메뉴 건너뛰기




Volumn 82, Issue , 2014, Pages 1-8

How can i halt thee? the puzzles involved in autophagic inhibition

Author keywords

3 Methyladenine; Apoptosis; Atg5; Autophagy; Beclin1

Indexed keywords

3 METHYLADENINE; ALOXISTATIN; AUTOPHAGY PROTEIN 12; AUTOPHAGY PROTEIN 5; BAFILOMYCIN A1; BECLIN 1; CELL PROTEIN; MONENSIN; PEPSTATIN; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG; WORTMANNIN;

EID: 84898729030     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2014.03.005     Document Type: Review
Times cited : (47)

References (59)
  • 2
    • 33846794896 scopus 로고    scopus 로고
    • Autophagy inhibition enhances therapy-induced apoptosis in a myc-induced model of lymphoma
    • R.K. Amaravadi, D. Yu, J.J. Lum, T. Bui, M.A. Christophorou, and G.I. Evan et al. Autophagy inhibition enhances therapy-induced apoptosis in a myc-induced model of lymphoma J Clin Invest 117 2007 326 336
    • (2007) J Clin Invest , vol.117 , pp. 326-336
    • Amaravadi, R.K.1    Yu, D.2    Lum, J.J.3    Bui, T.4    Christophorou, M.A.5    Evan, G.I.6
  • 3
    • 34249798692 scopus 로고    scopus 로고
    • Autophagic and apoptotic response to stress signals in mammalian cells
    • E. Ferraro, and F. Cecconi Autophagic and apoptotic response to stress signals in mammalian cells Arch Biochem Biophys 462 2007 210 219
    • (2007) Arch Biochem Biophys , vol.462 , pp. 210-219
    • Ferraro, E.1    Cecconi, F.2
  • 4
    • 79952244140 scopus 로고    scopus 로고
    • Inhibition of autophagy by 3-ma potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells
    • D. Liu, Y. Yang, Q. Liu, and J. Wang Inhibition of autophagy by 3-ma potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells Med Oncol 28 2011 105 111
    • (2011) Med Oncol , vol.28 , pp. 105-111
    • Liu, D.1    Yang, Y.2    Liu, Q.3    Wang, J.4
  • 5
    • 42149086603 scopus 로고    scopus 로고
    • Cisplatin treatment of nih/3t3 cultures induces a form of autophagic death in polyploid cells
    • A. Spano, G. Monaco, S. Barni, and L. Sciola Cisplatin treatment of nih/3t3 cultures induces a form of autophagic death in polyploid cells Histol Histopathol 23 2008 717 730
    • (2008) Histol Histopathol , vol.23 , pp. 717-730
    • Spano, A.1    Monaco, G.2    Barni, S.3    Sciola, L.4
  • 6
    • 56749170677 scopus 로고    scopus 로고
    • Autophagic cell death: The story of a misnomer
    • G. Kroemer, and B. Levine Autophagic cell death: the story of a misnomer Nat Rev Mol Cell Biol 9 2008 1004 1010
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 1004-1010
    • Kroemer, G.1    Levine, B.2
  • 7
    • 84856431622 scopus 로고    scopus 로고
    • The end of autophagic cell death
    • S. Shen, O. Kepp, and G. Kroemer The end of autophagic cell death Autophagy 8 2012 1 3
    • (2012) Autophagy , vol.8 , pp. 1-3
    • Shen, S.1    Kepp, O.2    Kroemer, G.3
  • 8
    • 33645078650 scopus 로고    scopus 로고
    • Regulation of membrane traffic by phosphoinositide 3-kinases
    • K. Lindmo, and H. Stenmark Regulation of membrane traffic by phosphoinositide 3-kinases J Cell Sci 119 2006 605 614
    • (2006) J Cell Sci , vol.119 , pp. 605-614
    • Lindmo, K.1    Stenmark, H.2
  • 9
    • 17144395975 scopus 로고    scopus 로고
    • The activation of akt/pkb signaling pathway and cell survival
    • G. Song, G. Ouyang, and S. Bao The activation of akt/pkb signaling pathway and cell survival J Cell Mol Med 9 2005 59 71
    • (2005) J Cell Mol Med , vol.9 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 10
    • 20044370874 scopus 로고    scopus 로고
    • Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific akt/pkb family members
    • D. DeFeo-Jones, S.F. Barnett, S. Fu, P.J. Hancock, K.M. Haskell, and K.R. Leander et al. Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific akt/pkb family members Mol Cancer Ther 4 2005 271 279
    • (2005) Mol Cancer Ther , vol.4 , pp. 271-279
    • Defeo-Jones, D.1    Barnett, S.F.2    Fu, S.3    Hancock, P.J.4    Haskell, K.M.5    Leander, K.R.6
  • 11
    • 52449092107 scopus 로고    scopus 로고
    • Breast tumor cells with pi3k mutation or her2 amplification are selectively addicted to akt signaling
    • Q.B. She, S. Chandarlapaty, Q. Ye, J. Lobo, K.M. Haskell, and K.R. Leander et al. Breast tumor cells with pi3k mutation or her2 amplification are selectively addicted to akt signaling PLoS ONE 3 2008 e3065
    • (2008) PLoS ONE , vol.3 , pp. 3065
    • She, Q.B.1    Chandarlapaty, S.2    Ye, Q.3    Lobo, J.4    Haskell, K.M.5    Leander, K.R.6
  • 12
    • 33646789810 scopus 로고    scopus 로고
    • Gene silencing reveals a specific function of hvps34 phosphatidylinositol 3-kinase in late versus early endosomes
    • E.E. Johnson, J.H. Overmeyer, W.T. Gunning, and W.A. Maltese Gene silencing reveals a specific function of hvps34 phosphatidylinositol 3-kinase in late versus early endosomes J Cell Sci 119 2006 1219 1232
    • (2006) J Cell Sci , vol.119 , pp. 1219-1232
    • Johnson, E.E.1    Overmeyer, J.H.2    Gunning, W.T.3    Maltese, W.A.4
  • 13
    • 0037007215 scopus 로고    scopus 로고
    • Membrane transport in caenorhabditis elegans: An essential role for vps34 at the nuclear membrane
    • L. Roggo, V. Bernard, A.L. Kovacs, A.M. Rose, F. Savoy, and M. Zetka et al. Membrane transport in caenorhabditis elegans: an essential role for vps34 at the nuclear membrane Embo J 21 2002 1673 1683
    • (2002) Embo J , vol.21 , pp. 1673-1683
    • Roggo, L.1    Bernard, V.2    Kovacs, A.L.3    Rose, A.M.4    Savoy, F.5    Zetka, M.6
  • 14
    • 58149104300 scopus 로고    scopus 로고
    • Non-canonical autophagy: An exception or an underestimated form of autophagy
    • F. Scarlatti, R. Maffei, I. Beau, R. Ghidoni, and P. Codogno Non-canonical autophagy: an exception or an underestimated form of autophagy Autophagy 4 2008 1083 1085
    • (2008) Autophagy , vol.4 , pp. 1083-1085
    • Scarlatti, F.1    Maffei, R.2    Beau, I.3    Ghidoni, R.4    Codogno, P.5
  • 15
    • 0005677775 scopus 로고
    • 3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
    • P.O. Seglen, and P.B. Gordon 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes Proc Natl Acad Sci USA 79 1982 1889 1892
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 1889-1892
    • Seglen, P.O.1    Gordon, P.B.2
  • 16
    • 0033978633 scopus 로고    scopus 로고
    • Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in ht-29 cells
    • A. Petiot, E. Ogier-Denis, E.F. Blommaart, A.J. Meijer, and P. Codogno Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in ht-29 cells J Biol Chem 275 2000 992 998
    • (2000) J Biol Chem , vol.275 , pp. 992-998
    • Petiot, A.1    Ogier-Denis, E.2    Blommaart, E.F.3    Meijer, A.J.4    Codogno, P.5
  • 17
    • 77951217000 scopus 로고    scopus 로고
    • Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class i and iii phosphoinositide 3-kinase
    • Y.T. Wu, H.L. Tan, G. Shui, C. Bauvy, Q. Huang, and M.R. Wenk et al. Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class i and iii phosphoinositide 3-kinase J Biol Chem 285 2010 10850 10861
    • (2010) J Biol Chem , vol.285 , pp. 10850-10861
    • Wu, Y.T.1    Tan, H.L.2    Shui, G.3    Bauvy, C.4    Huang, Q.5    Wenk, M.R.6
