Dynamics of body composition and bone in patients with juvenile idiopathic arthritis treated with growth hormone

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 1, 2010, Pages 178-185

  Bechtold, Susanne ^a   Ripperger, Peter ^b   Pozza, Robert Dalla ^a   Roth, Johannes ^c   Häfner, Renate ^b   Michels, Hartmut ^b   Schwarz, Hans Peter ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Center of Pediatric Rheumatology   (Germany)

^c CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE;

ADOLESCENT; ARTICLE; BODY COMPOSITION; BONE DENSITY; BONE MARROW; CHILD; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; GEOMETRY; HUMAN; JUVENILE RHEUMATOID ARTHRITIS; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCHOOL CHILD;

EID: 75149171776     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0979     Document Type: Article

References (35)

1. Kotaniemi A 1997 Growth retardation and bone loss as determinants of axial osteopenia in juvenile chronic arthritis. Scand J Rheumatol 26:14-18
2. Burnham JM, Shults J, Weinstein R, Lewis JD, Leonard MB 2006 Childhood onset arthritis is associated with an increased risk of fracture: a population based study using the general practice research database. Ann Rheum Dis 65:1074-1079
3. Cimaz R 2002 Osteoporosis in childhood rheumatic disease: prevention and therapy. Best Pract Res Clin Rheumatol 16:397-409
4. Bechtold S, Ripperger P, Dalla Pozza R, Schmidt H, Häfner R, Schwarz HP 2005 Musculoskeletal and functional muscle-bone analysis in children with rheumatic disease using peripheral quantitative computed tomography. Osteoporos Int 16:757-763
5. Roth J, Palm C, Scheunemann I, Ranke MB, Schweizer R, Dannecker GE 2004 Musculoskeletal abnormalities of the forearm in patients with juvenile idiopathic arthritis relate mainly to bone geometry. Arthritis Rheum 50:1277-1285
6. Mul D, van Suijlekom-Smit LW, ten Cate R, Bekkering WP, de Muinck Keizer-Schrama SM 2002 Bone mineral density and body composition and influencing factors in children with rheumatic diseases treated with corticosteroids. J Pediatr Endocrinol Metab 15: 187-192
7. Rall LC, Roubenoff R 2004 Rheumatoid cachexia: metabolic abnormalities, mechanisms and interventions. Rheumatology (Oxford) 43:1219-1223
8. Högler W, Briody J, Moore B, Lu PW, Cowell CT 2005 Effect of growth hormone therapy and puberty on bone and body composition in children with idiopathic short stature and growth hormone deficiency. Bone 37:642-650
9. Underwood LE 1999 Growth retardation in chronic disease: possible mechanisms. Acta Paediatr Suppl 88:93-96
10. Bechtold S, Ripperger P, Mühlbayer D, Truckenbrodt H, Häfner R, Butenandt O, Schwarz HP 2001 GH therapy in juvenile chronic arthritis: results of a two year controlled study on growth and bone. J Clin Endocrinol Metab 86:5737-5744
11. Touati G, Ruiz JC, Porquet D, Kindermans C, Prieur AM, Czernichow P 2000 Effects on bone metabolism of one year recombinant human growth hormone administration to children with juvenile chronic arthritis undergoing chronic steroid therapy. J Rheumatol 27:1287-1293
12. Rooney M, Davies UM, Reeve J, Preece M, Ansell BM, Woo PM 2000 Bone mineral content and bone mineral metabolism: changes after growth hormone treatment in juvenile chronic arthritis. J Rheumatol 27:1073-1081
13. Bechtold S, Ripperger P, Häfner R, Said E, Schwarz HP 2003 Growth hormone therapy in juvenile idiopathic arthritis: 4 years data of a controlled study. J Pediatr 143:512-519
14. Bechtold S, Ripperger P, Bonfig W, Schmidt H, Bitterling H, Häfner R, Schwarz HP 2004 Bone mass development and bone metabolism in juvenile idiopathic arthritis: treatment with growth hormone for 4 years. J Rheumatol 31:1407-1412
15. Bechtold S, Ripperger P, Bonfig W, Pozza RD, Haefner R, Schwarz HPBechtold S, Ripperger P, Bonfig W, Pozza RD, Haefner R, Schwarz HP 2005 Growth hormone changes bone geometry and body composition in patients with juvenile idiopathic arthritis requiring glucocorticoid treatment: a controlled study using peripheral quantitative computed tomography. J Clin Endocrinol Metab 90:3168-3173
