Protective role of sulforaphane against oxidative stress mediated mitochondrial dysfunction induced by benzo(a)pyrene in female Swiss albino mice

Pulmonary Pharmacology and Therapeutics

Volumn 24, Issue 1, 2011, Pages 110-117

  Kalpana Deepa Priya, D ^a   Gayathri, R ^a   Gunassekaran, G R ^a   Sakthisekaran, D ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antioxidants; Bcl 2; Benzo(a)pyrene; Electron transport chain complexes; GSH redox cycle enzymes; Kreb's cycle enzymes; Sulforaphane

Indexed keywords

ANTINEOPLASTIC AGENT; BENZO[A]PYRENE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SULFORAPHANE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER PREVENTION; CARCINOGEN TESTING; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER; LUNG CANCER; LUNG PARENCHYMA; MITOCHONDRION; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; ANTICARCINOGENIC AGENTS; BENZO(A)PYRENE; FEMALE; ISOCITRATE DEHYDROGENASE; MALATE DEHYDROGENASE; MICE; MITOCHONDRIA; OXIDATIVE STRESS; SUCCINATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; THIOCYANATES;

EID: 79251600224     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2010.09.002     Document Type: Article

References (50)

1. Proctor R.N. Tobacco and the global lung cancer epidemic. Nat Rev Cancer 2001, 1:82-86.
2. Nandakumar A., Gupta P.C., Gangadharan P., Visweswara R.N., Parkin D.M. Geographic pathology revisited: development of an atlas of cancer in India. Int J Cancer 2005, 116:740-754.
3. Alexandrov K., Cascorbi I., Rojas M., Bouvier G., Kriek E., Bartsch H. CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung: comparison with aromatic/hydrophobic adduct formation. Carcinogenesis 2002, 23:1969-1977.
4. Salaspuro V.J., Hietala J.M., Marvola M.L., Salaspuro M.P. Eliminating carcinogenic acetaldehyde by cysteine from saliva during smoking. Cancer Epidemiol Biomarkers Prev 2006, 15:146-149.
5. Kensler T.W., Chen J.G., Egner P.A., Fahey J.W., Jacobson L.P., Stephenson K.K., et al. Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Cancer Epidemiol Biomarkers Prev 2005, 14:2605-2613.
6. Talalay P. Chemoprotection against cancer by induction of phase 2 enzymes. Biofactors 2000, 12:5-11.
7. Kwak M.K., Itoh K., Yamamoto M., Sutter T.R., Kensler T.W. Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1,2-dithiole-3-thione. Mol Med 2001, 7:135-145.
8. Kassie F., Uhl M., Rabot S., Rabot Sylvie, Grasl-Kraupp B., Verkerk R., et al. Chemoprevention of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-induced colonic and hepatic preneoplastic lesions in the F344 rat by cruciferous vegetables administered simultaneously with the carcinogen. Carcinogenesis 2003, 24:255-261.
9. Chung F.L., Conaway C.C., Rao C.V., Reddy B.S. Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis 2000, 21:2287-2291.
10. Fahey J.W., Haristoy X., Dolan P.M., Kensler T.W., Scholtus I., Stephenson K.K., et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci U S A 2002, 99:7610-7615.
11. Hecht S.S., Kenney P.M., Wang M., Upadhyaya P. Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung. Cancer Lett 2002, 187:87-94.
12. Fahey J.W., Talalay P. Antioxidant functions of sulforaphane: a potent inducer of phase II detoxication enzymes. Food Chem Toxicol 1999, 37:973-979.
13. Green D.R., Reed J.C. Mitochondria and apoptosis. Science 1998, 281:1309-1312.
14. Pelicano H., Carney D., Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resist Updat 2004, 7:97-110.
15. Peluso G., Nicolai R., Reda E., Benatti P., Barbarisi A., Calvani M. Cancer and anticancer therapy-induced modifications on metabolism mediated by carnitine system. J Cell Physiol 2000, 182:339-350.
16. Warburg O. On respiratory impairment in cancer cells. Science 1956, 124:269-270.
17. Pelicano H., Xu R.H., Du M., Feng L., Sasaki R., Carew J.S., et al. Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J Cell Biol 2006, 175:913-923.
18. Burdon R.H. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic Biol Med 1995, 18:775-794.
19. Wattenberg Lee W., Weidmann Timothy S., Estensen Richard D., Zimmerman Cheryl D., Steele Vernon E., Kelloff Gary J. Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice. Cancer Res 1997, 57:5489-5492.
20. Johnson D., Lardy H. Isolation of liver and kidney mitochondria. Meth Enzymol 1967, 10:94-96.