  • 18
    • 0023729899 scopus 로고
    • 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism
    • L.H. Caro, P.J. Plomp, E.J. Wolvetang, C. Kerkhof, and A.J. Meijer 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism Eur J Biochem 175 1988 325 329
    • (1988) Eur J Biochem , vol.175 , pp. 325-329
    • Caro, L.H.1    Plomp, P.J.2    Wolvetang, E.J.3    Kerkhof, C.4    Meijer, A.J.5
  • 19
    • 84860159791 scopus 로고    scopus 로고
    • Inhibitors of phosphatidylinositol 3′-kinases promote mitotic cell death in hela cells
    • H. Hou, Y. Zhang, Y. Huang, Q. Yi, L. Lv, and T. Zhang et al. Inhibitors of phosphatidylinositol 3′-kinases promote mitotic cell death in hela cells PLoS ONE 7 2012 e35665
    • (2012) PLoS ONE , vol.7 , pp. 35665
    • Hou, H.1    Zhang, Y.2    Huang, Y.3    Yi, Q.4    Lv, L.5    Zhang, T.6
  • 20
    • 84875364684 scopus 로고    scopus 로고
    • 3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy
    • Y. Sheng, B. Sun, W.T. Guo, Y.H. Zhang, X. Liu, and Y. Xing et al. 3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy Biochem Biophys Res Commun 432 2013 5 9
    • (2013) Biochem Biophys Res Commun , vol.432 , pp. 5-9
    • Sheng, Y.1    Sun, B.2    Guo, W.T.3    Zhang, Y.H.4    Liu, X.5    Xing, Y.6
  • 21
    • 84877351008 scopus 로고    scopus 로고
    • Synthesis and screening of 3-MA derivatives for autophagy inhibitors
    • Y. Wu, X. Wang, H. Guo, B. Zhang, X.B. Zhang, and Z.J. Shi et al. Synthesis and screening of 3-MA derivatives for autophagy inhibitors Autophagy 9 2013 595 603
    • (2013) Autophagy , vol.9 , pp. 595-603
    • Wu, Y.1    Wang, X.2    Guo, H.3    Zhang, B.4    Zhang, X.B.5    Shi, Z.J.6
  • 22
    • 9744271049 scopus 로고    scopus 로고
    • Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase atm
    • I. Hickson, Y. Zhao, C.J. Richardson, S.J. Green, N.M. Martin, and A.I. Orr et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase atm Cancer Res 64 2004 9152 9159
    • (2004) Cancer Res , vol.64 , pp. 9152-9159
    • Hickson, I.1    Zhao, Y.2    Richardson, C.J.3    Green, S.J.4    Martin, N.M.5    Orr, A.I.6
  • 23
    • 80655144753 scopus 로고    scopus 로고
    • Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy
    • T. Farkas, M. Daugaard, and M. Jaattela Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy J Biol Chem 286 2011 38904 38912
    • (2011) J Biol Chem , vol.286 , pp. 38904-38912
    • Farkas, T.1    Daugaard, M.2    Jaattela, M.3
  • 24
    • 80053501671 scopus 로고    scopus 로고
    • Beclin1 controls the levels of p53 by regulating the deubiquitination activity of usp10 and usp13
    • J. Liu, H. Xia, M. Kim, L. Xu, Y. Li, and L. Zhang et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of usp10 and usp13 Cell 147 2011 223 234
    • (2011) Cell , vol.147 , pp. 223-234
    • Liu, J.1    Xia, H.2    Kim, M.3    Xu, L.4    Li, Y.5    Zhang, L.6
  • 26
    • 0035911162 scopus 로고    scopus 로고
    • Dissection of autophagosome formation using apg5-deficient mouse embryonic stem cells
    • N. Mizushima, A. Yamamoto, M. Hatano, Y. Kobayashi, Y. Kabeya, and K. Suzuki et al. Dissection of autophagosome formation using apg5-deficient mouse embryonic stem cells J Cell Biol 152 2001 657 668
    • (2001) J Cell Biol , vol.152 , pp. 657-668
    • Mizushima, N.1    Yamamoto, A.2    Hatano, M.3    Kobayashi, Y.4    Kabeya, Y.5    Suzuki, K.6
  • 27
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • T. Hara, K. Nakamura, M. Matsui, A. Yamamoto, Y. Nakahara, and R. Suzuki-Migishima et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice Nature 441 2006 885 889
