Clinical Use of Quantitative Computed Tomography and Peripheral Quantitative Computed Tomography in the Management of Osteoporosis in Adults: The 2007 ISCD Official Positions

Journal of Clinical Densitometry

Volumn 11, Issue 1, 2008, Pages 123-162

  Engelke, Klaus ^a,b   Adams, Judith E ^c   Armbrecht, Gabriele ^d   Augat, Peter ^e   Bogado, Cesar E ^f   Bouxsein, Mary L ^g   Felsenberg, Dieter ^d   Ito, Masako ^h   Prevrhal, Sven ⁱ   Hans, Didier B ^j   Lewiecki, E Michael ^k  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b Synarc Inc   (Germany)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e BG UNFALLKLINIK MURNAU   (Germany)

^f Instituto de Investigaciones Metabolicas   (Argentina)

^g HARVARD MEDICAL SCHOOL   (United States)

^h NAGASAKI UNIVERSITY HOSPITAL   (Japan)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^k NEW MEXICO CLINICAL RESEARCH AND OSTEOPOROSIS CENTER   (United States)

more..

Author keywords

Bone mineral density; diagnosis; fracture assessment; guideline; monitoring; osteoporosis; position; pQCT; QCT; standards

Indexed keywords

ALENDRONIC ACID; CALCITRIOL; CALCIUM; CALCIUM CARBONATE; ESTROGEN; FLUORIDE SODIUM; MEDROXYPROGESTERONE ACETATE; MESTEROLONE; PAMIDRONIC ACID; PARATHYROID HORMONE[1-34]; PLACEBO; TESTOSTERONE ENANTATE; TESTOSTERONE UNDECANOATE; VITAMIN D;

ARTICLE; BONE DENSITY; BONE STRUCTURE; CLINICAL ASSESSMENT; CLINICAL PRACTICE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CORTICAL BONE; DIAGNOSTIC ACCURACY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMUR; FOREARM; FRACTURE; GEOMETRY; HIP; HUMAN; IMAGE RECONSTRUCTION; LUMBAR SPINE; MEDICAL SOCIETY; MONITORING; OSTEOPOROSIS; PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE COMPUTED TOMOGRAPHY; RADIATION EXPOSURE; TIBIA; TRABECULAR BONE; WORLD HEALTH ORGANIZATION;

ADULT; BONE DENSITY; CALIBRATION; FEMUR; FOREARM; FRACTURES, BONE; HUMANS; OSTEOPOROSIS; RADIOGRAPHIC IMAGE INTERPRETATION, COMPUTER-ASSISTED; SOCIETIES, MEDICAL; SPINAL FRACTURES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 42649115770     PISSN: 10946950     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocd.2007.12.010     Document Type: Article

References (272)

