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Volumn 103, Issue 3, 2010, Pages 662-676

8-pCPT-conjugated cyclic AMP analogs exert thromboxane receptor antagonistic properties

Author keywords

Endothelial cells; Exchange protein directly activated by cyclic AMP; Human platelets; Thromboxane A2; Vascular tissue

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 8 (4 CHLOROPHENYLTHIO) 2' O METHYL CYCLIC ADENOSINE MONOPHOSPHATE; CYCLIC AMP DERIVATIVE; INTERCELLULAR ADHESION MOLECULE 1; NORADRENALIN; THROMBOXANE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

EID: 77749254922     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH09-06-0341     Document Type: Article
Times cited : (15)

References (73)
  • 1
    • 0036527429 scopus 로고    scopus 로고
    • Protein kinases - the major drug targets of the twenty-first century
    • Cohen P. Protein kinases - the major drug targets of the twenty-first century. Nat Rev Drug Discovery 2002; 1: 309-315.
    • (2002) Nat Rev Drug Discovery , vol.1 , pp. 309-315
    • Cohen, P.1
  • 2
    • 20844453092 scopus 로고    scopus 로고
    • Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A
    • Zambon AC, Zhang L, Minovitsky S, et al. Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proc Natl Acad Sci USA 2005; 102: 8561-8566.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8561-8566
    • Zambon, A.C.1    Zhang, L.2    Minovitsky, S.3
  • 3
    • 0041836339 scopus 로고    scopus 로고
    • Epac: A new cAMP target and new avenues in cAMP research
    • Bos JL. Epac: a new cAMP target and new avenues in cAMP research. Nat Rev Mol Cell Biol 2003; 4: 733-738.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 733-738
    • Bos, J.L.1
  • 5
    • 69249216479 scopus 로고    scopus 로고
    • Epac proteins transduce diverse cellular actions of cAMP
    • Borland G, Smith BO, Yarwood SJ. Epac proteins transduce diverse cellular actions of cAMP. Brit J Pharmacol 2009; 158: 70-86.
    • (2009) Brit J Pharmacol , vol.158 , pp. 70-86
    • Borland, G.1    Smith, B.O.2    Yarwood, S.J.3
  • 6
    • 75649097760 scopus 로고    scopus 로고
    • Grandoch M, Roscioni SS, Schmidt M. The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function. Brit J Pharmacol 2009; preub online doi:10.1111/j.1476-5381.2009.00458:
    • Grandoch M, Roscioni SS, Schmidt M. The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function. Brit J Pharmacol 2009; preub online doi:10.1111/j.1476-5381.2009.00458:
  • 8
    • 0035735452 scopus 로고    scopus 로고
    • A new phospholipase-C- calcium signalling pathway mediated by cyclic AMP and a Rap GTPase
    • Schmidt M, Evellin S, Oude Weernink PA, et al. A new phospholipase-C- calcium signalling pathway mediated by cyclic AMP and a Rap GTPase. Nature Cell Biol 2001; 3: 1020-1024.
    • (2001) Nature Cell Biol , vol.3 , pp. 1020-1024
    • Schmidt, M.1    Evellin, S.2    Oude Weernink, P.A.3
  • 9
    • 34247124160 scopus 로고    scopus 로고
    • Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes
    • Oestreich EA, Wang H, Malik S, et al. Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes. J Biol Chem 2007; 282: 5488-5495.
    • (2007) J Biol Chem , vol.282 , pp. 5488-5495
    • Oestreich, E.A.1    Wang, H.2    Malik, S.3
  • 10
    • 59449094232 scopus 로고    scopus 로고
    • Epac and phospholipase Cε regulate Ca2+ release in the heart by activation of protein kinase Cε and calcium-calmodulin kinase II
    • Oestreich EA, Malik S, Goonasekera SA, et al. Epac and phospholipase Cε regulate Ca2+ release in the heart by activation of protein kinase Cε and calcium-calmodulin kinase II. J Biol Chem 2009; 284: 1514-1522.
