-
2
-
-
34547692622
-
Trinucleotide repeat disorders
-
Orr H.T., and Zoghbi H.Y. Trinucleotide repeat disorders. Annu. Rev. Neurosci. 30 (2007) 575-621
-
(2007)
Annu. Rev. Neurosci.
, vol.30
, pp. 575-621
-
-
Orr, H.T.1
Zoghbi, H.Y.2
-
3
-
-
37849030901
-
Polyglutamine diseases: emerging concepts in pathogenesis and therapy
-
Shao J., and Diamond M.I. Polyglutamine diseases: emerging concepts in pathogenesis and therapy. Hum. Mol. Genet. 16 (2007) R115-R123
-
(2007)
Hum. Mol. Genet.
, vol.16
-
-
Shao, J.1
Diamond, M.I.2
-
4
-
-
52049093169
-
Polyglutamine neurodegeneration: protein misfolding revisited
-
Williams A.J., and Paulson H.L. Polyglutamine neurodegeneration: protein misfolding revisited. Trends Neurosci. 31 (2008) 521-528
-
(2008)
Trends Neurosci.
, vol.31
, pp. 521-528
-
-
Williams, A.J.1
Paulson, H.L.2
-
5
-
-
0032475941
-
Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice
-
Klement I.A., Skinner P.J., Kaytor M.D., Yi H., Hersch S.M., Clark H.B., Zoghbi H.Y., and Orr H.T. Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell 95 (1998) 41-53
-
(1998)
Cell
, vol.95
, pp. 41-53
-
-
Klement, I.A.1
Skinner, P.J.2
Kaytor, M.D.3
Yi, H.4
Hersch, S.M.5
Clark, H.B.6
Zoghbi, H.Y.7
Orr, H.T.8
-
6
-
-
67650330344
-
Molecular pathogenesis of spinocerebellar ataxia type 1 disease
-
Kang S., and Hong S. Molecular pathogenesis of spinocerebellar ataxia type 1 disease. Mol. Cells 27 (2009) 621-627
-
(2009)
Mol. Cells
, vol.27
, pp. 621-627
-
-
Kang, S.1
Hong, S.2
-
7
-
-
23944438950
-
The AXH domain of ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins
-
Tsuda H., Jafar-Nejad H., Patel A.J., Sun Y., Chen H.K., Rose M.F., Venken K.J., Botas J., Orr H.T., Bellen H.J., and Zoghbi H.Y. The AXH domain of ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell 26 (2005) 633-644
-
(2005)
Cell
, vol.26
, pp. 633-644
-
-
Tsuda, H.1
Jafar-Nejad, H.2
Patel, A.J.3
Sun, Y.4
Chen, H.K.5
Rose, M.F.6
Venken, K.J.7
Botas, J.8
Orr, H.T.9
Bellen, H.J.10
Zoghbi, H.Y.11
-
8
-
-
0036850456
-
Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila
-
Chan H.Y., Warrick J.M., Andriola I., Merry D., and Bonini N.M. Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila. Hum. Mol. Genet. 11 (2002) 2895-2904
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 2895-2904
-
-
Chan, H.Y.1
Warrick, J.M.2
Andriola, I.3
Merry, D.4
Bonini, N.M.5
-
9
-
-
0037015833
-
SUMO-1 co-localized with mutant atrophin-1 with expanded polyglutamines accelerates intranuclear aggregation and cell death
-
Terashima T., Kawai H., Fujitani M., Maeda K., and Yasuda H. SUMO-1 co-localized with mutant atrophin-1 with expanded polyglutamines accelerates intranuclear aggregation and cell death. Neuroreport 13 (2002) 2359-2364
-
(2002)
Neuroreport
, vol.13
, pp. 2359-2364
-
-
Terashima, T.1
Kawai, H.2
Fujitani, M.3
Maeda, K.4
Yasuda, H.5
-
10
-
-
20444467297
-
SUMOylation of the polyglutamine repeat protein, ataxin-1, is dependent on a functional nuclear localization signal
-
Riley B.E., Zoghbi H.Y., and Orr H.T. SUMOylation of the polyglutamine repeat protein, ataxin-1, is dependent on a functional nuclear localization signal. J. Biol. Chem. 280 (2005) 21942-21948
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 21942-21948
-
-
Riley, B.E.1
Zoghbi, H.Y.2
Orr, H.T.3
-
12
-
-
0041382926
-
Oxidative stimuli affect polyglutamine aggregation and cell death in human mutant ataxin-1-expressing cells
-
Kim S.J., Kim T.-S., Hong S., Rhim H., Kim I.Y., and Kang S. Oxidative stimuli affect polyglutamine aggregation and cell death in human mutant ataxin-1-expressing cells. Neurosci. Lett. 348 (2003) 21-24
-
(2003)
Neurosci. Lett.
