Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport

Biochemistry

Volumn 47, Issue 35, 2008, Pages 9090-9097

  Gui, Chunshan ^a   Hagenbuch, Bruno ^a,b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINATION; AMINES; AMINO ACIDS; ANIMAL CELL CULTURE; BIOLOGICAL MEMBRANES; CELL MEMBRANES; CHLORINE COMPOUNDS; NEGATIVE IONS; ORGANIC COMPOUNDS; PROTEINS; SUBSTRATES; SULFUR COMPOUNDS;

AMINO ACID RESIDUES; ORGANIC ANIONS; TRANS-MEMBRANE DOMAINS;

POLYPEPTIDES;

AMINO ACID DERIVATIVE; CHOLECYSTOKININ OCTAPEPTIDE; ORGANIC ANION TRANSPORT POLYPEPTIDE 1B3; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; HYDROGEN BOND; KINETICS; MUTAGENESIS; MUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; WILD TYPE;

AMINO ACID SEQUENCE; CELL LINE; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SINCALIDE;

EID: 50849142229     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi8008455     Document Type: Article

References (29)

1. Hediger, M. A., Romero, M. F., Peng, J. B., Rolfs, A., Takanaga, H., and Bruford, E. A. (2004) The ABCs of solute carriers: Physiological, pathological and therapeutic implications of human membrane transport proteins. Pfluegers Arch. 447, 465-468.
2. Hagenbuch, B., and Meier, P. J. (2004) Organic anion transporting polypeptides of the OATP/ SLC21 family: Phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pfluegers Arch. 447, 653-665.
3. Hagenbuch, B., and Meier, P. J. (2003) The superfamily of organic anion transporting polypeptides. Biochim. Biophys. Acta 1609, 1-18.
4. König, J., Seithel, A., Gradhand, U., and Fromm, M. F. (2006) Pharmacogenomics of human OATP transporters. Naunyn-Schmiedebergs Arch. Pharmacol. 372, 432-443.
5. Abe, T., Kakyo, M., Tokui, T., Nakagomi, R., Nishio, T., Nakai, D., Nomura, H., Unno, M., Suzuki, M., Naitoh, T., Matsuno, S., and Yawo, H. (1999) Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J. Biol. Chem. 274, 17159-17163.
6. Abe, T., Unno, M., Onoogawa, T., Tokui, T., Kondo, T. N., Nakagomi, R., Adachi, H., Fujiwara, K., Okabe, M., Suzuki, T., Nunoki, K., Sato, E., Kakyo, M., Nishio, T., Sugita, J., Asano, N., Tanemoto, M., Seki, M., Date, F., Ono, K., Kondo, Y., Shiiba, K., Suzuki, M., Ohtani, H., Shimosegawa, T., Iinuma,Nagura, H., Ito, S., and Matsuno, S. (2001) LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology 120, 1689-1699.
7. Hsiang, B., Zhu, Y., Wang, Z., Wu, Y., Sasseville, V., Yang, W. -P., and Kirchgessner, T. G. (1999) A novel human hepatic organic anion transporting polypeptide (OATP2). J. Biol. Chem. 274, 37161-37168.
8. König, J., Cui, Y., Nies, A. T., and Keppler, D. (2000) A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am. J. Physiol. 278, G156-G164.
9. König, J., Cui, Y., Nies, A. T., and Keppler, D. (2000) Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J. Biol. Chem. 275, 23161-23168.
10. Wang, P., Hata, S., Xiao, Y., Murray, J. W., and Wolkoff, A. W. (2008) Topological assessment of oatp1a1: A 12-transmembrane domain integral membrane protein with three N-linked carbohydrate chains. Am. J. Physiol. 294, G1052-G1059.
11. Ismair, M. G., Stieger, B., Cattori, V., Hagenbuch, B., Fried, M., Meier, P. J., and Kullak-Ublick, G. A. (2001) Hepatic uptake of cholecystikinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver. Gastroenterology 121, 1185-1190.
12. Smith, N. F., Acharya, M. R., Desai, N., Figg, W. D., and Sparreboom, A. (2005) Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel. Cancer Biol. Ther. 4, 815-818.
13. Kullak-Ublick, G. A., Ismair, M. G., Stieger, B., Landmann, L., Huber, R., Pizzagalli, F., Fattinger, K., Meier, P. J., and Hagenbuch, B. (2001) Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120, 525-533.
14. Tirona, R. G., Leake, B. F., Merino, G., and Kim, R. B. (2001) Polymorphisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European-and African-Americans. J. Biol. Chem. 276, 35669-35675.
15. Smith, N. F., Marsh, S., Scott-Horton, T. J., Hamada, A., Mielke, S., Mross, K., Figg, W. D., Verweij, J., McLeod, H. L., and Sparreboom, A. (2007) Variants in the SLCO1B3 gene: Interethnic distribution and association with paclitaxel pharmacokinetics. Clin. Pharmacol. Ther. 81, 76-82.
16. McGuffin, L. J., Bryson, K., and Jones, D. T. (2000) The PSIPRED protein structure prediction server. Bioinformatics 16, 404-405.
17. Accelrys (2005) InsightII, version 2005, Molecular Simulations Inc., San Diego.
18. Laskowski, R. A., Macarthur, M. W., Moss, D. S., and Thornton, J. M. (1993) Procheck: A Program to Check the Stereochemical Quality of Protein Structures. J. Appl. Crystallogr. 26, 283-291.
19. Morris, G. M., Goodsell, D. S., Halliday, R. S., Huey, R., Hart, W. E., Belew, R. K., and Olson, A. J. (1998) Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. J. Comput. Chem. 19, 1639-1662.
20. Tripos (2005) Sybyl, version 7.1, Tripos, St. Louis.
21. Wallace, A. C., Laskowski, R. A., and Thornton, J. M. (1995) LIGPLOT: A program to generate schematic diagrams of protein-ligand interactions. Protein Eng. 8, 127-134.
22. Huang, Y., Lemieux, M. J., Song, J., Auer, M., and Wang, D. N. (2003) Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli. Science 301, 616-620.
23. Yin, Y., He, X., Szewczyk, P., Nguyen, T., and Chang, G. (2006) Structure of the multidrug transporter EmrD from Escherichia coli. Science 312, 741-744.
24. Pao, S. S., Paulsen, I. T., and Saier, M. H., Jr. (1998) Major facilitator superfamily. Microbiol. Mol. Biol. Rev. 62, 1-34.
25. Pucci, M. L., Bao, Y., Chan, B., Itoh, S., Lu, R., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., and Schuster, V. L. (1999) Cloning of mouse prostaglandin transporter PGT cDNA: Species-specific substrate affinities. Am. J. Physiol. 299, R734-R741.
26. Chan, B. S., Satriano, J. A., and Schuster, V. L. (1999) Mapping the substrate binding site of the prostaglandin transporter PGT by cysteine scanning mutagenesis. J. Biol. Chem. 274, 25564-25570.
27. Morimoto, K., Oishi, T., Ueda, S., Ueda, M., Hosokawa, M., and Chiba, K. (2004) A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy. Drug Metab. Pharmacokinet. 19, 453-455.
28. Letschert, K., Keppler, D., and Konig, J. (2004) Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8). Pharmacogenetics 14, 441-452.
29. Gui, C., Miao, Y., Thompson, L., Wahlgren, B., Mock, M., Stieger, B., and Hagenbuch, B. (2008) Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur. J. Pharmacol. 584, 57-65.