    • (2009) J Biol Chem , vol.284 , pp. 1514-1522
    • Oestreich, E.A.1    Malik, S.2    Goonasekera, S.A.3
  • 11
    • 34548322692 scopus 로고    scopus 로고
    • Pereira L, Métrich M, Fernández-Velasco M, et al. The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes. J Physiol 2007; 583.2: 685-694.
    • Pereira L, Métrich M, Fernández-Velasco M, et al. The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes. J Physiol 2007; 583.2: 685-694.
  • 12
    • 66949178986 scopus 로고    scopus 로고
    • Functional characterization of the cAMP-binding proteins Epac in cardiac myocytes
    • Métrich M, Morel E, Berthouze M, et al. Functional characterization of the cAMP-binding proteins Epac in cardiac myocytes. Pharmacolog Rep 2009; 61: 146-153.
    • (2009) Pharmacolog Rep , vol.61 , pp. 146-153
    • Métrich, M.1    Morel, E.2    Berthouze, M.3
  • 13
    • 69549133920 scopus 로고    scopus 로고
    • The cAMP binding protein Epac regulates cardiac myofilament function
    • Cazorla O, Lucas A, Poirier F, et al. The cAMP binding protein Epac regulates cardiac myofilament function. Proc Natl Acad Sci USA 2009; 106: 14144-14149.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14144-14149
    • Cazorla, O.1    Lucas, A.2    Poirier, F.3
  • 14
    • 33847787444 scopus 로고    scopus 로고
    • Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons
    • Ster J, De Bock F, Guerineau NC, et al. Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons. Proc Natl Acad Sci USA 2007; 104: 2519-2524.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2519-2524
    • Ster, J.1    De Bock, F.2    Guerineau, N.C.3
  • 15
    • 33744937348 scopus 로고    scopus 로고
    • Glucagon activates Ca2+ and Cl-channels in rat hepatocytes
    • Aromataris EC, Roberts ML, Barritt GJ, et al. Glucagon activates Ca2+ and Cl-channels in rat hepatocytes. J Physiol 2006; 573: 611-625.
    • (2006) J Physiol , vol.573 , pp. 611-625
    • Aromataris, E.C.1    Roberts, M.L.2    Barritt, G.J.3
  • 16
    • 67651094123 scopus 로고    scopus 로고
    • Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels
    • Purves GI, Kamishima T, Davies LM, et al. Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels. J Physiol 2009; 587: 3639-3650.
    • (2009) J Physiol , vol.587 , pp. 3639-3650
    • Purves, G.I.1    Kamishima, T.2    Davies, L.M.3
  • 17
    • 33644667603 scopus 로고    scopus 로고
    • cAMP-binding protein Epac induces cardiomyocytes hypertrophy
    • Morel E, Marcantoni A, Gastineau M, et al. cAMP-binding protein Epac induces cardiomyocytes hypertrophy. Circ Res 2005; 97: 1296-1304.
    • (2005) Circ Res , vol.97 , pp. 1296-1304
    • Morel, E.1    Marcantoni, A.2    Gastineau, M.3
  • 18
    • 42549128214 scopus 로고    scopus 로고
    • Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy
    • Métrich M, Lucas A, Gastineau M, et al. Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy. Circ Res 2008; 102: 959-965.
    • (2008) Circ Res , vol.102 , pp. 959-965
    • Métrich, M.1    Lucas, A.2    Gastineau, M.3
  • 19
    • 33644696693 scopus 로고    scopus 로고
    • Phospholipase Cε modulates β-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy
    • Wang H, Oestreich EA, Maekawa N, et al. Phospholipase Cε modulates β-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy. Circ Res 2005; 97: 1305-1313.
    • (2005) Circ Res , vol.97 , pp. 1305-1313
    • Wang, H.1    Oestreich, E.A.2    Maekawa, N.3
  • 20
    • 34548385746 scopus 로고    scopus 로고
    • Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy
    • Ulucan C, Wang X, Baljinnyam E, et al. Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy. Am J Physiol Heart Circ Physiol 2007; 293: H1662-H1672.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Ulucan, C.1    Wang, X.2    Baljinnyam, E.3
  • 21
    • 28644439947 scopus 로고    scopus 로고
    • R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis
    • Komatsu M, Ruoslathi E. R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. Nat Med 2005; 11: 1346-1350.
