Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations

Genes and Development

Volumn 19, Issue 24, 2005, Pages 3055-3069

  Cobb, Jennifer A ^a   Schleker, Thomas ^c   Rojas, Vanesa ^b   Bjergbaek, Lotte ^a,d   Tercero, José Antonio ^b   Gasser, Susan M ^a,c  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

Checkpoint; Chromosome instability; DNA polymerases; Mec1; Replicative stress; Sgs1

Indexed keywords

ATR PROTEIN; CHECKPOINT KINASE 2; DNA POLYMERASE; HISTONE H2A; HYDROXYUREA; MINICHROMOSOME MAINTENANCE PROTEIN 2; PHOSPHOTRANSFERASE; PROTEIN MEC1; PROTEIN SGS1; PROTEIN SUBUNIT; PROTEIN TEL1; RECQ HELICASE; REPLISOME; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CELL CYCLE S PHASE; CHROMOSOMAL INSTABILITY; CHROMOSOME REARRANGEMENT; CHROMOSOME REPLICATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME STABILITY; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; STRESS; YEAST;

ADENOSINE TRIPHOSPHATASES; CELL CYCLE PROTEINS; DNA HELICASES; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; FUNGAL PROTEINS; HISTONES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RECQ HELICASES; S PHASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSLOCATION, GENETIC;

EID: 29144486147     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.361805     Document Type: Article

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