메뉴 건너뛰기




Volumn 1842, Issue 7, 2014, Pages 1088-1096

DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cells

Author keywords

Acute kidney injury; Apoptosis; ATP depletion; DNA damage response; Renal ischemia reperfusion

Indexed keywords

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ATM PROTEIN; CHECKPOINT KINASE 2; GLUCOSE; HISTONE H2AX; PROTEIN BCL 2; PROTEIN P53;

EID: 84898963572     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.04.002     Document Type: Article
Times cited : (64)

References (59)
  • 1
    • 80555157523 scopus 로고    scopus 로고
    • Cellular pathophysiology of ischemic acute kidney injury
    • Bonventre J.V., Yang L. Cellular pathophysiology of ischemic acute kidney injury. J. Clin. Invest. 2011, 121:4210-4221.
    • (2011) J. Clin. Invest. , vol.121 , pp. 4210-4221
    • Bonventre, J.V.1    Yang, L.2
  • 2
    • 79953175649 scopus 로고    scopus 로고
    • Pathophysiology of ischemic acute kidney injury
    • Sharfuddin A.A., Molitoris B.A. Pathophysiology of ischemic acute kidney injury. Nat. Rev. Nephrol. 2011, 7:189-200.
    • (2011) Nat. Rev. Nephrol. , vol.7 , pp. 189-200
    • Sharfuddin, A.A.1    Molitoris, B.A.2
  • 3
    • 84865273555 scopus 로고    scopus 로고
    • Acute kidney injury and chronic kidney disease: an integrated clinical syndrome
    • Chawla L.S., Kimmel P.L. Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. Kidney Int. 2012, 82:516-524.
    • (2012) Kidney Int. , vol.82 , pp. 516-524
    • Chawla, L.S.1    Kimmel, P.L.2
  • 5
    • 7744243520 scopus 로고    scopus 로고
    • The DNA damage response: sensing and signaling
    • McGowan C.H., Russell P. The DNA damage response: sensing and signaling. Curr. Opin. Cell Biol. 2004, 16:629-633.
    • (2004) Curr. Opin. Cell Biol. , vol.16 , pp. 629-633
    • McGowan, C.H.1    Russell, P.2
  • 6
    • 79952454660 scopus 로고    scopus 로고
    • ATR: a master conductor of cellular responses to DNA replication stress
    • Flynn R.L., Zou L. ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem. Sci. 2011, 36:133-140.
    • (2011) Trends Biochem. Sci. , vol.36 , pp. 133-140
    • Flynn, R.L.1    Zou, L.2
  • 8
    • 0037415380 scopus 로고    scopus 로고
    • Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney
    • Tsuruya K., Furuichi M., Tominaga Y., Shinozaki M., Tokumoto M., et al. Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney. DNA Repair (Amst) 2003, 2:211-229.
    • (2003) DNA Repair (Amst) , vol.2 , pp. 211-229
    • Tsuruya, K.1    Furuichi, M.2    Tominaga, Y.3    Shinozaki, M.4    Tokumoto, M.5
  • 9
    • 84861911907 scopus 로고    scopus 로고
    • Caspase-3-independent internucleosomal DNA fragmentation in ischemic acute kidney injury
    • Yoshida T., Shimizu A., Masuda Y., Mii A., Fujita E., et al. Caspase-3-independent internucleosomal DNA fragmentation in ischemic acute kidney injury. Nephron Exp. Nephrol. 2012, 120:e103-e113.
    • (2012) Nephron Exp. Nephrol. , vol.120
    • Yoshida, T.1    Shimizu, A.2    Masuda, Y.3    Mii, A.4    Fujita, E.5
  • 10
    • 0026551591 scopus 로고
    • Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia
    • Schumer M., Colombel M.C., Sawczuk I.S., Gobe G., Connor J., et al. Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am. J. Pathol. 1992, 140:831-838.
    • (1992) Am. J. Pathol. , vol.140 , pp. 831-838
    • Schumer, M.1    Colombel, M.C.2    Sawczuk, I.S.3    Gobe, G.4    Connor, J.5
  • 11
    • 84888789896 scopus 로고    scopus 로고
    • Silencing of p53 RNA through transarterial delivery ameliorates renal tubular injury and down-regulates GSK-3beta expression after ischemia-reperfusion injury
    • F1617-AAA1627
    • Fujino T., Muhib S., Sato N., Hasebe N. Silencing of p53 RNA through transarterial delivery ameliorates renal tubular injury and down-regulates GSK-3beta expression after ischemia-reperfusion injury. Am. J. Physiol. Ren. Physiol. 2013, 305:F1617-AAA1627.