    • (2005) Nat Med , vol.11 , pp. 1346-1350
    • Komatsu, M.1    Ruoslathi, E.2
  • 22
    • 57049155558 scopus 로고    scopus 로고
    • Epac1 is upregulated during neointima formation and promotes vascular smooth muscle migration
    • Yokoyama U, Minamisawa S, Quan H, et al. Epac1 is upregulated during neointima formation and promotes vascular smooth muscle migration. Am J Physiol Heart Circ Physiol 2008; 295: H1547-H1555.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Yokoyama, U.1    Minamisawa, S.2    Quan, H.3
  • 23
    • 57649120773 scopus 로고    scopus 로고
    • PGE2-activate EPAC promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of PKA
    • Yokoyama U, Minamisawa S, Quan H, et al. PGE2-activate EPAC promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of PKA. J Biol Chem 2008; 283: 28702-28709.
    • (2008) J Biol Chem , vol.283 , pp. 28702-28709
    • Yokoyama, U.1    Minamisawa, S.2    Quan, H.3
  • 24
    • 11144305139 scopus 로고    scopus 로고
    • Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway
    • Fukuhara S, Sakurai A, Sano H, et al. Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol 2005; 25: 136-146.
    • (2005) Mol Cell Biol , vol.25 , pp. 136-146
    • Fukuhara, S.1    Sakurai, A.2    Sano, H.3
  • 25
    • 14944377651 scopus 로고    scopus 로고
    • Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPases
    • Cullere X, Shaw SK, Andersson L, et al. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPases. Blood 2005; 105: 1950-1955.
    • (2005) Blood , vol.105 , pp. 1950-1955
    • Cullere, X.1    Shaw, S.K.2    Andersson, L.3
  • 26
    • 41649100672 scopus 로고    scopus 로고
    • Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function
    • Sehrawat S, Cullere X, Patel S, et al. Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. Mol Biol Cell 2008; 19: 1261-1270.
    • (2008) Mol Biol Cell , vol.19 , pp. 1261-1270
    • Sehrawat, S.1    Cullere, X.2    Patel, S.3
  • 27
    • 34250177621 scopus 로고    scopus 로고
    • Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation
    • Birukova AA, Zagranichnaya T, Fu P, et al. Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell Res 2007; 313: 2504-2520.
    • (2007) Exp Cell Res , vol.313 , pp. 2504-2520
    • Birukova, A.A.1    Zagranichnaya, T.2    Fu, P.3
  • 28
    • 42949131177 scopus 로고    scopus 로고
    • Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection
    • Birukova AA, Zagranichnaya T, Alekseeva E, et al. Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection. J Cell Physiol 2008; 215: 715-724.
    • (2008) J Cell Physiol , vol.215 , pp. 715-724
    • Birukova, A.A.1    Zagranichnaya, T.2    Alekseeva, E.3
  • 29
    • 36348946491 scopus 로고    scopus 로고
    • Microtubule dynamics and Rac-1 signaling independently regulate barrier function in lung epithelial cells
    • Lorenowicz MJ, Fernandez-Borja M, van Stalborch A-MD, et al. Microtubule dynamics and Rac-1 signaling independently regulate barrier function in lung epithelial cells. Am J Respir Cell Mol Biol 2007; 293: L1321-L1331.
    • (2007) Am J Respir Cell Mol Biol , vol.293
    • Lorenowicz, M.J.1    Fernandez-Borja, M.2    van Stalborch, A.-M.D.3
  • 30
    • 15744364621 scopus 로고    scopus 로고
    • Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function
    • Wittchen ES, Worthylake RA, Kelly P, et al. Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function. J Biol Chem 2005; 280: 11675-11682.
    • (2005) J Biol Chem , vol.280 , pp. 11675-11682
    • Wittchen, E.S.1    Worthylake, R.A.2    Kelly, P.3
  • 31
    • 18144401240 scopus 로고    scopus 로고
    • Inhibitory control of TGF-β1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes
    • Basoni C, Nobles M, Grimshaw A, et al. Inhibitory control of TGF-β1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes. FASEB J 2005; 19: 822-824.