    • (2006) Nature , vol.441 , pp. 885-889
    • Hara, T.1    Nakamura, K.2    Matsui, M.3    Yamamoto, A.4    Nakahara, Y.5    Suzuki-Migishima, R.6
  • 28
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: Core molecular machinery and signaling regulation
    • Z. Yang, and D.J. Klionsky Mammalian autophagy: core molecular machinery and signaling regulation Curr Opin Cell Biol 22 2010 124 131
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 29
    • 3042723794 scopus 로고    scopus 로고
    • Autophagy molecular mechanisms, physiological functions and relevance in human pathology
    • G. Marino, C. Lopez-Otin, and Autophagy Molecular mechanisms, physiological functions and relevance in human pathology Cell Mol Life Sci 61 2004 1439 1454
    • (2004) Cell Mol Life Sci , vol.61 , pp. 1439-1454
    • Marino, G.1    Lopez-Otin, C.2
  • 30
    • 77950252174 scopus 로고    scopus 로고
    • Cross talk between apoptosis and autophagy by caspase-mediated cleavage of beclin 1
    • M. Djavaheri-Mergny, M.C. Maiuri, and G. Kroemer Cross talk between apoptosis and autophagy by caspase-mediated cleavage of beclin 1 Oncogene 29 2010 1717 1719
    • (2010) Oncogene , vol.29 , pp. 1717-1719
    • Djavaheri-Mergny, M.1    Maiuri, M.C.2    Kroemer, G.3
  • 31
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit beclin 1-dependent autophagy
    • S. Pattingre, A. Tassa, X. Qu, R. Garuti, X.H. Liang, and N. Mizushima et al. Bcl-2 antiapoptotic proteins inhibit beclin 1-dependent autophagy Cell 122 2005 927 939
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3    Garuti, R.4    Liang, X.H.5    Mizushima, N.6
  • 32
    • 59249089394 scopus 로고    scopus 로고
    • Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian atg14 and uvrag
    • E. Itakura, C. Kishi, K. Inoue, and N. Mizushima Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian atg14 and uvrag Mol Biol Cell 19 2008 5360 5372
    • (2008) Mol Biol Cell , vol.19 , pp. 5360-5372
    • Itakura, E.1    Kishi, C.2    Inoue, K.3    Mizushima, N.4
  • 33
    • 64049113909 scopus 로고    scopus 로고
    • Distinct regulation of autophagic activity by atg14l and rubicon associated with beclin 1-phosphatidylinositol-3-kinase complex
    • Y. Zhong, Q.J. Wang, X. Li, Y. Yan, J.M. Backer, and B.T. Chait et al. Distinct regulation of autophagic activity by atg14l and rubicon associated with beclin 1-phosphatidylinositol-3-kinase complex Nat Cell Biol 11 2009 468 476
    • (2009) Nat Cell Biol , vol.11 , pp. 468-476
    • Zhong, Y.1    Wang, Q.J.2    Li, X.3    Yan, Y.4    Backer, J.M.5    Chait, B.T.6
  • 35
    • 38049115875 scopus 로고    scopus 로고
    • Apoptosis and autophagy. Regulatory connections between two supposedly different processes
    • A. Thorburn Apoptosis and autophagy. Regulatory connections between two supposedly different processes Apoptosis 13 2008 1 9
    • (2008) Apoptosis , vol.13 , pp. 1-9
    • Thorburn, A.1
  • 36
  • 38
    • 33646204392 scopus 로고    scopus 로고
    • Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size
    • N. Hosokawa, Y. Hara, and N. Mizushima Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size FEBS Lett 581 2007 2623 2629
    • (2007) FEBS Lett , vol.581 , pp. 2623-2629
    • Hosokawa, N.1    Hara, Y.2    Mizushima, N.3
  • 39
    • 84859639962 scopus 로고    scopus 로고
    • Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress
    • I.H. Lee, Y. Kawai, M.M. Fergusson, I.I. Rovira, A.J. Bishop, and N. Motoyama et al. Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress Science 336 2012 225 228
