메뉴 건너뛰기




Volumn 13, Issue 3, 2014, Pages 408-417

Diabetes of the brain: Computational approaches and interventional strategies

Author keywords

Advanced glycation end products; Alzheimer's disease; Amyloid Protein; Diabetes mellitus; Inflammation; Insulin resistance

Indexed keywords

AMYLOID BETA PROTEIN; CHOLESTEROL; TUMOR NECROSIS FACTOR ALPHA;

EID: 84897896981     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/18715273113126660156     Document Type: Article
Times cited : (13)

References (101)
  • 1
    • 79952574501 scopus 로고    scopus 로고
    • Epidemiology of Alzheimer disease
    • Reitz C, Brayne C, Mayeux R. Epidemiology of Alzheimer disease. Nat Rev Neurol 2011; 7(3): 137-152.
    • (2011) Nat Rev Neurol , vol.7 , Issue.3 , pp. 137-152
    • Reitz, C.1    Brayne, C.2    Mayeux, R.3
  • 2
    • 84866456583 scopus 로고    scopus 로고
    • Preventing Alzheimer's disease
    • Selkoe DJ. Preventing Alzheimer's disease. Science 2012; 337(6101): 1488-1492.
    • (2012) Science , vol.337 , Issue.6101 , pp. 1488-1492
    • Selkoe, D.J.1
  • 3
    • 0041385937 scopus 로고    scopus 로고
    • Cerebrovascular risk factors in Alzheimer's disease: Brain hemodynamics and pharmacogenomic implications
    • Cacabelos R, Fernandez-Novoa L, Lombardi V, Corzo L, Pichel V, Kubota Y. Cerebrovascular risk factors in Alzheimer's disease: brain hemodynamics and pharmacogenomic implications. Neurol Res 2003; 25(6): 567-580.
    • (2003) Neurol Res , vol.25 , Issue.6 , pp. 567-580
    • Cacabelos, R.1    Fernandez-Novoa, L.2    Lombardi, V.3    Corzo, L.4    Pichel, V.5    Kubota, Y.6
  • 4
    • 84874303866 scopus 로고    scopus 로고
    • Impaired transcription in Alzheimer's disease: Key role in mitochondrial dysfunction and oxidative stress
    • Caldeira GL, Ferreira IL, Rego AC. Impaired transcription in Alzheimer's disease: key role in mitochondrial dysfunction and oxidative stress. J Alzheimers Dis 2013; 34(1): 115-131.
    • (2013) J Alzheimers Dis , vol.34 , Issue.1 , pp. 115-131
    • Caldeira, G.L.1    Ferreira, I.L.2    Rego, A.C.3
  • 6
    • 73649135004 scopus 로고    scopus 로고
    • Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice
    • Liu B, Rasool S, Yang Z, et al. Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice. Am J Pathol 2009; 175(5): 2099-2110.
    • (2009) Am J Pathol , vol.175 , Issue.5 , pp. 2099-2110
    • Liu, B.1    Rasool, S.2    Yang, Z.3
  • 7
    • 19944424142 scopus 로고    scopus 로고
    • Preventing activation of receptor for advanced glycation endproducts in Alzheimer's disease
    • Lue LF, Yan SD, Stern DM, Walker DG. Preventing activation of receptor for advanced glycation endproducts in Alzheimer's disease. CNS Neurol Disord Drug Targets 2005; 4(3): 249-266.
    • (2005) CNS Neurol Disord Drug Targets , vol.4 , Issue.3 , pp. 249-266
    • Lue, L.F.1    Yan, S.D.2    Stern, D.M.3    Walker, D.G.4
  • 8
    • 84055193428 scopus 로고    scopus 로고
    • Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease
    • de la Monte SM. Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease. Drugs 2012; 72(1): 49-66.
    • (2012) Drugs , vol.72 , Issue.1 , pp. 49-66
    • de la Monte, S.M.1
  • 9
    • 71749121998 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
    • Moreira PI, Carvalho C, Zhu X, Smith MA, Perry G. Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. Biochim Biophys Acta 2010; 1802;(1): 2-10.
    • (2010) Biochim Biophys Acta , vol.1802 , Issue.1 , pp. 2-10
    • Moreira, P.I.1    Carvalho, C.2    Zhu, X.3    Smith, M.A.4    Perry, G.5
  • 10
    • 0033396991 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases
    • Mattson MP, Pedersen WA, Duan W, Culmsee C, Camandola S. Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases. Ann NY Acad Sci 1999; 893: 154-175.
    • (1999) Ann NY Acad Sci , vol.893 , pp. 154-175
    • Mattson, M.P.1    Pedersen, W.A.2    Duan, W.3    Culmsee, C.4    Camandola, S.5
  • 11
    • 78649962844 scopus 로고    scopus 로고
    • Brain fuel metabolism, aging, and Alzheimer's disease
    • Cunnane S, Nugent S, Roy M, et al. Brain fuel metabolism, aging, and Alzheimer's disease. Nutrition 2011; 27(1): 3-20.
    • (2011) Nutrition , vol.27 , Issue.1 , pp. 3-20
    • Cunnane, S.1    Nugent, S.2    Roy, M.3
  • 12
    • 0034805535 scopus 로고    scopus 로고
    • Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease
    • Engidawork E, Gulesserian T, Yoo BC, Cairns N, Lubec G. Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease. Biochem Biophys Res Commun 2001; 281(1): 84-93.