1. Rüegsegger P., Niederer P., and Anliker M. An extension of classical bone mineral measurements. Ann Biomed Eng 2 (1974) 194
2. Hounsfield G.N. Computerized transverse axial scanning (tomography). 1. Description of system. Br J Radiol 46 552 (1973) 1016-1022
3. Genant H.K., and Boyd D.P. Quantitative bone mineral analysis using dual-energy computed tomography. Invest Radiol 12 (1977) 545-551
4. Cameron J.R., and Sorenson J.A. Measurement of bone mineral in vivo: an improved method. Science 142 (1963) 230-232
5. Kalender W.A. Computed Tomography. 2nd ed. (2005), Publicis, Erlangen
6. Carter D.R., Bouxsein M.L., and Marcus R. New approaches for interpreting projected bone densitometry data. J Bone Miner Res 7 (1992) 137-145
7. Jergas M., Breitenseher M., Glüer C.C., et al. Estimates of volumetric bone density from projectional measurements improve the discriminatory capability of dual X-ray absorptiometry. J Bone Miner Res 10 7 (1995) 1101-1110
8. Mazess R.B., Barden H., Mautalen C., et al. Normalization of spine densitometry. J Bone Miner Res 9 4 (1994) 541-548
9. Cvijetic S., and Korsic M. Apparent bone mineral density estimated from DXA in healthy men and women. Osteoporos Int 15 4 (2004) 295-300
10. Delmas P.D., and Seeman E. Changes in bone mineral density explain little of the reduction in vertebral or nonvertebral fracture risk with anti resorptive therapy. Bone 34 4 (2004) 599-604
11. Li Z., Chines A.A., and Meredith M.P. Statistical validation of surrogate endpoints: is bone density a valid surrogate for fracture?. J Musculoskelet Neuronal Interact 4 1 (2004) 64-74
12. Silverman P.M., Kalender W.A., and Hazle J.D. Common terminology for single and multislice helical CT. AJR Am J Roentgenol 176 5 (2001) 1135-1136
13. Cann C.E., Genant H.K., Kolb F.O., et al. Quantitative computed tomography for prediction of vertebral fracture risk. Bone 6 1 (1985) 1-7
14. Genant H.K., Cann C.E., Ettinger B., et al. Quantitative computed tomography of vertebral spongiosa: a sensitive method for detecting early bone loss after oophorectomy. Ann Intern Med 97 5 (1982) 699-705
15. Kalender W.A., Klotz E., and Süss C. Vertebral bone mineral analysis: an integrated approach with CT. Radiology 164 (1987) 419-423
16. Steiger P., Block J.E., Steiger S., et al. Spinal bone mineral density measured with quantitative CT: effect of region of interest, vertebral level, and technique. Radiology 175 2 (1990) 537-543
17. Genant H.K., Grampp S., Glüer C.C., et al. Universal standardization for dual X-ray absorptiometry: patient and phantom cross-calibration results. J Bone Miner Res 9 10 (1994) 1503-1514
18. Kalender W.A., Felsenberg D., Louis O., et al. Reference values for trabecular and cortical vertebral bone density in single and dual-energy quantitative computed tomography. Eur J Radiol 9 (1989) 75-80
19. Prevrhal S., Engelke K., and Kalender W.A. Accuracy limits for the determination of cortical width and density: the influence of object size and CT imaging parameters. Phys Med Biol 44 (1999) 751-764
20. Augat P., Fuerst T., and Genant H.K. Quantitative bone mineral assessment at the forearm: a review. Osteoporos Int 8 4 (1998) 299-310
21. Tsurusaki K., Ito M., and Hayashi K. Differential effects of menopause and metabolic disease on trabecular and cortical bone assessed by peripheral quantitative computed tomography (pQCT). Br J Radiol 73 865 (2000) 14-22
22. Hangartner T.N. The OsteoQuant: an isotope-based CT scanner for precise measurement of bone density. J Comput Assist Tomogr 17 5 (1993) 798-805
23. Muller R., Hildebrand T., Hauselmann H.J., et al. In vivo reproducibility of three-dimensional structural properties of noninvasive bone biopsies using 3D-pQCT. J Bone Miner Res 11 11 (1996) 1745-1750
24. McCollough C.H., Bruesewitz M.R., and Kofler Jr. J.M. CT dose reduction and dose management tools: overview of available options. Radiographics 26 2 (2006) 503-512
25. Kalender W.A., Wolf H., Suess C., et al. Dose reduction in CT by on-line tube current control: principles and validation on phantoms and cadavers. Eur J Radiol 9 2 (1999) 323-328
26. Wilting J.E., Zwartkruis A., van Leeuwen M.S., et al. A rational approach to dose reduction in CT: individualized scan protocols. Eur J Radiol 11 12 (2001) 2627-2632
27. Namasivayam S., Kalra M.K., Pottala K.M., et al. Optimization of Z-axis automatic exposure control for multidetector row CT evaluation of neck and comparison with fixed tube current technique for image quality and radiation dose. AJNR Am J Neuroradiol 27 10 (2006) 2221-2225
28. Biggemann M., Hilweg D., and Brinckmann P. Prediction of the compressive strength of vertebral bodies of the lumbar spine by quantitative computed tomography. Skeletal Radiol 17 4 (1988) 264-269
29. Mosekilde L., Bentzen S.M., Ortoft G., et al. The predictive value of quantitative computed tomography for vertebral body compressive strength and ash density. Bone 10 6 (1989) 465-470
30. Eriksson S.A., Isberg B.O., and Lindgren J.U. Prediction of vertebral strength by dual photon absorptiometry and quantitative computed tomography. Calcif Tissue Int 44 4 (1989) 243-250
31. Brinckmann P., Biggemann M., and Hilweg D. Prediction of the compressive strength of human lumbar vertebrae. Spine 14 6 (1989) 606-610
32. Ebbesen E.N., Thomsen J.S., Beck-Nielsen H., et al. Lumbar vertebral body compressive strength evaluated by dual-energy X-ray absorptiometry, quantitative computed tomography, and ashing. Bone 25 6 (1999) 713-724
33. Lochmuller E.M., Lill C.A., Kuhn V., et al. Radius bone strength in bending, compression, and falling and its correlation with clinical densitometry at multiple sites. J Bone Miner Res 17 9 (2002) 1629-1638
34. Crawford R.P., Rosenberg W.S., and Keaveny T.M. Quantitative computed tomography-based finite element models of the human lumbar vertebral body: effect of element size on stiffness, damage, and fracture strength predictions. J Biomech Eng 125 4 (2003) 434-438
35. Buckley J.M., Loo K., and Motherway J. Comparison of quantitative computed tomography-based measures in predicting vertebral compressive strength. Bone 40 3 (2007) 767-774
36. Buckley J.M., Cheng L., Loo K., et al. Quantitative computed tomography-based predictions of vertebral strength in anterior bending. Spine 32 9 (2007) 1019-1027
37. Pistoia W., van Rietbergen B., Lochmuller E.M., et al. Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone 30 6 (2002) 842-848
38. Pistoia W., van Rietbergen B., Lochmuller E.M., et al. Image-based micro-finite-element modeling for improved distal radius strength diagnosis: moving from bench to bedside. J Clin Densitom 7 2 (2004) 153-160
39. Augat P., Iida H., Jiang Y., et al. Distal radius fractures: mechanisms of injury and strength prediction by bone mineral assessment. J Orthop Res 16 5 (1998) 629-635
40. Augat P., Reeb H., and Claes L.E. Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell. J Bone Miner Res 11 9 (1996) 1356-1363
41. Louis O., Boulpaep F., Willnecker J., et al. Cortical mineral content of the radius assessed by peripheral QCT predicts compressive strength on biomechanical testing. Bone 16 (1995) 375-379
42. Muller M.E., Webber C.E., and Bouxsein M.L. Predicting the failure load of the distal radius. Osteoporos Int 14 4 (2003) 345-352