    • (2012) Science , vol.336 , pp. 225-228
    • Lee, I.H.1    Kawai, Y.2    Fergusson, M.M.3    Rovira, I.I.4    Bishop, A.J.5    Motoyama, N.6
  • 41
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Z. Yue, S. Jin, C. Yang, A.J. Levine, and N. Heintz Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor Proc Natl Acad Sci USA 100 2003 15077 15082
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 42
    • 21044455137 scopus 로고    scopus 로고
    • Impairment of starvation-induced and constitutive autophagy in atg7-deficient mice
    • M. Komatsu, S. Waguri, T. Ueno, J. Iwata, S. Murata, and I. Tanida et al. Impairment of starvation-induced and constitutive autophagy in atg7-deficient mice J Cell Biol 169 2005 425 434
    • (2005) J Cell Biol , vol.169 , pp. 425-434
    • Komatsu, M.1    Waguri, S.2    Ueno, T.3    Iwata, J.4    Murata, S.5    Tanida, I.6
  • 43
    • 11144245626 scopus 로고    scopus 로고
    • The role of autophagy during the early neonatal starvation period
    • A. Kuma, M. Hatano, M. Matsui, A. Yamamoto, H. Nakaya, and T. Yoshimori et al. The role of autophagy during the early neonatal starvation period Nature 432 2004 1032 1036
    • (2004) Nature , vol.432 , pp. 1032-1036
    • Kuma, A.1    Hatano, M.2    Matsui, M.3    Yamamoto, A.4    Nakaya, H.5    Yoshimori, T.6
  • 44
    • 84255177532 scopus 로고    scopus 로고
    • Who put the "a" in Atg12: Autophagy or apoptosis?
    • T. Ni Chonghaile, and A. Letai Who put the "A" in Atg12: Autophagy or apoptosis? Mol Cell 44 2010 844 845
    • (2010) Mol Cell , vol.44 , pp. 844-845
    • Ni Chonghaile, T.1    Letai, A.2
  • 45
    • 84873407151 scopus 로고    scopus 로고
    • Non-autophagic roles of autophagy-related proteins
    • S. Subramani, and V. Malhotra Non-autophagic roles of autophagy-related proteins EMBO Rep 14 2013 143 151
    • (2013) EMBO Rep , vol.14 , pp. 143-151
    • Subramani, S.1    Malhotra, V.2
  • 46
    • 84874651096 scopus 로고    scopus 로고
    • No atg is an island - The connection of autophagy with diverse pathways and functions
    • M. Komatsu, A. Kuma, and K. Okamoto No atg is an island - the connection of autophagy with diverse pathways and functions EMBO Rep 14 2013 219 221
    • (2013) EMBO Rep , vol.14 , pp. 219-221
    • Komatsu, M.1    Kuma, A.2    Okamoto, K.3
  • 47
    • 0031593675 scopus 로고    scopus 로고
    • Bafilomycin a1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, h-4-ii-e cells
    • A. Yamamoto, Y. Tagawa, T. Yoshimori, Y. Moriyama, R. Masaki, and Y. Tashiro Bafilomycin a1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, h-4-ii-e cells Cell Struct Funct 23 1998 33 42
    • (1998) Cell Struct Funct , vol.23 , pp. 33-42
    • Yamamoto, A.1    Tagawa, Y.2    Yoshimori, T.3    Moriyama, Y.4    Masaki, R.5    Tashiro, Y.6
  • 48
    • 77951915586 scopus 로고    scopus 로고
    • Autophagy during cardiac stress: Joys and frustrations of autophagy
    • R.A. Gottlieb, and R.M. Mentzer Autophagy during cardiac stress: joys and frustrations of autophagy Annu Rev Physiol 72 2010 45 59
    • (2010) Annu Rev Physiol , vol.72 , pp. 45-59
    • Gottlieb, R.A.1    Mentzer, R.M.2
  • 49
    • 0031743946 scopus 로고    scopus 로고
    • Effect of bafilomycin a1 and nocodazole on endocytic transport in hela cells: Implications for viral uncoating and infection
    • N. Bayer, D. Schober, E. Prchla, R.F. Murphy, D. Blaas, and R. Fuchs Effect of bafilomycin a1 and nocodazole on endocytic transport in hela cells: implications for viral uncoating and infection J Virol 72 1998 9645 9655
    • (1998) J Virol , vol.72 , pp. 9645-9655
