메뉴 건너뛰기




Volumn 34, Issue 2, 2013, Pages 469-483

Blood transcriptomic biomarkers of Alzheimer's disease patients treated with EHT 0202

Author keywords

Alzheimer's disease; biomarker; blood; drug response; gene expression; microarray; molecular signature; transcriptome

Indexed keywords

DONEPEZIL; EHT 0202; GALANTAMINE; NOOTROPIC AGENT; PLACEBO; RIVASTIGMINE; UNCLASSIFIED DRUG;

EID: 84874301925     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-121501     Document Type: Article
Times cited : (13)

References (51)
  • 1
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe DJ (1991) The molecular pathology of Alzheimer's disease. Neuron 6, 4487-4498
    • (1991) Neuron , vol.6 , pp. 4487-4498
    • Selkoe, D.J.1
  • 2
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944 (Pubitemid 14076461)
    • (1984) Neurology , vol.34 , Issue.7 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3
  • 3
    • 35848962080 scopus 로고    scopus 로고
    • Disease-modifying therapies for Alzheimer disease: Challenges to early intervention
    • DOI 10.1212/01.wnl.0000295996.54210.69, PII 0000611420071016000012
    • Cummings JL, Doody R, Clark C (2007) Disease-modifying therapies for Alzheimer disease: Challenges to early intervention. Neurology 69, 1622-1634 (Pubitemid 350287147)
    • (2007) Neurology , vol.69 , Issue.16 , pp. 1622-1634
    • Cummings, J.L.1    Doody, R.2    Clark, C.3
  • 5
    • 79951819887 scopus 로고    scopus 로고
    • Transcriptional profiling of peripheral blood mononuclear cells in pancreatic cancer patients identifies novel genes with potential diagnostic utility
    • Baine MJ, Chakraborty S, Smith LM, Mallya K, Sasson AR, Brand RE, Batra SK (2011) Transcriptional profiling of peripheral blood mononuclear cells in pancreatic cancer patients identifies novel genes with potential diagnostic utility. PLoS One 6, e17014
    • (2011) PLoS One , vol.6
    • Baine, M.J.1    Chakraborty, S.2    Smith, L.M.3    Mallya, K.4    Sasson, A.R.5    Brand, R.E.6    Batra, S.K.7
  • 9
    • 35148814074 scopus 로고    scopus 로고
    • Transcriptional profiling of Alzheimer blood mononuclear cells by microarray
    • DOI 10.1016/j.neurobiolaging.2006.08.004, PII S0197458006002983
    • Maes OC, Xu S, Yu B, Chertkow HM,Wang E, Schipper HM (2007) Transcriptional profiling of Alzheimer blood mononuclear cells by microarray. Neurobiol Aging 28, 1795-1809 (Pubitemid 47539691)
    • (2007) Neurobiology of Aging , vol.28 , Issue.12 , pp. 1795-1809
    • Maes, O.C.1    Xu, S.2    Yu, B.3    Chertkow, H.M.4    Wang, E.5    Schipper, H.M.6
  • 15
    • 75849145292 scopus 로고    scopus 로고
    • Expansion of the eukaryotic proteome by alternative splicing
    • Nilsen TW, Graveley BR (2010) Expansion of the eukaryotic proteome by alternative splicing. Nature 463, 457-463
    • (2010) Nature , vol.463 , pp. 457-463
    • Nilsen, T.W.1    Graveley, B.R.2
  • 16
    • 79251644774 scopus 로고    scopus 로고
    • Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease
    • TwineNA, Janitz K,WilkinsMR,JanitzM(2011) Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease. PLoS One 6, e16266
    • (2011) PLoS One , vol.6
    • Twine, N.A.1    Janitz, K.2    Wilkins, M.R.3    Janitz, M.4
  • 17
    • 77955454185 scopus 로고    scopus 로고
    • Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways
    • Miller JA, Horvath S, Geschwind DH (2010) Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways. Proc Natl Acad Sci U S A 107, 12698-12703
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 12698-12703
    • Miller, J.A.1    Horvath, S.2    Geschwind, D.H.3
  • 18
    • 78650612766 scopus 로고    scopus 로고
    • Gene expression reveals overlap between normal aging and Alzheimer's disease genes
    • Avramopoulos D, Szymanski M, Wang R, Bassett S (2010) Gene expression reveals overlap between normal aging and Alzheimer's disease genes. Neurobiol Aging 32, 2319.e27-e34
    • (2010) Neurobiol Aging , vol.32 , Issue.2319
    • Avramopoulos, D.1    Szymanski, M.2    Wang, R.3    Bassett, S.4
  • 20
    • 77951206366 scopus 로고    scopus 로고
    • Etazolate improves performance in a foraging and homing task in aged rats
    • Drott J, Desire L, Drouin D, Pando M, Haun F (2010) Etazolate improves performance in a foraging and homing task in aged rats. Eur J Pharmacol 634, 95-100
    • (2010) Eur J Pharmacol , vol.634 , pp. 95-100
