Quantitative computer tomography in children and adolescents: The 2013 ISCD pediatric official positions

Journal of Clinical Densitometry

Volumn 17, Issue 2, 2014, Pages 258-274

  Adams, Judith E ^a   Engelke, Klaus ^b,c   Zemel, Babette S ^d   Ward, Kate A ^e  

^a MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c Synarc A S   (Germany)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e MRC HUMAN NUTRITION RESEARCH   (United Kingdom)

Author keywords

Bone mineral density; Children; Fracture assessment; PQCT; QCT

Indexed keywords

BONE STRENGTH; CHRONIC DISEASE; CLINICAL RESEARCH; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; DENSITOMETRY; ETHNICITY; FRACTURE; HEALTH CARE; HUMAN; METHODOLOGY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE STUDY; RADIATION EXPOSURE; REVIEW;

BONE MINERAL DENSITY; CHILDREN; FRACTURE ASSESSMENT; PQCT; QCT;

ADOLESCENT; BONE DENSITY; CHILD; FRACTURES, BONE; HUMANS; RADIUS FRACTURES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84899622417     PISSN: 10946950     EISSN: 15590747     Source Type: Journal    
DOI: 10.1016/j.jocd.2014.01.006     Document Type: Review

References (144)

1. Blake G., Adams J.E., Bishop N. DXA in adults and children. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 2013, 251-263. John Wiley & Sons, Inc., Ames, IA. 8th ed. C.J. Rosen (Ed.).
2. Leonard M.B., Zemel B.S. Current concepts in pediatric bone disease. Pediatr Clin North Am 2002, 49(1):143-173.
3. Crabtree N., Ward K. Bone densitometry: current status and future perspectives. Endocr Dev 2009, 16:58-72.
4. Fewtrell M.S. Bone densitometry in children assessed by dual x ray absorptiometry: uses and pitfalls. Arch Dis Child 2003, 88(9):795-798.
5. Prentice A., Parsons T.J., Cole T.J. Uncritical use of bone-mineral density in absorptiometry may lead to size-related artifacts in the identification of bone-mineral determinants. Am J Clin Nutr 1994, 60(6):837-842.
6. Engelke K., Adams J.E., Armbrecht G., et al. Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions. J Clin Densitom 2008, 11(1):123-162.
7. Zemel B., Bass S., Binkley T., et al. Peripheral quantitative computed tomography in children and adolescents: the 2007 ISCD Pediatric Official Positions. J Clin Densitom 2008, 11(1):59-74.
8. Engelke K. Assessment of bone quality and strength with new technologies. Curr Opin Endocrinol Diabetes Obes 2012, 19(6):474-482.
9. Gluer C.C., Genant H.K. Impact of marrow fat on accuracy of quantitative CT. J Comput Assist Tomogr 1989, 13(6):1023-1035.
10. Rittweger J., Moller K., Bareille M.P., et al. Muscle X-ray attenuation is not decreased during experimental bed rest. Muscle Nerve 2013, 47(5):722-730.
11. Tjong W., Kazakia G.J., Burghardt A.J., Majumdar S. The effect of voxel size on high-resolution peripheral computed tomography measurements of trabecular and cortical bone microstructure. Med Phys 2012, 39(4):1893-1903.
12. Burghardt A.J., Pialat J.B., Kazakia G.J., et al. Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT. Bone 2010, 47(3):519-528.
13. Gilsanz V. Bone density in children: a review of the available techniques and indications. Eur J Radiol 1998, 26(2):177-182.
14. Kaste S.C., Rai S.N., Fleming K., et al. Changes in bone mineral density in survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2006, 46(1):77-87.
15. Damilakis J., Adams J.E., Guglielmi G., Link T.M. Radiation exposure in X-ray-based imaging techniques used in osteoporosis. Eur Radiol 2010, 20(11):2707-2714.
16. Blake G.M., Naeem M., Boutros M. Comparison of effective dose to children and adults from dual X-ray absorptiometry examinations. Bone 2006, 38(6):935-942.
17. Ashby R.L., Ward K.A., Roberts S.A., et al. A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6-19 years. Osteoporos Int 2009, 20(8):1337-1346.
18. Kalender W.A., Schmidt B., Zankl M., Schmidt M. A PC program for estimating organ dose and effective dose values in computed tomography. Eur Radiol 1999, 9(3):555-562.
