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Volumn 9, Issue 3, 2013, Pages 218-227

Alzheimer's disease and diabetes: New insights and unifying therapies

Author keywords

Alzheimer's disease; Liraglutide; Metformin; Statins; Type 2 diabetes

Indexed keywords

ADVANCED GLYCATION END PRODUCT; AMINOGUANIDINE; ATORVASTATIN; CHOLESTEROL; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; LIRAGLUTIDE; METFORMIN; MEVINOLIN; PITAVASTATIN; PLACEBO; PRAVASTATIN; PYRIDOXAMINE; SIMVASTATIN; TENILSETAM;

EID: 84878643703     PISSN: 15733998     EISSN: 18756417     Source Type: Journal    
DOI: 10.2174/1573399811309030003     Document Type: Article
Times cited : (63)

References (103)
  • 1
    • 0033862760 scopus 로고    scopus 로고
    • Diabetes Guidelines: A Summary and comparison of the recommendations of the American Diabetes Association, Veterans Health Administration, and American Association of Clinical Endocrinologists
    • Clark MJ, Sterrett JJ, Carson DS. Diabetes Guidelines: A Summary and comparison of the recommendations of the American Diabetes Association, Veterans Health Administration, and American Association of Clinical Endocrinologists. Clinical Therapeutics 2000; 22: 899-910.
    • (2000) Clinical Therapeutics , vol.22 , pp. 899-910
    • Clark, M.J.1    Sterrett, J.J.2    Carson, D.S.3
  • 2
    • 84866013344 scopus 로고    scopus 로고
    • Examining the mechanisms of glucose regulation
    • 4supp-10
    • Triplitt CL. Examining the mechanisms of glucose regulation. Am J Manag Care 2012; 18(1 Suppl): 4supp-10
    • (2012) Am J Manag Care , vol.18 , Issue.1 SUPPL.
    • Triplitt, C.L.1
  • 3
    • 33244486544 scopus 로고    scopus 로고
    • American Diabetes Association Diagnosis and classification of diabetes mellitus
    • American Diabetes Association Diagnosis and classification of diabetes mellitus. Diabetes Care 2006; 29 Suppl 1: S43-8.
    • (2006) Diabetes Care , vol.29 , Issue.SUPPL. 1
  • 4
    • 0034333018 scopus 로고    scopus 로고
    • Cognition and synaptic plasticity in diabetes mellitus
    • Gispen WH, Biessels GJ. Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosc 2000; 23: 542-9.
    • (2000) Trends Neurosc , vol.23 , pp. 542-549
    • Gispen, W.H.1    Biessels, G.J.2
  • 6
    • 0021894451 scopus 로고
    • The nature and regulation of the insulin receptor: Structure and function
    • Czech MP. The nature and regulation of the insulin receptor: structure and function. Annu Rev Physiol 1985; 47: 357-81.
    • (1985) Annu Rev Physiol , vol.47 , pp. 357-381
    • Czech, M.P.1
  • 7
    • 84859735682 scopus 로고    scopus 로고
    • HMGA1 is anovel downstream nuclear target of the insulin receptor signaling pathway
    • Chiefari E, Nevolo MT, Arcidiacono B, et al. HMGA1 is anovel downstream nuclear target of the insulin receptor signaling pathway. Sci Rep 2012. 2: 251.
    • (2012) Sci Rep , vol.2 , pp. 251
    • Chiefari, E.1    Nevolo, M.T.2    Arcidiacono, B.3
  • 9
    • 80052800916 scopus 로고    scopus 로고
    • Insulin-activated Akt rescues Aβ oxidative stress-induced cell death by orchestrating molecular trafficking
    • Picone P, Giacomazza D, Vetri V, et al. Insulin-activated Akt rescues Aβ oxidative stress-induced cell death by orchestrating molecular trafficking. Aging Cell 2011. 10: 832-43.