    • (2005) FASEB J , vol.19 , pp. 822-824
    • Basoni, C.1    Nobles, M.2    Grimshaw, A.3
  • 32
    • 35448988935 scopus 로고    scopus 로고
    • Both protein kinase A and exhcange protein activated by cAMP coordinate adhesion of human vascular endothelial cells
    • Netherton SJ, Sutton JA, Wilson LS, et al. Both protein kinase A and exhcange protein activated by cAMP coordinate adhesion of human vascular endothelial cells. Circ Res 2007; 101: 768-776.
    • (2007) Circ Res , vol.101 , pp. 768-776
    • Netherton, S.J.1    Sutton, J.A.2    Wilson, L.S.3
  • 33
    • 51249118984 scopus 로고    scopus 로고
    • PKA and Epac1 regulate endothelial integrity and migration though parallel and independent pathways
    • Lorenowicz MJ, Fernandez-Borja M, Kooistra MRH, et al. PKA and Epac1 regulate endothelial integrity and migration though parallel and independent pathways. Eur J CellBiol 2008; 87: 779-792.
    • (2008) Eur J CellBiol , vol.87 , pp. 779-792
    • Lorenowicz, M.J.1    Fernandez-Borja, M.2    Kooistra, M.R.H.3
  • 34
    • 41949123680 scopus 로고    scopus 로고
    • Activation of Epac stimulates integrind-dependent homing of progenitor cells
    • Carmona G, Chavakis E, Koehl U, et al. Activation of Epac stimulates integrind-dependent homing of progenitor cells. Blood 2008; 111: 2640-2646.
    • (2008) Blood , vol.111 , pp. 2640-2646
    • Carmona, G.1    Chavakis, E.2    Koehl, U.3
  • 35
    • 33947150568 scopus 로고    scopus 로고
    • A-kinase anchoring proteins take shape
    • Beene DL, Scott JD. A-kinase anchoring proteins take shape. Curr Opin Cell Biol 2008; 19: 192-198.
    • (2008) Curr Opin Cell Biol , vol.19 , pp. 192-198
    • Beene, D.L.1    Scott, J.D.2
  • 36
    • 10044253425 scopus 로고    scopus 로고
    • AKAP signalling complexes: Focal points in space and time
    • Wong W, Scott JD. AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol 2004; 5: 959-970.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 959-970
    • Wong, W.1    Scott, J.D.2
  • 37
    • 54449097985 scopus 로고    scopus 로고
    • Protein kinase A Type I and II define distinct intracellular signaling compartments
    • Di Benedetto G, Zoccarato A, Lissandron V, et al. Protein kinase A Type I and II define distinct intracellular signaling compartments. Circ Res 2008; 103: 836-844.
    • (2008) Circ Res , vol.103 , pp. 836-844
    • Di Benedetto, G.1    Zoccarato, A.2    Lissandron, V.3
  • 38
    • 25644452031 scopus 로고    scopus 로고
    • The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
    • Dodge-Kafka KLSJ, Pare GC, Michel JJC, et al. The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature 2005; 437: 574-578.
    • (2005) Nature , vol.437 , pp. 574-578
    • Dodge-Kafka, K.L.S.J.1    Pare, G.C.2    Michel, J.J.C.3
  • 39
    • 49549107515 scopus 로고    scopus 로고
    • Neuronal AKAP150 coordinates PKA and Epac mediated PKB/Akt phosphorylation
    • Nijholt IM, Dolga AM, Ostroveanu A, et al. Neuronal AKAP150 coordinates PKA and Epac mediated PKB/Akt phosphorylation. Cell Signal 2008; 20: 1715-1724.
    • (2008) Cell Signal , vol.20 , pp. 1715-1724
    • Nijholt, I.M.1    Dolga, A.M.2    Ostroveanu, A.3
  • 40
    • 85006314494 scopus 로고    scopus 로고
    • A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
    • Enserink JM, Christensen AE, de Rooji J, et al. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol 2002; 4: 901-906.
