Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3

British Journal of Pharmacology

Volumn 159, Issue 3, 2010, Pages 698-708

  Glaeser, H ^a   Mandery, K ^a   Sticht, H ^a   Fromm, Mf ^a   Konig J ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Hepatic drug transport; Molecular modelling; Mutagenesis; Organic anion transport; Organic anion transporting polypeptide 1B3; Pravastatin; Side chain flexibility; Sulphobromophthalein; Transport activity

Indexed keywords

ALANINE; AMINO ACID; ARGININE; BROMSULFOPHTHALEIN; CELL SURFACE PROTEIN; GLUTAMINE; GLYCINE; LYSINE; ORGANIC ANION TRANSPORT POLYPEPTIDE 1B3; ORGANIC ANION TRANSPORTER; PRAVASTATIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CELL ASSAY; CELL MEMBRANE; CONTROLLED STUDY; DRUG UPTAKE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; KINETICS; MEMBRANE POTENTIAL; MUTAGENESIS; MUTANT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT;

ALANINE; ARGININE; BIOLOGICAL TRANSPORT; BIOLOGICAL TRANSPORT, ACTIVE; CELL MEMBRANE; CELLULAR STRUCTURES; ESTRONE; GLYCINE; HEPATOCYTES; HUMANS; KINETICS; LYSINE; ORGANIC ANION TRANSPORTERS; PHARMACEUTICAL PREPARATIONS; PRAVASTATIN; PROTEIN STRUCTURE, SECONDARY; SULFOBROMOPHTHALEIN;

EID: 76449098002     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00568.x     Document Type: Article

References (29)

1. Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R et al. (2001). LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology 120 (7 1689 1699.
2. Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S (2003). Structure and mechanism of the lactose permease of Escherichia coli. Science 301 (5633 610 615.
3. Bachmakov I, Glaeser H, Fromm MF, König J (2008). Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1. Diabetes 57 (6 1463 1469.
4. Cui Y, König J, Buchholz JK, Spring H, Leier I, Keppler D (1999). Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol 55 (5 929 937.
5. Cui Y, König J, Keppler D (2001). Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol 60 (5 934 943.
6. Devereux J, Haeberli P, Smithies O (1984). A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res 12 (1 Pt 1 387 395.
7. Ginalski K, Elofsson A, Fischer D, Rychlewski L (2003). 3D-Jury: a simple approach to improve protein structure predictions. Bioinformatics 19 (8 1015 1018.
8. Glaeser H, Fromm MF (2008). Animal models and intestinal drug transport. Expert Opin Drug Metab Toxicol 4 (4 347 361.
9. Glaeser H, Drescher S, van der Kuip H, Behrens C, Geick A, Burk O et al. (2002). Shed human enterocytes as a tool for the study of expression and function of intestinal drug-metabolizing enzymes and transporters. Clin Pharmacol Ther 71 (3 131 140.
10. Glaeser H, Bailey DG, Dresser GK, Gregor JC, Schwarz UI, McGrath JS et al. (2007). Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther 81 (3 362 370.
11. Gradhand U, Tegude H, Burk O, Eichelbaum M, Fromm MF, König J (2007). Functional analysis of the polymorphism-211C>T in the regulatory region of the human ABCC3 gene. Life Sci 80 (16 1490 1494.
12. Guex N, Peitsch MC (1997). SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18 (15 2714 2723.
13. Gui C, Hagenbuch B (2008). Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport. Biochemistry 47 (35 9090 9097.
14. Hagenbuch B, Meier PJ (2003). The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 1609 (1 1 18.
15. Hagenbuch B, Meier PJ (2004). Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch 447 (5 653 665.
16. Hänggi E, Grundschober AF, Leuthold S, Meier PJ, St-Pierre MV (2006). Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1. Mol Pharmacol 70 (3 806 817.
17. Ho RH, Tirona RG, Leake BF, Glaeser H, Lee W, Lemke CJ et al. (2006). Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression and pharmacogenetics. Gastroenterology 130 (6 1793 1806.
18. Hooft RW, Vriend G, Sander C, Abola EE (1996). Errors in protein structures. Nature 381 (6580 272.
19. Huang Y, Lemieux MJ, Song J, Auer M, Wang DN (2003). Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli. Science 301 (5633 616 620.
20. König J, Cui Y, Nies AT, Keppler D (2000). Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem 275 (30 23161 23168.
21. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F et al. (2001). Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120 (2 525 533.
22. Laskowski RA, Moss DS, Thornton JM (1993). Main-chain bond lengths and bond angles in protein structures. J Mol Biol 231 (4 1049 1067.
23. Lee W, Glaeser H, Smith LH, Roberts RL, Moeckel GW, Gervasini G et al. (2005). Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. J Biol Chem 280 (10 9610 9617.
24. Letschert K, Keppler D, König J (2004). Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8). Pharmacogenetics 14 (7 441 452.
25. Meier-Abt F, Mokrab Y, Mizuguchi K (2005). Organic anion transporting polypeptides of the OATP/SLCO superfamily: identification of new members in nonmammalian species, comparative modeling and a potential transport mode. J Membr Biol 208 (3 213 227.
26. Nozawa T, Sugiura S, Nakajima M, Goto A, Yokoi T, Nezu J et al. (2004). Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity. Drug Metab Dispos 32 (3 291 294.
27. Sanchez R, Sali A (2000). Comparative protein structure modeling. Introduction and practical examples with modeller. Methods Mol Biol 143 : 97 129.
28. Seithel A, Eberl S, Singer K, Auge D, Heinkele G, Wolf NB et al. (2007). The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3. Drug Metab Dispos 35 (5 779 786.
29. Senger M, Glatting KH, Ritter O, Suhai S (1995). X-HUSAR, an X-based graphical interface for the analysis of genomic sequences. Comput Methods Programs Biomed 46 (2 131 141.