Actions of β-amyloid protein on human neurons are expressed through the amylin receptor

American Journal of Pathology

Volumn 178, Issue 1, 2011, Pages 140-149

  Jhamandas, Jack H ^a   Li, Zongming ^a   Westaway, David ^a,b   Yang, Jing ^a,b   Jassar, Simran ^a   MacTavish, David ^a  

^a Department of Medicine   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AC253; AMYLIN; AMYLOID BETA PROTEIN[1-42]; CASPASE 6; CASPASE 9; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CELL DEATH; CONTROLLED STUDY; DRUG INHIBITION; FETUS; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MOUSE; NERVE CELL CULTURE; NEUROMODULATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 79251473696     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2010.11.022     Document Type: Article

References (47)

1. Brouwers N, Sleegers K, Van Broeckhoven C: Molecular genetics of Alzheimer's disease: an update. Ann Med 2008, 40:562-583
2. Yankner BA, Lu T: Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem 2009, 284:4755-4759
3. Price DL, Wong PC, Markowska AL, Lee MK, Thinakaren G, Cleveland DW, Sisodia SS, Borchelt DR: The value of transgenic models for the study of neurodegenerative diseases. Ann N Y Acad Sci 2000, 920:179-191
4. Chen X, Walker DG, Schmidt AM, Arancio O, Lue LF, Yan SD: RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease. Curr Mol Med 2007, 7:735-742
5. Salminen A, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T: Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors. Prog Neurobiol 2009, 87:181-194
6. Sotthibundhu A, Sykes AM, Fox B, Underwood CK, Thangnipon W, Coulson EJ: Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor. J Neurosci 2008, 28:3941-3946
7. Parri RH, Dineley TK: Nicotinic acetylcholine receptor interaction with beta-amyloid: molecular, cellular, and physiological consequences. Curr Alzheimer Res 2010, 7:27-39
8. Mehta TK, Dougherty JJ, Wu J, Choi CH, Khan GM, Nichols RA: Defining pre-synaptic nicotinic receptors regulated by beta amyloid in mouse cortex and hippocampus with receptor null mutants. J Neurochem 2009, 109:1452-1458
9. Sun MK, Alkon DL: Links between Alzheimer's disease and diabetes. Drugs Today (Barc) 2006, 42:481-489
10. Craft S: Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res 2007, 4:147-152
11. Lin L, Hölscher C: Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res Rev 2007, 56:384-402
12. Cooper GJ, Willis AC, Clark A, Turner RC, Sim RB, Reid KB: Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 1987, 84:8628-8632
13. Arispe N, Pollard HB, Rojas E: Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membrane. Proc Natl Acad Sci USA 1993, 90:10573-10577
14. May PC, Boggs LN, Fuson KS: Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer's disease amyloid- beta neurotoxicity. J Neurochem 1993, 61:2330-2333
15. Tucker HM, Rydel RE, Wright S, Estus S: Human amylin induces "apoptotic" pattern of gene expression concomitant with cortical neuronal atrophy. J Neurochem 1998, 71:506-516
16. Jhamandas JH, Cho C, Jassar B, Harris K, MacTavish D, Easaw J: Cellular mechanisms for amyloid-beta protein activation of rat cholinergic basal forebrain neurons. J Neurophysiol 2001, 86:1312-1320
17. Jhamandas JH, Harris KH, Cho C, Fu W, MacTavish D: Human amylin actions on rat cholinergic basal forebrain neurons: antagonism of beta-amyloid effects. J Neurophysiol 2003, 90:3130-3136
18. Lim YA, Ittner LM, Lim YL, Götz J: Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures. FEBS Lett 2008, 582:2188-2194
19. Lim YA, Rhein V, Baysang G, Meier F, Poljak A, Raftery MJ, Guilhaus M, Ittner LM, Eckert A, Götz J: Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics 2010, 10:1621-1633
20. Poyner DR, Sexton PM, Marshall I, Smith DM, Quirion R, Born W, Muff R, Fischer JA, Foord SM: International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 2002, 54:233-246
21. Young A: Receptor pharmacology. Adv Pharmacol 2005, 52:47-65
22. Hay DL, Christopoulos G, Christopoulos A, Sexton PM: Amylin receptors: molecular composition and pharmacology. Biochem Soc Trans 2004, 32:865-867
23. Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM: Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes. Mol Pharmacol 2005, 67:1655-1665
24. Cantarella G, Martinez G, Di Benedetto G, Loreto C, Musumeci G, Prato A, Lempereur L, Matera M, Amico-Roxas M, Bernardini R, Clementi G: Protective effects of amylin on reserpine-induced gastric damage in the rat. Pharmacol Res 2007, 56:27-34
25. Morfis M, Tilakaratne N, Furness SG, Christopoulos G, Werry TD, Christopoulos A, Sexton PM: Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology 2008, 149: 5423-5431
26. Jhamandas JH, MacTavish D: Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci 2004, 24:5579-5584
27. Power C, McArthur JC, Nath A, Wehrly K, Mayne M, Nishio J, Langelier T, Johnson RT, Chesebro B: Neuronal death induced by brainderived human immunodeficiency virus type 1 envelope genes differs between demented and nondemented AIDS patients. J Virol 1998, 72:9045-9053
28. Stine WB Jr, Dahlgren KN, Krafft GA, LaDu MJ: In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis. J Biol Chem 2003, 278:11612-11622
29. White JA, Manelli AM, Holmberg KH, Van Eldik LJ, Ladu MJ: Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation. Neurobiol Dis 2005, 18:459-465
30. Ding X, MacTavish D, Kar S, Jhamandas JH: Galanin attenuates betaamyloid (Abeta) toxicity in rat cholinergic basal forebrain neurons. Neurobiol Dis 2006, 21:413-420
31. Riediger T, Rauch M, Schmid HA: Actions of amylin on subfornical organ neurons and on drinking behaviour in rats. Am J Physiol 1999, 276:R514-521
32. Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE: beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 1992, 12:376-389
33. Afkhami-Goli A, Noorbakhsh F, Keller AJ, Vergnolle N, Westaway D, Jhamandas JH, Andrade-Gordon P, Hollenberg MD, Arab H, Dyck RH, Power C: Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease. J Immunol 2007, 179:5493-5503
34. Ryan SD, Whitehead SN, Swayne LA, Moffat TC, Hou W, Ethier M, Bourgeois AJ, Rashidian J, Blanchard AP, Fraser PE, Park DS, Figeys D, Bennett SA: Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism. Proc Natl Acad Sci USA 2009, 106:20936-20941
35. Villa P, Kaufmann SH, Earnshaw WC: Caspases and caspase inhibitors. Trends Biochem Sci 1997, 22:388-393
36. Yuan J, Yankner BA: Apoptosis in the nervous system. Nature 2000, 407:802-809
37. Cregan SP, Dawson VL, Slack RS: Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene 2004, 23: 2785-2796
38. Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, George-Hyslop PS, Westaway D: Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein. J Biol Chem 2001, 276:21562-21570
39. Bredesen DE, Rao RV, Mehlen P: Cell death in the nervous system. Nature 2006, 443:796-802
40. Krantic S, Mechawar N, Reix S, Quirion R: Apoptosis-inducing factor: a matter of neuron life and death. Prog Neurobiol 2007, 81:179-196
41. Van Vickle GD, Esh CL, Kalback WM, Patton RL, Luehrs DC, Kokjohn TA, Fifield FG, Fraser PE, Westaway D, McLaurin J, Lopez J, Brune D, Newel AJ, Poston M, Beach TG, Roher AE: TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gammasecretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation. Biochemistry 2007, 46:10317-10327
42. Götz J, Ittner LM, Lim YA: Common features between diabetes mellitus and Alzheimer's disease. Cell Mol Life Sci 2009, 66:1321-1325
43. Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S: Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci USA 2003, 100:4162-4167
44. Gasparini L, Xu H: Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends Neurosci 2003, 26:404-406
45. Münch G, Schinzel R, Loske C, Wong A, Durany N, Li JJ, Vlassara H, Smith MA, Perry G, Riederer P: Alzheimer's disease - synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. J Neural Transm 1998, 105:439-461
46. Yamagishi S, Takeuchi M, Inagaki Y, Nakamura K, Imaizumi T: Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy. Int J Clin Pharmacol Res 2003, 23:129-134 (Pubitemid 38821763)
47. Ledesma MD, Bonay P, Colaço C, Avila J: Analysis of microtubule-associated protein tau glycation in paired helical filaments. J Biol Chem 1994, 269:21614-21619 (Pubitemid 24274797)