16. Petty RE, Southwood TR, Baum J, Bhettay E, Glass DN, Manners P, Maldonado-Cocco J, Suarez-Almazor M, Orozco-Alcala J, Prieur AM 1998 Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban1997. J Rheumatol 25:1991-1994
17. Bechtold S, Ripperger P, Dalla Pozza R, Bonfig W, Häfner R, Michels H, Schwarz HP 2007 Growth hormone increases final height in patients with juvenile idiopathic arthritis: data from a randomized controlled study. J Clin Endocrinol Metab 92:3013-3018
18. Reinken L, van Oost G 1992 Longitudinal physical development of healthy children 0 to 18 years of age. Body length/height, body weight and growth velocity. Klin Pädiatr 204:129-133
19. Neu CM, Manz F, Rauch F, Merkel A, Schoenau E 2001 Bone density and bone size at the distal radius in healthy children and adolescents: a study using peripheral quantitative computed tomography. Bone 28:227-232
20. Neu C, Manz F, Rauch F, Schönau E 2000 Modeling of cross-sectional bone size and geometry at the proximal radius: a study of normal bone development using peripheral quantitative computed tomography. Osteoporosis Int 12:538-547
21. Tanner JM 1962 Growth at adolescence. 2nd ed. Oxford, London: Blackwell
22. Greulich WW, Pyle SI 1959 Radiographic atlas of skeletal development of the hand and wrist. 2nd ed. Palo Alto, CA: Stanford University Press
23. Rauch F, Schoenau E 2008 Peripheral quantitative computed tomography of the proximal radius in young subjects: new reference data and interpretation of results. J Musculoskelet Neuronal Interact 8:217-226
24. Perez MD, Abrams SA, Loddeke L, Shypailo R, Ellis KJ 2000 Effects of rheumatic disease and corticosteroid treatment on calcium metabolism and bone density in children assessed one year after diagnosis, using stable isotopes and dual energy x-ray absorptiometry. J Rheumatol 27(Suppl 58):38-43
25. Lien G, Selvaag AM, Flatø B, Haugen M, Vinje O, Sørskaar D, Dale K, Egeland T, Førre ∅ 2005 A two-year prospective controlled study of bone mass and bone turnover in children with early juvenile idiopathic arthritis. Arthritis Rheum 52: 833-840
26. Eley HL, Russell ST, Tisdale MJ 2008 Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-α and angiotensin II by β-hydroxy-β-methylbutyrate. Am J Physiol Endocrinol Metab 295:1417-1426
27. Walsmith J, Roubenoff R 2002 Cachexia in rheumatoid arthritis. Int J Cardiol 85:89-99
28. Simon D, Lucidarme N, Prieur AM, Ruiz JC, Czernichow P 2003 Effects on growth and body composition of growth hormone treatment in children with juvenile idiopathic arthritis requiring steroid therapy. J Rheumatol 30:2492-2499
29. Frost HM 2003 Bone's mechanostat: a 2003 update. Anat Rec A Discov Mol Cell Evol Biol 275:1081-1101
30. Frost HM 2000 Growth hormone and osteoporosis: an overview of endocrinological and pharmacological insights from the Utah paradigm of skeletal physiology. Horm Res 54(Suppl 1):36-43
31. Schoenau E, Frost HM 2002 The muscle-bone unit in children and adolescents. Calcif Tissue Int 70:405-407
32. Roth J, Linge M, Tzaribachev N, Schweizer R, Kuemmerle-Deschner J 2007 Musculoskeletal abnormalities in juvenile idiopathic arthritis: a 4-year longitudinal study. Rheumatology 46:1180-1184
33. Haugen M, Lien G, Flatø B, Kvammen J, Vinje O, Sørskaar D, Førre O 2000 Young adults with juvenile arthritis in remission attain normal peak bone mass at the lumbar spine and forearm. Arthritis Rheum 43:1504-1510
34. Schoenau E, Neu CM, Rauch F, Manz F 2002 Gender-specific pubertal changes in volumetric cortical bone mineral density at the proximal radius. Bone 31:110-113
35. Schweizer R, Martin DD, Schwarze CP, Binder G, Georgiadou A, Ihle J, Ranke MB 2003 Cortical bone density is normal in prepubertal children with growth hormone (GH) deficiency, but initially decreases during GH replacement due to early bone remodeling. J Clin Endocrinol Metab 88:5266-5272