19. ICRP, 2007. 2007 Recommendations of the International Commission on Radiological Protection (Users Edition). ICRP Publication 103 (Users Edition). Ann. ICRP 37 (2-4).
20. Kalpakcioglu B.B., Engelke K., Genant H.K. Advanced imaging assessment of bone fragility in glucocorticoid-induced osteoporosis. Bone 2011, 48(6):1221-1231.
21. Kaste S.C., Tong X., Hendrick J.M., et al. QCT versus DXA in 320 survivors of childhood cancer: association of BMD with fracture history. Pediatr Blood Cancer 2006, 47(7):936-943.
22. Feber J., Gaboury I., Ni A., et al. Skeletal findings in children recently initiating glucocorticoids for the treatment of nephrotic syndrome. Osteoporos Int 2012, 23(2):751-760.
23. Rousseau-Nepton I., Lang B., Rodd C. Long-term bone health in glucocorticoid-treated children with rheumatic diseases. Curr Rheumatol Rep 2013, 15(3):315.
24. Engelke K., Libanati C., Fuerst T., et al. Advanced CT based in vivo methods for the assessment of bone density, structure, and strength. Curr Osteoporos Rep 2013, 11(3):246-255.
25. Engelke K., Libanati C., Liu Y., et al. Quantitative computed tomography (QCT) of the forearm using general purpose spiral whole-body CT scanners: accuracy, precision and comparison with dual-energy X-ray absorptiometry (DXA). Bone 2009, 45(1):110-118.
26. Ward K., Alsop C., Caulton J., et al. Low magnitude mechanical loading is osteogenic in children with disabling conditions. J Bone Miner Res 2004, 19(3):360-369.
27. Zemel B.S., Paulhamus D., Dilzer C., et al. Precision of peripheral quantitative computed tomography measures of the tibia in children. J Bone Miner Res 2004, 19(Suppl 1):S232.
28. Burrows M., Cooper D.M., Liu D., McKay H.A. Bone and muscle parameters of the tibia: agreement between the XCT 2000 and XCT 3000 instruments. J Clin Densitom 2009, 12(2):186-194.
29. Burghardt A.J., et al. Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography. J Bone Miner Res 2013, 28(3):524-536.
30. Burrows M., Liu D., McKay H. High-resolution peripheral QCT imaging of bone micro-structure in adolescents. Osteoporos Int 2010, 21(3):515-520.
31. Burrows M., Liu D., Moore S., McKay H. Bone microstructure at the distal tibia provides a strength advantage to males in late puberty: an HR-pQCT study. J Bone Miner Res 2010, 25(6):1423-1432.
32. Burrows M., Liu D., Perdios A., et al. Assessing bone microstructure at the distal radius in children and adolescents using HR-pQCT: a methodological pilot study. J Clin Densitom 2010, 13(4):451-455.
33. Chevalley T., Bonjour J.P., Ferrari S., Rizzoli R. Pubertal timing and body mass index gain from birth to maturity in relation with femoral neck BMD and distal tibia microstructure in healthy female subjects. Osteoporos Int 2011, 22(10):2689-2698.
34. Kirmani S., Amin S., McCready L.K., et al. Sclerostin levels during growth in children. Osteoporos Int 2012, 23(3):1123-1130.
35. Kirmani S., Christen D., van Lenthe G.H., et al. Bone structure at the distal radius during adolescent growth. J Bone Miner Res 2009, 24(6):1033-1042.
36. Liu D., Burrows M., Egeli D., McKay H. Site specificity of bone architecture between the distal radius and distal tibia in children and adolescents: an HR-pQCT study. Calcif Tissue Int 2010, 87(4):314-323.
37. Nishiyama K.K., Macdonald H.M., Moore S.A., et al. Cortical porosity is higher in boys compared with girls at the distal radius and distal tibia during pubertal growth: an HR-pQCT study. J Bone Miner Res 2012, 27(2):273-282.
38. Wang Q., Ghasem-Zadeh A., Wang X.F., et al. Trabecular bone of growth plate origin influences both trabecular and cortical morphology in adulthood. J Bone Miner Res 2011, 26(7):1577-1583.
39. Wang Q., Wang X.F., Iuliano-Burns S., et al. Rapid growth produces transient cortical weakness: a risk factor for metaphyseal fractures during puberty. J Bone Miner Res 2010, 25(7):1521-1526.
