Acyloxymethyl esterification of nodularin-R and microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells

Journal of Medicinal Chemistry

Volumn 52, Issue 18, 2009, Pages 5759-5762

  Herfindal, Lars ^a   Kasprzykowski, Franciszek ^b   Schwede, Frank ^c,e   Łankiewicz, Leszek ^b   Fladmark, Kari E ^a,f   Łukomska, Joanna ^b   Wahlsten, Matti ^d   Sivonen, Kaarina ^d   Grzonka, Zbigniew ^b   Jastorff, Bernd ^c   Døskeland, Stein Ove ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b UNIVERSITY OF GDA SK   (Poland)

^c UNIVERSITY OF BREMEN   (Germany)

^d UNIVERSITY OF HELSINKI   (Finland)

^e BIOLOG Life Science Institute   (Germany)

^f Department of Molecular Biology ^*  (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLOXYMETHYL ESTER DERIVATIVE; BACTERIAL TOXIN; DIACETOXYMETHYL ESTER DERIVATIVE; DIPROPIONYLOXYMETHYL ESTER DERIVATIVE; ESTER DERIVATIVE; ESTERASE; MICROCYSTIN; MICROCYSTIN LA DERIVATIVE; NODULARIN; NODULARIN R DERIVATIVE; PHENYLGLYOXAL; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTOXIN; UNCLASSIFIED DRUG; CYANOGINOSIN-LA; CYCLOPEPTIDE; CYTOTOXIN; NODULARIN R;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL STRAIN 3T3; DRUG ISOLATION; DRUG PROTEIN BINDING; DRUG TARGETING; ENDOCYTOSIS; ESTERIFICATION; FIBROBLAST CULTURE; LIPOPHILICITY; LIVER CELL; MALE; MICROINJECTION; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; CYANOGINOSIN LA; DRUG EFFECT; HUMAN; METABOLISM;

ANIMALS; APOPTOSIS; CYTOTOXINS; ESTERASES; ESTERIFICATION; HEPATOCYTES; HUMANS; MALE; MICE; MICROCYSTINS; PEPTIDES, CYCLIC; PHENYLGLYOXAL; RATS;

EID: 70349220944     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900502e     Document Type: Article

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