    • (2001) Biochem Biophys Res Commun , vol.281 , Issue.1 , pp. 84-93
    • Engidawork, E.1    Gulesserian, T.2    Yoo, B.C.3    Cairns, N.4    Lubec, G.5
  • 13
    • 79955646293 scopus 로고    scopus 로고
    • Hyperphosphorylated truncated protein tau induces caspase-3 independent apoptosis-like pathway in the Alzheimer's disease cellular model
    • Zilkova M, Zilka N, Kovac A, et al. Hyperphosphorylated truncated protein tau induces caspase-3 independent apoptosis-like pathway in the Alzheimer's disease cellular model. J Alzheimers Dis 2011; 23(1): 161-9.
    • (2011) J Alzheimers Dis , vol.23 , Issue.1 , pp. 161-169
    • Zilkova, M.1    Zilka, N.2    Kovac, A.3
  • 14
    • 84895897607 scopus 로고    scopus 로고
    • Epigenetic regulation in neurodevelopment and neurodegenerative diseases
    • Gapp K, Woldemichael BT, Bohacek J, Mansuy IM. Epigenetic regulation in neurodevelopment and neurodegenerative diseases. Neuroscience 2012; 264C: 99-111.
    • (2012) Neuroscience , vol.264 C , pp. 99-111
    • Gapp, K.1    Woldemichael, B.T.2    Bohacek, J.3    Mansuy, I.M.4
  • 15
    • 84871556202 scopus 로고    scopus 로고
    • Organochlorine pesticide levels and risk of Alzheimer's disease in north Indian population
    • Singh N, Chhillar N, Banerjee B, et al. Organochlorine pesticide levels and risk of Alzheimer's disease in north Indian population. Hum Exp Toxicol 2013; 32(1): 24-30.
    • (2013) Hum Exp Toxicol , vol.32 , Issue.1 , pp. 24-30
    • Singh, N.1    Chhillar, N.2    Banerjee, B.3
  • 17
    • 47949111598 scopus 로고    scopus 로고
    • Central obesity and increased risk of dementia more than three decades later
    • Whitmer RA, Gustafson DR, Barrett-Connor E, et al. Central obesity and increased risk of dementia more than three decades later. Neurology 2008; 71(14): 1057-1064.
    • (2008) Neurology , vol.71 , Issue.14 , pp. 1057-1064
    • Whitmer, R.A.1    Gustafson, D.R.2    Barrett-Connor, E.3
  • 18
    • 38649137302 scopus 로고    scopus 로고
    • Prevention and treatment of obesity with lifestyle interventions: Review and meta-analysis
    • Galani C, Schneider H. Prevention and treatment of obesity with lifestyle interventions: review and meta-analysis. Int J Public Health 2007; 52(6): 348-359.
    • (2007) Int J Public Health , vol.52 , Issue.6 , pp. 348-359
    • Galani, C.1    Schneider, H.2
  • 19
    • 68949089312 scopus 로고    scopus 로고
    • Alzheimer's disease is type 3 diabetesevidence reviewed
    • de la Monte SM, Wands JR. Alzheimer's disease is type 3 diabetesevidence reviewed. J Diabetes Sci Technol 2008; 2(6): 1101-1113.
    • (2008) J Diabetes Sci Technol , vol.2 , Issue.6 , pp. 1101-1113
    • de la Monte, S.M.1    Wands, J.R.2
  • 20
    • 75249106915 scopus 로고    scopus 로고
    • Insulin is a two-edged knife on the brain
    • Cardoso S, Correia S, Santos RX, et al. Insulin is a two-edged knife on the brain. J Alzheimers Dis 2009; 18(3): 483-507.
    • (2009) J Alzheimers Dis , vol.18 , Issue.3 , pp. 483-507
    • Cardoso, S.1    Correia, S.2    Santos, R.X.3
  • 21
    • 67649687039 scopus 로고    scopus 로고
    • An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease
    • Moreira PI, Duarte AI, Santos MS, Rego AC, Oliveira CR. An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease. J Alzheimers Dis 2009; 16(4): 741-761.
    • (2009) J Alzheimers Dis , vol.16 , Issue.4 , pp. 741-761
    • Moreira, P.I.1    Duarte, A.I.2    Santos, M.S.3    Rego, A.C.4    Oliveira, C.R.5
  • 22
    • 85056046161 scopus 로고    scopus 로고
    • Diabetes and Alzheimer's disease-is there a connection?
    • Sima AA, Li ZG. Diabetes and Alzheimer's disease-is there a connection? Rev Diabet Stud 2006; 3(4): 161-8.
    • (2006) Rev Diabet Stud , vol.3 , Issue.4 , pp. 161-168
    • Sima, A.A.1    Li, Z.G.2
  • 23
    • 67649726059 scopus 로고    scopus 로고
    • Common pathological processes and transcriptional pathways in Alzheimer's disease and type 2 diabetes
    • Jones A, Kulozik P, Ostertag A, Herzig S. Common pathological processes and transcriptional pathways in Alzheimer's disease and type 2 diabetes. J Alzheimers Dis 2009; 16(4): 787-808.
    • (2009) J Alzheimers Dis , vol.16 , Issue.4 , pp. 787-808
    • Jones, A.1    Kulozik, P.2    Ostertag, A.3    Herzig, S.4
  • 24
    • 67649726060 scopus 로고    scopus 로고
    • Growth factors, AGEing, and the diabetes link in Alzheimer's disease
    • Loy CT, Twigg SM. Growth factors, AGEing, and the diabetes link in Alzheimer's disease. J Alzheimers Dis 2009; 16(4): 823-831.
    • (2009) J Alzheimers Dis , vol.16 , Issue.4 , pp. 823-831
    • Loy, C.T.1    Twigg, S.M.2
  • 25
    • 77949283280 scopus 로고
    • Dysregulation of the nutrient/stress sensor O-GlcNAcylation is involved in the etiology of cardiovascular disorders, type-2 diabetes and Alzheimer's disease
    • Lefebvre T, Dehennaut V, Guinez C, et al. Dysregulation of the nutrient/stress sensor O-GlcNAcylation is involved in the etiology of cardiovascular disorders, type-2 diabetes and Alzheimer's disease. Biochim Biophys Acta 2010; 1800;(2): 67-79.
