Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Herfindal, Lars ^a,b   Krakstad, Camilla ^a   Myhren, Lene ^a   Hagland, Hanne ^a   Kopperud, Reidun ^a   Teigen, Knut ^a   Schwede, Frank ^c   Kleppe, Rune ^a   Ove Døskeland, Stein ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c BIOLOG Life Science Institute   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

8 (4 CHLOROPHENYLTHIO) 2' DEOXYADENOSINE 3',5' CYCLIC MONOPHOSPHATE; 8 (4 CHLOROPHENYLTHIO) 2' O METHYLADENOSINE; 8 (4 CHLOROPHENYLTHIO) 2' O METHYLADENOSINE 3',5' CYCLIC MONOPHOSPHATE; 8 (4 CHLOROPHENYLTHIO) 2' O METHYLADENOSINE 3',5' CYCLIC MONOPHOSPHATE ACETOXYMETHYL ESTER; 8 (4 CHLOROPHENYLTHIO) 2' O METHYLADENOSINE 3',5' CYCLIC MONOPHOSPHOROTHIOATE; 8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; 8 (4 CHLOROPHENYLTHIO) CYCLIC GMP; 8 (4 CHLOROPHENYLTHIO) N6 PHENYLADENOSINE 2' DEOXYADENOSINE 3',5' CYCLIC MONOPHOSPHATE; 8 (4 CHLOROPHENYLTHIO) N6 PHENYLADENOSINE 3',5' CYCLIC MONOPHOSPHATE; 8 (4 CHLOROPHENYLTHIO)ADENOSINE; 8 BROMO 2' O METHYLADENOSINE 3',5' CYCLIC MONOPHOSPHATE; 8 BROMO CYCLIC AMP; 8 BROMO CYCLIC GMP; 8 BROMOADENOSINE 3',5' CYCLIC MONOPHOSPHOROTHIOATE; ADENOSINE DERIVATIVE; BILE ACID; CHOLIC ACID; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DERIVATIVE; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DERIVATIVE; N6 MONOBUTYRYLADENOSINE 3',5' CYCLIC MONOPHOSPHATE; N6, 2' O DIBUTYRYLADENOSINE 3',5 CYCLIC MONOPHOSPHATE; NODULARIN; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B3; UNCLASSIFIED DRUG; 8-(4-CHLORO-PHENYLTHIO)-2'-O-METHYLADENOSINE-3'-5'-CYCLIC MONOPHOSPHATE; BACTERIAL TOXIN; CYCLIC GMP; CYCLIC NUCLEOTIDE; CYCLOPEPTIDE; GLYCOCHOLIC ACID; GUANINE NUCLEOTIDE EXCHANGE FACTOR; ORGANIC ANION TRANSPORTER; SLCO1B1 PROTEIN, HUMAN; SLCO1B3 PROTEIN, HUMAN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG POTENCY; EMBRYO; ENZYME ACTIVATION; HEK293 CELL LINE; HUMAN; HUMAN CELL; IC 50; ISOTOPE LABELING; LIVER CELL; LIVER METABOLISM; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; ANALOGS AND DERIVATIVES; ANIMAL; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ANIMALS; APOPTOSIS; BACTERIAL TOXINS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOCHOLIC ACID; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEK293 CELLS; HEPATOCYTES; HUMANS; MALE; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; NUCLEOTIDES, CYCLIC; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PEPTIDES, CYCLIC; PROTEIN STRUCTURE, TERTIARY; RATS, WISTAR;

EID: 84899741149     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094926     Document Type: Article

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