Cortical porosity is higher in boys compared with girls at the distal radius and distal tibia during pubertal growth: An HR-pQCT study

Journal of Bone and Mineral Research

Volumn 27, Issue 2, 2012, Pages 273-282

  Nishiyama, Kyle K ^a   MacDonald, Heather M ^b,c,d   Moore, Sarah A ^b,d   Fung, Tak ^a   Boyd, Steven K ^a   McKay, Heather A ^b,d  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d VANCOUVER COASTAL HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

ADOLESCENT GROWTH; BONE MICROSTRUCTURE; BONE STRENGTH; FINITE ELEMENT ANALYSIS; HR pQCT

Indexed keywords

ADULT; ADULTHOOD; ARTICLE; BONE DENSITY; BONE STRENGTH; CHILD; CONTROLLED STUDY; CORTICAL BONE; FEMALE; FINITE ELEMENT ANALYSIS; FRACTURE; HUMAN; MALE; POROSITY; PUBERTY; RADIUS; SCHOOL CHILD; SEX DIFFERENCE; TIBIA;

EID: 84856204236     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.552     Document Type: Article

References (52)

1. Jones IE, Williams SM, Dow N, Goulding A,. How many children remain fracture-free during growth? A longitudinal study of children and adolescents participating in the Dunedin Multidisciplinary Health and Development Study. Osteoporos Int. 2002; 13: 990-5. (Pubitemid 36050277)
2. Landin LA,. Fracture patterns in children. Analysis of 8,682 fractures with special reference to incidence, etiology and secular changes in a Swedish urban population 1950-1979. Acta Orthop Scand. 1983; 202 (Suppl): 1-109.
3. Khosla S, Melton LJ, Dekutoski MB, Achenbach SJ, Oberg AL, Riggs BL,. Incidence of childhood distal forearm fractures over 30 years: a population-based study. JAMA. 2003; 290: 1479-85. (Pubitemid 37430403)
4. Kramhøft M, Bødtker S,. Epidemiology of distal forearm fractures in Danish children. Acta Orthop Scand. 1988; 59: 557-9. (Pubitemid 18264556)
5. Bailey DA, Wedge JH, McCulloch RG, Martin AD, Bernhardson SC,. Epidemiology of fractures of the distal end of the radius in children as associated with growth. J Bone Joint Surg Am. 1989; 71: 1225-31. (Pubitemid 19262372)
6. Cooper C, Dennison EM, Leufkens HG, Bishop N, van Staa TP,. Epidemiology of childhood fractures in Britain: a study using the general practice research database. J Bone Miner Res. 2004; 19: 1976-81. (Pubitemid 41103412)
7. Bailey DA, McKay HA, Mirwald RL, Crocker PR, Faulkner RA,. A six-year longitudinal study of the relationship of physical activity to bone mineral accrual in growing children: the university of Saskatchewan bone mineral accrual study. J Bone Miner Res. 1999; 14: 1672-9. (Pubitemid 29455815)
8. Cadogan J, Blumsohn A, Barker ME, Eastell R,. A longitudinal study of bone gain in pubertal girls: anthropometric and biochemical correlates. J Bone Miner Res. 1998; 13: 1602-12. (Pubitemid 28465301)
9. Baxter-Jones ADG, Mirwald RL, McKay HA, Bailey DA,. A longitudinal analysis of sex differences in bone mineral accrual in healthy 8-19-year-old boys and girls. Ann Hum Biol. 2003; 30: 160-75. (Pubitemid 36439850)
10. Petit MA, Beck TJ, Kontulainen SA,. Examining the developing bone: what do we measure and how do we do it?. J Musculoskelet Neuronal Interact. 2005; 5: 213-24. (Pubitemid 41684170)
11. Neu CM, Manz F, Rauch F, Merkel A, Schoenau E,. Bone densities and bone size at the distal radius in healthy children and adolescents: a study using peripheral quantitative computed tomography. Bone. 2001; 28: 227-32. (Pubitemid 32140979)
12. Macdonald HM, Kontulainen SA, MacKelvie-O'Brien KJ, Petit MA, Janssen P, Khan KM, McKay HA,. Maturity- and sex-related changes in tibial bone geometry, strength and bone-muscle strength indices during growth: a 20-month pQCT study. Bone. 2005; 36: 1003-11. (Pubitemid 40798001)