    • (2013) Am. J. Physiol. Ren. Physiol. , vol.305
    • Fujino, T.1    Muhib, S.2    Sato, N.3    Hasebe, N.4
  • 12
    • 0037218760 scopus 로고    scopus 로고
    • P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor
    • Kelly K.J., Plotkin Z., Vulgamott S.L., Dagher P.C. P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor. J. Am. Soc. Nephrol. 2003, 14:128-138.
    • (2003) J. Am. Soc. Nephrol. , vol.14 , pp. 128-138
    • Kelly, K.J.1    Plotkin, Z.2    Vulgamott, S.L.3    Dagher, P.C.4
  • 13
    • 79953186673 scopus 로고    scopus 로고
    • HMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis
    • Pabla N., Ma Z., McIlhatton M.A., Fishel R., Dong Z. hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis. J. Biol. Chem. 2011, 286:10411-10418.
    • (2011) J. Biol. Chem. , vol.286 , pp. 10411-10418
    • Pabla, N.1    Ma, Z.2    McIlhatton, M.A.3    Fishel, R.4    Dong, Z.5
  • 14
    • 44249118962 scopus 로고    scopus 로고
    • ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis
    • Pabla N., Huang S., Mi Q.S., Daniel R., Dong Z. ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. J. Biol. Chem. 2008, 283:6572-6583.
    • (2008) J. Biol. Chem. , vol.283 , pp. 6572-6583
    • Pabla, N.1    Huang, S.2    Mi, Q.S.3    Daniel, R.4    Dong, Z.5
  • 15
    • 33745778238 scopus 로고    scopus 로고
    • Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis
    • Jiang M., Wei Q., Wang J., Du Q., Yu J., et al. Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis. Oncogene 2006, 25:4056-4066.
    • (2006) Oncogene , vol.25 , pp. 4056-4066
    • Jiang, M.1    Wei, Q.2    Wang, J.3    Du, Q.4    Yu, J.5
  • 16
    • 84870484737 scopus 로고    scopus 로고
    • Mouse model of ischemic acute kidney injury: technical notes and tricks
    • Wei Q., Dong Z. Mouse model of ischemic acute kidney injury: technical notes and tricks. Am. J. Physiol. 2012, 303:F1487-F1494.
    • (2012) Am. J. Physiol. , vol.303
    • Wei, Q.1    Dong, Z.2
  • 17
    • 66449121454 scopus 로고    scopus 로고
    • Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
    • Brooks C., Wei Q., Cho S.G., Dong Z. Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J. Clin. Invest. 2009, 119:1275-1285.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1275-1285
    • Brooks, C.1    Wei, Q.2    Cho, S.G.3    Dong, Z.4
  • 18
    • 0032585644 scopus 로고    scopus 로고
    • Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury
    • Saikumar P., Dong Z., Patel Y., Hall K., Hopfer U., et al. Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury. Oncogene 1998, 17:3401-3415.
    • (1998) Oncogene , vol.17 , pp. 3401-3415
    • Saikumar, P.1    Dong, Z.2    Patel, Y.3    Hall, K.4    Hopfer, U.5
  • 19
    • 0142136826 scopus 로고    scopus 로고
    • Requirement of the MRN complex for ATM activation by DNA damage
    • Uziel T., Lerenthal Y., Moyal L., Andegeko Y., Mittelman L., et al. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 2003, 22:5612-5621.
    • (2003) EMBO J. , vol.22 , pp. 5612-5621
    • Uziel, T.1    Lerenthal, Y.2    Moyal, L.3    Andegeko, Y.4    Mittelman, L.5
  • 20
    • 47949121598 scopus 로고    scopus 로고
    • Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
    • Jazayeri A., Balestrini A., Garner E., Haber J.E., Costanzo V. Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO J. 2008, 27:1953-1962.
    • (2008) EMBO J. , vol.27 , pp. 1953-1962
    • Jazayeri, A.1    Balestrini, A.2    Garner, E.3    Haber, J.E.4    Costanzo, V.5
  • 21
    • 84875423827 scopus 로고    scopus 로고
    • The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
    • Shiloh Y., Ziv Y. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat. Rev. Mol. Cell Biol. 2013, 14:197-210.