, vol.348
, pp. 21-24
-
-
Kim, S.J.1
Kim, T.-S.2
Hong, S.3
Rhim, H.4
Kim, I.Y.5
Kang, S.6
-
13
-
-
33845864451
-
Co-chaperone CHIP promotes aggregation of ataxin-1
-
Choi J.Y., Ryu J.H., Kim H.S., Park S.G., Bae K.H., Kang S., Myung P.K., Cho S., Park B.C., and Lee D.H. Co-chaperone CHIP promotes aggregation of ataxin-1. Mol. Cell. Neurosci. 34 (2007) 69-79
-
(2007)
Mol. Cell. Neurosci.
, vol.34
, pp. 69-79
-
-
Choi, J.Y.1
Ryu, J.H.2
Kim, H.S.3
Park, S.G.4
Bae, K.H.5
Kang, S.6
Myung, P.K.7
Cho, S.8
Park, B.C.9
Lee, D.H.10
-
14
-
-
39749151070
-
G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1
-
Lee J.A., Park J.E., Lee D.H., Park S.G., Myung P.K., Park B.C., and Cho S. G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1. Oncogene 27 (2008) 1297-1305
-
(2008)
Oncogene
, vol.27
, pp. 1297-1305
-
-
Lee, J.A.1
Park, J.E.2
Lee, D.H.3
Park, S.G.4
Myung, P.K.5
Park, B.C.6
Cho, S.7
-
15
-
-
0036237383
-
Versatile protein tag, SUMO: its enzymology and biological function
-
Kim K.I., Baek S.H., and Chung C.H. Versatile protein tag, SUMO: its enzymology and biological function. J. Cell. Physiol. 191 (2002) 257-268
-
(2002)
J. Cell. Physiol.
, vol.191
, pp. 257-268
-
-
Kim, K.I.1
Baek, S.H.2
Chung, C.H.3
-
16
-
-
0037077265
-
Identification of a substrate recognition site on Ubc9
-
Lin D., Tatham M.H., Yu B., Kim S., Hay R.T., and Chen Y. Identification of a substrate recognition site on Ubc9. J. Biol. Chem. 277 (2002) 21740-21748
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 21740-21748
-
-
Lin, D.1
Tatham, M.H.2
Yu, B.3
Kim, S.4
Hay, R.T.5
Chen, Y.6
-
17
-
-
0037846441
-
Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice
-
Emamian E.S., Kaytor M.D., Duvick L.A., Zu T., Tousey S.K., Zoghbi H.Y., Clark H.B., and Orr H.T. Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice. Neuron 38 (2003) 375-387
-
(2003)
Neuron
, vol.38
, pp. 375-387
-
-
Emamian, E.S.1
Kaytor, M.D.2
Duvick, L.A.3
Zu, T.4
Tousey, S.K.5
Zoghbi, H.Y.6
Clark, H.B.7
Orr, H.T.8
-
18
-
-
0037726598
-
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1
-
Chen H.K., Fernandez-Funez P., Acevedo S.F., Lam Y.C., Kaytor M.D., Fernandez M.H., Aitken A., Skoulakis E.M.C., Orr H.T., Botas J., and Zoghbi H.Y. Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. Cell 113 (2003) 457-468
-
(2003)
Cell
, vol.113
, pp. 457-468
-
-
Chen, H.K.1
Fernandez-Funez, P.2
Acevedo, S.F.3
Lam, Y.C.4
Kaytor, M.D.5
Fernandez, M.H.6
Aitken, A.7
Skoulakis, E.M.C.8
Orr, H.T.9
Botas, J.10
Zoghbi, H.Y.11
-
19
-
-
0036260697
-
Cellular response to oxidative stress: signaling for suicide and survival
-
Martindale J.L., and Holbrook N.J. Cellular response to oxidative stress: signaling for suicide and survival. J. Cell. Physiol. 192 (2002) 1-15
-
(2002)
J. Cell. Physiol.
, vol.192
, pp. 1-15
-
-
Martindale, J.L.1
Holbrook, N.J.2
-
20
-
-
0038039288
-
Polyglutamine protein aggregation and toxicity are linked to the cellular stress response
-
Cowan K.J., Diamond M.I., and Welch W.J. Polyglutamine protein aggregation and toxicity are linked to the cellular stress response. Hum. Mol. Genet. 12 (2003) 1377-1391
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 1377-1391
-
-
Cowan, K.J.1
Diamond, M.I.2
Welch, W.J.3
-
21
-
-
0038269098
-
Polyglutamine expansion induces a protein-damaging stress connecting heat shock protein 70 to the JNK pathway
-
Merienne K., Helmlinger D., Perkin G.R., Devys D., and Trottier Y. Polyglutamine expansion induces a protein-damaging stress connecting heat shock protein 70 to the JNK pathway. J. Biol. Chem. 278 (2003) 16957-16967
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 16957-16967
-
-
Merienne, K.1
Helmlinger, D.2
Perkin, G.R.3
Devys, D.4
Trottier, Y.5
-
22
-
-
0034597833
-
Identification of genes that modify ataxin-1-induced neurodegeneration
-
Fernandez-Funez P., Nino-Rosales M.L., de Gouyon B., She W.-C., Luchak J.-M., Martinez P., Turiegano E., et al. Identification of genes that modify ataxin-1-induced neurodegeneration. Nature 408 (2000) 101-106
-
(2000)
Nature
, vol.408
, pp. 101-106
-
-
Fernandez-Funez, P.1
Nino-Rosales, M.L.2
de Gouyon, B.3
She, W.-C.4
Luchak, J.-M.5
Martinez, P.6
Turiegano, E.7
-
23
-
-
0035858883
-
Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1
-
Meriin A.B., Mabuchi K., Gabai V.L., Yaglom J.A., Kazantsev A., and Sherman M.Y. Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1. J. Cell Biol. 153 (2001) 851-864
-
(2001)