43. Alho A., Hoiseth A., Husby T., et al. Femoral bone density measurements by single energy computed tomography related to hip fractures. Ann Chir Gynaecol 77 5-6 (1988) 208-211
44. Keyak J.H., Rossi S.A., Jones K.A., et al. Prediction of femoral fracture load using automated finite element modeling. J Biomech 31 2 (1998) 125-133
45. Lang T.F., Keyak J.H., Heitz M.W., et al. Volumetric quantitative computed tomography of the proximal femur: precision and relation to bone strength. Bone 21 1 (1997) 101-108
46. Cody D.D., Gross G.J., Hou F.J., et al. Femoral strength is better predicted by finite element models than QCT and DXA. J Biomech 32 10 (1999) 1013-1020
47. Lochmuller E.M., Muller R., Kuhn V., et al. Can novel clinical densitometric techniques replace or improve DXA in predicting bone strength in osteoporosis at the hip and other skeletal sites?. J Bone Miner Res 18 5 (2003) 906-912
48. Bousson V., Le Bras A., Roqueplan F., et al. Volumetric quantitative computed tomography of the proximal femur: relationships linking geometric and densitometric variables to bone strength. Role for compact bone. Osteoporos Int 17 6 (2006) 855-864
49. Lotz J.C., and Hayes W.C. The use of quantitative computed tomography to estimate risk of fracture of the hip from falls. J Bone Joint Surg Am 72 5 (1990) 689-700
50. Cheng X.G., Lowet G., Boonen S., et al. Assessment of the strength of proximal femur in vitro: relationship to femoral bone mineral density and femoral geometry. Bone 20 3 (1997) 213-218
51. Bauer J.S., Kohlmann S., Eckstein F., et al. Structural analysis of trabecular bone of the proximal femur using multislice computed tomography: a comparison with dual X-ray absorptiometry for predicting biomechanical strength in vitro. Calcif Tissue Int 78 2 (2006) 78-89
52. Ashe M.C., Khan K.M., Kontulainen S.A., et al. Accuracy of pQCT for evaluating the aged human radius: an ashing, histomorphometry and failure load investigation. Osteoporos Int 17 8 (2006) 1241-1251
53. Gordon C.L., Webber C.E., and Nicholson P.S. Relation between image-based assessment of distal radius trabecular structure and compressive strength. Can Assoc Radiol J 49 6 (1998) 390-397
54. Spadaro J.A., Werner F.W., Brenner R.A., et al. Cortical and trabecular bone contribute strength to the osteopenic distal radius. J Orthop Res 12 2 (1994) 211-218
55. Huiskes R. If bone is the answer, then what is the question?. J Anat 197 Pt 2 (2000) 145-156
56. Myers B.S., Arbogast K.B., Lobaugh B., et al. Improved assessment of lumbar vertebral body strength using supine lateral dual-energy X-ray absorptiometry. J Bone Miner Res 9 5 (1994) 687-693
57. Myers E.R., Hecker A.T., Rooks D.S., et al. Geometric variables from DXA of the radius predict forearm fracture load. Calcif Tissue Int 52 (1993) 199-204
58. Sandor T., Felsenberg D., Kalender W., et al. Global and regional variations in the spinal trabecular bone: single and dual-energy examinations. J Clin Endocrinol Metab 72 (1991) 1157-1168
59. Cody D.D., Goldstein S.A., Flynn M.J., et al. Correlations between vertebral regional bone mineral density (rBMD) and whole bone fracture load. Spine 16 2 (1991) 146-154
60. Sandor T., Felsenberg D., and Brown E. Discriminability of fracture and nonfracture cases based on the spatial distribution of spinal bone mineral. J Comput Assist Tomogr 21 3 (1997) 498-505
61. Majumdar S., Weinstein R.S., and Prasad R.R. Application of fractal geometry techniques to the study of trabecular bone. Med Phys 20 6 (1993) 1611-1619
62. Andresen R., Werner H.J., and Schober H.C. Contribution of the cortical shell of vertebrae to mechanical behaviour of the lumbar vertebrae with implications for predicting fracture risk. Br J Radiol 71 847 (1998) 759-765
63. Haidekker M.A., Andresen R., and Werner H.J. Relationship between structural parameters, bone mineral density and fracture load in lumbar vertebrae, based on high-resolution computed tomography, quantitative computed tomography and compression tests. Osteoporos Int 9 5 (1999) 433-440
64. Cendre E., Mitton D., Roux J.P., et al. High-resolution computed tomography for architectural characterization of human lumbar cancellous bone: relationships with histomorphometry and biomechanics. Osteoporos Int 10 5 (1999) 353-360
65. Link T.M., Bauer J., Kollstedt A., et al. Trabecular bone structure of the distal radius, the calcaneus, and the spine: which site predicts fracture status of the spine best?. Invest Radiol 39 8 (2004) 487-497
66. Tabor Z., and Rokita E. Quantifying anisotropy of trabecular bone from gray-level images. Bone 40 4 (2007) 966-972
67. Saparin P., Thomsen J.S., Kurths J., et al. Segmentation of bone CT images and assessment of bone structure using measures of complexity. Med Phys 33 10 (2006) 3857-3873
68. Link T.M., Majumdar S., Lin J.C., et al. Assessment of trabecular structure using high resolution CT images and texture analysis. J Comput Assist Tomogr 22 1 (1998) 15-24
69. Link T.M., Majumdar S., Lin J.C., et al. A comparative study of trabecular bone properties in the spine and femur using high resolution MRI and CT. J Bone Miner Res 13 1 (1998) 122-132
70. Gordon C.L., Webber C.E., Adachi J.D., Christoforou N., et al. In vivo assessment of trabecular bone structure at the distal radius from high-resolution computed tomography images. Phys Med Biol 41 3 (1996) 495-508
71. Müller R., Hahn M., Vogel M., et al. Morphometric analysis of noninvasively assessed bone biopsies: comparison of high-resolution computed tomography and histologic sections. [Published erratum appears in Bone 1996 Sep;19(3):299]. Bone 18 3 (1996) 215-220
72. Boutroy S., Bouxsein M.L., Munoz F., et al. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 90 12 (2005) 6508-6515
73. Macneil J.A., and Boyd S.K. Load distribution and the predictive power of morphological indices in the distal radius and tibia by high resolution peripheral quantitative computed tomography. Bone 41 1 (2007) 129-137
74. Macneil J.A., and Boyd S.K. Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys 29 10 (2007) 1096-1105
75. Engelke K., and Gluer C.C. Quality and performance measures in bone densitometry: Part 1: errors and diagnosis. Osteoporos Int 17 9 (2006) 1283-1292
76. Consensus Development Conference. Diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 94 (1993) 646-650
77. WHO. Assessment of osteoporotic fracture risk and its application to screening for postmenopausal osteoporosis (1994), World Health Organization, Geneva
78. Faulkner K.G., von Stetten E., and Miller P. Discordance in patient classification using T-scores. J Clin Densitom 2 3 (1999) 343-350
79. Kroger H., Lunt M., Reeve J., et al. Bone density reduction in various measurement sites in men and women with osteoporotic fractures of spine and hip: the European quantitation of osteoporosis study. Calcif Tissue Int 64 3 (1999) 191-199
80. Faulkner K.G., and Orwoll E. Implications in the use of T-scores for the diagnosis of osteoporosis in men. J Clin Densitom 5 1 (2002) 87-93
81. Cardenas J.L., Revilla M., Hernandez E.R., et al. Comparison of three bone densitometry methods in osteoporotic women. Calcif Tissue Int 61 5 (1997) 358-361
82. Masala S., Annibale B., Fiori R., et al. DXA vs QCT for subclinical celiac disease patients. Acta Diabetol 40 Suppl 1 (2003) S174-S176