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 197-210
    • Shiloh, Y.1    Ziv, Y.2
  • 22
    • 84868519888 scopus 로고    scopus 로고
    • Histone H2AX phosphorylation: a marker for DNA damage
    • Sharma A., Singh K., Almasan A. Histone H2AX phosphorylation: a marker for DNA damage. Methods Mol. Biol. 2012, 920:613-626.
    • (2012) Methods Mol. Biol. , vol.920 , pp. 613-626
    • Sharma, A.1    Singh, K.2    Almasan, A.3
  • 23
    • 79951516811 scopus 로고    scopus 로고
    • Cytometric analysis of DNA damage: phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs)
    • Tanaka T., Halicka D., Traganos F., Darzynkiewicz Z. Cytometric analysis of DNA damage: phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs). Methods Mol. Biol. 2009, 523:161-168.
    • (2009) Methods Mol. Biol. , vol.523 , pp. 161-168
    • Tanaka, T.1    Halicka, D.2    Traganos, F.3    Darzynkiewicz, Z.4
  • 24
    • 84879684865 scopus 로고    scopus 로고
    • Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models
    • Wei Q., Dong G., Chen J.K., Ramesh G., Dong Z. Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models. Kidney Int. 2013, 84:138-148.
    • (2013) Kidney Int. , vol.84 , pp. 138-148
    • Wei, Q.1    Dong, G.2    Chen, J.K.3    Ramesh, G.4    Dong, Z.5
  • 25
    • 84870580153 scopus 로고    scopus 로고
    • Autophagy in proximal tubules protects against acute kidney injury
    • Jiang M., Wei Q., Dong G., Komatsu M., Su Y., et al. Autophagy in proximal tubules protects against acute kidney injury. Kidney Int. 2012, 82:1271-1283.
    • (2012) Kidney Int. , vol.82 , pp. 1271-1283
    • Jiang, M.1    Wei, Q.2    Dong, G.3    Komatsu, M.4    Su, Y.5
  • 26
    • 0042845994 scopus 로고    scopus 로고
    • Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2
    • Dong Z., Wang J.Z., Yu F., Venkatachalam M.A. Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2. Am. J. Pathol. 2003, 163:663-671.
    • (2003) Am. J. Pathol. , vol.163 , pp. 663-671
    • Dong, Z.1    Wang, J.Z.2    Yu, F.3    Venkatachalam, M.A.4
  • 27
    • 0025126555 scopus 로고
    • Role of free radicals and catalytic metal ions in human disease: an overview
    • Halliwell B., Gutteridge J.M. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol. 1990, 186:1-85.
    • (1990) Methods Enzymol. , vol.186 , pp. 1-85
    • Halliwell, B.1    Gutteridge, J.M.2
  • 28
    • 3242752786 scopus 로고    scopus 로고
    • Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells
    • Boonstra J., Post J.A. Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene 2004, 337:1-13.
    • (2004) Gene , vol.337 , pp. 1-13
    • Boonstra, J.1    Post, J.A.2
  • 29
    • 9644270341 scopus 로고    scopus 로고
    • N-Acetyl-L-cysteine enhances apoptosis through inhibition of nuclear factor-kappaB in hypoxic murine embryonic fibroblasts
    • Qanungo S., Wang M., Nieminen A.L. N-Acetyl-L-cysteine enhances apoptosis through inhibition of nuclear factor-kappaB in hypoxic murine embryonic fibroblasts. J. Biol. Chem. 2004, 279:50455-50464.
    • (2004) J. Biol. Chem. , vol.279 , pp. 50455-50464
    • Qanungo, S.1    Wang, M.2    Nieminen, A.L.3
  • 30
    • 54349122238 scopus 로고    scopus 로고
    • Mitochondria-dependent reactive oxygen species-mediated programmed cell death induced by 3,3'-diindolylmethane through inhibition of F0F1-ATP synthase in unicellular protozoan parasite Leishmania donovani
    • Roy A., Ganguly A., BoseDasgupta S., Das B.B., Pal C., et al. Mitochondria-dependent reactive oxygen species-mediated programmed cell death induced by 3,3'-diindolylmethane through inhibition of F0F1-ATP synthase in unicellular protozoan parasite Leishmania donovani. Mol. Pharmacol. 2008, 74:1292-1307.