    • (2011) Aging Cell , vol.10 , pp. 832-843
    • Picone, P.1    Giacomazza, D.2    Vetri, V.3
  • 10
    • 84655160766 scopus 로고    scopus 로고
    • Proteolytic processing of Alzheimer's β-amyloid precursor protein
    • Zhang H, Ma Q, Zhang Y, Xu H. Proteolytic processing of Alzheimer's β-amyloid precursor protein. J Neurochem 2012. 120(Suppl.1): 9-21.
    • (2012) J Neurochem , vol.120 , Issue.SUPPL. 1 , pp. 9-21
    • Zhang, H.1    Ma, Q.2    Zhang, Y.3    Xu, H.4
  • 11
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • Kang J, Lemaire HG, Unterbeck A, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987; 325: 733-6.
    • (1987) Nature , vol.325 , pp. 733-736
    • Kang, J.1    Lemaire, H.G.2    Unterbeck, A.3
  • 12
    • 0026595567 scopus 로고
    • Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs
    • Burdick D, Soreghan B, Kwon M, et al. Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. J Biol Chem 1992; 267: 546-54.
    • (1992) J Biol Chem , vol.267 , pp. 546-554
    • Burdick, D.1    Soreghan, B.2    Kwon, M.3
  • 13
    • 0027258525 scopus 로고
    • The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
    • Jarrett JT, Berger EP, Lansbury PT. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 1993; 32: 4693-97.
    • (1993) Biochemistry , vol.32 , pp. 4693-4697
    • Jarrett, J.T.1    Berger, E.P.2    Lansbury, P.T.3
  • 14
    • 0028169925 scopus 로고
    • Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43)
    • Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron 1994; 13: 45-53.
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 15
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992; 256: 184-5.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 16
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002; 297: 353-6.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 17
    • 77958592688 scopus 로고    scopus 로고
    • Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficts in an Alzheimer transgenic mouse model
    • Wang X, Zheng W, Xie JW, et al. Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficts in an Alzheimer transgenic mouse model. Mol Neurodegener 2010; 5: 46.
    • (2010) Mol Neurodegener , vol.5 , pp. 46
    • Wang, X.1    Zheng, W.2    Xie, J.W.3
  • 18
    • 85043726941 scopus 로고    scopus 로고
    • Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AβPP-overexpressing mice
    • Plaschke K, Kopitzb J, Siegelinc M, et al. Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AβPP-overexpressing mice. J Alzheimer's Dis 2010; 19691-704.
    • (2010) J Alzheimer's Dis , pp. 19691-19704
    • Plaschke, K.1    Kopitzb, J.2    Siegelinc, M.3
  • 20
    • 67349085203 scopus 로고    scopus 로고
    • Uncontolled diabetes increase the risk of Alzheimer's disease: A population-based cohort study
    • Xu WL, von Strauss E, Qiu CX, Winbland B. Uncontolled diabetes increase the risk of Alzheimer's disease: a population-based cohort study. Diabetologia 2009; 52: 1031-39.
    • (2009) Diabetologia , vol.52 , pp. 1031-1039
    • Xu, W.L.1    von Strauss, E.2    Qiu, C.X.3    Winbland, B.4
  • 21
    • 54549127447 scopus 로고    scopus 로고
    • Impaired insulin secretion increases the risk of Alzheimer disease
    • Rönnemaa E, Zethelius B, Sundelöf J, et al. Impaired insulin secretion increases the risk of Alzheimer disease Neurology 2008; 71(14): 1065-71.
    • (2008) Neurology , vol.71 , Issue.14 , pp. 1065-1071
    • Rönnemaa, E.1    Zethelius, B.2    Sundelöf, J.3
  • 22
    • 38349059065 scopus 로고    scopus 로고
    • Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: The Cardiovascular Health Study Cognition Study
    • Irie F, Fitzpatrick AL, Lopez OL, et al. Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study. Arch Neurol 2008; 65(1): 89-93.
    • (2008) Arch Neurol , vol.65 , Issue.1 , pp. 89-93
    • Irie, F.1    Fitzpatrick, A.L.2    Lopez, O.L.3
  • 23
    • 15444339756 scopus 로고    scopus 로고
    • Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease
    • Frolich L, Blum-Degen D, Bernstein HG, et al. Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. J Neural Transm 1998; 105: 423-38.