    • (1800) Biochim Biophys Acta , vol.2010 , Issue.2 , pp. 67-79
    • Lefebvre, T.1    Dehennaut, V.2    Guinez, C.3
  • 26
    • 76849101075 scopus 로고    scopus 로고
    • Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders
    • Profenno LA, Porsteinsson AP, Faraone SV. Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders. Biol Psychiatry 2010; 67(6): 505-512.
    • (2010) Biol Psychiatry , vol.67 , Issue.6 , pp. 505-512
    • Profenno, L.A.1    Porsteinsson, A.P.2    Faraone, S.V.3
  • 27
    • 79960881826 scopus 로고    scopus 로고
    • Diabetes as a risk factor for Alzheimer's disease: Insulin signalling impairment in the brain as an alternative model of Alzheimer's disease
    • Holscher C. Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease. Biochem Soc Trans 2011; 39(4): 891-7.
    • (2011) Biochem Soc Trans , vol.39 , Issue.4 , pp. 891-897
    • Holscher, C.1
  • 28
    • 79956359796 scopus 로고    scopus 로고
    • A common pathogenic mechanism linking type-2 diabetes and Alzheimer's disease: Evidence from animal models
    • Park SA. A common pathogenic mechanism linking type-2 diabetes and Alzheimer's disease: evidence from animal models. J Clin Neurol 2011; 7(1): 10-8.
    • (2011) J Clin Neurol , vol.7 , Issue.1 , pp. 10-18
    • Park, S.A.1
  • 29
    • 84869776924 scopus 로고    scopus 로고
    • Diabetes mellitus in patients with Alzheimer's disease: Clinical description and correlation with the APOE genotype in a sample population from the province of Antioquia, Colombia
    • Botero LE, Toro AE, Patino AJ, et al. Diabetes mellitus in patients with Alzheimer's disease: clinical description and correlation with the APOE genotype in a sample population from the province of Antioquia, Colombia. Biomedica 2012; 32(2): 239-251.
    • (2012) Biomedica , vol.32 , Issue.2 , pp. 239-251
    • Botero, L.E.1    Toro, A.E.2    Patino, A.J.3
  • 30
    • 84862523849 scopus 로고    scopus 로고
    • Alzheimer's disease and type 2 diabetes: Exploring the association to obesity and tyrosine hydroxylase
    • Priyadarshini M, Kamal MA, Greig NH, et al. Alzheimer's disease and type 2 diabetes: exploring the association to obesity and tyrosine hydroxylase. CNS Neurol Disord Drug Targets 2012; 11(4): 482-9.
    • (2012) CNS Neurol Disord Drug Targets , vol.11 , Issue.4 , pp. 482-489
    • Priyadarshini, M.1    Kamal, M.A.2    Greig, N.H.3
  • 31
    • 0033378682 scopus 로고    scopus 로고
    • A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease
    • Frolich L, Blum-Degen D, Riederer P, Hoyer S. A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease. Ann NY Acad Sci 1999; 893: 290-3.
    • (1999) Ann NY Acad Sci , vol.893 , pp. 290-293
    • Frolich, L.1    Blum-Degen, D.2    Riederer, P.3    Hoyer, S.4
  • 32
    • 33644591150 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine
    • Rivera EJ, Goldin A, Fulmer N, et al. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimers Dis 2005; 8(3): 247-268.
    • (2005) J Alzheimers Dis , vol.8 , Issue.3 , pp. 247-268
    • Rivera, E.J.1    Goldin, A.2    Fulmer, N.3
  • 33
    • 15244351255 scopus 로고    scopus 로고
    • Impaired insulin and insulinlike growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?
    • Steen E, Terry BM, Rivera EJ, et al. Impaired insulin and insulinlike growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? J Alzheimers Dis 2005; 7(1): 63-80.
    • (2005) J Alzheimers Dis , vol.7 , Issue.1 , pp. 63-80
    • Steen, E.1    Terry, B.M.2    Rivera, E.J.3
  • 34
    • 84856496197 scopus 로고    scopus 로고
    • Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease
    • de la Monte SM. Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease. Curr Alzheimer Res 2012; 9(1): 35-66.
    • (2012) Curr Alzheimer Res , vol.9 , Issue.1 , pp. 35-66
    • de la Monte, S.M.1
  • 35
    • 84863002103 scopus 로고    scopus 로고
    • Alzheimer's disease and diabetes: An integrative view of the role of mitochondria, oxidative stress, and insulin
    • Moreira PI. Alzheimer's disease and diabetes: an integrative view of the role of mitochondria, oxidative stress, and insulin. J Alzheimers Dis 2012; 30(Suppl 2): S199-S215.
    • (2012) J Alzheimers Dis , vol.30 , Issue.SUPPL. 2
    • Moreira, P.I.1
  • 36
    • 0037221379 scopus 로고    scopus 로고
    • The role of insulin resistance in the pathogenesis of Alzheimer's disease: Implications for treatment
    • Watson GS, Craft S. The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment. CNS Drugs 2003; 17(1): 27-45.
    • (2003) CNS Drugs , vol.17 , Issue.1 , pp. 27-45
    • Watson, G.S.1    Craft, S.2
  • 37
    • 33646846157 scopus 로고    scopus 로고
    • Insulin resistance, inflammation, and cognition in Alzheimer's Disease: Lessons for multiple sclerosis
    • Watson GS, Craft S. Insulin resistance, inflammation, and cognition in Alzheimer's Disease: lessons for multiple sclerosis. J Neurol Sci 2006; 245(1-2): 21-33.