21. Marklund S., Marklund G. Involvement of superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974, 47:469-474.
22. Sinha A.K. Colorimetric assay of catalase. Anal Biochem 1972, 47:389-394.
23. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase purification and assay. Science 1973, 179:588-590.
24. Stahl G.E.J., Visser J., Veeger C. Purification and properties of glutathione reducatse of human erythrocytes. Biochim Biophys Acta 1969, 185:39-48.
25. Beutler E. Active transport of glutathione disulphide from erythrocytes. Functions of glutathione: biochemical, physiological, toxicological and clinical aspects 1983, 65-74. Raven Press, New York. A. Larsson, S. Orrenius, A. Holmgren, B. Mannervick (Eds.).
26. Moron M.S., DePierre J.W., Manerwik K.B. Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979, 582:67-68.
27. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95:351-358.
28. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin's phenol reagent. J Biol Chem 1951, 193:265-276.
29. Slater E.C., Bonner W.D. Effect fluoride on succinate oxidase system. Biochem J 1952, 52:185-196.
30. Bernt E., Bergmeyer H.U. Methods of enzymatic analysis 1974, Academic Press, New York, p. 624-7.
31. Reed L.J., Mukherjee B.B. α-Ketoglutarate dehydrogenase complex from Escherichia coli. Meth Enzymol 1969, 13:55-61.
32. Mehler A.H., Kornberg A., Grisolia S., Ochoa S. The enzymatic mechanisms of oxidation reduction between malate or isocitrate and pyruvate. J Biol Chem 1948, 174:961-977.
33. Hatefi Y., Rieske J.S. Preparation and properties of DPNH-coenzyme Q reductase (complex I of the respiratory chain) 1967, pp. 235-9.
34. Hatefi Y., Stiggall D.L. Preparation and properties of succinate: ubiquinone oxidoreductase (complex II) 1978, pp. 21-7.
35. Shimomura Y., Nishikimi M., Ozawa T. Isolation and reconstitution of the iron-sulfur protein in ubiquinol-cytochrome c oxidoreductase complex. Phospholipids are essential for the integration of the iron-sulfur protein in the complex. J Biol Chem 1984, 25:14059-14063.
36. Wharton D.C., Tzagoloff A. Studies on the electron transfer system. LVII. The near infrared absorption band of cytochrome oxidase. J Biol Chem 1964, 239:2036-2041.
37. Winzer K., Becker W., Van Noorden C.J.F., Köhler A. Short time induction of oxidative stress in hepatocytes of the European flounder (Platichthys flesus). Mar Environ Res 2000, 50:495-501.
38. Kakkar R., Mantha S., Radhi J., Prasad K., Karla J. Antioxidant defense system in diabetic kidney. Life Sci 1997, 60:667-679.
39. Selvam R. Calcium oxalate stone disease: role of lipid peroxidation and antioxidants. Urol Res 2002, 30:35-47.
40. Kono Y., Fridovich I. Superoxide radical inhibits catalase. J Biol Chem 1982, 257:5751-5754.
41. Arnaudeau S., Kelley W.L., Walsh J.V., Demaurex N. Mitochondria recycle Ca2+ to the endoplasmic reticulum and prevent the depletion of neighboring endoplasmic reticulum regions. J Biol Chem 2001, 276:29430-29439.
42. Fernandez-Checa J.C., Garcia-Ruiz C., Colell A., Morales A., Mari M., Mirandi M., et al. Oxidative stress: role of mitochondria and protection by glutathione. Biofactors 1998, 8:7-11.
43. Palmeira C.M., Moreno A.J., Madeira V.M.C. Thiols metabolism is altered by the herbicides paraquat, dinoseb and 2,4- D: a study in isolated hepatocytes. Toxicol Lett 1995, 81:115-123.
44. Meister A. Glutathione. The liver biology and pathobiology 1994, 401-417. Raven Press, New York. I.M. Arias, J.L. Boyer, W.B. Jakoby, D. Farsto, D. Schacter, D.A. Shafritz (Eds.).
45. Kowalski D.P., Feeley R.M., Jones D.P. Use of exogenous glutathione for metabolism of peroxidized methyl linoleate in rat small intestine. J Nutr 1990, 120(9):1115-1121.
46. Murray G.I., Burke M.D., Ewen S.W. Glutathione localization in benign and malignant. Human breast lesions. Br J Cancer 1987, 55:605-609.
47. Esterbauer H. Estimation of peroxidative damage: a critical review. Pathol Biol 1996, 44:25-28.
48. Salet C., Moreno G. New trends in photobiology. Photosensitization of mitochondria. Molecular and cellular aspects. J Photochem Photobiol B 1990, 5:133-150.
49. Cadenas E., Davies K.J. Mitochondrial free radical generation. oxidative stress, and aging. Free Radic Biol Med 2000, 29:222-230.
50. Kroemer G. The proto-oncogene bcl-2 and its role in regulating apoptosis. Nat Med 1997, 3:614-620.