    • (2002) Nat Cell Biol , vol.4 , pp. 901-906
    • Enserink, J.M.1    Christensen, A.E.2    de Rooji, J.3
  • 41
    • 0041315574 scopus 로고    scopus 로고
    • cAMP analog mapping of Epac 1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension
    • Christensen AE, Selheim F, de Rooji J, et al. cAMP analog mapping of Epac 1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. J Biol Chem 2003; 278: 35394-35402.
    • (2003) J Biol Chem , vol.278 , pp. 35394-35402
    • Christensen, A.E.1    Selheim, F.2    de Rooji, J.3
  • 42
    • 33750730215 scopus 로고    scopus 로고
    • Holz GG, Kang G, Harbeck M, et al. Cell physiology of cAMP sensor Epac. J Physiol 2006; 577: 5-15.
    • Holz GG, Kang G, Harbeck M, et al. Cell physiology of cAMP sensor Epac. J Physiol 2006; 577: 5-15.
  • 43
    • 36249019009 scopus 로고    scopus 로고
    • Epac-selelctive cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors
    • Holz GG, Chepurny OG, Schwede F. Epac-selelctive cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors. Cell Signal 2008; 20: 10-20.
    • (2008) Cell Signal , vol.20 , pp. 10-20
    • Holz, G.G.1    Chepurny, O.G.2    Schwede, F.3
  • 44
    • 33845914060 scopus 로고    scopus 로고
    • Activators of Epac proteins induce relaxation of isolated rat aorta
    • Sukhanova IF, Kozhevnikova LM, Popov EG, et al. Activators of Epac proteins induce relaxation of isolated rat aorta. Dokl Biol Sci 2006; 411: 441-444.
    • (2006) Dokl Biol Sci , vol.411 , pp. 441-444
    • Sukhanova, I.F.1    Kozhevnikova, L.M.2    Popov, E.G.3
  • 45
    • 35548951903 scopus 로고    scopus 로고
    • Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms
    • Laxman S, Riechers A, Sadilek M, et al. Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms. Proc Natl Acad Sci USA 2006; 103: 19194-19199.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 19194-19199
    • Laxman, S.1    Riechers, A.2    Sadilek, M.3
  • 46
    • 41449112813 scopus 로고    scopus 로고
    • Cyclic nucleotide analogs as probes of signaling pathways
    • Poppe H, Rybalkin SD, Rehmann H, et al. Cyclic nucleotide analogs as probes of signaling pathways. Nat Methods 2008; 5: 277-278.
    • (2008) Nat Methods , vol.5 , pp. 277-278
    • Poppe, H.1    Rybalkin, S.D.2    Rehmann, H.3
  • 47
    • 67650511673 scopus 로고    scopus 로고
    • Metabolites of an Epac-selective cAMP anlog induce cortisol synthesis by adrenocortical cells through a cAMP-independent pathway
    • Enyeart JA, Enyeart JJ. Metabolites of an Epac-selective cAMP anlog induce cortisol synthesis by adrenocortical cells through a cAMP-independent pathway. Plos One 2009; 4: e6088
    • (2009) Plos One , vol.4
    • Enyeart, J.A.1    Enyeart, J.J.2
  • 48
    • 0028820256 scopus 로고
    • Comparative effects of angiotensin II and its degradation products angiotensin III and angiotensin IV in rat aorta
    • Li Q, Zhang L, Pfaffendorf M, et al. Comparative effects of angiotensin II and its degradation products angiotensin III and angiotensin IV in rat aorta. Brit J Pharmacol 1995; 116: 2963-2970.
    • (1995) Brit J Pharmacol , vol.116 , pp. 2963-2970
    • Li, Q.1    Zhang, L.2    Pfaffendorf, M.3
  • 49
    • 0037331175 scopus 로고    scopus 로고
    • Sphingosylphosphorylcholine, a naturally occuring lipid mediator, inhibits human platelet function
    • Altmann C, Meyer zu Heringdorf D, Böyükbas D, et al. Sphingosylphosphorylcholine, a naturally occuring lipid mediator, inhibits human platelet function. Brit J Pharmacol 2003; 138: 435-444.
