Early Embryonic Lethality Caused by Targeted Disruption of the 3-Hydroxy-3-methylglutaryl-CoA Reductase Gene

Journal of Biological Chemistry

Volumn 278, Issue 44, 2003, Pages 42936-42941

  Ohashi, Ken ^a   Osuga, Jun Ichi ^a   Tozawa, Ryuichi ^a   Kitamine, Tetsuya ^a   Yagyu, Hiroaki ^b   Sekiya, Motohiro ^a   Tomita, Sachiko ^a   Okazaki, Hiroaki ^a   Tamura, Yoshiaki ^a   Yahagi, Naoya ^a   Iizuka, Yoko ^a   Harada, Kenji ^a   Gotoda, Takanari ^c   Shimano, Hitoshi ^d   Yamada, Nobuhiro ^d   Ishibashi, Shun ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^d UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYST ACTIVITY; CHOLESTEROL; ENZYMES; GENES;

LETHALITY;

BIOCHEMISTRY;

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; MEVALONIC ACID;

ANIMAL CELL; ARTICLE; CATALYSIS; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FIBROBLAST; GENE DISRUPTION; GENE TARGETING; KNOCKOUT GENE; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0242290361     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M307228200     Document Type: Article

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