Bone density, structure, and strength in juvenile idiopathic arthritis: Importance of disease severity and muscle deficits

Arthritis and Rheumatism

Volumn 58, Issue 8, 2008, Pages 2518-2527

  Burnham, Jon M ^a,b   Shults, Justine ^a   Dubner, Sarah E ^a   Sembhi, Harjeet ^a   Zemel, Babette S ^a   Leonard, Mary B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; INFLIXIMAB;

ADOLESCENT; ADULT; ARTICLE; BONE DENSITY; BONE STRENGTH; BONE STRUCTURE; CHILD; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; CORTICOSTEROID THERAPY; DISABILITY; DISEASE DURATION; FEMALE; HUMAN; JUVENILE RHEUMATOID ARTHRITIS; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MUSCLE FORCE; OLIGOARTICULAR ARTHRITIS; POLYARTICULAR ARTHRITIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RACE DIFFERENCE; SEX DIFFERENCE; SHORT STATURE; SPONDYLOSIS; SYSTEMIC ARTHRITIS; TEMPOROMANDIBULAR JOINT DISORDER; TIBIA;

ADOLESCENT; ADULT; ARTHRITIS, JUVENILE RHEUMATOID; BONE AND BONES; BONE DENSITY; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; GLUCOCORTICOIDS; HUMANS; LINEAR MODELS; MALE; MUSCLE, SKELETAL; SEVERITY OF ILLNESS INDEX; TOMOGRAPHY, X-RAY COMPUTED;

EID: 49449106358     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.23683     Document Type: Article

References (45)