    • (2003) Brit J Pharmacol , vol.138 , pp. 435-444
    • Altmann, C.1    Meyer zu Heringdorf, D.2    Böyükbas, D.3
  • 50
    • 34548086211 scopus 로고    scopus 로고
    • Modulation of ADP-induced platelet activation by aspirin and pravastatin: Role of lectin-like oxidized low-density lipoprotein receptor-1, nitric oxide, oxidative stress, and inside-out integrin signaling
    • Marwali MR, Hu C-P, Mohandas B, et al. Modulation of ADP-induced platelet activation by aspirin and pravastatin: Role of lectin-like oxidized low-density lipoprotein receptor-1, nitric oxide, oxidative stress, and inside-out integrin signaling. J Pharmacol Exp Ther 2007; 322: 1324-1332.
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 1324-1332
    • Marwali, M.R.1    Hu, C.-P.2    Mohandas, B.3
  • 51
    • 33746859372 scopus 로고    scopus 로고
    • Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation
    • López de Jesús M, Stope MB, Oude Weernink PA, et al. Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation. J Biol Chem 2006; 281: 21837-21847.
    • (2006) J Biol Chem , vol.281 , pp. 21837-21847
    • López de Jesús, M.1    Stope, M.B.2    Oude Weernink, P.A.3
  • 52
    • 8744232106 scopus 로고    scopus 로고
    • Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors
    • Keiper M, Stope MB, Szatkowski D, et al. Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors. J Biol Chem 2004; 279: 46497-46508.
    • (2004) J Biol Chem , vol.279 , pp. 46497-46508
    • Keiper, M.1    Stope, M.B.2    Szatkowski, D.3
  • 53
    • 24144444059 scopus 로고    scopus 로고
    • Epac1 regulates integrity of endothelial cell junctions through VE-cadherin
    • Kooistra MRH, Corada M, Dejana E, et al. Epac1 regulates integrity of endothelial cell junctions through VE-cadherin. FEBS Lett 2005; 579: 4966-4972.
    • (2005) FEBS Lett , vol.579 , pp. 4966-4972
    • Kooistra, M.R.H.1    Corada, M.2    Dejana, E.3
  • 54
    • 0036011164 scopus 로고    scopus 로고
    • Hermann A, Schrör K, Weber A-A. CD40 ligand (CD40L) does not stimulate proliferation of vascular smooth muscle cells. Eur J CellBiol 2002; 81: 213-221.
    • Hermann A, Schrör K, Weber A-A. CD40 ligand (CD40L) does not stimulate proliferation of vascular smooth muscle cells. Eur J CellBiol 2002; 81: 213-221.
  • 55
    • 71649097766 scopus 로고    scopus 로고
    • Epac inhibits migration and proliferation of human prostate carcinoma cells
    • in press
    • Grandoch M, Rose A, ter Braak M, et al. Epac inhibits migration and proliferation of human prostate carcinoma cells. Brit J Cancer 2009; in press:
    • (2009) Brit J Cancer
    • Grandoch, M.1    Rose, A.2    ter Braak, M.3
  • 56
    • 0342298429 scopus 로고    scopus 로고
    • Flow cytometric determination of E-selectin, vascular cell adhesion molecule-1, and intercellular cell adhesion molecule-1 in formaldehyde-fixed endothelial cell monolayers
    • Gräbner R, Till U, Heller R. Flow cytometric determination of E-selectin, vascular cell adhesion molecule-1, and intercellular cell adhesion molecule-1 in formaldehyde-fixed endothelial cell monolayers. Cytometry 2000; 40: 238-244.
    • (2000) Cytometry , vol.40 , pp. 238-244
    • Gräbner, R.1    Till, U.2    Heller, R.3
  • 57
    • 0034283723 scopus 로고    scopus 로고
    • Mature dendritic cells pulsed wih freeze-thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4(+) and CD(+) T lymphocytes
    • Herr W, Ranieri E, Olson W, et al. Mature dendritic cells pulsed wih freeze-thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4(+) and CD(+) T lymphocytes. Blood 2000; 96: 1857-1864.