    • (2006) J Neurol Sci , vol.245 , Issue.1-2 , pp. 21-33
    • Watson, G.S.1    Craft, S.2
  • 38
    • 84892780571 scopus 로고    scopus 로고
    • Brain Insulin Dysregulation: Implication for Neurological and Neuropsychiatric Disorders
    • Ghasemi R, Dargahi L, Haeri A, et al. Brain Insulin Dysregulation: Implication for Neurological and Neuropsychiatric Disorders. Mol Neurobiol 2013; 47(3): 1045-1065.
    • (2013) Mol Neurobiol , vol.47 , Issue.3 , pp. 1045-1065
    • Ghasemi, R.1    Dargahi, L.2    Haeri, A.3
  • 39
    • 0035936763 scopus 로고    scopus 로고
    • New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
    • Saltiel AR. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 2001; 104(4): 517-529.
    • (2001) Cell , vol.104 , Issue.4 , pp. 517-529
    • Saltiel, A.R.1
  • 40
    • 33745215607 scopus 로고    scopus 로고
    • Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat
    • Horwood JM, Dufour F, Laroche S, Davis S. Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat. Eur J Neurosci 2006; 23(12): 3375-3384.
    • (2006) Eur J Neurosci , vol.23 , Issue.12 , pp. 3375-3384
    • Horwood, J.M.1    Dufour, F.2    Laroche, S.3    Davis, S.4
  • 41
    • 84878643703 scopus 로고    scopus 로고
    • Alzheimer's disease And Diabetes: New Insights and Unifying Therapies
    • Vignini A, Giulietti A, Nanetti L, et al. Alzheimer's disease And Diabetes: New Insights and Unifying Therapies. Curr Diabetes Rev 2013; 9(3): 218-227.
    • (2013) Curr Diabetes Rev , vol.9 , Issue.3 , pp. 218-227
    • Vignini, A.1    Giulietti, A.2    Nanetti, L.3
  • 42
    • 84859718265 scopus 로고    scopus 로고
    • Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
    • Talbot K, Wang HY, Kazi H, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 2012; 122(4): 1316-1338.
    • (2012) J Clin Invest , vol.122 , Issue.4 , pp. 1316-1338
    • Talbot, K.1    Wang, H.Y.2    Kazi, H.3
  • 43
    • 84862999971 scopus 로고    scopus 로고
    • Triangulated mal-signaling in Alzheimer's disease: Roles of neurotoxic ceramides, ER stress, and insulin resistance reviewed
    • de la Monte SM. Triangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewed. J Alzheimers Dis 2012; 30(Suppl 2): S231-S249.
    • (2012) J Alzheimers Dis , vol.30 , Issue.SUPPL. 2
    • de la Monte, S.M.1
  • 44
    • 76249083449 scopus 로고    scopus 로고
    • Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairment
    • de la Monte SM, Tong M, Lawton M, Longato L. Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairment. Mol Neurodegener 2009; 4: 54.
    • (2009) Mol Neurodegener , vol.4 , pp. 54
    • de la Monte, S.M.1    Tong, M.2    Lawton, M.3    Longato, L.4
  • 45
    • 33747058235 scopus 로고    scopus 로고
    • The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: A magnetoencephalographic study
    • Tschritter O, Preissl H, Hennige AM, et al. The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study. Proc Natl Acad Sci USA 2006; 103(32): 12103-8.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.32 , pp. 12103-12108
    • Tschritter, O.1    Preissl, H.2    Hennige, A.M.3
  • 46
    • 70349581633 scopus 로고    scopus 로고
    • Insulin resistance and Alzheimer's disease
    • de la Monte SM. Insulin resistance and Alzheimer's disease. BMB Rep 2009; 42(8): 475-481.
    • (2009) BMB Rep , vol.42 , Issue.8 , pp. 475-481
    • de la Monte, S.M.1
  • 47
    • 84867051523 scopus 로고    scopus 로고
    • Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales
    • Clark I, Atwood C, Bowen R, Paz-Filho G, Vissel B. Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales. Pharmacol Rev 2012; 64(4): 1004-1026.
    • (2012) Pharmacol Rev , vol.64 , Issue.4 , pp. 1004-1026
    • Clark, I.1    Atwood, C.2    Bowen, R.3    Paz-Filho, G.4    Vissel, B.5
  • 48
    • 84867812582 scopus 로고    scopus 로고
    • The role of glucose transporters in brain disease: Diabetes and Alzheimer's disease
    • Shah K, Desilva S, Abbruscato T. The role of glucose transporters in brain disease: diabetes and Alzheimer's disease. Int J Mol Sci 2012; 13(10): 12629-12655.
    • (2012) Int J Mol Sci , vol.13 , Issue.10 , pp. 12629-12655
    • Shah, K.1    Desilva, S.2    Abbruscato, T.3
  • 49
    • 67650072530 scopus 로고    scopus 로고
    • Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease
    • Liu F, Shi J, Tanimukai H, et al. Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain 2009; 132(Pt 7): 1820-1832.
    • (2009) Brain , vol.132 , Issue.Pt 7 , pp. 1820-1832
    • Liu, F.1    Shi, J.2    Tanimukai, H.3
  • 50
    • 79251473696 scopus 로고    scopus 로고
    • Actions of beta-amyloid protein on human neurons are expressed through the amylin receptor
    • Jhamandas JH, Li Z, Westaway D, et al. Actions of beta-amyloid protein on human neurons are expressed through the amylin receptor. Am J Pathol 2011; 178(1): 140-9.