    • Bayer, N.1    Schober, D.2    Prchla, E.3    Murphy, R.F.4    Blaas, D.5    Fuchs, R.6
  • 50
    • 53549084325 scopus 로고    scopus 로고
    • Does bafilomycin a1 block the fusion of autophagosomes with lysosomes
    • D.J. Klionsky, Z. Elazar, P.O. Seglen, and D.C. Rubinsztein Does bafilomycin a1 block the fusion of autophagosomes with lysosomes Autophagy 4 2008 849 950
    • (2008) Autophagy , vol.4 , pp. 849-950
    • Klionsky, D.J.1    Elazar, Z.2    Seglen, P.O.3    Rubinsztein, D.C.4
  • 51
    • 84898729899 scopus 로고    scopus 로고
    • Vacuolar h(+)-atpase in cancer cells: Structure and function
    • X. Lu, and W. Qin Vacuolar h(+)-atpase in cancer cells: structure and function Atlas Genet Cytogenet Oncol Haematol 2011
    • (2011) Atlas Genet Cytogenet Oncol Haematol
    • Lu, X.1    Qin, W.2
  • 52
    • 75149171923 scopus 로고    scopus 로고
    • Control of basal autophagy by calpain1 mediated cleavage of atg5
    • H.G. Xia, L. Zhang, G. Chen, T. Zhang, J. Liu, and M. Jin et al. Control of basal autophagy by calpain1 mediated cleavage of atg5 Autophagy 6 2010 61 66
    • (2010) Autophagy , vol.6 , pp. 61-66
    • Xia, H.G.1    Zhang, L.2    Chen, G.3    Zhang, T.4    Liu, J.5    Jin, M.6
  • 54
    • 79955677000 scopus 로고    scopus 로고
    • Autophagic cell death: Loch Ness monster or endangered species
    • H.M. Shen, and P. Codogno Autophagic cell death: Loch Ness monster or endangered species Autophagy 7 2011 457 465
    • (2011) Autophagy , vol.7 , pp. 457-465
    • Shen, H.M.1    Codogno, P.2
  • 55
    • 77955893249 scopus 로고    scopus 로고
    • A second signal for autophagic cell death
    • C. Giusti, M.F. Luciani, and P. Golstein A second signal for autophagic cell death Autophagy 6 2010 823 824
    • (2010) Autophagy , vol.6 , pp. 823-824
    • Giusti, C.1    Luciani, M.F.2    Golstein, P.3
  • 56
    • 80054038340 scopus 로고    scopus 로고
    • A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin d
    • E.N. Wilson, M.L. Bristol, X. Di, W.A. Maltese, K. Koterba, and M.J. Beckman et al. A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin d Horm Cancer 2 2011 272 285
    • (2011) Horm Cancer , vol.2 , pp. 272-285
    • Wilson, E.N.1    Bristol, M.L.2    Di, X.3    Maltese, W.A.4    Koterba, K.5    Beckman, M.J.6
  • 57
    • 84859118387 scopus 로고    scopus 로고
    • Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning
    • R. Sheng, X.Q. Liu, L.S. Zhang, B. Gao, R. Han, and Y.Q. Wu et al. Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning Autophagy 8 2012 310 325
    • (2012) Autophagy , vol.8 , pp. 310-325
    • Sheng, R.1    Liu, X.Q.2    Zhang, L.S.3    Gao, B.4    Han, R.5    Wu, Y.Q.6
  • 58
    • 84877337914 scopus 로고    scopus 로고
    • Inhibiting autophagy potentiates the anticancer activity of ifn1/ifnalpha in chronic myeloid leukemia cells
    • S. Zhu, L. Cao, Y. Yu, L. Yang, M. Yang, and K. Liu et al. Inhibiting autophagy potentiates the anticancer activity of ifn1/ifnalpha in chronic myeloid leukemia cells Autophagy 9 2013 317 327
    • (2013) Autophagy , vol.9 , pp. 317-327
    • Zhu, S.1    Cao, L.2    Yu, Y.3    Yang, L.4    Yang, M.5    Liu, K.6
  • 59
    • 77955880894 scopus 로고    scopus 로고
    • Finding a fitting shoe for Cinderella: Searching for an autophagy inhibitor
    • S. Miller, A. Oleksy, O. Perisic, and R.L. Williams Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor Autophagy 6 2010 805 807
    • (2010) Autophagy , vol.6 , pp. 805-807
    • Miller, S.1    Oleksy, A.2    Perisic, O.3    Williams, R.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.