13. Macdonald HM, Kontulainen SA, Petit MA, Janssen P, McKay HA,. Bone strength and its determinants in pre- and early pubertal boys and girls. Bone. 2006; 39: 598-608. (Pubitemid 44164639)
14. Kontulainen SA, Macdonald HM, Khan KM, McKay HA,. Examining bone surfaces across puberty: a 20-month pQCT trial. J Bone Miner Res. 2005; 20: 1202-7. (Pubitemid 40863808)
15. Kontulainen SA, Macdonald HM, McKay HA,. Change in cortical bone density and its distribution differs between boys and girls during puberty. J Clin Endocrinol Metab. 2006; 91: 2555-61. (Pubitemid 44024617)
16. Moyer-Mileur L, Xie B, Ball S, Bainbridge C, Stadler D, Jee WS,. Predictors of bone mass by peripheral quantitative computed tomography in early adolescent girls. J Clin Densitom. 2001; 4: 313-23. (Pubitemid 34073201)
17. Rauch F, Neu C, Manz F, Schoenau E,. The development of metaphyseal cortex-implications for distal radius fractures during growth. J Bone Miner Res. 2001; 16: 1547-55. (Pubitemid 32675207)
18. MacNeil JA, Boyd SK,. Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys. 2007; 29: 1096-105. (Pubitemid 350052626)
19. Liu XS, Zhang XH, Sekhon KK, Adams MF, McMahon DJ, Bilezikian JP, Shane E, Guo XE,. High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone. J Bone Miner Res. 2010; 25: 746-56.
20. Buie HR, Campbell GM, Klinck RJ, MacNeil JA, Boyd SK,. Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis. Bone. 2007; 41: 505-15. (Pubitemid 47385446)
21. Nishiyama KK, Macdonald HM, Buie HR, Hanley DA, Boyd SK,. Postmenopausal women with osteopenia have higher cortical porosity and thinner cortices at the distal radius and tibia than women with normal aBMD: an in vivo HR-pQCT study. J Bone Miner Res. 2010; 25: 882-90.
22. Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S,. Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia. J Bone Miner Res. 2010; 25: 983-93.
23. Parfitt AM,. The two faces of growth: benefits and risks to bone integrity. Osteoporos Int. 1994; 4: 382-98.
24. Wachter NJ, Augat P, Krischak GD, Mentzel M, Kinzl L, Claes L,. Prediction of cortical bone porosity in vitro by microcomputed tomography. Calcif Tissue Int. 2001; 68: 38-42. (Pubitemid 33658481)
25. Yeni YN, Brown CU, Wang Z, Norman TL,. The influence of bone morphology on fracture toughness of the human femur and tibia. Bone. 1997; 21: 453-9. (Pubitemid 27485315)
26. MacNeil JA, Boyd SK,. Improved reproducibility of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys. 2008; 30: 792-9.
27. Macdonald HM, Nishiyama KK, Kang J, Hanley DA, Boyd SK,. Age-related patterns of trabecular and cortical bone loss differ between sexes and skeletal sites: a population-based HR-pQCT study. J Bone Miner Res. 2011; 26: 50-62.
28. Dalzell N, Kaptoge S, Morris N, Berthier A, Koller B, Braak L, van Rietbergen B, Reeve J,. Bone micro-architecture and determinants of strength in the radius and tibia: age-related changes in a population-based study of normal adults measured with high-resolution pQCT. Osteoporos Int. 2009; 20: 1683-94.
29. Khosla S, Riggs BL, Atkinson EJ, Oberg AL, McDaniel LJ, Holets M, Peterson JM, Melton LJ,. Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J Bone Miner Res. 2006; 21: 124-31. (Pubitemid 43023234)
30. Wang Q, Wang XF, Iuliano-Burns S, Ghasem-Zadeh A, Zebaze R, Seeman E,. Rapid growth produces transient cortical weakness: a risk factor for metaphyseal fractures during puberty. J Bone Miner Res. 2010; 25: 1521-6.
31. Kirmani S, Christen D, van Lenthe GH, Fischer PR, Bouxsein ML, McCready LK, Melton LJ, Riggs BL, Amin S, Müller R, Khosla S,. Bone structure at the distal radius during adolescent growth. J Bone Miner Res. 2009; 24: 1033-42.