    • (2011) Am J Pathol , vol.178 , Issue.1 , pp. 140-149
    • Jhamandas, J.H.1    Li, Z.2    Westaway, D.3
  • 51
    • 73649112749 scopus 로고    scopus 로고
    • Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease
    • Deng Y, Li B, Liu Y, et al. Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease. Am J Pathol 2009; 175(5): 2089-2098.
    • (2009) Am J Pathol , vol.175 , Issue.5 , pp. 2089-2098
    • Deng, Y.1    Li, B.2    Liu, Y.3
  • 52
    • 84869179307 scopus 로고    scopus 로고
    • Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice
    • Currais A, Prior M, Lo D, et al. Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice. Aging Cell 2012; 11(6): 1017-1026.
    • (2012) Aging Cell , vol.11 , Issue.6 , pp. 1017-1026
    • Currais, A.1    Prior, M.2    Lo, D.3
  • 53
    • 77956364857 scopus 로고    scopus 로고
    • Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama study
    • Matsuzaki T, Sasaki K, Tanizaki Y, et al. Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study. Neurology 2010; 75(9): 764-770.
    • (2010) Neurology , vol.75 , Issue.9 , pp. 764-770
    • Matsuzaki, T.1    Sasaki, K.2    Tanizaki, Y.3
  • 54
    • 84860778998 scopus 로고    scopus 로고
    • Staging and natural history of cerebrovascular pathology in dementia
    • Deramecourt V, Slade JY, Oakley AE, et al. Staging and natural history of cerebrovascular pathology in dementia. Neurology 2012; 78(14): 1043-1050.
    • (2012) Neurology , vol.78 , Issue.14 , pp. 1043-1050
    • Deramecourt, V.1    Slade, J.Y.2    Oakley, A.E.3
  • 55
    • 70449732132 scopus 로고    scopus 로고
    • Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus
    • Valente T, Gella A, Fernandez-Busquets X, Unzeta M, Durany N. Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus. Neurobiol Dis 2010; 37(1): 67-76.
    • (2010) Neurobiol Dis , vol.37 , Issue.1 , pp. 67-76
    • Valente, T.1    Gella, A.2    Fernandez-Busquets, X.3    Unzeta, M.4    Durany, N.5
  • 56
    • 84874301925 scopus 로고    scopus 로고
    • Blood Transcriptomic Biomarkers of Alzheimer's Disease Patients Treated with EHT 0202
    • Desire L, Blondiaux E, Carriere J, et al. Blood Transcriptomic Biomarkers of Alzheimer's Disease Patients Treated with EHT 0202. J Alzheimers Dis 2012; 34(2): 469-483.
    • (2012) J Alzheimers Dis , vol.34 , Issue.2 , pp. 469-483
    • Desire, L.1    Blondiaux, E.2    Carriere, J.3
  • 57
    • 0031853666 scopus 로고    scopus 로고
    • Gene-environment interaction in Alzheimer's disease: A potential role for cholesterol
    • Chandra V, Pandav R. Gene-environment interaction in Alzheimer's disease: a potential role for cholesterol. Neuroepidemiology 1998; 17(5): 225-232.
    • (1998) Neuroepidemiology , vol.17 , Issue.5 , pp. 225-232
    • Chandra, V.1    Pandav, R.2
  • 58
    • 67749114631 scopus 로고    scopus 로고
    • Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later
    • Solomon A, Kivipelto M, Wolozin B, Zhou J, Whitmer RA. Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later. Dement Geriatr Cogn Disord 2009; 28(1): 75-80.
    • (2009) Dement Geriatr Cogn Disord , vol.28 , Issue.1 , pp. 75-80
    • Solomon, A.1    Kivipelto, M.2    Wolozin, B.3    Zhou, J.4    Whitmer, R.A.5
  • 59
    • 78650094288 scopus 로고    scopus 로고
    • Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease
    • Reitz C, Tang MX, Schupf N, et al. Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease. Arch Neurol 2010; 67(12): 1491-7.
    • (2010) Arch Neurol , vol.67 , Issue.12 , pp. 1491-1497
    • Reitz, C.1    Tang, M.X.2    Schupf, N.3
  • 60
    • 62449242294 scopus 로고    scopus 로고
    • Contribution of vascular risk factors to the progression in Alzheimer disease
    • Helzner EP, Luchsinger JA, Scarmeas N, et al. Contribution of vascular risk factors to the progression in Alzheimer disease. Arch Neurol 2009; 66(3): 343-8.
    • (2009) Arch Neurol , vol.66 , Issue.3 , pp. 343-348
    • Helzner, E.P.1    Luchsinger, J.A.2    Scarmeas, N.3
  • 61
    • 80051508807 scopus 로고    scopus 로고
    • Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline
    • Debette S, Seshadri S, Beiser A, et al. Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology 2011; 77(5): 461-8.
    • (2011) Neurology , vol.77 , Issue.5 , pp. 461-468
    • Debette, S.1    Seshadri, S.2    Beiser, A.3
  • 62
    • 84863694005 scopus 로고    scopus 로고
    • Mitochondrial alterations, oxidative stress and neuroinflammation in Alzheimer's disease
    • Verri M, Pastoris O, Dossena M, et al. Mitochondrial alterations, oxidative stress and neuroinflammation in Alzheimer's disease. Int J Immunopathol Pharmacol 2012; 25(2): 345-353.
    • (2012) Int J Immunopathol Pharmacol , vol.25 , Issue.2 , pp. 345-353
    • Verri, M.1    Pastoris, O.2    Dossena, M.3
  • 64
    • 79960555700 scopus 로고    scopus 로고
    • Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis
    • Bosco D, Fava A, Plastino M, Montalcini T, Pujia A. Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis. J Cell Mol Med 2011; 15(9): 1807-1821.