    • (2000) Blood , vol.96 , pp. 1857-1864
    • Herr, W.1    Ranieri, E.2    Olson, W.3
  • 58
    • 0025641739 scopus 로고
    • Endothelin-1 and platelet activating factor stimulate thromboxane A2 biosytnhesis in rat vascular smooth muscle cells
    • Takayasu-Okishio M, Terashita Z, Kondo K. Endothelin-1 and platelet activating factor stimulate thromboxane A2 biosytnhesis in rat vascular smooth muscle cells. Biochem Pharmacol 1990; 40: 2713-2717.
    • (1990) Biochem Pharmacol , vol.40 , pp. 2713-2717
    • Takayasu-Okishio, M.1    Terashita, Z.2    Kondo, K.3
  • 59
    • 0024532116 scopus 로고
    • Molecular mechanisms of platelet activation
    • Siess W. Molecular mechanisms of platelet activation. Physiol Rev 1989; 69: 58-178.
    • (1989) Physiol Rev , vol.69 , pp. 58-178
    • Siess, W.1
  • 60
    • 0028293483 scopus 로고
    • Structure and function of rap proteins in human platelets
    • Torti M, Lapetina EG. Structure and function of rap proteins in human platelets. Thromb Haemost 1994; 71: 533-543.
    • (1994) Thromb Haemost , vol.71 , pp. 533-543
    • Torti, M.1    Lapetina, E.G.2
  • 61
    • 0031014969 scopus 로고    scopus 로고
    • Rapid Ca2+-mediated activation of Rap1 in human platelets
    • Franke B, Akkerman J-W, Bos JL. Rapid Ca2+-mediated activation of Rap1 in human platelets. EMBO J 1997; 16: 252-259.
    • (1997) EMBO J , vol.16 , pp. 252-259
    • Franke, B.1    Akkerman, J.-W.2    Bos, J.L.3
  • 62
    • 33845463670 scopus 로고    scopus 로고
    • Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis
    • Lorenowicz MJ, van Gils J, de Boer M, et al. Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis. J Leukoc Biol 2006; 80: 1542-1552.
    • (2006) J Leukoc Biol , vol.80 , pp. 1542-1552
    • Lorenowicz, M.J.1    van Gils, J.2    de Boer, M.3
  • 63
    • 0032493663 scopus 로고    scopus 로고
    • Analysis and regulation of vasodilator-stimulated phosphoprotein serin 239 phosphorylation in vitro and in intact cells using a phosphospecific monoclonal antibody
    • Smolenski A, Bachmann C, Reinhard K, et al. Analysis and regulation of vasodilator-stimulated phosphoprotein serin 239 phosphorylation in vitro and in intact cells using a phosphospecific monoclonal antibody. J Biol Chem 1998; 273: 20029-20035.
    • (1998) J Biol Chem , vol.273 , pp. 20029-20035
    • Smolenski, A.1    Bachmann, C.2    Reinhard, K.3
  • 64
    • 0030567875 scopus 로고    scopus 로고
    • Thromboxane A2 receptor blockade suppresses intercellular adhesion molecule-1 expression by stumlated vascular endothelial cells
    • Ishizuka T, Suzuki K, Kawakami M, et al. Thromboxane A2 receptor blockade suppresses intercellular adhesion molecule-1 expression by stumlated vascular endothelial cells. Eur J Pharmacol 1996; 312: 367-377.
    • (1996) Eur J Pharmacol , vol.312 , pp. 367-377
    • Ishizuka, T.1    Suzuki, K.2    Kawakami, M.3
  • 65
    • 0031595603 scopus 로고    scopus 로고
    • Stimulation with thromboxane A2 (TXA2) receptor agonist enhances ICAM-1, VCAM-1 or ELAM-1 expression by human vascular endothelial cells
    • Ishizuka T, Kawakami M, Matsuki Y, et al. Stimulation with thromboxane A2 (TXA2) receptor agonist enhances ICAM-1, VCAM-1 or ELAM-1 expression by human vascular endothelial cells. Clin Exp Immunol 1998; 112: 464-470.