32. Burrows M, Liu D, Perdios A, Moore S, Mulpuri K, McKay H,. Assessing bone microstructure at the distal radius in children and adolescents using HR-pQCT: a methodological pilot study. J Clin Densitom. 2010; 13: 451-5.
33. Mackelvie KJ, McKay HA, Khan KM, Crocker PR,. Lifestyle risk factors for osteoporosis in Asian and Caucasian girls. Med Sci Sports Exerc. 2001; 33: 1818-24. (Pubitemid 33035475)
34. Petit MA, McKay HA, MacKelvie KJ, Heinonen A, Khan KM, Beck TJ,. A randomized school-based jumping intervention confers site and maturity-specific benefits on bone structural properties in girls: a hip structural analysis study. J Bone Miner Res. 2002; 17: 363-72. (Pubitemid 34171750)
35. Macdonald HM, Kontulainen SA, Khan KM, McKay HA,. Is a school-based physical activity intervention effective for increasing tibial bone strength in boys and girls?. J Bone Miner Res. 2007; 22: 434-46. (Pubitemid 46797127)
36. Tanner JM,. Foetus into man. Cambridge, MA: Harvard University Press; 1978.
37. Laib A, Häuselmann HJ, Rüegsegger P,., In vivo high resolution 3D-QCT of the human forearm. Technol Health Care. 1998; 6: 329-7.
38. Boutroy S, Bouxsein ML, Munoz F, Delmas PD,. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab. 2005; 90: 6508-15. (Pubitemid 41759306)
39. Sekhon K, Kazakia GJ, Burghardt AJ, Hermannsson B, Majumdar S,. Accuracy of volumetric bone mineral density measurement in high-resolution peripheral quantitative computed tomography. Bone. 2009; 45: 473-9.
40. Hildebrand T, Rüegsigger P,. Quantification of bone microarchitecture with the structure model index. Comput Methods Biomech Biomed Engin. 1997; 1: 15-23.
41. Müller R, Rüegsegger P,. Three-dimensional finite element modelling of non-invasively assessed trabecular bone structures. Med Eng Phys. 1995; 17: 126-33.
42. Van Rietbergen B, Weinans H, Huiskes R, Odgaard A,. A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models. J Biomech. 1995; 28: 69-81. (Pubitemid 24343733)
43. Hayes WC, Piazza SJ, Zysset PK,. Biomechanics of fracture risk prediction of the hip and spine by quantitative computed tomography. Radiol Clin North Am. 1991; 29: 1-18.
44. Keaveny TM, Bouxsein ML,. Theoretical implications of the biomechanical fracture threshold. J Bone Miner Res. 2008; 23: 1541-7.
45. Chiu J, Robinovitch SN,. Prediction of upper extremity impact forces during falls on the outstretched hand. J Biomech. 1998; 31: 1169-76. (Pubitemid 29005186)
46. Liang KY, Zeger SL,. Longitudinal data analysis using generalized linear models. Biometrika. 1986; 73: 3-22.
47. Burrows M, Liu D, Moore S, McKay H,. Bone microstructure at the distal tibia provides a strength advantage to males in late puberty: an HR-pQCT study. J Bone Miner Res. 2010; 25: 1423-32.
48. Tanner JM, Whitehouse RH, Marubini E, Resele LF,. The adolescent growth spurt of boys and girls of the Harpenden growth study. Ann Hum Biol. 1976; 3: 109-26.
49. Ruff CB, Hayes WC,. Subperiosteal expansion and cortical remodeling of the human femur and tibia with aging. Science. 1982; 217: 945-8. (Pubitemid 12047356)
50. Pritchett JW,. Growth plate activity in the upper extremity. Clin Orthop Relat Res. 1991; 235-42.
51. Pritchett JW,. Longitudinal growth and growth-plate activity in the lower extremity. Clin Orthop Relat Res. 1992; 274-9.
52. Burrows M, Baxter-Jones A, Mirwald R, Macdonald H, McKay H,. Bone mineral accrual across growth in a mixed-ethnic group of children: are Asian children disadvantaged from an early age?. Calcif Tissue Int. 2009; 84: 366-78.