    • (2008) Mol. Pharmacol. , vol.74 , pp. 1292-1307
    • Roy, A.1    Ganguly, A.2    BoseDasgupta, S.3    Das, B.B.4    Pal, C.5
  • 31
    • 0036936654 scopus 로고    scopus 로고
    • Apoptotic pathways of oxidative damage to renal tubular epithelial cells
    • Basnakian A.G., Kaushal G.P., Shah S.V. Apoptotic pathways of oxidative damage to renal tubular epithelial cells. Antioxid. Redox Signal. 2002, 4:915-924.
    • (2002) Antioxid. Redox Signal. , vol.4 , pp. 915-924
    • Basnakian, A.G.1    Kaushal, G.P.2    Shah, S.V.3
  • 33
    • 3242886115 scopus 로고    scopus 로고
    • DNA damage responses to oxidative stress
    • Barzilai A., Yamamoto K. DNA damage responses to oxidative stress. DNA Repair (Amst) 2004, 3:1109-1115.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1109-1115
    • Barzilai, A.1    Yamamoto, K.2
  • 34
    • 84857116578 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
    • Ray P.D., Huang B.W., Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell. Signal. 2012, 24:981-990.
    • (2012) Cell. Signal. , vol.24 , pp. 981-990
    • Ray, P.D.1    Huang, B.W.2    Tsuji, Y.3
  • 35
    • 0035098162 scopus 로고    scopus 로고
    • Production of DNA strand breaks in vitro and reactive oxygen species in vitro and in HL-60 cells by PCB metabolites
    • Srinivasan A., Lehmler H.J., Robertson L.W., Ludewig G. Production of DNA strand breaks in vitro and reactive oxygen species in vitro and in HL-60 cells by PCB metabolites. Toxicol. Sci. 2001, 60:92-102.
    • (2001) Toxicol. Sci. , vol.60 , pp. 92-102
    • Srinivasan, A.1    Lehmler, H.J.2    Robertson, L.W.3    Ludewig, G.4
  • 36
    • 0029973192 scopus 로고    scopus 로고
    • Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion
    • Liu P.K., Hsu C.Y., Dizdaroglu M., Floyd R.A., Kow Y.W., et al. Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion. J. Neurosci. 1996, 16:6795-6806.
    • (1996) J. Neurosci. , vol.16 , pp. 6795-6806
    • Liu, P.K.1    Hsu, C.Y.2    Dizdaroglu, M.3    Floyd, R.A.4    Kow, Y.W.5
  • 38
    • 0034014316 scopus 로고    scopus 로고
    • Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain
    • Cui J., Holmes E.H., Greene T.G., Liu P.K. Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain. FASEB J. 2000, 14:955-967.
    • (2000) FASEB J. , vol.14 , pp. 955-967
    • Cui, J.1    Holmes, E.H.2    Greene, T.G.3    Liu, P.K.4
  • 39
    • 84455180756 scopus 로고    scopus 로고
    • BRCA1 is an essential regulator of heart function and survival following myocardial infarction
    • Shukla P.C., Singh K.K., Quan A., Al-Omran M., Teoh H., et al. BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nat. Commun. 2011, 2:593.
    • (2011) Nat. Commun. , vol.2 , pp. 593
    • Shukla, P.C.1    Singh, K.K.2    Quan, A.3    Al-Omran, M.4    Teoh, H.5
  • 41
    • 84921776529 scopus 로고    scopus 로고
    • Tubular p53 regulates multiple genes to mediate acute kidney injury
    • (in press) (Epub ahead of print)
    • Zhang D., Liu Y., Wei Q., Huo Y., Liu K., Liu F., Dong Z. Tubular p53 regulates multiple genes to mediate acute kidney injury. J. Am. Soc. Nephrol. 2014, (in press) (Epub ahead of print).
    • (2014) J. Am. Soc. Nephrol.
    • Zhang, D.1    Liu, Y.2    Wei, Q.3    Huo, Y.4    Liu, K.5    Liu, F.6    Dong, Z.7
  • 42
    • 68049136123 scopus 로고    scopus 로고
    • SiRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury
    • Molitoris B.A., Dagher P.C., Sandoval R.M., Campos S.B., Ashush H., et al. siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury. J. Am. Soc. Nephrol. 2009, 20:1754-1764.
    • (2009) J. Am. Soc. Nephrol. , vol.20 , pp. 1754-1764
    • Molitoris, B.A.1    Dagher, P.C.2    Sandoval, R.M.3    Campos, S.B.4    Ashush, H.5
  • 43
    • 0035810054 scopus 로고    scopus 로고
    • Regulation of the G2/M transition by p53
    • Taylor W.R., Stark G.R. Regulation of the G2/M transition by p53. Oncogene 2001, 20:1803-1815.
