Impact of heat treatment on miscibility of proteins and disaccharides in frozen solutions

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 2, 2013, Pages 177-183

  Izutsu, Ken Ichi ^a   Yomota, Chikako ^a   Okuda, Haruhiro ^a   Kawanishi, Toru ^a   Randolph, Theodore W ^b   Carpenter, John F ^c  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b UCB 450   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Freeze concentration; Freeze drying; Heat treatment; Phase separation; Protein formulation; Stability

Indexed keywords

DISACCHARIDE; HUMAN ALBUMIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; LYSOZYME; RECOMBINANT PROTEIN; PROTEIN; SOLUTION AND SOLUBILITY;

ARTICLE; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; HEAT TREATMENT; MISCIBILITY; SOLUTE; THERMAL ANALYSIS; CHEMISTRY; FREEZE-CONCENTRATION; FREEZE-DRYING; FREEZING; HEAT; MEDICINAL CHEMISTRY; METHODOLOGY; PHASE SEPARATION; PROTEIN FORMULATION; SOLUTION AND SOLUBILITY; STABILITY; TRANSITION TEMPERATURE; PROCEDURES;

FREEZE-CONCENTRATION; FREEZE-DRYING; HEAT TREATMENT; PHASE SEPARATION; PROTEIN FORMULATION; STABILITY;

CHEMISTRY, PHARMACEUTICAL; DISACCHARIDES; FREEZE DRYING; FREEZING; HOT TEMPERATURE; PROTEINS; SOLUTIONS; TRANSITION TEMPERATURE;

EID: 84899779189     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.05.004     Document Type: Article

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