Diammonium glycyrrhizinate upregulates PGC-1α and protects against Aβ 1-42-induced neurotoxicity

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Zhu, Xiaolei ^a,b   Chen, Cong ^b   Ye, Dan ^b   Guan, Dening ^b   Ye, Lan ^b   Jin, Jiali ^b   Zhao, Hui ^b   Chen, Yanting ^b   Wang, Zhongyuan ^a,b   Wang, Xin ^a   Xu, Yun ^a,b,c  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CASPASE 3; CASPASE 9; DIAMMONIUM GLYCYRRHIZINATE; GLYCYRRHIZIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; PPARGC1A PROTEIN, MOUSE; SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOACCUMULATION; BRAIN MITOCHONDRION; CELL LOSS; CELL VIABILITY; COGNITIVE DEFECT; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LATENT PERIOD; LIPID PEROXIDATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; CELL CULTURE; CYTOLOGY; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; MITOCHONDRION; NERVE CELL; PATHOLOGY; RNA INTERFERENCE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GLYCYRRHIZIC ACID; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANS-ACTIVATORS; UP-REGULATION;

EID: 84859949806     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035823     Document Type: Article

References (34)

1. Winner B, Kohl Z, Gage FH, (2011) Neurodegenerative disease and adult neurogenesis. Eur J Neurosci 33: 1139-1151.
2. Miranda S, Opazo C, Larrondo LF, Munoz FJ, Ruiz F, et al. (2000) The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease. Prog Neurobiol 62: 633-648.
3. Sultana R, Butterfield DA, (2010) Role of oxidative stress in the progression of Alzheimer's disease. J Alzheimers Dis 19: 341-353.
4. Selkoe DJ, (2000) Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann N Y Acad Sci 924: 17-25.
5. Sheng B, Wang X, Su B, Lee HG, Casadesus G, et al. (2012) Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease. J Neurochem 120: 419-429.
6. Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, et al. (2008) Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci U S A 105: 19318-19323.
7. Wang X, Su B, Lee HG, Li X, Perry G, et al. (2009) Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 29: 9090-9103.
8. Allen JW, Eldadah BA, Huang X, Knoblach SM, Faden AI, (2001) Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis. J Neurosci Res 65: 45-53.
9. Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, et al. (2006) Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease. Exp Gerontol 41: 668-673.
10. Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, et al. (2004) ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science 304: 448-452.
11. Liu C, Lin JD, (2011) PGC-1 coactivators in the control of energy metabolism. Acta Biochim Biophys Sin (Shanghai) 43: 248-257.
12. Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, et al. (2005) PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol 3: e101.
13. Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, et al. (2004) Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119: 121-135.
14. Zhu HR, Wang ZY, Zhu XL, Wu XX, Li EG, et al. (2010) Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke. Neuropharmacology 59: 70-76.
15. Rasouri S, Lagouge M, Auwerx J, (2007) [SIRT1/PGC-1: a neuroprotective axis?]. Med Sci (Paris) 23: 840-844.
16. Wareski P, Vaarmann A, Choubey V, Safiulina D, Liiv J, et al. (2009) PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. J Biol Chem 284: 21379-21385.
17. St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, et al. (2006) Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127: 397-408.
18. Scott Bitner R, (2011) Cyclic AMP response element-binding protein (CREB) phosphorylation: A mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics. Biochem Pharmacol.
19. Jeong HG, You HJ, Park SJ, Moon AR, Chung YC, et al. (2002) Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression. Pharmacol Res 46: 221-227.
20. Arjumand W, Sultana S, (2011) Glycyrrhizic acid: A phytochemical with a protective role against cisplatin-induced genotoxicity and nephrotoxicity. Life Sci 89: 422-429.
21. Michaelis M, Geiler J, Naczk P, Sithisarn P, Leutz A, et al. (2011) Glycyrrhizin exerts antioxidative effects in H5N1 influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression. PLoS One 6: e19705.
22. Ishikawa A, Kanamaru R, Wakui A, Kanno S, Ohtsuki K, (1990) Characterization of glycyrrhizin-binding protein kinase from the crude membrane fraction of rat liver. Biochem Biophys Res Commun 167: 876-882.
23. Fiore C, Eisenhut M, Krausse R, Ragazzi E, Pellati D, et al. (2008) Antiviral effects of Glycyrrhiza species. Phytother Res 22: 141-148.
24. Feng C, Wang H, Yao C, Zhang J, Tian Z, (2007) Diammonium glycyrrhizinate, a component of traditional Chinese medicine Gan-Cao, prevents murine T-cell-mediated fulminant hepatitis in IL-10- and IL-6-dependent manners. Int Immunopharmacol 7: 1292-1298.
25. Xu Y, Traystman RJ, Hurn PD, Wang MM, (2004) Membrane restraint of estrogen receptor alpha enhances estrogen-dependent nuclear localization and genomic function. Mol Endocrinol 18: 86-96.
26. Qin W, Ho L, Wang J, Peskind E, Pasinetti GM, (2009) S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10. PLoS One 4: e4183.
27. Gumpricht E, Dahl R, Devereaux MW, Sokol RJ, (2005) Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes. J Biol Chem 280: 10556-10563.
28. Yoshida T, Tsuda Y, Takeuchi D, Kobayashi M, Pollard RB, et al. (2006) Glycyrrhizin inhibits neutrophil-associated generation of alternatively activated macrophages. Cytokine 33: 317-322.
29. Yamamura Y, Santa T, Kotaki H, Uchino K, Sawada Y, et al. (1995) Administration-route dependency of absorption of glycyrrhizin in rats: intraperitoneal administration dramatically enhanced bioavailability. Biol Pharm Bull 18: 337-341.
30. Lin JD, (2009) Minireview: the PGC-1 coactivator networks: chromatin-remodeling and mitochondrial energy metabolism. Mol Endocrinol 23: 2-10.
31. Shoag J, Arany Z, (2010) Regulation of hypoxia-inducible genes by PGC-1 alpha. Arterioscler Thromb Vasc Biol 30: 662-666.
32. Pallas M, Casadesus G, Smith MA, Coto-Montes A, Pelegri C, et al. (2009) Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection. Curr Neurovasc Res 6: 70-81.
33. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, et al. (2001) CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413: 179-183.
34. Saura CA, Valero J, (2011) The role of CREB signaling in Alzheimer's disease and other cognitive disorders. Rev Neurosci 22: 153-169.