Inhibitory role of the KEAP1-NRF2 pathway in TGFbβ1-stimulated renal epithelial transition to fibroblastic cells: A modulatory effect on SMAD signaling

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Ryoo, In Geun ^a   Ha, Hunjoo ^b   Kwak, Mi Kyoung ^a  

^a The Catholic University of Korea   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ACTIVATING TRANSCRIPTION FACTOR 3; COLLAGEN TYPE 1; COLLAGEN TYPE 1A1; FIBRONECTIN; FIBRONECTIN 1; GLUTATHIONE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PROTEIN SMURF1; REACTIVE OXYGEN METABOLITE; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; COLLAGEN TYPE I, ALPHA 1 CHAIN; KEAP1 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ARTICLE; CELL STRAIN; CELL STRAIN HK2; CELL TRANSFORMATION; CONTROLLED STUDY; EMT GENE; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; GENE; GENE ACTIVATION; GENE SILENCING; GENETIC STABILITY; HUMAN; HUMAN CELL; KEAP1 GENE; KIDNEY EPITHELIUM; KIDNEY TUBULE CELL; MOLECULAR GENETICS; NONHUMAN; NRF2 GENE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SMAD7 GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; CELL TRANSDIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; KIDNEY; KIDNEY TUBULE; METABOLISM; RNA INTERFERENCE;

CELL TRANSDIFFERENTIATION; COLLAGEN TYPE I; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROBLASTS; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; GLUTATHIONE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; KIDNEY TUBULES; NF-E2-RELATED FACTOR 2; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84898618699     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093265     Document Type: Article

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