40. Engelke K., Stampa B., Timm W., et al. Short-term in vivo precision of BMD and parameters of trabecular architecture at the distal forearm and tibia. Osteoporos Int 2012, 23(8):2151-2158.
41. Pauchard Y., Ayres F.J., Boyd S.K. Automated quantification of three-dimensional subject motion to monitor image quality in high-resolution peripheral quantitative computed tomography. Phys Med Biol 2011, 56(20):6523-6543.
42. Pauchard Y., Liphardt A.M., Macdonald H.M., et al. Quality control for bone quality parameters affected by subject motion in high-resolution peripheral quantitative computed tomography. Bone 2012, 50(6):1304-1310.
43. Pialat J.B., Liphardt A.M., Macdonald H.M., et al. Visual grading of motion induced image degradation in high resolution peripheral computed tomography: impact of image quality on measures of bone density and micro-architecture. Bone 2012, 50(1):111-118.
44. Miglioretti D.L., Johnson E., Williams A., et al. The use of computed tomography in pediatrics and the associated radiation exposure and estimated cancer risk. JAMA Pediatr 2013, 167(8):700-707.
45. Paterson A., Frush D.P. Dose reduction in paediatric MDCT: general principles. Clin Radiol 2007, 62(6):507-517.
46. Zacharias C., Alessio A.M., Otto R.K., et al. Pediatric CT: strategies to lower radiation dose. AJR Am J Roentgenol 2013, 200(5):950-956.
47. Cann C.E. Quantitative CT for determination of bone-mineral density-a review. Radiology 1988, 166(2):509-522.
48. Cann C.E., Genant H.K. Precise measurement of vertebral mineral-content using computed-tomography. J Comput Assist Tomogr 1980, 4(4):493-500.
49. Museyko O., Heinemann A., Krause M., et al. A low radiation exposure protocol for 3D QCT of the spine. Osteoporos Int 2014, 25(3):983-992.
50. Engelke K., Mastmeyer A., Bousson V., et al. Reanalysis precision of 3D quantitative computed tomography (QCT) of the spine. Bone 2009, 44(4):566-572.
51. Damilakis J., Guglielmi G. Quality assurance and dosimetry in bone densitometry. Radiol Clin North Am 2010, 48(3):629-640.
52. Guglielmi G., Damilakis J., Solomou G., Bazzocchi A. Quality assurance of imaging techniques used in the clinical management of osteoporosis. Radiol Med 2012, 117(8):1347-1354.
53. Pearson J., Rueqsegger P., Dequeker J., et al. European semi-anthropomorphic phantom for the cross-calibration of peripheral bone densitometers: assessment of precision accuracy and stability. Bone Miner 1994, 27(2):109-120.
54. Reeve J., et al. Radial cortical and trabecular bone densities of men and women standardized with the European Forearm Phantom. Calcif Tissue Int 1996, 58(3):135-143.
55. Kalender W.A., Felsenberg D., Genant H.K., et al. The European Spine Phantom-a tool for standardization and quality control in spinal bone mineral measurements by DXA and QCT. Eur J Radiol 1995, 20(2):83-92.
56. Rauch F., Neu C., Manz F., et al. The development of metaphyseal cortex-implications for distal radius fractures during growth. J Bone Miner Res 2001, 16(8):1547-1555.
57. Anliker E., Toigo M. Functional assessment of the muscle-bone unit in the lower leg. J Musculoskelet Neuronal Interact 2012, 12(2):46-55.
58. Schoenau E. The "functional muscle-bone unit": a two-step diagnostic algorithm in pediatric bone disease. Pediatr Nephrol 2005, 20(3):356-359.
59. Veilleux L.N., Cheung M., Ben Amor M., et al. Abnormalities in muscle density and muscle function in hypophosphatemic rickets. J Clin Endocrinol Metab 2012, 97(8):E1492-E1498.
60. Bouxsein M.L. Bone structure and fracture risk: do they go arm in arm?. J Bone Miner Res 2011, 26(7):1389-1391.
61. Parfitt A.M., Drezner M.K., Glorieux F.H., et al. Bone histomorphometry-standardization of nomenclature, symbols, and units. J Bone Miner Res 1987, 2(6):595-610.
62. Leib A., Ruegsegger P. Calibration of trabecular bone structure measures of in vivo three-dimensional peripheral quantitative computed tomography with 28-microm-resolution microcomputed tomography. Bone 1999, 24(1):35-39.