    • (2001) Oncogene , vol.20 , pp. 1803-1815
    • Taylor, W.R.1    Stark, G.R.2
  • 44
    • 0032484084 scopus 로고    scopus 로고
    • Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    • Matsuoka S., Huang M., Elledge S.J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 1998, 282:1893-1897.
    • (1998) Science , vol.282 , pp. 1893-1897
    • Matsuoka, S.1    Huang, M.2    Elledge, S.J.3
  • 45
    • 84882807441 scopus 로고    scopus 로고
    • Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia/reperfusion injury
    • Jang H.S., Han S.J., Kim J.I., Lee S., Lipschutz J.H., et al. Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia/reperfusion injury. Biochim. Biophys. Acta 2013, 1832:1998-2008.
    • (2013) Biochim. Biophys. Acta , vol.1832 , pp. 1998-2008
    • Jang, H.S.1    Han, S.J.2    Kim, J.I.3    Lee, S.4    Lipschutz, J.H.5
  • 46
    • 77952174830 scopus 로고    scopus 로고
    • Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
    • (531 pp. following 143)
    • Yang L., Besschetnova T.Y., Brooks C.R., Shah J.V., Bonventre J.V. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat. Med. 2010, 16:535-543. (531 pp. following 143).
    • (2010) Nat. Med. , vol.16 , pp. 535-543
    • Yang, L.1    Besschetnova, T.Y.2    Brooks, C.R.3    Shah, J.V.4    Bonventre, J.V.5
  • 47
    • 0032409943 scopus 로고    scopus 로고
    • Mechanisms of cell death in hypoxia/reoxygenation injury
    • Saikumar P., Dong Z., Weinberg J.M., Venkatachalam M.A. Mechanisms of cell death in hypoxia/reoxygenation injury. Oncogene 1998, 17:3341-3349.
    • (1998) Oncogene , vol.17 , pp. 3341-3349
    • Saikumar, P.1    Dong, Z.2    Weinberg, J.M.3    Venkatachalam, M.A.4
  • 48
    • 72049131104 scopus 로고    scopus 로고
    • N-acetylcysteine amide protects renal proximal tubular epithelial cells against iohexol-induced apoptosis by blocking p38 MAPK and iNOS signaling
    • Gong X., Celsi G., Carlsson K., Norgren S., Chen M. N-acetylcysteine amide protects renal proximal tubular epithelial cells against iohexol-induced apoptosis by blocking p38 MAPK and iNOS signaling. Am. J. Nephrol. 2010, 31:178-188.
    • (2010) Am. J. Nephrol. , vol.31 , pp. 178-188
    • Gong, X.1    Celsi, G.2    Carlsson, K.3    Norgren, S.4    Chen, M.5
  • 49
    • 84863348583 scopus 로고    scopus 로고
    • N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity
    • Sun L., Gu L., Wang S., Yuan J., Yang H., et al. N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity. PLoS One 2012, 7:e32503.
    • (2012) PLoS One , vol.7
    • Sun, L.1    Gu, L.2    Wang, S.3    Yuan, J.4    Yang, H.5
  • 50
    • 84886483694 scopus 로고    scopus 로고
    • Antioxidant N-acetylcysteine protects pancreatic beta-cells against aldosterone-induced oxidative stress and apoptosis in female db/db mice and insulin-producing MIN6 cells
    • Jin H.M., Zhou D.C., Gu H.F., Qiao Q.Y., Fu S.K., et al. Antioxidant N-acetylcysteine protects pancreatic beta-cells against aldosterone-induced oxidative stress and apoptosis in female db/db mice and insulin-producing MIN6 cells. Endocrinology 2013, 154:4068-4077.
    • (2013) Endocrinology , vol.154 , pp. 4068-4077
    • Jin, H.M.1    Zhou, D.C.2    Gu, H.F.3    Qiao, Q.Y.4    Fu, S.K.5
  • 51
    • 77951669082 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates glycerol-induced acute kidney injury by regulating MAPKs and Bcl-2 family proteins
    • Kim J.H., Lee S.S., Jung M.H., Yeo H.D., Kim H.J., et al. N-acetylcysteine attenuates glycerol-induced acute kidney injury by regulating MAPKs and Bcl-2 family proteins. Nephrol. Dial. Transplant. 2010, 25:1435-1443.