    • Drott, J.1    Desire, L.2    Drouin, D.3    Pando, M.4    Haun, F.5
  • 21
    • 33644535477 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptor inhibition in transgenic Alzheimer-like Tg2576 mice by scopolamine favours the amyloidogenic route of processing of amyloid precursor protein
    • DOI 10.1016/j.ijdevneu.2005.11.010, PII S0736574805001450, Neural Signal Transduction in Health and Disease - Cytokinesd, Mitochondrial Dysfunction and Transport Processes
    • Liskowsky W, Schliebs R (2006) Muscarinic acetylcholine receptor inhibition in transgenic Alzheimer-like Tg2576 mice by scopolamine favours the amyloidogenic route of processing of amyloid precursor protein. Int J Dev Neurosci 24, 149-156 (Pubitemid 43294621)
    • (2006) International Journal of Developmental Neuroscience , vol.24 , Issue.2-3 , pp. 149-156
    • Liskowsky, W.1    Schliebs, R.2
  • 23
    • 77949335693 scopus 로고    scopus 로고
    • Drug treatment of Alzheimer's disease patients leads to expression changes in peripheral blood cells
    • Calciano MA, Zhou W, Snyder PJ, Einstein R (2010) Drug treatment of Alzheimer's disease patients leads to expression changes in peripheral blood cells. Alzheimers Dement 5, 386-393
    • (2010) Alzheimers Dement , vol.5 , pp. 386-393
    • Calciano, M.A.1    Zhou, W.2    Snyder, P.J.3    Einstein, R.4
  • 24
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources
    • Huang DW, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources. Nature Protoc 4, 44-57
    • (2009) Nature Protoc , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 27
    • 67649682161 scopus 로고    scopus 로고
    • Adiposity, type 2 diabetes, and Alzheimer's disease
    • Luchsinger JA, Gustafson DR (2009) Adiposity, type 2 diabetes, and Alzheimer's disease. J Alzheimers Dis 16, 693-704
    • (2009) J Alzheimers Dis , vol.16 , pp. 693-704
    • Luchsinger, J.A.1    Gustafson, D.R.2
  • 28
    • 1842734649 scopus 로고    scopus 로고
    • Modulation of memory by insulin and glucose: Neuropsychological observations in Alzheimer's disease
    • DOI 10.1016/j.ejphar.2004.02.048, PII S0014299904002055
    • Watson GS, Craft S (2004) Modulation of memory by insulin and glucose: Neuropsychological observations in Alzheimer's disease. Eur J Pharmacol 490, 97-113 (Pubitemid 38482164)
    • (2004) European Journal of Pharmacology , vol.490 , Issue.1-3 , pp. 97-113
    • Watson, G.S.1    Craft, S.2
  • 32
    • 80053894087 scopus 로고    scopus 로고
    • Analternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model
    • Asai M, Yagishita S, Iwata N, Saido TC, Ishiura S, Maruyama K(2011)Analternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model. FASEB J 25, 3720-3730
    • (2011) FASEB J , vol.25 , pp. 3720-3730
    • Asai, M.1    Yagishita, S.2    Iwata, N.3    Saido, T.C.4    Ishiura, S.5    Maruyama, K.6
  • 34
    • 0035884954 scopus 로고    scopus 로고
    • Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia
    • Pasinetti GM (2001) Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia. J Neurosci Res 65, 71-76
    • (2001) J Neurosci Res , vol.65 , pp. 71-76
    • Pasinetti, G.M.1
  • 35
    • 85047694516 scopus 로고    scopus 로고
    • Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment
    • DOI 10.1172/JCI200422831
    • Gong B, Vitolo OV, Trinchese F, Liu S, Shelanski M, Arancio O (2004) Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J Clin Invest 114, 1624-1634 (Pubitemid 40385553)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.11 , pp. 1624-1634
    • Gong, B.1    Vitolo, O.V.2    Trinchese, F.3    Liu, S.4    Shelanski, M.5    Arancio, O.6
  • 36
    • 0034043203 scopus 로고    scopus 로고
    • CaM-kinases: Modulators of synaptic plasticity
    • DOI 10.1016/S0959-4388(00)00090-8
    • Soderling T (2000) CaM-kinases: Modulators of synaptic plasticity. Curr Opin Neurobiol 10, 375-380 (Pubitemid 30389306)
    • (2000) Current Opinion in Neurobiology , vol.10 , Issue.3 , pp. 375-380
    • Soderling, T.R.1
  • 37
    • 77953892400 scopus 로고    scopus 로고
    • Molecular mechanisms of neurodegeneration in Alzheimer's disease
    • Crews L, Masliah E (2010) Molecular mechanisms of neurodegeneration in Alzheimer's disease. Hum Mol Genet 19(R1), R12-R20
    • (2010) Hum Mol Genet , vol.19 , Issue.R1
    • Crews, L.1    Masliah, E.2
  • 38
    • 79960566233 scopus 로고    scopus 로고
    • AMP-activated protein kinase:Apotential player in Alzheimer's disease. AMP-activated protein kinase: A potential player in Alzheimer's disease