83. Wendlova J. Differences in distribution of T-scores and Z-scores among bone densitometry tests in postmenopausal women (a comparative study). Wien Med Wochenschr 152 23-24 (2002) 591-595
84. Grampp S., Genant H.K., Mathur A., et al. Comparisons of noninvasive bone mineral measurements in assessing age-related loss, fracture discrimintion, and diagnostic classification. J Bone Miner Res 12 (1997) 697-711
85. Bergot C., Laval-Jeantet A.M., Hutchinson K., et al. A comparison of spinal quantitative computed tomography with dual-energy X-ray absorptiometry in European women with vertebral and nonvertebral fractures. Calcif Tissue Int 68 2 (2001) 74-82
86. Siris E.S., Brenneman S.K., Barrett-Connor E., et al. The effect of age and bone mineral density on the absolute, excess, and relative risk of fracture in postmenopausal women aged 50-99: results from the National Osteoporosis Risk Assessment (NORA). Osteoporos Int 17 4 (2006) 565-574
87. Miller P.D. Guidelines for the diagnosis of osteoporosis: T-scores vs fractures. Rev Endocr Metab Disord 7 1-2 (2006) 75-89
88. Melton III L.J., Johnell O., Lau E., et al. Osteoporosis and the global competition for health care resources. J Bone Miner Res 19 7 (2004) 1055-1058
89. Kanis J.A., Black D., Cooper C., et al. A new approach to the development of assessment guidelines for osteoporosis. Osteoporos Int 13 7 (2002) 527-536
90. Pfeilschifter J. 2006 DVO-guideline for prevention, diagnosis, and therapy of osteoporosis for women after menopause, for men after age 60 executive summary guidelines. Exp Clin Endocrinol Diabetes 114 10 (2006) 611-622
91. Riggs B.L., Melton Iii III L.J., Robb R.A., et al. Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res 19 12 (2004) 1945-1954
92. Marshall L.M., Lang T.F., Lambert L.C., et al. Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men. J Bone Miner Res 21 8 (2006) 1197-1206
93. Sigurdsson G., Aspelund T., Chang M., et al. Increasing sex difference in bone strength in old age: the Age, Gene/Environment Susceptibility-Reykjavik study (AGES-REYKJAVIK). Bone 39 3 (2006) 644-651
94. DVO, and D.d.D.W.O.G.f.O.-. Osteoporose-Leitlinie (2006), Schattauer Verlag, Stuttgart
95. Bjarnason N.H., Sarkar S., Duong T., et al. Six and twelve month changes in bone turnover are related to reduction in vertebral fracture risk during 3 years of raloxifene treatment in postmenopausal osteoporosis. Osteoporos Int 12 11 (2001) 922-930
96. Cummings S.R., Karpf D.B., Harris F., et al. Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs. Am J Med 112 4 (2002) 281-289
97. Mastmeyer A., Engelke K., Fuchs C., et al. Institute of Medical Physics, A hierarchical 3D segmentation method and the definition of vertebral body coordinate systems for QCT of the lumbar spine. Med Image Anal 10 4 (2006) 560-577
98. Kang Y., Engelke K., and Kalender W.A. A new accurate and precise 3-D segmentation method for skeletal structures in volumetric CT data. IEEE Trans Med Imaging 22 5 (2003) 586-598
99. Kang Y., Engelke K., Fuchs C., et al. An anatomic coordinate system of the femoral neck for highly reproducible BMD measurements using 3D QCT. Comput Med Imaging Graph 29 7 (2005) 533-541
100. Li W., Sode M., Saeed I., et al. Automated registration of hip and spine for longitudinal QCT studies: integration with 3D densitometric and structural analysis. Bone 38 2 (2006) 273-279
101. Kemmler W., Engelke K., Baumann H., et al. Bone status in elite male runners. Eur J Appl Physiol 96 1 (2006) 78-85
102. Fink H.A., Kuskowski M.A., Orwoll E.S., et al. Association between Parkinson's disease and low bone density and falls in older men: the osteoporotic fractures in men study. J Am Geriatr Soc 53 9 (2005) 1559-1564
103. Khosla S., Melton III L.J., Robb R.A., et al. Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men. J Bone Miner Res 20 5 (2005) 730-740
104. Louis O., Luypaert R., Kalender W., et al. Reproducibility of CT bone densitometry: operator versus automated ROI definition. Eur J Radiol 8 2 (1988) 82-84
105. Ito M., Hayashi K., Yamada M., et al. Relationship of osteophytes to bone mineral density and spinal fracture in men. Radiology 189 2 (1993) 497-502
106. Ito M., Ohki M., Hayashi K., et al. Relationship of spinal fracture to bone density, textural, and anthropometric parameters. Calcif Tissue Int 60 3 (1997) 240-244
107. Guglielmi G., Grimston S.K., Fischer K.C., et al. Osteoporosis: diagnosis with lateral and posteroanterior dual X-ray absorptiometry compared with quantitative CT. Radiology 192 3 (1994) 845-850
108. Bouxsein M.L., Melton III L.J., Riggs B.L., et al. Age- and sex-specific differences in the factor of risk for vertebral fracture: a population-based study using QCT. J Bone Miner Res 21 9 (2006) 1475-1482
109. Boden S.D., Goodenough D.J., Stockham C.D., et al. Precise measurement of vertebral bone density using computed tomography without the use of an external reference phantom. J Digit Imaging 2 1 (1989) 31-38
110. Link T.M., Koppers B.B., Licht T., et al. In vitro and in vivo spiral CT to determine bone mineral density: initial experience in patients at risk for osteoporosis. Radiology 231 3 (2004) 805-811
111. Theodorou D.J., Theodorou S.J., Andre M.P., et al. Quantitative computed tomography of spine: comparison of three-dimensional and two-dimensional imaging approaches in clinical practice. J Clin Densitom 4 1 (2001) 57-62
112. Block J., Smith R., Glüer C.C., et al. Models of spinal trabecular bone loss as determined by quantitative computed tomography. J Bone Miner Res 4 (1989) 249-257
113. Yu W., Glüer C.-C., Grampp S., et al. Spinal bone mineral assessment in postmenopausal women: a comparison between dual X-ray absorptiometry and quantitative computed tomography. Osteoporos Int 5 (1995) 433-439
114. Ito M., Hayashi K., Ishida Y., et al. Discrimination of spinal fracture with various bone mineral measurements. Calcif Tissue Int 60 (1997) 11-15
115. Ross P.D., Genant H.K., Davis J.W., et al. Predicting vertebral fracture incidence from prevalent fractures and bone density among non-black, osteoporotic women. Osteoporos Int 3 3 (1993) 120-126
116. Lafferty F.W., and Rowland D.Y. Correlations of dual-energy X-ray absorptiometry, quantitative computed tomography, and single photon absorptiometry with spinal and non-spinal fractures. [see comments]. Osteoporos Int 6 5 (1996) 407-415
117. Lang T.F., Augat P., Lane N.E., et al. Trochanteric hip fracture: strong association with spinal trabecular bone mineral density measured with quantitative CT. Radiology 209 2 (1998) 525-530
118. Firooznia H., Golimbu C., Rafii M., et al. Quantitative computed tomography assessment of spinal trabecular bone. II. In osteoporotic women with and without vertebral fractures. J Comput Assist Tomogr 8 2 (1984) 99-103
119. Odvina C.V., Wergedal J.E., Libanati C.R., et al. Relationship between trabecular vertebral body density and fractures: a quantitative definition of spinal osteoporosis. Metabolism 37 3 (1988) 221-228
120. Laval-Jeantet A.M., Bergot C., Williams M., et al. Dual-energy X-ray absorptiometry of the calcaneus: comparison with vertebral dual-energy X-ray absorptiometry and quantitative computed tomography. Calcif Tissue Int 56 1 (1995) 14-18
121. Ott S.M., Kilcoyne R.F., and Chesnut III C.H. Comparisons among methods of measuring bone mass and relationship to severity of vertebral fractures in osteoporosis. J Clin Endocrinol Metab 66 3 (1988) 501-507