    • (2011) J Cell Mol Med , vol.15 , Issue.9 , pp. 1807-1821
    • Bosco, D.1    Fava, A.2    Plastino, M.3    Montalcini, T.4    Pujia, A.5
  • 65
    • 13644253800 scopus 로고    scopus 로고
    • Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer's disease and in other neurodegenerative diseases
    • Migliore L, Fontana I, Colognato R, et al. Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer's disease and in other neurodegenerative diseases. Neurobiol Aging 2005; 26(5): 587-595.
    • (2005) Neurobiol Aging , vol.26 , Issue.5 , pp. 587-595
    • Migliore, L.1    Fontana, I.2    Colognato, R.3
  • 66
    • 13644249114 scopus 로고    scopus 로고
    • Peripheral biomarkers of oxidative damage in Alzheimer's disease: The road ahead
    • Pratico D. Peripheral biomarkers of oxidative damage in Alzheimer's disease: the road ahead. Neurobiol Aging 2005; 26(5): 581-3.
    • (2005) Neurobiol Aging , vol.26 , Issue.5 , pp. 581-583
    • Pratico, D.1
  • 67
    • 84863798868 scopus 로고    scopus 로고
    • Nuclear factor-kappaB regulates betaAPP and beta-and gamma-secretases differently at physiological and supraphysiological Abeta concentrations
    • Chami L, Buggia-Prevot V, Duplan E, et al. Nuclear factor-kappaB regulates betaAPP and beta-and gamma-secretases differently at physiological and supraphysiological Abeta concentrations. J Biol Chem 2012; 287(29): 24573-24584.
    • (2012) J Biol Chem , vol.287 , Issue.29 , pp. 24573-24584
    • Chami, L.1    Buggia-Prevot, V.2    Duplan, E.3
  • 68
    • 84870932482 scopus 로고    scopus 로고
    • Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline
    • Vom Berg J, Prokop S, Miller KR, et al. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nat Med 2012; 18(12): 1812-9.
    • (2012) Nat Med , vol.18 , Issue.12 , pp. 1812-1819
    • Vom, B.J.1    Prokop, S.2    Miller, K.R.3
  • 69
    • 84864857755 scopus 로고    scopus 로고
    • Transforming growth factor-beta stimulates beta amyloid uptake by microglia through Smad3-dependent mechanisms
    • Tichauer JE, von Bernhardi R. Transforming growth factor-beta stimulates beta amyloid uptake by microglia through Smad3-dependent mechanisms. J Neurosci Res 2012; 90(10): 1970-1980.
    • (2012) J Neurosci Res , vol.90 , Issue.10 , pp. 1970-1980
    • Tichauer, J.E.1    von Bernhardi, R.2
  • 70
    • 84859726053 scopus 로고    scopus 로고
    • An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Abeta oligomers
    • Bomfim TR, Forny-Germano L, Sathler LB, et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Abeta oligomers. J Clin Invest 2012; 122(4): 1339-1353.
    • (2012) J Clin Invest , vol.122 , Issue.4 , pp. 1339-1353
    • Bomfim, T.R.1    Forny-Germano, L.2    Sathler, L.B.3
  • 71
    • 84862552464 scopus 로고    scopus 로고
    • APL-1: The Alzheimer's Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development
    • Ewald CY, Raps DA, Li C. APL-1: the Alzheimer's Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development. Genetics 2012; 191(2): 493-507.
    • (2012) Genetics , vol.191 , Issue.2 , pp. 493-507
    • Ewald, C.Y.1    Raps, D.A.2    Li, C.3
  • 72
    • 84862834663 scopus 로고    scopus 로고
    • Caenorhabditis elegans as a model organism to study APP function
    • Ewald CY, Li C. Caenorhabditis elegans as a model organism to study APP function. Exp Brain Res 2012; 217(3-4): 397-411.
    • (2012) Exp Brain Res , vol.217 , Issue.3-4 , pp. 397-411
    • Ewald, C.Y.1    Li, C.2
  • 73
    • 84861553118 scopus 로고    scopus 로고
    • Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice
    • Hiltunen M, Khandelwal VK, Yaluri N, et al. Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice. J Cell Mol Med 2012; 16(6): 1206-1222.
    • (2012) J Cell Mol Med , vol.16 , Issue.6 , pp. 1206-1222
    • Hiltunen, M.1    Khandelwal, V.K.2    Yaluri, N.3
  • 74
    • 84867270258 scopus 로고    scopus 로고
    • Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes
    • Lane RF, St George-Hyslop P, Hempstead BL, et al. Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes. J Neurosci 2012; 32(41): 14080-6.
    • (2012) J Neurosci , vol.32 , Issue.41 , pp. 14080-14086
    • Lane, R.F.1    St, G.-H.P.2    Hempstead, B.L.3
  • 75
    • 78650122129 scopus 로고    scopus 로고
    • Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease
    • Frisardi V, Solfrizzi V, Seripa D, et al. Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer's disease. Ageing Res Rev 2010; 9(4): 399-417.
    • (2010) Ageing Res Rev , vol.9 , Issue.4 , pp. 399-417
    • Frisardi, V.1    Solfrizzi, V.2    Seripa, D.3
  • 76
    • 84855525518 scopus 로고    scopus 로고
    • Genetics of late-onset Alzheimer's disease: Update from the alzgene database and analysis of shared pathways
    • Olgiati P, Politis AM, Papadimitriou GN, De Ronchi D, Serretti A. Genetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathways. Int J Alzheimers Dis 2011; 2011: 832379.
    • (2011) Int J Alzheimers Dis , vol.2011 , pp. 832379
    • Olgiati, P.1    Politis, A.M.2    Papadimitriou, G.N.3    de Ronchi, D.4    Serretti, A.5
  • 77
    • 33645960672 scopus 로고    scopus 로고
    • Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer's disease
    • Lester-Coll N, Rivera EJ, Soscia SJ, et al. Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. J Alzheimers Dis 2006; 9(1): 13-33.