    • (1998) J Neural Transm , vol.105 , pp. 423-438
    • Frolich, L.1    Blum-Degen, D.2    Bernstein, H.G.3
  • 24
    • 79960896430 scopus 로고    scopus 로고
    • Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
    • Liu Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes. J Pathol 2011; 225: 54-62.
    • (2011) J Pathol , vol.225 , pp. 54-62
    • Liu, Y.1    Liu, F.2    Grundke-Iqbal, I.3    Iqbal, K.4    Gong, C.X.5
  • 25
    • 15244351255 scopus 로고    scopus 로고
    • Impaired insulin and insulinlike growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes?
    • Steen E, Terry BM, Rivera EJ, et al. Impaired insulin and insulinlike growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes? J Alzheimers Dis 2005; 7: 63-80.
    • (2005) J Alzheimers Dis , vol.7 , pp. 63-80
    • Steen, E.1    Terry, B.M.2    Rivera, E.J.3
  • 26
    • 33644591150 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine
    • Rivera EJ, Goldin A, Fulmer N, Tavares R, Wands JR, de la Monte SM. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimers Dis 2005; 8: 247-68.
    • (2005) J Alzheimers Dis , vol.8 , pp. 247-268
    • Rivera, E.J.1    Goldin, A.2    Fulmer, N.3    Tavares, R.4    Wands, J.R.5    de la Monte, S.M.6
  • 27
    • 78650827898 scopus 로고    scopus 로고
    • Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease
    • Baker LD, Frank LL, Foster-Schubert K, et al. Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease. J Alzheimers Dis 2010; 22(2): 569-79.
    • (2010) J Alzheimers Dis , vol.22 , Issue.2 , pp. 569-579
    • Baker, L.D.1    Frank, L.L.2    Foster-Schubert, K.3
  • 28
    • 1242316296 scopus 로고    scopus 로고
    • Insulin and neurodegenerative disease: Shared and specific mechanisms
    • Craft S, Stennis Watson G. Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol 2004; 3: 169-78.
    • (2004) Lancet Neurol , vol.3 , pp. 169-178
    • Craft, S.1    Stennis Watson, G.2
  • 29
    • 0030053556 scopus 로고    scopus 로고
    • Memory improvement following induced hyperinsulinemia in Alzheimer's disease
    • Craft S, Newcomer J, Kanne S, et al. Memory improvement following induced hyperinsulinemia in Alzheimer's disease. Neurobiol Aging 1996; 17: 123-30.
    • (1996) Neurobiol Aging , vol.17 , pp. 123-130
    • Craft, S.1    Newcomer, J.2    Kanne, S.3
  • 30
    • 79960896430 scopus 로고    scopus 로고
    • Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
    • Liu Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes. J Pathol 2011; 225: 54-62.
    • (2011) J Pathol , vol.225 , pp. 54-62
    • Liu, Y.1    Liu, F.2    Grundke-Iqbal, I.3    Iqbal, K.4    Gong, C.X.5
  • 31
    • 0035967193 scopus 로고    scopus 로고
    • Neuronal synthesized insulin roles on neural differentiation within fetal rat neuron cell cultures
    • Schechter R, Abboud M. Neuronal synthesized insulin roles on neural differentiation within fetal rat neuron cell cultures. Brain Res Dev Brain Res 2001; 127: 41-49.
    • (2001) Brain Res Dev Brain Res , vol.127 , pp. 41-49
    • Schechter, R.1    Abboud, M.2
  • 32
    • 0030583645 scopus 로고    scopus 로고
    • Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system
    • Schechter R, Beju D, Gaffney T, Schaefer F, Whetsell L. Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system. Brain Res 1996; 736: 16-27.