J. Cell Biol.
, vol.153
, pp. 851-864
-
-
Meriin, A.B.1
Mabuchi, K.2
Gabai, V.L.3
Yaglom, J.A.4
Kazantsev, A.5
Sherman, M.Y.6
-
24
-
-
37749021009
-
A role for SUMO modification in transcriptional repression and activation
-
Lyst M.J., and Stancheva I. A role for SUMO modification in transcriptional repression and activation. Biochem. Soc. Trans. 35 (2007) 1389-1392
-
(2007)
Biochem. Soc. Trans.
, vol.35
, pp. 1389-1392
-
-
Lyst, M.J.1
Stancheva, I.2
-
25
-
-
69249090927
-
Small ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregation
-
Mukherjee S., Thomas M., Dadgar N., Lieberman A.P., and Iniguez-Lluhí J.A. Small ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregation. J. Biol. Chem. 284 (2009) 21296-21306
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 21296-21306
-
-
Mukherjee, S.1
Thomas, M.2
Dadgar, N.3
Lieberman, A.P.4
Iniguez-Lluhí, J.A.5
-
26
-
-
77649186048
-
SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7
-
Janer A., Werner A., Takahashi-Fujigasaki J., Daret A., Fujigasaki H., Takada K., Duyckaerts C., Brice A., Dejean A., and Sittler A. SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7. Hum. Mol. Genet. 19 (2010) 181-195
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 181-195
-
-
Janer, A.1
Werner, A.2
Takahashi-Fujigasaki, J.3
Daret, A.4
Fujigasaki, H.5
Takada, K.6
Duyckaerts, C.7
Brice, A.8
Dejean, A.9
Sittler, A.10
-
27
-
-
0037295721
-
Modification with SUMO. A role in transcriptional regulation
-
Verger A., Perdomo J., and Crossley M. Modification with SUMO. A role in transcriptional regulation. EMBO Rep. 4 (2003) 137-142
-
(2003)
EMBO Rep.
, vol.4
, pp. 137-142
-
-
Verger, A.1
Perdomo, J.2
Crossley, M.3
-
29
-
-
0041669469
-
Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity
-
Yang S.-H., Jaffray E., Hay R.T., and Sharrocks A.D. Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. Mol. Cell 12 (2003) 63-74
-
(2003)
Mol. Cell
, vol.12
, pp. 63-74
-
-
Yang, S.-H.1
Jaffray, E.2
Hay, R.T.3
Sharrocks, A.D.4
-
30
-
-
0347065367
-
Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4
-
Ohshima T., and Shimotohno K. Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4. J. Biol. Chem. 278 (2003) 50833-50842
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 50833-50842
-
-
Ohshima, T.1
Shimotohno, K.2
-
31
-
-
0036606540
-
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
-
Nishitoh H., Matsuzawa A., Tobiume K., Saegusa K., Takeda K., Inoue K., Hori S., Kakizuka A., and Ichijo H. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 16 (2002) 1345-1355
-
(2002)
Genes Dev.
, vol.16
, pp. 1345-1355
-
-
Nishitoh, H.1
Matsuzawa, A.2
Tobiume, K.3
Saegusa, K.4
Takeda, K.5
Inoue, K.6
Hori, S.7
Kakizuka, A.8
Ichijo, H.9
-
32
-
-
76249091683
-
Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington Disease
-
Cho K.J., Lee B.I., Cheon S.Y., Kim H.W., Kim H.J., and Kim G.W. Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington Disease. Neuroscience 163 (2009) 1128-1134
-
(2009)
Neuroscience
, vol.163
, pp. 1128-1134
-
-
Cho, K.J.1
Lee, B.I.2
Cheon, S.Y.3
Kim, H.W.4
Kim, H.J.5
Kim, G.W.6
-
33
-
-
77649185172
-
Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors
-
de Chiara C., Menon R.P., Strom M., Gibson T.J., and Pastore A. Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors. PLoS ONE 4 (2009) e8372
-
(2009)
PLoS ONE
, vol.4
-
-
de Chiara, C.1
Menon, R.P.2
Strom, M.3
Gibson, T.J.4
Pastore, A.5
|