    • (2006) J Alzheimers Dis , vol.9 , Issue.1 , pp. 13-33
    • Lester-Coll, N.1    Rivera, E.J.2    Soscia, S.J.3
  • 78
    • 84868663948 scopus 로고    scopus 로고
    • NF-kappaB-regulated, proinflammatory miRNAs in Alzheimer's disease
    • Lukiw WJ. NF-kappaB-regulated, proinflammatory miRNAs in Alzheimer's disease. Alzheimers Res Ther 2012; 4(6): 47.
    • (2012) Alzheimers Res Ther , vol.4 , Issue.6 , pp. 47
    • Lukiw, W.J.1
  • 79
    • 15244350991 scopus 로고    scopus 로고
    • Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimer's disease
    • de la Monte SM, Wands JR. Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease. J Alzheimers Dis 2005; 7(1): 45-61.
    • (2005) J Alzheimers Dis , vol.7 , Issue.1 , pp. 45-61
    • de la Monte, S.M.1    Wands, J.R.2
  • 80
    • 64249129005 scopus 로고    scopus 로고
    • Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease
    • Zhao WQ, Townsend M. Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease. Biochim Biophys Acta 2009; 1792;(5): 482-496.
    • (2009) Biochim Biophys Acta , vol.1792 , Issue.5 , pp. 482-496
    • Zhao, W.Q.1    Townsend, M.2
  • 81
    • 3543142498 scopus 로고    scopus 로고
    • Intranasal insulin improves memory in humans
    • Benedict C, Hallschmid M, Hatke A, et al. Intranasal insulin improves memory in humans. Psychoneuroendocrinology 2004; 29(10): 1326-1334.
    • (2004) Psychoneuroendocrinology , vol.29 , Issue.10 , pp. 1326-1334
    • Benedict, C.1    Hallschmid, M.2    Hatke, A.3
  • 82
    • 78650673534 scopus 로고    scopus 로고
    • Ocular biomarkers for early detection of Alzheimer's disease
    • Frost S, Martins RN, Kanagasingam Y. Ocular biomarkers for early detection of Alzheimer's disease. J Alzheimers Dis 2010; 22(1): 1-16.
    • (2010) J Alzheimers Dis , vol.22 , Issue.1 , pp. 1-16
    • Frost, S.1    Martins, R.N.2    Kanagasingam, Y.3
  • 83
    • 77949692461 scopus 로고    scopus 로고
    • Alzheimer's disease and retinal neurodegeneration
    • Guo L, Duggan J, Cordeiro MF. Alzheimer's disease and retinal neurodegeneration. Curr Alzheimer Res 2010; 7(1): 3-14.
    • (2010) Curr Alzheimer Res , vol.7 , Issue.1 , pp. 3-14
    • Guo, L.1    Duggan, J.2    Cordeiro, M.F.3
  • 84
    • 80051551540 scopus 로고    scopus 로고
    • Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer's disease
    • Alexandrov PN, Pogue A, Bhattacharjee S, Lukiw WJ. Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer's disease. Neuroreport 2011; 22(12): 623-7.
    • (2011) Neuroreport , vol.22 , Issue.12 , pp. 623-627
    • Alexandrov, P.N.1    Pogue, A.2    Bhattacharjee, S.3    Lukiw, W.J.4
  • 85
    • 80053935409 scopus 로고    scopus 로고
    • Characterisation of amyloidinduced inflammatory responses in the rat retina
    • Howlett DR, Bate ST, Collier S, et al. Characterisation of amyloidinduced inflammatory responses in the rat retina. Exp Brain Res 2011; 214(2): 185-197.
    • (2011) Exp Brain Res , vol.214 , Issue.2 , pp. 185-197
    • Howlett, D.R.1    Bate, S.T.2    Collier, S.3
  • 86
    • 84867537762 scopus 로고    scopus 로고
    • Amyloid-beta and tau pathology of Alzheimer's disease induced by diabetes in a rabbit animal model
    • Bitel CL, Kasinathan C, Kaswala RH, Klein WL, Frederikse PH. Amyloid-beta and tau pathology of Alzheimer's disease induced by diabetes in a rabbit animal model. J Alzheimers Dis 2012; 32(2): 291-305.
    • (2012) J Alzheimers Dis , vol.32 , Issue.2 , pp. 291-305
    • Bitel, C.L.1    Kasinathan, C.2    Kaswala, R.H.3    Klein, W.L.4    Frederikse, P.H.5
  • 87
    • 84863717137 scopus 로고    scopus 로고
    • Neurodegeneration of the retina in mouse models of Alzheimer's disease: What can we learn from the retina?
    • Chiu K, Chan TF, Wu A, et al. Neurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina? Age(Dordr) 2012; 34(3): 633-649.
    • (2012) Age(Dordr) , vol.34 , Issue.3 , pp. 633-649
    • Chiu, K.1    Chan, T.F.2    Wu, A.3
  • 88
    • 84860217982 scopus 로고    scopus 로고
    • Alzheimer's disease in the retina: Imaging retinal abeta plaques for early diagnosis and therapy assessment
    • Koronyo Y, Salumbides BC, Black KL, Koronyo-Hamaoui M. Alzheimer's disease in the retina: imaging retinal abeta plaques for early diagnosis and therapy assessment. Neurodegener Dis 2012; 10(1-4): 285-293.