122. Felsenberg D., and Gowin W. Bone densitometry by dual-energy methods. Radiologe 39 3 (1999) 186-193
123. Adams J.E., Alsop C., Harrison E., et al. Quantitative Computed Tomography (QCT): The forgotten gold standard?. 22nd ASBMR Annual Meeting (2000), JBMR, Toronto, Canada
124. Black D.M., Bilezikian J.P., Ensrud K.E., et al. One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis. N Engl J Med 353 6 (2005) 555-565
125. Black D.M., Greenspan S.L., Ensrud K.E., et al. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 349 13 (2003) 1207-1215
126. Genant H.K., Lang T., Fuerst T., et al. Treatment with raloxifene for 2 years increases vertebral bone mineral density as measured by volumetric quantitative computed tomography. Bone 35 5 (2004) 1164-1168
127. Bauer D.C., Garnero P., Bilezikian J.P., et al. Short-term changes in bone turnover markers and bone mineral density response to parathyroid hormone in postmenopausal women with osteoporosis. J Clin Endocrinol Metab 91 4 (2006) 1370-1375
128. Greenspan S.L., Bone H.G., Ettinger M.P., et al. Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: a randomized trial. Ann Intern Med 146 5 (2007) 326-339
129. Sosa M., Hernandez D., Segarra M.C., et al. Effect of two forms of alendronate administration upon bone mass after two years of treatment. J Clin Densitom 5 1 (2002) 27-34
130. Arnala I., Saastamoinen J., and Alhava E.M. Salmon calcitonin in the prevention of bone loss at perimenopause. Bone 18 6 (1996) 629-632
131. Flicker L., Hopper J.L., Larkins R.G., et al. Nandrolone decanoate and intranasal calcitonin as therapy in established osteoporosis. Osteoporos Int 7 1 (1997) 29-35
132. Ettinger B., Genant H.K., and Cann C.E. Postmenopausal bone loss is prevented by treatment with low-dosage estrogen with calcium. Ann Intern Med 106 1 (1987) 40-45
133. Fujita T., Fukase M., Miyamoto H., et al. Increase of bone mineral density by calcium supplement with oyster shell electrolysate. J Bone Miner Res 11 1 (1990) 85-91
134. Genant H.K., Baylink D.J., Gallagher J.C., et al. Effect of estrone sulfate on postmenopausal bone loss. Obstet Gynecol 76 4 (1990) 579-584
135. Ettinger B., Genant H.K., Steiger P., et al. Low-dosage micronized 17 beta-estradiol prevents bone loss in postmenopausal women. Am J Obstet Gynecol 166 2 (1992) 479-488
136. Speroff L., Rowan J., Symons J., et al. The comparative effect on bone density, endometrium, and lipids of continuous hormones as replacement therapy (CHART study). A randomized controlled trial. JAMA 276 17 (1996) 1397-1403
137. Prior J.C., Vigna Y.M., Wark J.D., et al. Premenopausal ovariectomy-related bone loss: a randomized, double-blind, one-year trial of conjugated estrogen or medroxyprogesterone acetate. J Bone Miner Res 12 11 (1997) 1851-1863
138. Lane N.E., Sanchez S., Modin G.W., et al. Parathyroid hormone treatment can reverse corticosteroid-induced osteoporosis. Results of a randomized controlled clinical trial. J Clin Invest 102 8 (1998) 1627-1633
139. Laan R.F., van Riel P.L., van de Putte L.B., et al. Low-dose prednisone induces rapid reversible axial bone loss in patients with rheumatoid arthritis. A randomized, controlled study. Ann Intern Med 119 10 (1993) 963-968
140. Lane N.E., Sanchez S., Genant H.K., et al. Short-term increases in bone turnover markers predict parathyroid hormone-induced spinal bone mineral density gains in postmenopausal women with glucocorticoid-induced osteoporosis. Osteoporos Int 11 5 (2000) 434-442
141. Berning B., Kuijk C.V., Kuiper J.W., et al. Effects of two doses of tibolone on trabecular and cortical bone loss in early postmenopausal women: a two-year randomized, placebo-controlled study. Bone 19 4 (1996) 395-399
142. Engelke K., Kemmler W., Lauber D., et al. Exercise maintains bone density at spine and hip EFOPS: a 3-year longitudinal study in early postmenopausal women. Osteoporos Int 17 1 (2006) 133-142
143. Finkelstein J.S., Hayes A., Hunzelman J.L., et al. The effects of parathyroid hormone, alendronate, or both in men with osteoporosis. N Engl J Med 349 13 (2003) 1216-1226
144. Howell S.J., Radford J.A., Adams J.E., et al. Randomized placebo-controlled trial of testosterone replacement in men with mild Leydig cell insufficiency following cytotoxic chemotherapy. Clin Endocrinol (Oxf) 55 3 (2001) 315-324
145. Orwoll E.S., Oviatt S.K., McClung M.R., et al. The rate of bone mineral loss in normal men and the effects of calcium and cholecalciferol supplementation. Ann Intern Med 112 1 (1990) 29-34
146. Yu W., Qin M., Xu L., et al. Normal changes in spinal bone mineral density in a Chinese population: assessment by quantitative computed tomography and dual-energy X-ray absorptiometry. Osteoporos Int 9 2 (1999) 179-187
147. Lang T.F., Li J., Harris S.T., et al. Assessment of vertebral bone mineral density using volumetric quantitative CT. J Comput Assist Tomogr 23 1 (1999) 130-137
148. Grampp S., Lang P., Jergas M., et al. Assessment of the skeletal status by peripheral quantitative computed tomography of the forearm: short-term precision in vivo and comparison to dual X-ray absorptiometry. J Bone Miner Res 10 10 (1995) 1566-1576
149. Ito M., Nishida A., Kono J., et al. Which bone densitometry and which skeletal site are clinically useful for monitoring bone mass?. Osteoporos Int 14 12 (2003) 959-964
150. Hoonpongsimanon S., Santipapmonthon M., and Chuntana M. Spinal bone mineral density by quantitative computed tomography in Thais compared with Westerners. J Med Assoc Thai 88 11 (2005) 1666-1673
151. Clowes J.A., Eastell R., and Peel N.F. The discriminative ability of peripheral and axial bone measurements to identify proximal femoral, vertebral, distal forearm and proximal humeral fractures: a case control study. Osteoporos Int 16 12 (2005) 1794-1802
152. Formica C.A., Nieves J.W., Cosman F., et al. Comparative assessment of bone mineral measurements using dual X-ray absorptiometry and peripheral quantitative computed tomography. Osteoporos Int 8 5 (1998) 460-467
153. Majumdar S., Link T.M., Augat P., et al. Trabecular bone architecture in the distal radius using magnetic resonance imaging in subjects with fractures of the proximal femur. Osteoporos Int 10 3 (1999) 231-239
154. Augat P., Fan B., Lane N.E., et al. Assessment of bone mineral at appendicular sites in females with fractures of the proximal femur. Bone 22 4 (1998) 395-402
155. Clowes J.A., Peel N.F., and Eastell R. Device-specific thresholds to diagnose osteoporosis at the proximal femur: an approach to interpreting peripheral bone measurements in clinical practice. Osteoporos Int 17 9 (2006) 1293-1302
156. Prevhral S., Engelke K., and Genant H.K. pQCT-peripheral quantitative computed tomography. In: Grampp S. (Ed). Radiology of Osteoporosis (2002), Springer, Berlin 115-129
157. Reeve J., Kroger H., Nijs J., et al. Radial cortical and trabecular bone densities of men and women standardized with the European Forearm Phantom. Calcif Tissue Int 58 3 (1996) 135-143
158. Schneider P., Butz S., Allolio B., et al. Multicenter German reference data base for peripheral quantitative computer tomography. Technol Health Care 3 2 (1995) 69-73
159. Schneider P.F., Fischer M., Allolio B., et al. Alendronate increases bone density and bone strength at the distal radius in postmenopausal women. J Bone Miner Res 14 8 (1999) 1387-1393
