Mitochondria-dependent reactive oxygen species-mediated programmed cell death induced by 3,3′-diindolylmethane through inhibition of F0F1-ATP synthase in unicellular protozoan parasite Leishmania donovani

Molecular Pharmacology

Volumn 74, Issue 5, 2008, Pages 1292-1307

  Roy, Amit ^a   Ganguly, Agneyo ^a   BoseDasgupta, Somdeb ^a   Das, Benu Brata ^b   Pal, Churala ^a   Jaisankar, Parasuraman ^a   Majumder, Hemanta K ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,3' DIINDOLYLMETHANE; ADENOSINE TRIPHOSPHATE; CYTOCHROME C; DNA TOPOISOMERASE INHIBITOR; MITOCHONDRIAL DNA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; APOPTOSIS; ARTICLE; DNA FRAGMENTATION; ENZYME INHIBITION; LEISHMANIA DONOVANI; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; DNA REPLICATION; ENZYME ACTIVATION; ENZYME INHIBITORS; GLUTATHIONE; INDOLES; LEISHMANIA DONOVANI; LIPID PEROXIDATION; MEMBRANE POTENTIALS; MITOCHONDRIA; OXIDATIVE STRESS; PROTON-TRANSLOCATING ATPASES; REACTIVE OXYGEN SPECIES;

EID: 54349122238     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.050161     Document Type: Article

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