63. Donnelly E. Methods for assessing bone quality: a review. Clin Orthop Relat Res 2011, 469(8):2128-2138.
64. Rauch F., Schoenau E. Peripheral quantitative computed tomography of the proximal radius in young subjects-new reference data and interpretation of results. J Musculoskelet Neuronal Interact 2008, 8(3):217-226.
65. Moyer-Mileur L.J., Quick J.L., Murray M.A. Peripheral quantitative computed tomography of the tibia: pediatric reference values. J Clin Densitom 2008, 11(2):283-294.
66. Leonard M.B., Elmi A., Mostoufi-Moab S., et al. Effects of sex, race, and puberty on cortical bone and the functional muscle bone unit in children, adolescents, and young adults. J Clin Endocrinol Metab 2010, 95(4):1681-1689.
67. Cole T.J., Green P.J. Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med 1992, 11(10):1305-1319.
68. Anliker E., Dick C., Rawer R., et al. Effects of jumping exercise on maximum ground reaction force and bone in 8- to 12-year-old boys and girls: a 9-month randomized controlled trial. J Musculoskelet Neuronal Interact 2012, 12(2):56-67.
69. Anliker E., Rawer R., Boutellier U., et al. Maximum ground reaction force in relation to tibial bone mass in children and adults. Med Sci Sports Exerc 2011, 43(11):2102-2109.
70. Ducher G., Bass S.L., Naughton G.A., et al. Overweight children have a greater proportion of fat mass relative to muscle mass in the upper limbs than in the lower limbs: implications for bone strength at the distal forearm. Am J Clin Nutr 2009, 90(4):1104-1111.
71. Farr J.N., Blew R.M., Lee V.R., et al. Associations of physical activity duration, frequency, and load with volumetric BMD, geometry, and bone strength in young girls. Osteoporos Int 2011, 22(5):1419-1430.
72. Farr J.N., Chen Z., Lisse J.R., et al. Relationship of total body fat mass to weight-bearing bone volumetric density, geometry, and strength in young girls. Bone 2010, 46(4):977-984.
73. Farr J.N., Funk J.L., Chen Z., et al. Skeletal muscle fat content is inversely associated with bone strength in young girls. J Bone Miner Res 2011, 26(9):2217-2225.
74. Farr J.N., Lee V.R., Blew R.M., et al. Quantifying bone-relevant activity and its relation to bone strength in girls. Med Sci Sports Exerc 2011, 43(3):476-483.
75. Farr J.N., Tomas R., Chen Z., et al. Lower trabecular volumetric BMD at metaphyseal regions of weight-bearing bones is associated with prior fracture in young girls. J Bone Miner Res 2011, 26(2):380-387.
76. Ashby R.L., Adams J.E., Roberts S.A., et al. The muscle-bone unit of peripheral and central skeletal sites in children and young adults. Osteoporos Int 2011, 22(1):121-132.
77. Darelid A., Ohlsson C., Rudang R., et al. Trabecular volumetric bone mineral density is associated with previous fracture during childhood and adolescence in males: the GOOD study. J Bone Miner Res 2010, 25(3):537-544.
78. Dowthwaite J.N., Flowers P.P., Scerpella T.A. Agreement between pQCT- and DXA-derived indices of bone geometry, density, and theoretical strength in females of varying age, maturity, and physical activity. J Bone Miner Res 2011, 26(6):1349-1357.
79. Micklesfield L.K., Norris S.A., Pettifor J.M. Determinants of bone size and strength in 13-year-old South African children: the influence of ethnicity, sex and pubertal maturation. Bone 2011, 48(4):777-785.
80. Warden S.J., Hill K.M., Ferira A.J., et al. Racial differences in cortical bone and their relationship to biochemical variables in Black and White children in the early stages of puberty. Osteoporos Int 2013, 24(6):1869-1879.
81. Erlandson M.C., Kontulainen S.A., Baxter-Jones A.D. Precompetitive and recreational gymnasts have greater bone density, mass, and estimated strength at the distal radius in young childhood. Osteoporos Int 2011, 22(1):75-84.
82. Wetzsteon R.J., Zemel B.S., Shults J., et al. Mechanical loads and cortical bone geometry in healthy children and young adults. Bone 2011, 48(5):1103-1108.
83. Wey H.E., Binkley T.L., Beare T.M., et al. Cross-sectional versus longitudinal associations of lean and fat mass with pQCT bone outcomes in children. J Clin Endocrinol Metab 2011, 96(1):106-114.