160. Ruegsegger P., Keller A., and Dambacher M.A. Comparison of the treatment effects of ossein-hydroxyapatite compound and calcium carbonate in osteoporotic females. Osteoporos Int 5 1 (1995) 30-34
161. Fujita T., Fujii Y., Goto B., et al. Peripheral computed tomography (pQCT) detected short-term effect of AAACa (heated oyster shell with heated algal ingredient HAI): a double-blind comparison with CaCO3 and placebo. J Bone Miner Metab 18 4 (2000) 212-215
162. Prince R.L., Devine A., Dhaliwal S.S., et al. Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med 166 8 (2006) 869-875
163. Sawada K., Morishige K.I., Ohmichi M., et al. Peripheral quantitative computed tomography (pQCT) is useful for monitoring bone mineral density of the patients who receive hormone replacement therapy. Maturitas 56 (2007) 343-349
164. Merki-Feld G.S., Neff M., and Keller P.J. A 2-year prospective study on the effects of depot medroxyprogesterone acetate on bone mass-response to estrogen and calcium therapy in individual users. Contraception 67 2 (2003) 79-86
165. Dambacher M.A., Ittner J., and Ruegsegger P. Long-term fluoride therapy of postmenopausal osteoporosis. Bone 7 3 (1986) 199-205
166. Reeve J., Davies U.M., Hesp R., et al. Treatment of osteoporosis with human parathyroid peptide and observations on effect of sodium fluoride. BMJ 301 6747 (1990) 314-318
167. Dambacher M.A., Kranich M., Schacht E., et al. Can the fast bone loss in osteoporotic and osteopenic patients be stopped with active vitamin D metabolites?. Calcif Tissue Int 60 1 (1997) 115-118
168. Torvinen S., Kannus P., Sievanen H., et al. Effect of 8-month vertical whole body vibration on bone, muscle performance, and body balance: a randomized controlled study. J Bone Miner Res 18 5 (2003) 876-884
169. Zanchetta J.R., Bogado C.E., Ferretti J.L., et al. Effects of teriparatide [recombinant human parathyroid hormone (1-34)] on cortical bone in postmenopausal women with osteoporosis. J Bone Miner Res 18 3 (2003) 539-543
170. Ito M., Nakamura T., Tsurusaki K., et al. Effects of menopause on age-dependent bone loss in the axial and appendicular skeletons in healthy Japanese women. Osteoporos Int 10 5 (1999) 377-383
171. Butz S., Weuster C., Scheidt-Nave C., et al. Forearm BMD as measured by peripheral quantitative computed tomography pQCT in a German reference population. Osteoporos Int 4 4 (1994) 179-184
172. Eastell R. Treatment of postmenopausal osteoporosis. N Engl J Med 338 11 (1998) 736-746
173. Hosking D., Chilvers C.E., Christiansen C., et al. Prevention of bone loss with alendronate in postmenopausal women under 60 years of age. Early Postmenopausal Intervention Cohort Study Group. N Engl J Med 338 8 (1998) 485-492
174. Bouxsein M.L., Parker R.A., and Greenspan S.L. Forearm bone mineral densitometry cannot be used to monitor response to alendronate therapy in postmenopausal women. Osteoporos Int 10 6 (1999) 505-509
175. Black D.M., Cummings S.R., Karpf D.B., et al. Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet 348 9041 (1996) 1535-1541
176. Ravn P., Overgaard K., Huang C., et al., E.S. Group. Comparison of bone densitometry of the phalanges, distal forearm, and axial skeleton in early postmenopausal women participating in the EPIC study. Osteoporos Int 6 (1996) 308-313
177. Bjarnason K., Hassager C., Svendsen O.L., et al. Anteroposterior and lateral spinal DXA for the assessment of vertebral body strength: comparison with hip and forearm measurement. Osteoporos Int 6 (1996) 37-42
178. Nielsen N.M., von der Recke P., Hansen M.A., et al. Estimation of the effect of salmon calcitonin in established osteoporosis by biochemical bone markers. Calcif Tissue Int 55 1 (1994) 8-11
179. Schubert M., Bullmann C., Minnemann T., et al. Osteoporosis in male hypogonadism: responses to androgen substitution differ among men with primary and secondary hypogonadism. Horm Res 60 1 (2003) 21-28
180. Augat P., Gordon C.L., Lang T.F., et al. Accuracy of cortical and trabecular bone measurements with peripheral quantitative computed tomography (pQCT). Phys Med Biol 43 10 (1998) 2873-2883
181. Binkley T.L., and Specker B.L. pQCT measurement of bone parameters in young children: validation of technique. J Clin Densitom 3 1 (2000) 9-14
182. Ward K.A., Adams J.E., and Hangartner T.N. Recommendations for thresholds for cortical bone geometry and density measurement by peripheral quantitative computed tomography. Calcif Tissue Int 77 5 (2005) 275-280
183. Hasegawa Y., Schneider P., Reiners C., et al. Estimation of the architectural properties of cortical bone using peripheral quantitative computed tomography. Osteoporos Int 11 1 (2000) 36-42
184. Hangartner T.N., and Gilsanz V. Evaluation of cortical bone by computed tomography. J Bone Miner Res 11 (1996) 1518-1525
185. Newman D.L., Dougherty G., al Obaid A., al Hajrasy H., et al. Limitations of clinical CT in assessing cortical thickness and density. Phys Med Biol 43 3 (1998) 619-626
186. Rauch F., Tutlewski B., and Schoenau E. Peripheral quantitative computed tomography at the distal radius: cross-calibration between two scanners. J Musculoskelet Neuronal Interact 2 2 (2001) 153-155
187. Laan R.F., Buijs W.C., van Erning L.J., et al. Differential effects of glucocorticoids on cortical appendicular and cortical vertebral bone mineral content. Calcif Tissue Int 52 1 (1993) 5-9
188. Hernandez E.R., Revilla M., Seco-Durban C., et al. Heterogeneity of trabecular and cortical postmenopausal bone loss: a longitudinal study with pQCT. Bone 20 3 (1997) 283-287
189. Boonen S., Cheng X.G., Nijs J., et al. Factors associated with cortical and trabecular bone loss as quantified by peripheral computed tomography (pQCT) at the ultradistal radius in aging women. Calcif Tissue Int 60 2 (1997) 164-170
190. Nijs J., Westhovens R., Joly J., et al. Diagnostic sensitivity of peripheral quantitative computed tomography measurements at ultradistal and proximal radius in postmenopausal women. Bone 22 6 (1998) 659-664
191. Qin L., Au S.K., Chan K.M., et al. Peripheral volumetric bone mineral density in pre- and postmenopausal Chinese women in Hong Kong. Calcif Tissue Int 67 1 (2000) 29-36
192. Gatti D., Rossini M., Zamberlan N., et al. Effect of aging on trabecular and compact bone components of proximal and ultradistal radius. Osteoporos Int 6 5 (1996) 355-360
193. Hasegawa Y., Kushida K., Yamazaki K., et al. Volumetric bone mineral density using peripheral quantitative computed tomography in Japanese women. Osteoporos Int 7 3 (1997) 195-199
194. Neu C.M., Rauch F., Manz F., et al. Modeling of cross-sectional bone size, mass and geometry at the proximal radius: a study of normal bone development using peripheral quantitative computed tomography. Osteoporos Int 12 7 (2001) 538-547
195. Rittweger J., Frost H.M., Schiessl H., et al. Muscle atrophy and bone loss after 90 days' bed rest and the effects of flywheel resistive exercise and pamidronate: results from the LTBR study. Bone 36 6 (2005) 1019-1029
196. Russo C.R., Lauretani F., Seeman E., et al. Structural adaptations to bone loss in aging men and women. Bone 38 1 (2006) 112-118
197. Vico L., Prallet B., Chappard D., et al. Contributions of chronological age, age at menarche and menopause and of anthropometric parameters to axial and peripheral bone densities. Osteoporos Int 2 3 (1992) 153-158