    • (1998) Clin Exp Immunol , vol.112 , pp. 464-470
    • Ishizuka, T.1    Kawakami, M.2    Matsuki, Y.3
  • 66
    • 0036021816 scopus 로고    scopus 로고
    • Time course of lung ischemia-reperfusion- induced ICAM-1 expression and its role in ischemia-reperfusion lung injury
    • Lu Y-T, Chen P-G, Liu SF. Time course of lung ischemia-reperfusion- induced ICAM-1 expression and its role in ischemia-reperfusion lung injury. J Appl Physiol 2002; 93: 620-628.
    • (2002) J Appl Physiol , vol.93 , pp. 620-628
    • Lu, Y.-T.1    Chen, P.-G.2    Liu, S.F.3
  • 67
    • 66949136652 scopus 로고    scopus 로고
    • ICAM-1 signaling in endothelial cells
    • Lawson C, Wolf S. ICAM-1 signaling in endothelial cells. Pharmacol Rep 2009; 61: 22-32.
    • (2009) Pharmacol Rep , vol.61 , pp. 22-32
    • Lawson, C.1    Wolf, S.2
  • 68
    • 0033535613 scopus 로고    scopus 로고
    • Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors
    • Soyka R, Guth BD, Weisenberger HM et al. Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors. J Med Chem 1999; 42: 1235-1249.
    • (1999) J Med Chem , vol.42 , pp. 1235-1249
    • Soyka, R.1    Guth, B.D.2    Weisenberger, H.M.3
  • 69
    • 0023694604 scopus 로고
    • Evidence for homogeneity of thromboxane A2 receptor using structurally different antagonists
    • Swayne GT, Maguire J, Dolan J, et al. Evidence for homogeneity of thromboxane A2 receptor using structurally different antagonists. Eur J Pharmacol 1988; 152: 311-319.
    • (1988) Eur J Pharmacol , vol.152 , pp. 311-319
    • Swayne, G.T.1    Maguire, J.2    Dolan, J.3
  • 70
    • 0032474559 scopus 로고    scopus 로고
    • New tetrahydronapthalene derivatives as combined thromboxane receptor antagonists and thromboxane synthase inhibitors
    • Cimetière B, Dubuffet T, Landras C, et al. New tetrahydronapthalene derivatives as combined thromboxane receptor antagonists and thromboxane synthase inhibitors. Biorgan Med Chem Lett 1998; 8: 1381-1396.
    • (1998) Biorgan Med Chem Lett , vol.8 , pp. 1381-1396
    • Cimetière, B.1    Dubuffet, T.2    Landras, C.3
  • 71
    • 0023129137 scopus 로고    scopus 로고
    • Hall RA, Gillard J, Guindon Y, et al. Pharmacology of L-655,240 (3-[1-(4-chlrobenzyl)-5-fluoro-3-methyl-indol-2yl]2,2-dimethylpropanoiacid); a potent, selective thromboxane/prostaglandine endoperoxide antagonist. Eur J Pharmacol 1987; 135: 193-201.
    • Hall RA, Gillard J, Guindon Y, et al. Pharmacology of L-655,240 (3-[1-(4-chlrobenzyl)-5-fluoro-3-methyl-indol-2yl]2,2-dimethylpropanoiacid); a potent, selective thromboxane/prostaglandine endoperoxide antagonist. Eur J Pharmacol 1987; 135: 193-201.
  • 72
    • 0026533774 scopus 로고
    • Interspecies differences in thromboxane receptors: Studies with thromboxane receptor antagonists in rat and guinea pigs smooth muscles
    • Ogletree ML, Allen GT. Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pigs smooth muscles. J Pharmacol Exp Ther 1992; 260: 789-794.
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 789-794
    • Ogletree, M.L.1    Allen, G.T.2
  • 73
    • 33746469525 scopus 로고    scopus 로고
    • Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition
    • Dao KK, Teigen K, Kopperud R, et al. Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. J Biol Chem 2006; 281: 21500-21511.
    • (2006) J Biol Chem , vol.281 , pp. 21500-21511
    • Dao, K.K.1    Teigen, K.2    Kopperud, R.3


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