84. Xu L., Nicholson P., Wang Q.J., et al. Fat mass accumulation compromises bone adaptation to load in Finnish women: a cross-sectional study spanning three generations. J Bone Miner Res 2010, 25(11):2341-2349.
85. Xu L., Wang Q., Lyytikainen A., et al. Concerted actions of insulin-like growth factor 1, testosterone, and estradiol on peripubertal bone growth: a 7-year longitudinal study. J Bone Miner Res 2011, 26(9):2204-2211.
86. Kalkwarf H.J., Laor T., Bean J.A. Fracture risk in children with a forearm injury is associated with volumetric bone density and cortical area (by peripheral QCT) and areal bone density (by DXA). Osteoporos Int 2011, 22(2):607-616.
87. Cole Z.A., Harvey N.C., Kim M., et al. Increased fat mass is associated with increased bone size but reduced volumetric density in pre pubertal children. Bone 2012, 50(2):562-567.
88. Deere K., Sayers A., Rittweger J., et al. A cross-sectional study of the relationship between cortical bone and high-impact activity in young adult males and females. J Clin Endocrinol Metab 2012, 97(10):3734-3743.
89. Sayers A., Tobias J.H. Fat mass exerts a greater effect on cortical bone mass in girls than boys. J Clin Endocrinol Metab 2010, 95(2):699-706.
90. Beccard R., Land C., Semler O., et al. Do bone mineral density, bone geometry and the functional muscle-bone unit explain bone fractures in healthy children and adolescents?. Horm Res Paediatr 2010, 74(5):312-318.
91. Cheng S.L., Xu L.T., Nicholson P.H.F., et al. Low volumetric BMD is linked to upper-limb fracture in pubertal girls and persists into adulthood: a seven-year cohort study. Bone 2009, 45(3):480-486.
92. Soucek O., Lebl J., Snajderova M., et al. Bone geometry and volumetric bone mineral density in girls with Turner syndrome of different pubertal stages. Clin Endocrinol (Oxf) 2011, 74(4):445-452.
93. Armstrong L., Jett K., Birch P., et al. The generalized bone phenotype in children with neurofibromatosis 1: a sibling matched case-control study. Am J Med Genet A 2013, 161(7):1654-1661.
94. De Schepper J., Roggen I., Van Biervliet S., et al. Comparative bone status assessment by dual energy X-ray absorptiometry, peripheral quantitative computed tomography and quantitative ultrasound in adolescents and young adults with cystic fibrosis. J Cyst Fibros 2012, 11(2):119-124.
95. Soucek O., Komrska V., Hlavka Z., et al. Boys with haemophilia have low trabecular bone mineral density and sarcopenia, but normal bone strength at the radius. Haemophilia 2012, 18(2):222-228.
96. Kohler J.A., Moon R.J., Sands R., et al. Selective reduction in trabecular volumetric bone mineral density during treatment for childhood acute lymphoblastic leukemia. Bone 2012, 51(4):765-770.
97. Mostoufi-Moab S., Brodsky J., Isaacoff E.J., et al. Longitudinal assessment of bone density and structure in childhood survivors of acute lymphoblastic leukemia without cranial radiation. J Clin Endocrinol Metab 2012, 97(10):3584-3592.
98. Mostoufi-Moab S., Ginsberg J.P., Bunin N., et al. Bone density and structure in long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation. J Bone Miner Res 2012, 27(4):760-769.
99. Saha M.T., Sievanen H., Salo M.K., et al. Bone mass and structure in adolescents with type 1 diabetes compared to healthy peers. Osteoporos Int 2009, 20(8):1401-1406.
100. Gronowitz E., Lorentzon M., Ohlsson C., et al. Docosahexaenoic acid is associated with endosteal circumference in long bones in young males with cystic fibrosis. Br J Nutr 2008, 99(1):160-167.
101. Gordon C.M., Gordon L.B., Snyder B.D., et al. Hutchinson-Gilford progeria is a skeletal dysplasia. J Bone Miner Res 2011, 26(7):1670-1679.
102. Stevenson D.A., Viskochil D.H., Carey J.C., et al. Tibial geometry in individuals with neurofibromatosis type 1 without anterolateral bowing of the lower leg using peripheral quantitative computed tomography. Bone 2009, 44(4):585-589.
103. Edouard T., Deal C., Van Vliet G., et al. Muscle-bone characteristics in children with Prader-Willi syndrome. J Clin Endocrinol Metab 2012, 97(2):E275-E281.
