Impact of heat treatment on the physical properties of noncrystalline multisolute systems concentrated in frozen aqueous solutions

Journal of Pharmaceutical Sciences

Volumn 100, Issue 12, 2011, Pages 5244-5253

  Izutsu, Ken Ichi ^a   Yomota, Chikako ^a   Kawanishi, Toru ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Calorimetry (DSC); Excipients; Formulation; Freeze drying; Freezing; Miscibility; Phase separation; Stabilization; Thermal analysis

Indexed keywords

DEXTRAN; GLUCOSE; POVIDONE; SUCROSE; TREHALOSE;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CRYSTALLIZATION; DRUG FORMULATION; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; HEAT TREATMENT; MISCIBILITY; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; PHASE SEPARATION; PHASE TRANSITION; PHYSICAL CHEMISTRY; SOLUTE; THERMODYNAMICS; TIME;

EID: 80054943738     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22706     Document Type: Article

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