    • (1996) Brain Res , vol.736 , pp. 16-27
    • Schechter, R.1    Beju, D.2    Gaffney, T.3    Schaefer, F.4    Whetsell, L.5
  • 33
    • 1842734659 scopus 로고    scopus 로고
    • The source of cerebral insulin
    • Banks WA. The source of cerebral insulin. Eur J Pharmacol 2004; 490: 5-12.
    • (2004) Eur J Pharmacol , vol.490 , pp. 5-12
    • Banks, W.A.1
  • 34
    • 57649187117 scopus 로고    scopus 로고
    • Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease
    • Mosconi L, Pupi A, De Leo MJ. Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease. Ann N Y Acad Sci 2008; 1147: 180-95.
    • (2008) Ann N Y Acad Sci , vol.1147 , pp. 180-195
    • Mosconi, L.1    Pupi, A.2    de Leo, M.J.3
  • 35
    • 3242739968 scopus 로고    scopus 로고
    • OGlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease
    • Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong CX. OGlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A. 2004; 101(29): 10804-9.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.29 , pp. 10804-10809
    • Liu, F.1    Iqbal, K.2    Grundke-Iqbal, I.3    Hart, G.W.4    Gong, C.X.5
  • 38
    • 79956359796 scopus 로고    scopus 로고
    • A common pathogenic mechanism linking type-2 diabetes and Alzheimer's disease: Evidence from animal models
    • Park SA. A common pathogenic mechanism linking type-2 diabetes and Alzheimer's disease: evidence from animal models. J Clin Neurol 2011; 7:10-18.
    • (2011) J Clin Neurol , vol.7 , pp. 10-18
    • Park, S.A.1
  • 39
    • 14744294296 scopus 로고    scopus 로고
    • Insulin protects against amyloid β-peptide toxicity in brain mitochondria of diabetic rats
    • Moreira PI, Santos MS, Sena C, Seic Ŗ Oliveira CR. Insulin protects against amyloid β-peptide toxicity in brain mitochondria of diabetic rats. Neurobiology of Disease 2005; 18(3): 628-37.
    • (2005) Neurobiology of Disease , vol.18 , Issue.3 , pp. 628-637
    • Moreira, P.I.1    Santos, M.S.2    Sena, C.3    Seic, R.4    Oliveira, C.R.5
  • 40
    • 77953486096 scopus 로고    scopus 로고
    • Insulin Promotes Survival of Amyloid-Beta Oligomers Neuroblastoma Damaged Cells via Caspase 9 Inhibition and Hsp70 Upregulation
    • Di Carlo M, Picone P, Carrotta R, Giacomazza D, San Biagio PL. Insulin Promotes Survival of Amyloid-Beta Oligomers Neuroblastoma Damaged Cells via Caspase 9 Inhibition and Hsp70 Upregulation. J Biomed Biotechnol 2010; 2010: 147835.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 147835
    • Di Carlo, M.1    Picone, P.2    Carrotta, R.3    Giacomazza, D.4    San Biagio, P.L.5
  • 41
    • 0031053586 scopus 로고    scopus 로고
    • Regulation of neuronal survival by the serine-threonine protein kinase Akt
    • Dudek H, Datta SR, Franke TF, et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997; 275: 661-665.
    • (1997) Science , vol.275 , pp. 661-665
    • Dudek, H.1    Datta, S.R.2    Franke, T.F.3
  • 42
    • 65249113325 scopus 로고    scopus 로고
    • The Insulin /Akt signaling pathway is targeted by intracellular b-amyloid
    • Lee HK, Kumar P, Fu Q, Rosen KM, Querfurth HW. The Insulin /Akt signaling pathway is targeted by intracellular b-amyloid. Mol Biol Cell 2009; 20: 1533-44.
    • (2009) Mol Biol Cell , vol.20 , pp. 1533-1544
    • Lee, H.K.1    Kumar, P.2    Fu, Q.3    Rosen, K.M.4    Querfurth, H.W.5
  • 44
    • 0035911163 scopus 로고    scopus 로고
    • Hsp70 and antifibrillogenic peptides promote degradation and inhibit intracellular aggregation of amyloidogenic light chains
    • Dul JL, Davis DP, Williamson EK, Stevens FJ, Argon Y. Hsp70 and antifibrillogenic peptides promote degradation and inhibit intracellular aggregation of amyloidogenic light chains. J Cell BioloL 2001; 152(4): 705-15.
