531
16. Broek, D., Bartlett, R., Crawford, K., and Nurse, P. (1991) Nature 349, 388-393
17. Hayles, J., Fisher, D., Woollard, A., and Nurse, P. (1994) Cell 78, 813-822
18. Moreno, S., and Nurse, P. (1994) Nature 367, 236-242
19. Dahmann, C., Diffley, J. F., and Nasmyth, K. A. (1995) Curr. Biol. 5, 1257-1269
20. Sauer, K., Knoblich, J. A., Richardson, H., and Lehner, C. F. (1995) Genes Dev. 9, 1327-1339
21. Itzhaki, J. E., Gilbert, C. S., and Porter, A. C. (1997) Nat. Genet. 15, 258-265
22. Tanaka, T., Knapp, D., and Nasmyth, K. (1997) Cell 90, 649-660
23. Detweiler, C. S., and Li, J. J. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 2384-2389
24. Jallepalli, P. V., Brown, G. W., Muzi-Falconi, M., Tien, D., and Kelly, T. J. (1997) Genes Dev. 11, 2767-2779
25. Saha, P., Chen, J., Thome, K. C., Lawlis, S. J., Hou, Z. H., Hendricks, M., Parvin, J. D., and Dutta, A. (1998) Mol. Cell. Biol. 18, 2758-2767
26. Petersen, B. O., Lukas, J., Sørensen, C. S., Bartek, J., and Helin, K. (1999) EMBO J. 18, 396-410
27. Jiang, W., Wells, N. J., and Hunter, T. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 6193-6198
28. Labib, K., Diffley, J. F. X., and Kearsey, S. E. (1999) Nat. Cell Biol. 1, 415-422
29. Nguyen, V. Q., Co, C., Irie, K., and Li, J. J. (2000) Curr. Biol. 10, 195-205
30. Jallepalli, P. V., and Kelly, T. J. (1997) Curr. Opin. Cell Biol. 9, 358-363
31. McGarry, T. J., and Kirschner, M. W. (1998) Cell 93, 1043-1053
32. Wohlschlegel, J. A., Dwyer, B. T., Dhar, S. K., Cvetic, C., Walter, J. C., and Dutta, A. (2000) Science 290, 2309-2312
33. Koonin, E. V. (1993) Nucleic Acids Res. 21, 2541-2547
34. Ishimi, Y. (1997) J. Biol. Chem. 272, 24508-24513
35. Ishimi, Y., Komamura, Y., You, Z., and Kimura, H. (1998) J. Biol. Chem. 273, 8369-8375
36. You, Z., Komamura, Y., and Ishimi, Y. (1999) Mol. Cell. Biol. 19, 8003-8015
37. Lee, J.-K., and Hurwitz, J. (2000) J. Biol. Chem. 275, 18871-18878
38. Lee, J.-K., and Hurwitz, J. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 54-59
39. Aparicio, O. M., Weinstein, D. M., and Bell, S. P. (1997) Cell 91, 59-69
40. Labib, K., Tercero, J. A., and Diffley. (2000) Science 288, 1643-1647
41. Tye, B. K., and Sawyer, S. (2000) J. Biol. Chem. 275, 34833-34836
42. Lei, M., and Tye, B. K. (2001) J. Cell Sci. 114, 1447-1454
43. Labib, K., and Diffley, J. F. X. (2001) Curr. Opin. Genet. Dev. 11, 64-70
44. Kimura, H., Nozaki, N., and Sugimoto, K. (1994) EMBO J. 13, 4311-4320
45. Coue, M., Kearsey, S. E., and Mechali, M. (1996) EMBO J. 15, 1085-1097
46. Hendrickson, M., Madine, M., Dalton, S., and Gautier, J. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 12223-12228
47. Fujita, M., Yamada, C., Tsurumi, T., Hanaoka, F., Matsuzawa, K., and Inagaki, M. (1998) J. Biol. Chem. 273, 17095-17101
48. Findeisen, M., El-Denary, M., Kapitza, T., Graf, R., and Strausfeld, U. (1999) Eur. J. Biochem. 264, 415-426
49. Pereverzeva, I., Whitmire, E., Khan, B., and Coue, M. (2000) Mol. Cell. Biol. 20, 3667-3676
50. Ishimi, Y., Komamura-Kohno, Y., You, Z., Omori, A., and Kitagawa, M. (2000) J. Biol. Chem. 275, 16235-16241
51. Fujita, M., Kiyono, T., Hayashi, Y., and Ishibashi, M. (1997) J. Biol. Chem. 272, 10928-10935
52. Richter, A., and Knippers, R. (1997) Eur. J. Biochem. 247, 136-141
53. Sato, M., Gotow, T., You, Z., Komamura-Khono, Y., Uchiyama, Y., Yabuta, N., Nojima, H., and Ishimi, Y. (2000) J. Mol. Biol. 300, 421-431
54. Suzuki, M. (1989) J. Mol. Biol. 207, 61-84
55. Coverley, D., Pelizon, C., Trewick, S., and Laskey, R. A. (2000) J. Cell Sci. 113, 1929-1938
56. Coverley, D., Wilkinson, H. R., Madine, M. A., Mills, A. D., and Laskey, R. A. (1998) Exp. Cell Res. 238, 63-69