198. Melton III L.J., Riggs B.L., Achenbach S.J., et al. Does reduced skeletal loading account for age-related bone loss?. J Bone Miner Res 21 12 (2006) 1847-1855
199. Riggs B.L., Melton III L.J., Robb R.A., et al. Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures. J Bone Miner Res 21 2 (2006) 315-323
200. Nieves J.W., Formica C., Ruffing J., et al. Males have larger skeletal size and bone mass than females, despite comparable body size. J Bone Miner Res 20 3 (2005) 529-535
201. Adami S., Gatti D., Braga V., et al. Site-specific effects of strength training on bone structure and geometry of ultradistal radius in postmenopausal women. J Bone Miner Res 14 1 (1999) 120-124
202. Ito M., Nakamura T., Ikeda S., et al. Effects of lifetime volleyball exercise on bone mineral densities in lumbar spine, calcaneus and tibia for pre-, peri- and postmenopausal women. Osteoporos Int 12 2 (2001) 104-111
203. Heinonen A., Sievanen H., Kannus P., et al. Site-specific skeletal response to long-term weight training seems to be attributable to principal loading modality: a pQCT study of female weightlifters. Calcif Tissue Int 70 6 (2002) 469-474
204. Uusi-Rasi K., Sievanen H., Pasanen M., et al. Associations of calcium intake and physical activity with bone density and size in premenopausal and postmenopausal women: a peripheral quantitative computed tomography study. J Bone Miner Res 17 3 (2002) 544-552
205. Kontulainen S., Sievanen H., Kannus P., et al. Effect of long-term impact-loading on mass, size, and estimated strength of humerus and radius of female racquet-sports players: a peripheral quantitative computed tomography study between young and old starters and controls. J Bone Miner Res 17 12 (2002) 2281-2289
206. Kontulainen S., Sievanen H., Kannus P., et al. Effect of long-term impact-loading on mass, size, and estimated strength of humerus and radius of female racquet-sports players: a peripheral quantitative computed tomography study between young and old starters and controls. J Bone Miner Res 18 2 (2003) 352-359
207. Ferretti J., Mazure R., Tanoue P., et al. Analysis of the structure and strength of bones in celiac disease patients. Am J Gastroenterol 98 2 (2003) 382-390
208. Ladis V.A., Gandaifis N., Papadopoulos E.C., et al. Bone density study at the distal radius, using pQCT analysis, in Greek thalassemic patients. Pediatr Endocrinol Rev 2 Suppl 2 (2004) 307-309
209. Backstrom M.C., Kuusela A.L., Koivisto A.M., et al. Bone structure and volumetric density in young adults born prematurely: a peripheral quantitative computed tomography study. Bone 36 4 (2005) 688-693
210. Dick I.M., Devine A., and Prince R.L. Association of an aromatase TTTA repeat polymorphism with circulating estrogen, bone structure, and biochemistry in older women. Am J Physiol Endocrinol Metab 288 5 (2005) E989-E995
211. Eser P., Frotzler A., Zehnder Y., et al. Relationship between the duration of paralysis and bone structure: a pQCT study of spinal cord injured individuals. Bone 34 5 (2004) 869-880
212. Khosla S., Riggs B.L., Atkinson E.J., et al. Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J Bone Miner Res 21 1 (2006) 124-131
213. Lauretani F., Bandinelli S., Russo C.R., et al. Correlates of bone quality in older persons. Bone 39 4 (2006) 915-921
214. Durand E.P., and Ruegsegger P. Cancellous bone structure: analysis of high-resolution CT images with the run-length method. J Comput Assist Tomogr 15 1 (1991) 133-139
215. Laib A., Hildebrand T., Hauselmann H.J., et al. Ridge number density: a new parameter for in vivo bone structure analysis. Bone 21 6 (1997) 541-546
216. Gowin W., Saparin P.I., Kurths J., et al. Measures of complexity for cancellous bone. Technol Health Care 6 5-6 (1998) 373-390
217. Laib A., and Ruegsegger P. Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with 28-microm-resolution microcomputed tomography. Bone 24 1 (1999) 35-39
218. Laib A., and Ruegsegger P. Comparison of structure extraction methods for in vivo trabecular bone measurements. Comput Med Imaging Graph 23 2 (1999) 69-74
219. Cendre E., Kaftandjian V., Peix G., et al. An investigation of segmentation methods and texture analysis applied to tomographic images of human vertebral cancellous bone. J Microsc 197 Pt 3 (2000) 305-316
220. Elmoutaouakkil A., Peyrin F., Elkafi J., et al. Segmentation of cancellous bone from high-resolution computed tomography images: influence on trabecular bone measurements. IEEE Trans Med Imaging 21 4 (2002) 354-362
221. MacIntyre N.J., Adachi J.D., and Webber C.E. In vivo detection of structural differences between dominant and nondominant radii using peripheral quantitative computed tomography. J Clin Densitom 2 4 (1999) 413-422
222. MacIntyre N.J., Adachi J.D., and Webber C.E. Gender differences in normal age-dependent patterns of radial bone structure and density: a cross-sectional study using peripheral quantitative computed tomography. J Clin Densitom 2 2 (1999) 163-173
223. Milos G., Spindler A., Ruegsegger P., et al. Cortical and trabecular bone density and structure in anorexia nervosa. Osteoporos Int 16 7 (2005) 783-790
224. Mylona M., Leotsinides M., Alexandrides T., et al. Comparison of DXA, QCT and trabecular structure in beta-thalassaemia. Eur J Haematol 74 5 (2005) 430-437
225. Zankl, M., G. Drexler, N. Petoussi-Henss, et al. The calculation of dose from external photon exposures using reference human phantoms and Monte Carlo methods: Part VII. Organ doses due to parallel and environmental exposure geometries, in GSF-Report 8/97. 1997 Institut fuer Strahlenschutz, GSF-Forschungszentrum fuer Umwelt und Gesundheit: Neuherberg-Muenchen.
226. Firooznia H., Golimbu C., Rafii M., et al. Quantitative computed tomography assessment of spinal trabecular bone. I. Age-related regression in normal men and women. J Comput Assist Tomogr 8 2 (1984) 91-97
227. Pacifici R., Susman N., Carr P.L., et al. Single and dual-energy tomographic analysis of spinal trabecular bone: a comparative study in normal and osteoporotic women. J Clin Endocrinol Metab 64 2 (1987) 209-214
228. Compston J.E., Evans W.D., Crawley E.O., et al. Bone mineral content in normal UK subjects. Br J Radiol 61 727 (1988) 631-636
229. Nilsson M., Johnell O., Jonsson K., et al. Quantitative computed tomography in measurement of vertebral trabecular bone mass. A modified method. Acta Radiol 29 6 (1988) 719-725
230. Fujii Y., Tsutsumi M., Tsunenari T., et al. Quantitative computed tomography of lumbar vertebrae in Japanese patients with osteoporosis. Bone Miner 6 1 (1989) 87-94
231. Karantanas A.H., Kalef-Ezra J.A., and Glaros D.C. Quantitative computed tomography for bone mineral measurement: technical aspects, dosimetry, normal data and clinical applications. Br J Radiol 64 760 (1991) 298-304
232. Jahng J.S., Kang K.S., Park H.W., et al. Assessment of bone mineral density in postmenopausal and senile osteoporosis using quantitative CT. Orthopedics 14 10 (1991) 1101-1105
233. Harbison J., Daly L., Murphy B., et al. Normal bone density in Irish women: is American normative data suitable for use in Ireland?. Ir J Med Sci 161 3 (1992) 66-69
234. Gudmundsdottir H., Jonsdottir B., Kristinsson S., et al. Vertebral bone density in Icelandic women using quantitative computed tomography without an external reference phantom. Osteoporos Int 3 2 (1993) 84-89
