Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion

Neurobiology of Disease

Volumn 46, Issue 1, 2012, Pages 147-156

  Kim, Seung Woo ^a   Jin, Yinchuan ^a   Shin, Joo Hyun ^a   Kim, Il Doo ^a   Lee, Hye Kyung ^a   Park, Sunghyouk ^b   Han, Pyung Lim ^c   Lee, Ja Kyeong ^a  

^a Inha University School of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Ewha Womans University   (South Korea)

Author keywords

Anti inflammation; Glycyrrhizin; HMGB1; MCAO; Neuroprotection

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE IV; CHEMOATTRACTANT; CYCLOOXYGENASE 2; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCYRRHIZIC ACID; HIGH MOBILITY GROUP B1 PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; PROTEIN KINASE C; TRITERPENE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIEXCITOTOXIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN ISCHEMIA; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG SCREENING; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOGENICITY; MOLECULAR DYNAMICS; MOTOR DYSFUNCTION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; TREATMENT DURATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRAIN ISCHEMIA; GLYCYRRHIZIC ACID; HMGB1 PROTEIN; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84862779194     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2011.12.056     Document Type: Article

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