Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes

Hepatology

Volumn 32, Issue 3, 2000, Pages 547-555

  Ding, Wen Xing ^a   Shen, Han Ming ^a   Ong, Choon Nam ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CALCEIN; CYANOGINOSIN LR; CYCLOSPORIN A; DEFEROXAMINE; REACTIVE OXYGEN METABOLITE; RHODAMINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CONFOCAL MICROSCOPY; CYTOTOXICITY; LASER MICROSCOPY; LIVER CELL; MALE; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033844686     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2000.16183     Document Type: Article

References (41)

1. The toxins of cyanobacteria
2. Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil
3. Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil
4. Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases
5. Enhancement of glutathione S-transferase placental-form positive liver cell loci development by microcystin-LR in aflatoxin B-1-initiated rats
6. Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments
7. The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types
8. Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors
9. The mitochondrial permeability transition in cell death: A common mechanism in necrosis, apoptosis and autophagy
10. The mitochondrial permeability transition pore and its role in cell death
11. Biochemical pathways of caspase activation during apoptosis
12. The biochemistry of programmed cell death
13. Mitochondria as regulators of apoptosis: Doubt no more
14. Bcl-2 inhibits the mitochondrial release of an apotogenic protease
15. Bcl-2 family proteins
16. Mechanisms controlling cellular suicide: Role of Bcl-2 and caspases
17. BCL-2 family members and the mitochondria in apoptosis
18. Contribution of increased mitochondrial free Ca2+ to the mitochondrial permeability transition induced by tert-butylhydroperoxide in rat hepatocytes
19. The mitochondrial permeability transition
20. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
21. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release
22. Mitochondria and cell death. Mechanistic aspects and methodological issues
23. Genotoxicity of microcystic cyanobacteria extract of a water source in China
24. Studies on oxidative damage induced by cyanobacteria extract in primary cultured rat hepatocytes
25. Microcystic cyanobacteria causes mitochondrial membrane potential alteration and reactive oxygen species formation in primary cultured rat hepatocytes
26. Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species
27. Non-chelation dependent redox actions of desferrioxamine
28. The retinoblastoma gene product inhibits TGF-beta 1 induced apoptosis in primary rat hepatocytes and human HuH-7 hepatoma cells
29. Necrapoptosis and the mitochondrial permeability transition: Shared pathways to necrosis and apoptosis
30. From calcium signaling to cell death: Two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state
31. Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence
32. The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187
33. The thiol-specific antioxidant enzyme prevents mitochondrial permeability transition. Evidence for the participation of reactive oxygen species in this mechanism
34. The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents
35. Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites
36. Evaluation of potential chemoprotectants against microcystin-LR hepatotoxicity in mice
37. Microcystin uptake and inhibition of protein phosphatases: Effects of chemoprotectants and self-inhibition in relation to known hepatic transporters
38. Cyclosporin A protects hepatocytes subjected to high Ca2+ and oxidative stress
39. Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition
40. The uptake of the cyanobacterial hepatotoxin microcystin by isolated rat hepatocytes
41. Cyclosporine A decreases rat skeletal muscle mitochondrial respiration in vitro