N-acetylcysteine enhances UV-mediated caspase-3 activation, fragmentation of E2F-4, and apoptosis in human C8161 melanoma: Inhibition by ectopic Bcl-2 expression

Biochemical Pharmacology

Volumn 65, Issue 10, 2003, Pages 1593-1601

  Rieber, Manuel ^a   Rieber, Mary Strasberg ^a  

^a Instituto Venezolano de Investigaciones Cientificas Centro de Microbiologia y Biologia Celular   (Venezuela)

Author keywords

Apoptosis; Caspase 3 substrates; E2F 1 induction; E2F 4 fragmentation

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CASPASE 3; ETOPOSIDE; HYDROGEN PEROXIDE; PROTEIN BCL 2; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F4; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; ENZYME ACTIVATION; FIBROBLAST; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; TUMOR CELL; ULTRAVIOLET RADIATION;

EID: 0038732425     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00147-3     Document Type: Article

References (31)

1. Senturker S., Tschirret-Guth R., Morrow J., Levine R., Schecter E. Induction of apoptosis by chemotherapeutic drugs without generation of reactive oxygen species. Arch. Biochem. Biophys. 397:2002;262-272.
2. 2+-dependent endonuclease. Biochem. Pharmacol. 63:2002;225-236.
3. Katsuda K., Kataoka M., Uno F., Murakami T., Kondo T., Roth J.A., Tanaka N., Fujiwara T. Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells. Oncogene. 21:2002;2108-2113.
4. Fattman C.L., Delach S.M., Dou Q.P., Johnson D.E. Sequential two-step cleavage of the retinoblastoma protein by caspase-3/-7 during etoposide-induced apoptosis. Oncogene. 20:2001;2918-2926.
5. Tsai J.C., Jain M., Hsieh C.M., Lee W.S., Yoshizumi M., Patterson C., Perrella M.A., Cooke C., Wang H., Haber E., Schlegel R., Lee M.E. Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J. Biol. Chem. 271:1996;3667-3670.
6. Liu M., Pelling J.C., Ju J., Chu E., Brash D.E. Antioxidant action via p53-mediated apoptosis. Cancer Res. 58:1998;1723-1729.
7. 1 prolongation by the chemopreventive agent N-acetylcysteine. Carcinogenesis. 20:1999;1869-1872.
8. Kagan V.E., Kuzmenko A.I., Tyurina Y.Y., Shvedova A.A., Matsura T., Yalowich J.C. Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: role of myeloperoxidase. Cancer Res. 61:2001;7777-7784.
9. O'Reilly S., McCormick J.J., Brash D.E. Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol anti-oxidants, N-acetyl cysteine and penicillamine. Cancer Res. 62:2002;1443-1449.
10. Goldman Y., Peled A., Shinitzky M. Effective elimination of lung metastases induced by tumor cells treated with hydrostatic pressure and N-acetyl-L-cysteine. Cancer Res. 60:2000;350-358.
11. Riley P.A. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int. J. Radiat. Biol. 65:1994;27-33.
12. Renzing J., Hansen S., Lane D.P. Oxidative stress is involved in the UV activation of p53. J. Cell Sci. 109:1996;1105-1112.
13. Strasberg-Rieber M., Zangemeister-Wittke U., Rieber M. p53-independent induction of apoptosis in human melanoma cells by a bcl-2/bcl-xL bispecific antisense oligonucleotide. Clin. Cancer Res. 7:2001;1446-1451.
14. Woo M., Hakem R., Soengas M.S., Duncan G.S., Shahinian A., Kägi D., Hakem A., McCurrach M., Khoo W., Kaufman S.A., Senaldi G., Howard T., Lowe S.W., Mak T.W. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev. 12:1998;806-819.
15. Luo K.Q., Yu V.C., Pu Y., Chang D.C. Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in living HeLa cells. Biochem. Biophys. Res. Commun. 283:2001;1054-1060.
16. WAF1/Cip1-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin E. Neoplasia. 1:1999;544-556.
17. Hofmann F., Martelli F., Livingston D.M., Wang Z. The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes Dev. 10:1996;2949-2959.
18. Moberg K., Starz M.A., Lees J.A. E2F4 switches from p130 to p107 and pRb in response to cell cycle entry. Mol. Cell Biol. 6:1996;1436-1449.
19. Wang D., Russell J.L., Johnson D.G. E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo. Mol. Cell Biol. 20:2000;3417-3424.
20. Furukawa Y., Iwase S., Kikuchi J., Nakamura M., Yamada H., Matsuda M. Transcriptional repression of the E2F-1 gene by interferon-α is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes. Oncogene. 18:1999;2003-2014.
21. Hou S.T., Cowan E., Dostanic S., Rasquinha I., Comas T., Morley P., MacManus J.P. Increased expression of the transcription factor E2F1 during dopamine-evoked, caspase-3-mediated apoptosis in rat cortical neurons. Neurosci. Lett. 306:2001;153-156.
22. Zhang X., Kiechle F.L. Hoechst 33342-induced apoptosis is associated with intracellular accumulation of E2F-1 protein in BC3H-1 myocytes and HL-60 cells. Arch. Pathol. Lab. Med. 125:2001;99-104.
23. Rice P.L., Goldberg R.J., Ray E.C., Driggers L.J., Ahnen D.J. Inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and induction of apoptosis by sulindac metabolites. Cancer Res. 61:2001;1541-1547.
24. McCurrach M.E., Connor T.M.F., Knudson C.M., Korsmeyer S.J., Lowe S.W. bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc. Natl. Acad. Sci. U.S.A. 94:1997;2345-2349.
25. O'Brien J., Wilson I., Orton T., Pognan F. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur. J. Biochem. 267:2000;5421-5426.
26. Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:1992;493-501.
27. Sebolt-Leopold J.S. Development of anticancer drugs targeting the MAP kinase pathway. Review Oncogene. 19:2000;6594-6599.
28. Peus D., Meves A., Pott M., Beyerle A., Pittelkow M.R. Vitamin E analog modulates UVB-induced signaling pathway activation and enhances cell survival. Free Radic. Biol. Med. 30:2001;425-432.
29. 2. Role in cell survival following oxidant injury. J. Biol. Chem. 271:1996;4138-4142.
30. L inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein. J. Biol. Chem. 277:2002;11345-11351.
31. Bi B., Littlewood N.K., Crispe I.N. Cleavage of E2F-1-regulating proteins and activation of E2F-1 during CD95-induced death of thymocytes. Immunology. 104:2001;37-42.