Impact of sucrose level on storage stability of proteins in freeze-dried solids: I. Correlation of protein-sugar interaction with native structure preservation

Journal of Pharmaceutical Sciences

Volumn 98, Issue 9, 2009, Pages 3131-3144

  Wang, Bingquan ^a   Tchessalov, Serguei ^b   Warne, Nicholas W ^b   Pikal, Michael J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b PFIZER INC   (United States)

Author keywords

Amorphous solid; Cytokine; Freeze drying lyophilization; FTIR; Fusion protein; H bond; Protein structure; Protein sugar interactions; Solid state interaction; Structure preservation; Water binding site; Water monolayer; Water sorption isotherm

Indexed keywords

HYBRID PROTEIN; IMMUNOGLOBULIN G1; RECOMBINANT CYTOKINE; SUCROSE;

ARTICLE; DRUG STABILITY; DRUG STORAGE; FREEZE DRYING; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SOLID STATE;

EID: 68949142809     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21621     Document Type: Article

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