Low dose of oleanolic acid Protects against lithocholic acid-induced cholestasis in mice: Potential involvement of nuclear Factor-E2-Related factor 2-Mediated upregulation of multidrug Resistance-Associated proteinss

Drug Metabolism and Disposition

Volumn 42, Issue 5, 2014, Pages 844-852

  Chen, Pan ^a   Zeng, Hang ^a   Wang, Yongtao ^a   Fan, Xiaomei ^a   Xu, Chenshu ^b   Deng, Rongrong ^a   Zhou, Xunian ^a   Bi, Huichang ^a   Huang, Min ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILE ACID; BILE SALT EXPORT PUMP; BILIRUBIN; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 2B10; CYTOCHROME P450 3A11; FARNESOID X RECEPTOR; GLUCURONOSYLTRANSFERASE 1A1; LITHOCHOLIC ACID; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; NUCLEAR PROTEIN; OLEANOLIC ACID; ORGANIC ANION TRANSPORTER 1B2; PREGNANE X RECEPTOR; SODIUM BILE ACID COTRANSPORTER; SULFOTRANSFERASE; SULFOTRANSFERASE 2A1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE ACID BLOOD LEVEL; BILE ACID METABOLISM; BILE SALT EXPORT PUMP GENE; BILIRUBIN BLOOD LEVEL; CHOLESTASIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYP2B10 GENE; CYP3A11 GENE; GENE EXPRESSION; GENE SILENCING; LIVER NECROSIS; LIVER TOXICITY; LOW DRUG DOSE; MALE; MOUSE; MRP2 GENE; MRP3 GENE; MRP4 GENE; NONHUMAN; NRF2 GENE; ORGANIC ANION TRANSPORTER 1B2 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SODIUM BILE ACID COTRANSPORTER GENE; SULT2A1 GENE; SURVIVAL RATE; UGT1A1 GENE; UPREGULATION; AGONISTS; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; GENETICS; HEPG2 CELL LINE; HUMAN; LIVER CELL; LIVER FUNCTION TEST; METABOLISM; PRIMARY CELL CULTURE;

ANIMALS; CHOLESTASIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION; HEP G2 CELLS; HEPATOCYTES; HUMANS; LITHOCHOLIC ACID; LIVER FUNCTION TESTS; MALE; MICE; MICE, INBRED C57BL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NF-E2-RELATED FACTOR 2; OLEANOLIC ACID; PRIMARY CELL CULTURE; UP-REGULATION;

EID: 84898772349     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.056549     Document Type: Article

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