235. Guglielmi G., Giannatempo G.M., Blunt B.A., et al. Spinal bone mineral density by quantitative CT in a normal Italian population. Eur J Radiol 5 (1995) 269-275
236. Dinc H., Sadikoglu Y., Savci G., et al. Bone mineral density measurement by quantitative computed tomography in a normal Turkish population. Eur J Radiol 21 2 (1995) 79-83
237. Fujii Y., Chikawa T., Nakamura T., et al. Comparison of trabecular bone density at vertebral and radial sites using quantitative computed tomography. Osteoporos Int 6 6 (1996) 486-490
238. Manisal M., Ozaksoy D., and Kabakc N. Quantitative computed tomography BMD reference values in women of Izmir, Turkey. Clin Orthop Relat Res 443 (2006) 109-112
239. Ruegsegger P., Dambacher M.A., Ruegsegger E., et al. Bone loss in premenopausal and postmenopausal women. A cross-sectional and longitudinal study using quantitative computed tomography. J Bone Joint Surg Am 66 7 (1984) 1015-1023
240. Horikoshi T., Endo N., Uchiyama T., et al. Peripheral quantitative computed tomography of the femoral neck in 60 Japanese women. Calcif Tissue Int 65 6 (1999) 447-453
241. Guglielmi G., De Serio A., Fusilli S., et al. Age-related changes assessed by peripheral QCT in healthy Italian women. Eur J Radiol 10 4 (2000) 609-614
242. Gorai I., Nonaka K., Kishimoto H., et al. Cut-off values determined for vertebral fracture by peripheral quantitative computed tomography in Japanese women. Osteoporos Int 12 9 (2001) 741-748
243. Russo C.R., Lauretani F., Bandinelli S., et al. Aging bone in men and women: beyond changes in bone mineral density. Osteoporos Int 14 7 (2003) 531-538
244. Cummings S.R., Bates D., and Black D.M. Clinical use of bone densitometry: scientific review. JAMA 288 15 (2002) 1889-1897
245. Johnell O., Kanis J.A., Oden A., et al. Predictive value of BMD for hip and other fractures. J Bone Miner Res 20 7 (2005) 1185-1194
246. Guglielmi G., Cammisa M., De Serio A., et al. Phalangeal US velocity discriminates between normal and vertebrally fractured subjects. Eur J Radiol 9 8 (1999) 1632-1637
247. Duboeuf F., Jergas M., Schott A.M., et al. A comparison of bone densitometry measurements of the central skeleton in post-menopausal women with and without vertebral fracture. Br J Radiol 68 811 (1995) 747-753
248. Rosenthal D.I., Ganott M.A., Wyshak G., et al. Quantitative computed tomography for spinal density measurement. Factors affecting precision. Invest Radiol 20 3 (1985) 306-310
249. Muller A., Ruegsegger E., and Ruegsegger P. Peripheral QCT: a low-risk procedure to identify women predisposed to osteoporosis. Phys Med Biol 34 6 (1989) 741-749
250. Guglielmi G., Cammisa M., De Serio A., et al. Long-term in vitro precision of single-slice peripheral Quantitative Computed Tomography (pQCT): multicenter comparison. Technol Health Care 5 5 (1997) 375-381
251. Cody D.D., Hou F.J., Divine G.W., et al. Femoral structure and stiffness in patients with femoral neck fracture. J Orthop Res 18 3 (2000) 443-448
252. Cheng X., Li J., Lu Y., et al. Proximal femoral density and geometry measurements by quantitative computed tomography: association with hip fracture. Bone 40 1 (2007) 169-174
253. Lang T.F., Guglielmi G., van Kuijk C., et al. Measurement of bone mineral density at the spine and proximal femur by volumetric quantitative computed tomography and dual-energy X-ray absorptiometry in elderly women with and without vertebral fractures. Bone 30 1 (2002) 247-250
254. Guglielmi G., Floriani I., Torri V., et al. Effect of spinal degenerative changes on volumetric bone mineral density of the central skeleton as measured by quantitative computed tomography. Acta Radiol 46 3 (2005) 269-275
255. Hanton L., Axelrod L., Bakalov V., et al. The importance of estrogen replacement in young women with Turner syndrome. J Womens Health (Larchmt) 12 10 (2003) 971-977
256. Lian K.C., Lang T.F., Keyak J.H., et al. Differences in hip quantitative computed tomography (QCT) measurements of bone mineral density and bone strength between glucocorticoid-treated and glucocorticoid-naive postmenopausal women. Osteoporos Int 16 6 (2005) 642-650
257. Rehman Q., Lang T., Modin G., et al. Quantitative computed tomography of the lumbar spine, not dual X-ray absorptiometry, is an independent predictor of prevalent vertebral fractures in postmenopausal women with osteopenia receiving long-term glucocorticoid and hormone-replacement therapy. Arthritis Rheum 46 5 (2002) 1292-1297
258. Lang T., LeBlanc A., Evans H., et al. Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J Bone Miner Res 19 6 (2004) 1006-1012
259. Qin L., Au S.K., Leung P.C., et al. Baseline BMD and bone loss at distal radius measured by peripheral quantitative computed tomography in peri- and postmenopausal Hong Kong Chinese women. Osteoporos Int 13 12 (2002) 962-970
260. Link T.M., Doren M., Lewing G., et al. Cross-sectional area of lumbar vertebrae in peri- and postmenopausal patients with and without osteoporosis. Osteoporos Int 11 4 (2000) 304-309
261. Bouxsein M.L., Myburgh K.H., van der Meulen M.C., et al. Age-related differences in cross-sectional geometry of the forearm bones in healthy women. Calcif Tissue Int 54 2 (1994) 113-118
262. Schneider P., Reiners C., Cointry G.R., et al. Bone quality parameters of the distal radius as assessed by pQCT in normal and fractured women. Osteoporos Int 12 8 (2001) 639-646
263. Andresen R., Haidekker M.A., Radmer S., et al. CT determination of bone mineral density and structural investigations on the axial skeleton for estimating the osteoporosis-related fracture risk by means of a risk score. Br J Radiol 72 858 (1999) 569-578
264. Andresen R., Radmer S., and Banzer D. Bone mineral density and spongiosa architecture in correlation to vertebral body insufficiency fractures. Acta Radiol 39 5 (1998) 538-542
265. Chevalier F., Laval-Jeantet A.M., Laval-Jeantet M., et al. CT image analysis of the vertebral trabecular network in vivo. Calcif Tissue Int 51 1 (1992) 8-13
266. Engelke K., Grampp S., Glüer C.C., et al. Significance of QCT bone mineral density and its standard deviation as parameters to evaluate osteoporosis. J Comput Assist Tomogr 19 (1995) 111-116
267. Gordon C.L., Lang T.F., Augat P., et al. Image-based assessment of spinal trabecular bone structure from high-resolution CT images. Osteoporos Int 8 4 (1998) 317-325
268. Ito M., Ohki M., Hayashi K., et al. Trabecular texture analysis of CT images in the relationship with spinal fracture. Radiology 194 1 (1995) 55-59
269. MacIntyre N.J., Adachi J.D., and Webber C.E. In vivo measurement of apparent trabecular bone structure of the radius in women with low bone density discriminates patients with recent wrist fracture from those without fracture. J Clin Densitom 6 1 (2003) 35-43
270. Tomomitsu T., Mimura H., Murase K., et al. Fractal analysis of bone architecture at distal radius. Nippon Hoshasen Gijutsu Gakkai Zasshi 61 12 (2005) 1592-1598
271. Keaveny T.M., Donley D.W., Hoffmann P.F., et al. Effects of teriparatide and alendronate on vertebral strength as assessed by finite element modeling of QCT scans in women with osteoporosis. J Bone Miner Res 22 1 (2007) 149-157
272. Faulkner K.G., Cann C.E., and Hasegawa B.H. Effect of bone distribution on vertebral strength: assessment with patient-specific nonlinear finite element analysis. Radiology 179 3 (1991) 669-674