    • (2001) J Cell BioloL , vol.152 , Issue.4 , pp. 705-715
    • Dul, J.L.1    Davis, D.P.2    Williamson, E.K.3    Stevens, F.J.4    Argon, Y.5
  • 45
    • 84857714157 scopus 로고    scopus 로고
    • Mechanisms underlying insulin deficiency-induced acceleration of b-amyloidosis in a mouse model of Alzheimer's Disease
    • Devi L, Alldred MJ, Ginsberg SD, Ohno M. Mechanisms underlying insulin deficiency-induced acceleration of b-amyloidosis in a mouse model of Alzheimer's Disease. PloS One 2012; 7(3): e32792.
    • (2012) PloS One , vol.7 , Issue.3
    • Devi, L.1    Alldred, M.J.2    Ginsberg, S.D.3    Ohno, M.4
  • 46
    • 0038177803 scopus 로고    scopus 로고
    • Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: Interactions with apolipoprotein
    • Craft S, Asthana S, Cook DG, et al. Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype. Psychoneuroendocrinology 2003; 28: 809-22.
    • (2003) E Genotype. Psychoneuroendocrinology , vol.28 , pp. 809-822
    • Craft, S.1    Asthana, S.2    Cook, D.G.3
  • 47
    • 40349091597 scopus 로고    scopus 로고
    • Intranasal insulin improves cognition and modulates betaamyloid in early AD
    • Reger MA, Watson GS, Green PS, et al. Intranasal insulin improves cognition and modulates betaamyloid in early AD. Neurology 2008; 70: 440-8.
    • (2008) Neurology , vol.70 , pp. 440-448
    • Reger, M.A.1    Watson, G.S.2    Green, P.S.3
  • 49
    • 3242740239 scopus 로고    scopus 로고
    • Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    • Thorne RG, Pronk GJ, Padmanabhan V, Frey WH. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 2004; 127: 481-96.
    • (2004) Neuroscience , vol.127 , pp. 481-496
    • Thorne, R.G.1    Pronk, G.J.2    Padmanabhan, V.3    Frey, W.H.4
  • 50
    • 79952439187 scopus 로고    scopus 로고
    • Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's- like changes
    • Gupta A, Bisht B, Sankar Dey C. Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's- like changes. Neuropharmacology 2011; 60: 910-20.
    • (2011) Neuropharmacology , vol.60 , pp. 910-920
    • Gupta, A.1    Bisht, B.2    Sankar Dey, C.3
  • 51
    • 0035947044 scopus 로고    scopus 로고
    • Role of insulin and insulin receptor in learning and memory
    • Zhao WQ, Alkon DL. Role of insulin and insulin receptor in learning and memory. Molecular and Cellular Endocrinology 2001; 177: 125-34.
    • (2001) Molecular and Cellular Endocrinology , vol.177 , pp. 125-134
    • Zhao, W.Q.1    Alkon, D.L.2
  • 52
    • 78650746798 scopus 로고    scopus 로고
    • Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
    • Kickstein E, Krauss S, Thornhill P, et al. Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc Natl Acad Sci U S A 2010; 107(50): 21830-5.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.50 , pp. 21830-21835
    • Kickstein, E.1    Krauss, S.2    Thornhill, P.3
  • 54
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    • Currie CJ, Poole CD, Gale EA. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia 2009. 52: 1766-77.