    • Salminen A, Kaarniranta K, Haapasalo A, Soininen H, HiltunenM(2011) AMP-activated protein kinase:Apotential player in Alzheimer's disease. AMP-activated protein kinase: A potential player in Alzheimer's disease. J Neurochem 118, 460-474
    • (2011) J Neurochem , vol.118 , pp. 460-474
    • Salminen, A.1    Kaarniranta, K.2    Haapasalo, A.3    Soininen, H.4    Hiltunen, M.5
  • 41
    • 0035228759 scopus 로고    scopus 로고
    • Analysis of strain and regional variation in gene expression in mouse brain
    • RESEARCH0042.1-0042.15
    • Pavlidis P, Noble WS (2001) Analysis of strain and regional variation in gene expression in mouse brain. Genome Biology 2, RESEARCH0042.1-0042.15
    • (2001) Genome Biology , vol.2
    • Pavlidis, P.1    Noble, W.S.2
  • 42
    • 4544318151 scopus 로고    scopus 로고
    • Bayesian hierarchical error model for analysis of gene expression data
    • Cho H, Lee JK (2001) Bayesian hierarchical error model for analysis of gene expression data. Bioinformatics 20, 2016-2025
    • (2001) Bioinformatics , vol.20 , pp. 2016-2025
    • Cho, H.1    Lee, J.K.2
  • 43
    • 21444453140 scopus 로고    scopus 로고
    • Control and variability of gene expression in mouse brain and in a neuroblastoma cell line
    • Iacobas DA, Urban M, Iacobas S, Spray DC (2003) Control and variability of gene expression in mouse brain and in a neuroblastoma cell line. Rom J Physiol 39-40, 71-90
    • (2003) Rom J Physiol , vol.39-40 , pp. 71-90
    • Iacobas, D.A.1    Urban, M.2    Iacobas, S.3    Spray, D.C.4
  • 44
    • 84859223046 scopus 로고    scopus 로고
    • Multivariate protein signatures of pre-clinical Alzheimer's disease in the Alzheimer's disease neuroimaging initiative (ADNI) plasma proteome dataset
    • Alzheimer's Disease Neuroimaging Initiative
    • Johnstone D, Milward EA, Berretta R, Moscato P, Alzheimer's Disease Neuroimaging Initiative (2012) Multivariate protein signatures of pre-clinical Alzheimer's disease in the Alzheimer's disease neuroimaging initiative (ADNI) plasma proteome dataset. PLoS One 7, e34341
    • (2012) PLoS One , vol.7
    • Johnstone, D.1    Milward, E.A.2    Berretta, R.3    Moscato, P.4
  • 46
    • 79251644774 scopus 로고    scopus 로고
    • Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease
    • TwineNA, Janitz K,WilkinsMR,JanitzM(2011) Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease. PLoS One 6, e16266
    • (2011) PLoS One , vol.6
    • Twine, N.A.1    Janitz, K.2    Wilkins, M.R.3    Janitz, M.4
  • 48
    • 44849130695 scopus 로고    scopus 로고
    • Messenger ribonucleic acid expression profile in peripheral blood cells from RA patients following treatment with an anti-TNF-α monoclonal antibody, infliximab
    • DOI 10.1093/rheumatology/ken083
    • Sekiguchi N, Kawauchi S, Furuya T, Inaba N, Matsuda K, Ando S, Ogasawara M, Aburatani H, Kameda H, Amano K, Abe T, Ito S, Takeuchi T (2008) Messenger ribonucleic acid expression profile in peripheral blood cells from RA patients following treatment with an anti-TNF-alpha monoclonal antibody, infliximab.Messenger ribonucleic acid expression profile in peripheral blood cells from RA patients following treatment with an anti-TNF-alpha monoclonal antibody, infliximab. Rheumatology 47, 780-788 (Pubitemid 351796361)
    • (2008) Rheumatology , vol.47 , Issue.6 , pp. 780-788
    • Sekiguchi, N.1    Kawauchi, S.2    Furuya, T.3    Inaba, N.4    Matsuda, K.5    Ando, S.6    Ogasawara, M.7    Aburatani, H.8    Kameda, H.9    Amano, K.10    Abe, T.11    Ito, S.12    Takeuchi, T.13
  • 49
    • 70849117739 scopus 로고    scopus 로고
    • Can peripheral leukocytes be used as Alzheimer's disease biomarkers?
    • Rezai-Zadeh K, Gate D, Szekely CA, Town T (2009) Can peripheral leukocytes be used as Alzheimer's disease biomarkers? Expert Rev Neurother 9, 1623-1633
    • (2009) Expert Rev Neurother , vol.9 , pp. 1623-1633
    • Rezai-Zadeh, K.1    Gate, D.2    Szekely, C.A.3    Town, T.4
  • 50
    • 80052330506 scopus 로고    scopus 로고
    • Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease
    • Biron KE, Dickstein DL, Gopaul R, Jefferies WA (2011) Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease. PLoS One 6, e23789
    • (2011) PLoS One , vol.6
    • Biron, K.E.1    Dickstein, D.L.2    Gopaul, R.3    Jefferies, W.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.