1. Bowyer S, Roettcher P, for the Pediatric Rheumatology Database Research Group. Pediatric rheumatology clinic populations in the United States: results of a 3 year survey. J Rheumatol 1996;23:1968-74.
2. Burnham JM, Leonard MB. Bone disease in pediatric rheumatologic disorders. Curr Rheumatol Rep 2004;6:70-8.
3. Burnham JM, Shults J, Weinstein R, Lewis JD, Leonard MB. Childhood onset arthritis is associated with an elevated risk of fracture: a population-based study using the General Practice Research Database. Ann Rheum Dis 2006;1074-9.
4. Roth J, Palm C, Scheunemann I, Ranke MB, Schweizer R, Dannecker GE. Musculoskeletal abnormalities of the forearm in patients with juvenile idiopathic arthritis relate mainly to bone geometry. Arthritis Rheum 2004;50:1277-85.
5. Felin EM, Prahalad S, Askew EW, Moyer-Mileur LJ. Musculoskeletal abnormalities of the tibia in juvenile rheumatoid arthritis. Arthritis Rheum 2007;56:984-94.
6. Bechtold S, Ripperger P, Dalla Pozza R, Schmidt H, Hafner R, Schwarz HP. Musculoskeletal and functional muscle-bone analysis in children with rheumatic disease using peripheral quantitative computed tomography. Osteoporos Int 2005;16:757-63.
7. Frost HM. Changing concepts in skeletal physiology: Wolff's law, the mechanostat, and the "Utah paradigm." Am J Hum Biol 1998;10:599-605.
8. Schoenau E, Neu CM, Beck B, Manz F, Rauch F. Bone mineral content per muscle cross-sectional area as an index of the functional muscle-bone unit. J Bone Miner Res 2002;17:1095-101.
9. Macdonald H, Kontulainen S, Petit M, Janssen P, McKay H. Bone strength and its determinants in pre- and early pubertal boys and girls. Bone 2006;39:598-608.
10. Lovell DJ, Reiff A, Jones OY, Schneider R, Nocton J, Stein LD, et al, for the Pediatric Rheumatology Collaborative Study Group. Long-term safety and efficacy of etanercept in children with polyarticular-course juvenile rheumatoid arthritis. Arthritis Rheum 2006;54:1987-94.
11. Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 2004;31:390-2.
12. Singh G, Athreya BH, Fries JF, Goldsmith DP. Measurement of health status in children with juvenile rheumatoid arthritis. Arthritis Rheum 1994;37:1761-9.
13. Kvien TK, Hoyeraal HM, Sandstad B. Assessment methods of disease activity in juvenile rheumatoid arthritis - evaluated in a prednisolone/placebo double blind study. J Rheumatol 1982;9:696-702.
14. Wallace CA, Huang B, Bandeira M, Ravelli A, Giannini EH. Patterns of clinical remission in select categories of juvenile idiopathic arthritis. Arthritis Rheum 2005;52:3554-62.
15. Ogden CL, Kuczmarski RJ, Flegal KM, Mei Z, Guo S, Wei R, et al. Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics 2002;109:45-60.
16. Tanner JM. Growth at adolescence. 2nd ed. Oxford: Blackwell Scientific; 1962.
17. Morris NN, Udry JR. Validation of a self-administered instrument to assess stage of adolescent development. J Youth Adolesc 1980:271-80.
18. Sievanen H, Koskue V, Rauhio A, Kannus P, Heinonen A, Vuori I. Peripheral quantitative computed tomography in human long bones: evaluation of in vitro and in vivo precision. J Bone Miner Res 1998;13:871-82.
19. Schoenau E, Neu CM, Rauch F, Manz F. Gender-specific pubertal changes in volumetric cortical bone mineral density at the proximal radius. Bone 2002;31:110-3.
20. Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ. Relationship between bone morphology and bone quality in male tibias: implications for stress fracture risk. J Bone Miner Res 2005;20:1372-80.
21. Schoenau E, Neu CM, Rauch F, Manz F. The development of bone strength at the proximal radius during childhood and adolescence. J Clin Endocrinol Metab 2001;86:613-8.
22. Gilsanz V, Kovanlikaya A, Costin G, Roe TF, Sayre J, Kaufman F. Differential effect of gender on the sizes of the bones in the axial and appendicular skeletons. J Clin Endocrinol Metab 1997;82:1603-7.
23. Altman DG. Construction of age-related reference centiles using absolute residuals. Stat Med 1993;12:917-24.
24. Kalkwarf HJ, Zemel BS, Gilsanz V, Lappe JM, Horlick M, Oberfield S, et al. The bone mineral density in childhood study: bone mineral content and density according to age, sex, and race. J Clin Endocrinol Metab 2007;92:2087-99.
25. Skaggs DL, Loro ML, Pitukcheewanont P, Tolo V, Gilsanz V. Increased body weight and decreased radial cross-sectional dimensions in girls with forearm fractures. J Bone Miner Res 2001;16:1337-42.
26. Ma D, Jones G. The association between bone mineral density, metacarpal morphometry, and upper limb fractures in children: a population-based case-control study. J Clin Endocrinol Metab 2003;88:1486-91.
27. Lien G, Flato B, Haugen M, Vinje O, Sorskaar D, Dale K, et al. Frequency of osteopenia in adolescents with early-onset juvenile idiopathic arthritis: a long-term outcome study of one hundred five patients. Arthritis Rheum 2003;48:2214-23.
28. Parfitt AM. The two faces of growth: benefits and risks to bone integrity. Osteoporos Int 1994;4:382-98.
29. Jepsen KJ, Pennington DE, Lee YL, Warman M, Nadeau J. Bone brittleness varies with genetic background in A/J and C57BL/6J inbred mice. J Bone Miner Res 2001;16:1854-62.
30. Beck TJ, Ruff CB, Mourtada FA, Shaffer RA, Maxwell-Williams K, Kao GL, et al. Dual-energy X-ray absorptiometry derived structural geometry for stress fracture prediction in male U.S. Marine Corps recruits. J Bone Miner Res 1996;11:645-53.
31. Ashe MC, Khan KM, Kontulainen SA, Guy P, Liu D, Beck TJ, et al. Accuracy of pQCT for evaluating the aged human radius: an ashing, histomorphometry and failure load investigation. Osteoporos Int 2006;17:1241-51.
32. Kaneki H, Guo R, Chen D, Yao Z, Schwarz EM, Zhang YE, et al. Tumor necrosis factor promotes Runx2 degradation through upregulation of Smurf1 and Smurf2 in osteoblasts. J Biol Chem 2006;281:4326-33.
33. Gilbert L, He X, Farmer P, Rubin J, Drissi H, van Wijnen AJ, et al. Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/ Pebp2αA) is inhibited by tumor necrosis factor-α. J Biol Chem 2002;277:2695-701.
34. Kudo O, Sabokbar A, Pocock A, Itonaga I, Fujikawa Y, Athanasou NA. Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism. Bone 2003;32:1-7.
35. Marotte H, Pallot-Prades B, Grange L, Gaudin P, Alexandre C, Miossec P. A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximab. Arthritis Res Ther 2007;9:R61.
36. Li Y, Li A, Strait K, Zhang H, Nanes MS, Weitzmann MN. Endogenous TNFα lowers maximum peak bone mass and inhibits osteoblastic Smad activation through NF-κB. J Bone Miner Res 2007;22:646-55.
37. De Benedetti F, Rucci N, Del Fattore A, Peruzzi B, Paro R, Longo M, et al. Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system. Arthritis Rheum 2006;54:3551-63.
38. Weinstein RS, Chen JR, Powers CC, Stewart SA, Landes RD, Bellido T, et al. Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J Clin Invest 2002;109:1041-8.
39. Canalis E, Bilezikian JP, Angeli A, Giustina A. Perspectives on glucocorticoid-induced osteoporosis. Bone 2004;34:593-8.
40. Burnham JM, Shults J, Petit MA, Semeao E, Beck TJ, Zemel BS, et al. Alterations in proximal femur geometry in children treated with glucocorticoids for Crohn disease or nephrotic syndrome: impact of the underlying disease. J Bone Miner Res 2007;22:551-9.
41. Xian CJ, Cool JC, Scherer MA, Macsai CE, Fan C, Covino M, et al. Cellular mechanisms for methotrexate chemotherapy-induced bone growth defects. Bone 2007;41:842-50.
42. Minaur NJ, Jefferiss C, Bhalla AK, Beresford JN. Methotrexate in the treatment of rheumatoid arthritis. I. In vitro effects on cells of the osteoblast lineage. Rheumatology (Oxford) 2002;41:735-40.
43. Bianchi ML, Cimaz R, Galbiati E, Corona F, Cherubini R, Bardare M. Bone mass change during methotrexate treatment in patients with juvenile rheumatoid arthritis. Osteoporos Int 1999;10:20-5.
44. Valta H, Lahdenne P, Jalanko H, Aalto K, Makitie O. Bone health and growth in glucocorticoid-treated patients with juvenile idiopathic arthritis. J Rheumatol 2007;34:831-6.
45. Dubner SE, Shults J, Leonard MB, Zemel BS, Sembhi H, Burnham JM. Assessment of spine bone mineral density in juvenile idiopathic arthritis: impact of scan projection. J Clin Densitom 2007. E-pub ahead of print.