104. Holroyd C.R., Davies J.H., Taylor P., et al. Reduced cortical bone density with normal trabecular bone density in girls with Turner syndrome. Osteoporos Int 2010, 21(12):2093-2099.
105. Cheung M., Roschger P., Klaushofer K., et al. Cortical and trabecular bone density in X-linked hypophosphatemic rickets. J Clin Endocrinol Metab 2013, 98(5):954-961.
106. Bechtold S., Bachmann S., Putzker S., et al. Early changes in body composition after cessation of growth hormone therapy in childhood-onset growth hormone deficiency. J Clin Densitom 2011, 14(4):471-477.
107. Schweizer R., Martin D.D., Haase M., et al. Similar effects of long-term exogenous growth hormone (GH) on bone and muscle parameters: a pQCT study of GH-deficient and small-for-gestational-age (SGA) children. Bone 2007, 41(5):875-881.
108. Bechtold S., Putzker S., Birnbaum J., et al. Impaired bone geometry after heart and heart-lung transplantation in childhood. Transplantation 2010, 90(9):1006-1010.
109. Ranta S., Viljakainen H., Makipernaa A., et al. Peripheral quantitative computed tomography (pQCT) reveals alterations in the three-dimensional bone structure in children with haemophilia. Haemophilia 2012, 18(6):955-961.
110. Fung E.B., Vichinsky E.P., Kwiatkowski J.L., et al. Characterization of low bone mass in young patients with thalassemia by DXA, pQCT and markers of bone turnover. Bone 2011, 48(6):1305-1312.
111. Bechtold S., Alberer M., Arenz T., et al. Reduced muscle mass and bone size in pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis 2010, 16(2):216-225.
112. Dubner S.E., Shults J., Baldassano R.N., et al. Longitudinal assessment of bone density and structure in an incident cohort of children with Crohn's disease. Gastroenterology 2009, 136(1):123-130.
113. Werkstetter K.J., Pozza S.B., Filipiak-Pittroff B., et al. Long-term development of bone geometry and muscle in pediatric inflammatory bowel disease. Am J Gastroenterol 2011, 106(5):988-998.
114. Bechtold S., Ripperger P., Dalla Pozza R., et al. Dynamics of body composition and bone in patients with juvenile idiopathic arthritis treated with growth hormone. J Clin Endocrinol Metab 2010, 95(1):178-185.
115. Burnham J.M., Shults J., Dubner S.E., et al. Bone density, structure, and strength in juvenile idiopathic arthritis: importance of disease severity and muscle deficits. Arthritis Rheum 2008, 58(8):2518-2527.
116. Terpstra A.M., Kalkwarf H.J., Shults J., et al. Bone density and cortical structure after pediatric renal transplantation. J Am Soc Nephrol 2012, 23(4):715-726.
117. Tsampalieros A., Kalkwarf H.J., Wetzsteon R.J., et al. Changes in bone structure and the muscle-bone unit in children with chronic kidney disease. Kidney Int 2013, 83(3):495-502.
118. Wesseling-Perry K., Bacchetta J. CKD-MBD after kidney transplantation. Pediatr Nephrol 2011, 26(12):2143-2151.
119. Wetzsteon R.J., Kalkwarf H.J., Shults J., et al. Volumetric bone mineral density and bone structure in childhood chronic kidney disease. J Bone Miner Res 2011, 26(9):2235-2244.
120. Wetzsteon R.J., Shults J., Zemel B.S., et al. Divergent effects of glucocorticoids on cortical and trabecular compartment BMD in childhood nephrotic syndrome. J Bone Miner Res 2009, 24(3):503-513.
121. Biggin A., Briody J.N., Ramjan K.A., et al. Evaluation of bone mineral density and morphology using pQCT in children after spinal cord injury. Dev Neurorehabil 2013, 16(6):391-397.
122. Ooi H.L., Briody J., McQuade M., et al. Zoledronic acid improves bone mineral density in pediatric spinal cord injury. J Bone Miner Res 2012, 27(7):1536-1540.
123. Sherk V.D., Bemben M.G., Bemben D.A. BMD and bone geometry in transtibial and transfemoral amputees. J Bone Miner Res 2008, 23(9):1449-1457.
124. Calarge C.A., Zimmerman B., Xie D., et al. A cross-sectional evaluation of the effect of risperidone and selective serotonin reuptake inhibitors on bone mineral density in boys. J Clin Psychiatry 2010, 71(3):338-347.