    • (2012) Neurodegener Dis , vol.10 , Issue.1-4 , pp. 285-293
    • Koronyo, Y.1    Salumbides, B.C.2    Black, K.L.3    Koronyo-Hamaoui, M.4
  • 89
    • 4644286910 scopus 로고    scopus 로고
    • Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
    • Ho L, Qin W, Pompl PN, et al. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. Faseb J 2004; 18(7): 902-4.
    • (2004) Faseb J , vol.18 , Issue.7 , pp. 902-904
    • Ho, L.1    Qin, W.2    Pompl, P.N.3
  • 90
    • 77950219236 scopus 로고    scopus 로고
    • Increased food intake leads to obesity and insulin resistance in the tg2576; Alzheimer's disease mouse model
    • Kohjima M, Sun Y, Chan L. Increased food intake leads to obesity and insulin resistance in the tg2576; Alzheimer's disease mouse model. Endocrinology 2010; 151(4): 1532-1540.
    • (2010) Endocrinology , vol.151 , Issue.4 , pp. 1532-1540
    • Kohjima, M.1    Sun, Y.2    Chan, L.3
  • 91
    • 27744480577 scopus 로고    scopus 로고
    • A text-mining tool for integrating associations between genetic and biochemical entities with genome annotation and biochemical terms lists
    • Dragon Plant Biology Explorer
    • Bajic VB, Veronika M, Veladandi PS, et al. Dragon Plant Biology Explorer. A text-mining tool for integrating associations between genetic and biochemical entities with genome annotation and biochemical terms lists. Plant Physiol 2005; 138(4): 1914-1925.
    • (2005) Plant Physiol , vol.138 , Issue.4 , pp. 1914-1925
    • Bajic, V.B.1    Veronika, M.2    Veladandi, P.S.3
  • 92
    • 41949096408 scopus 로고    scopus 로고
    • Towards ontologydriven navigation of the lipid bibliosphere
    • Baker CJ, Kanagasabai R, Ang WT, et al. Towards ontologydriven navigation of the lipid bibliosphere. BMC Bioinform 2008; 9(Suppl 1): S5.
    • (2008) BMC Bioinform , vol.9 , Issue.SUPPL. 1
    • Baker, C.J.1    Kanagasabai, R.2    Ang, W.T.3
  • 93
    • 53149152594 scopus 로고    scopus 로고
    • Ontology-centric integration and navigation of the dengue literature
    • Rajapakse M, Kanagasabai R, Ang WT, et al. Ontology-centric integration and navigation of the dengue literature. J Biomed Inform 2008; 41(5): 806-815.
    • (2008) J Biomed Inform , vol.41 , Issue.5 , pp. 806-815
    • Rajapakse, M.1    Kanagasabai, R.2    Ang, W.T.3
  • 95
    • 84856606017 scopus 로고    scopus 로고
    • Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease
    • de la Monte SM. Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease. Front Biosci 2012; 4: 1582-1605.
    • (2012) Front Biosci , vol.4 , pp. 1582-1605
    • de la Monte, S.M.1
  • 96
    • 62449166389 scopus 로고    scopus 로고
    • PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
    • Qin W, Haroutunian V, Katsel P, et al. PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia. Arch Neurol 2009; 66(3): 352-361.
    • (2009) Arch Neurol , vol.66 , Issue.3 , pp. 352-361
    • Qin, W.1    Haroutunian, V.2    Katsel, P.3
  • 97
    • 84869406107 scopus 로고    scopus 로고
    • Molecular mechanisms of the neuroprotective/neurorescue action of multitarget green tea polyphenols
    • Mandel SA, Weinreb O, Amit T, Youdim MB. Molecular mechanisms of the neuroprotective/neurorescue action of multitarget green tea polyphenols. Front Biosci 2012; 4: 581-598.
    • (2012) Front Biosci , vol.4 , pp. 581-598
    • Mandel, S.A.1    Weinreb, O.2    Amit, T.3    Youdim, M.B.4
  • 98
    • 79959639874 scopus 로고    scopus 로고
    • Dementia, diabetes, Alzheimer's disease, and insulin resistance in the brain: Progress, dilemmas, new opportunities, and a hypothesis to tackle intersecting epidemics
    • Kuljis RO, Salkovic-Petrisic M. Dementia, diabetes, Alzheimer's disease, and insulin resistance in the brain: progress, dilemmas, new opportunities, and a hypothesis to tackle intersecting epidemics. J Alzheimers Dis 2011; 25(1): 29-41.
    • (2011) J Alzheimers Dis , vol.25 , Issue.1 , pp. 29-41
    • Kuljis, R.O.1    Salkovic-Petrisic, M.2
  • 99
    • 84875245617 scopus 로고    scopus 로고
    • Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-gamma coactivator 1alpha regulated beta-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models
    • Gong B, Pan Y, Vempati P, et al. Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-gamma coactivator 1alpha regulated beta-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models. Neurobiol Aging 2013; 34: 1581-1588.
    • (2013) Neurobiol Aging , vol.34 , pp. 1581-1588
    • Gong, B.1    Pan, Y.2    Vempati, P.3
  • 100
    • 84872516664 scopus 로고    scopus 로고
    • Alzheimer's disease and the quest for its biological measures
    • Pratico D. Alzheimer's disease and the quest for its biological measures. J Alzheimers Dis 2013; 33 Suppl 1: S237-S241.
    • (2013) J Alzheimers Dis , vol.33 , Issue.SUPPL. 1
    • Pratico, D.1
  • 101
    • 84859316471 scopus 로고    scopus 로고
    • Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits
    • Tong XK, Lecrux C, Rosa-Neto P, Hamel E. Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits. J Neurosci 2012; 32(14): 4705-4715.
    • (2012) J Neurosci , vol.32 , Issue.14 , pp. 4705-4715
    • Tong, X.K.1    Lecrux, C.2    Rosa-Neto, P.3    Hamel, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.