    • (2010) Nephrol. Dial. Transplant. , vol.25 , pp. 1435-1443
    • Kim, J.H.1    Lee, S.S.2    Jung, M.H.3    Yeo, H.D.4    Kim, H.J.5
  • 52
    • 84874624276 scopus 로고    scopus 로고
    • N-acetylcysteine protects against cadmium-induced germ cell apoptosis by inhibiting endoplasmic reticulum stress in testes
    • Ji Y.L., Wang H., Zhang C., Zhang Y., Zhao M., et al. N-acetylcysteine protects against cadmium-induced germ cell apoptosis by inhibiting endoplasmic reticulum stress in testes. Asian J. Androl. 2013, 15:290-296.
    • (2013) Asian J. Androl. , vol.15 , pp. 290-296
    • Ji, Y.L.1    Wang, H.2    Zhang, C.3    Zhang, Y.4    Zhao, M.5
  • 53
    • 41349105979 scopus 로고    scopus 로고
    • L-N-Acetylcysteine protects against radiation-induced apoptosis in a cochlear cell line
    • Low W.K., Sun L., Tan M.G., Chua A.W., Wang D.Y. L-N-Acetylcysteine protects against radiation-induced apoptosis in a cochlear cell line. Acta Otolaryngol. 2008, 128:440-445.
    • (2008) Acta Otolaryngol. , vol.128 , pp. 440-445
    • Low, W.K.1    Sun, L.2    Tan, M.G.3    Chua, A.W.4    Wang, D.Y.5
  • 54
    • 74249099955 scopus 로고    scopus 로고
    • N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway
    • Guan D., Xu Y., Yang M., Wang H., Wang X., et al. N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway. Mol. Carcinog. 2010, 49:68-74.
    • (2010) Mol. Carcinog. , vol.49 , pp. 68-74
    • Guan, D.1    Xu, Y.2    Yang, M.3    Wang, H.4    Wang, X.5
  • 55
    • 0038732425 scopus 로고    scopus 로고
    • N-Acetylcysteine enhances UV-mediated caspase-3 activation, fragmentation of E2F-4, and apoptosis in human C8161 melanoma: inhibition by ectopic Bcl-2 expression
    • Rieber M., Rieber M.S. N-Acetylcysteine enhances UV-mediated caspase-3 activation, fragmentation of E2F-4, and apoptosis in human C8161 melanoma: inhibition by ectopic Bcl-2 expression. Biochem. Pharmacol. 2003, 65:1593-1601.
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 1593-1601
    • Rieber, M.1    Rieber, M.S.2
  • 56
    • 79551580561 scopus 로고    scopus 로고
    • ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
    • Cosentino C., Grieco D., Costanzo V. ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. EMBO J. 2011, 30:546-555.
    • (2011) EMBO J. , vol.30 , pp. 546-555
    • Cosentino, C.1    Grieco, D.2    Costanzo, V.3
  • 57
    • 84855607470 scopus 로고    scopus 로고
    • The ATM protein kinase and cellular redox signaling: beyond the DNA damage response
    • Ditch S., Paull T.T. The ATM protein kinase and cellular redox signaling: beyond the DNA damage response. Trends Biochem. Sci. 2012, 37:15-22.
    • (2012) Trends Biochem. Sci. , vol.37 , pp. 15-22
    • Ditch, S.1    Paull, T.T.2
  • 58
    • 84856673305 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase in cerebella of Atm-/- mice is attributable to accumulation of reactive oxygen species
    • Kuang X., Yan M., Ajmo J.M., Scofield V.L., Stoica G., et al. Activation of AMP-activated protein kinase in cerebella of Atm-/- mice is attributable to accumulation of reactive oxygen species. Biochem. Biophys. Res. Commun. 2012, 418:267-272.
    • (2012) Biochem. Biophys. Res. Commun. , vol.418 , pp. 267-272
    • Kuang, X.1    Yan, M.2    Ajmo, J.M.3    Scofield, V.L.4    Stoica, G.5
  • 59
    • 0035266308 scopus 로고    scopus 로고
    • Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice
    • Kamsler A., Daily D., Hochman A., Stern N., Shiloh Y., et al. Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice. Cancer Res. 2001, 61:1849-1854.
    • (2001) Cancer Res. , vol.61 , pp. 1849-1854
    • Kamsler, A.1    Daily, D.2    Hochman, A.3    Stern, N.4    Shiloh, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.