125. Bechtold S., Putzker S., Bonfig W., et al. Bone size normalizes with age in children and adolescents with type 1 diabetes. Diabetes Care 2007, 30(8):2046-2050.
126. Griffin L.M., Kalkwarf H.J., Zemel B.S., et al. Assessment of dual-energy X-ray absorptiometry measures of bone health in pediatric chronic kidney disease. Pediatr Nephrol 2012, 27(7):1139-1148.
127. Gilsanz V., Varterasian M., Senac M.O., Cann C.E. Quantitative spinal mineral analysis in children. Ann Radiol (Paris) 1986, 29(3-4):380-382.
128. Gilsanz V., Gibbens D.T., Roe T.F., et al. Vertebral bone density in children: effect of puberty. Radiology 1988, 166(3):847-850.
129. Mora S., Goodman W.G., Loro M.L., et al. Age-related changes in cortical and cancellous vertebral bone density in girls: assessment with quantitative CT. AJR Am J Roentgenol 1994, 162(2):405-409.
130. Mora S., Pitukcheewanont P., Kaufman F.R., et al. Biochemical markers of bone turnover and the volume and the density of bone in children at different stages of sexual development. J Bone Miner Res 1999, 14(10):1664-1671.
131. Loro M.L., Sayre J., Roe T.F., et al. Early identification of children predisposed to low peak bone mass and osteoporosis later in life. J Clin Endocrinol Metab 2000, 85(10):3908-3918.
132. Gilsanz V., Boechat M.I., Roe T.F., et al. Gender differences in vertebral body sizes in children and adolescents. Radiology 1994, 190(3):673-677.
133. Gilsanz V., Skaggs D.L., Kovanlikaya A., et al. Differential effect of race on the axial and appendicular skeletons of children. J Clin Endocrinol Metab 1998, 83(5):1420-1427.
134. Caulton J.M., Ward K.A., Alsop C.W., et al. A randomised controlled trial of standing programme on bone mineral density in non-ambulant children with cerebral palsy. Arch Dis Child 2004, 89(2):131-135.
135. Wren T.A.L., Lee D.C., Hara R., et al. Effect of high-frequency, low-magnitude vibration on bone and muscle in children with cerebral palsy. J Pediatr Orthop 2010, 30(7):732-738.
136. Roe T.F., Mora S., Costin G., et al. Vertebral bone density in insulin-dependent diabetic children. Metabolism 1991, 40(9):967-971.
137. Pitukcheewanont P., Safani D., Church J., et al. Bone measures in HIV-1 infected children and adolescents: disparity between quantitative computed tomography and dual-energy X-ray absorptiometry measurements. Osteoporos Int 2005, 16(11):1393-1396.
138. Pitukcheewanont P., Numbenjapon N., Safani D., et al. Bone size and density measurements in prepubertal children with Turner syndrome prior to growth hormone therapy. Osteoporos Int 2011, 22(6):1709-1715.
139. Pitukcheewanont P., Safani D., Gilsanz V., et al. Quantitative computed tomography measurements of bone mineral density in prepubertal children with congenital hypothyroidism treated with L-thyroxine. J Pediatr Endocrinol Metab 2004, 17(6):889-893.
140. Numbenjapon N., Costin G., Gilsanz V., et al. Low cortical bone density measured by computed tomography in children and adolescents with untreated hyperthyroidism. J Pediatr 2007, 150(5):527-530.
141. Gilsanz V., Kovanlikaya A., Costin G., et al. Differential effect of gender on the sizes of the bones in the axial and appendicular skeletons. J Clin Endocrinol Metab 1997, 82(5):1603-1607.
142. Mora S., Pitukcheewanont P., Nelson J.C., Gilsanz V. Serum levels of insulin-like growth factor I and the density, volume, and cross-sectional area of cortical bone in children. J Clin Endocrinol Metab 1999, 84(8):2780-2783.
143. Bacchetta J., Wesseling-Perry K., Gilsanz V., et al. Idiopathic juvenile osteoporosis: a cross-sectional single-centre experience with bone histomorphometry and quantitative computed tomography. Pediatr Rheumatol Online J 2013, 11(1):6.
144. Gilsanz V., Perez F.J., Campbell P.P., et al. Quantitative CT reference values for vertebral trabecular bone density in children and young adults. Radiology 2009, 250(1):222-227.