    • (2009) Diabetologia , vol.52 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.3
  • 55
    • 62649115914 scopus 로고    scopus 로고
    • Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription
    • Chen Y, Zhoua K, Wang R, et al. Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription. Proc Natl Acad Sci U S A 2009; 106(10): 3907-12.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.10 , pp. 3907-3912
    • Chen, Y.1    Zhoua, K.2    Wang, R.3
  • 56
    • 77649187436 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease
    • McClean PL, Gault VA, Harriott P, Hölscher C. Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease. Eur J Pharmacol 2010; 630: 158-62
    • (2010) Eur J Pharmacol , vol.630 , pp. 158-162
    • McClean, P.L.1    Gault, V.A.2    Harriott, P.3    Hölscher, C.4
  • 57
    • 0041592594 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes
    • Gault VA, Flatt PR, O'Harte FP. Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes. Biochem Biophys Res Commun 2003; 308: 207-13.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 207-213
    • Gault, V.A.1    Flatt, P.R.2    O'Harte, F.P.3
  • 58
    • 0042379840 scopus 로고    scopus 로고
    • Glucagon like peptide- 1 (7-36) amide (GLP-1) nerve terminals densely innervate corticotropin- releasing hormone neurons in the hypothalamic paraventricular nucleus
    • Sarkar S, Fekete C, Legradi G, Lechan RM. Glucagon like peptide- 1 (7-36) amide (GLP-1) nerve terminals densely innervate corticotropin- releasing hormone neurons in the hypothalamic paraventricular nucleus. Brain Res 2003; 985: 163-68.
    • (2003) Brain Res , vol.985 , pp. 163-168
    • Sarkar, S.1    Fekete, C.2    Legradi, G.3    Lechan, R.M.4
  • 59
    • 69549138878 scopus 로고    scopus 로고
    • Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
    • Abbas T, Faivre E, Hölscher C. Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease. Behav Brain Res 2009; 205: 265-71.
    • (2009) Behav Brain Res , vol.205 , pp. 265-271
    • Abbas, T.1    Faivre, E.2    Hölscher, C.3
  • 60
    • 77649188009 scopus 로고    scopus 로고
    • Val(8)GLP-1, a protease- resistant incretin analogue, prevents the impairment of hippocampal synaptic plasticity in an APP/PS-1 mouse model of Alzheimer's disease
    • Gengler S, Gault V, Jucker M, Holscher C. Val(8)GLP-1, a protease- resistant incretin analogue, prevents the impairment of hippocampal synaptic plasticity in an APP/PS-1 mouse model of Alzheimer's disease. Annual Soc Neurosci meeting 2008; 38.
    • (2008) Annual Soc Neurosci Meeting , pp. 38
    • Gengler, S.1    Gault, V.2    Jucker, M.3    Holscher, C.4
  • 61
    • 33748988258 scopus 로고    scopus 로고
    • Aß42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
    • Radde R, Bolmont T, Käser S, et al. Aß42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep 2006; 7: 940-7.
    • (2006) EMBO Rep , vol.7 , pp. 940-947
    • Radde, R.1    Bolmont, T.2    Käser, S.3
  • 62
    • 84873735760 scopus 로고    scopus 로고
    • Liraglutide protects against amyloid-protein-induced impairment of spatial learning and memory in rats
    • In press
    • Han WN, Hölscher C, Yuan L, et al. Liraglutide protects against amyloid-protein-induced impairment of spatial learning and memory in rats. Neurobiol Aging 2012. (In press)
    • (2012) Neurobiol Aging
    • Han, W.N.1    Hölscher, C.2    Yuan, L.3
  • 63
    • 84865070709 scopus 로고    scopus 로고
    • Effect of the once-daily human GLP-1 analogue liraglutide on appetite, energy intake, energy expenditure and gastric emptying in type 2 diabetes
    • In press
    • Horowitz M, Flint A, Jones KL, et al. Effect of the once-daily human GLP-1 analogue liraglutide on appetite, energy intake, energy expenditure and gastric emptying in type 2 diabetes. Diabetes Res Clin Pract 2012. (In press)
    • (2012) Diabetes Res Clin Pract
    • Horowitz, M.1    Flint, A.2    Jones, K.L.3
  • 64
    • 79955749452 scopus 로고    scopus 로고
    • The Diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's Disease
    • McClean PL, Parthsarathy V, Faivre E, Holscher C. The Diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's Disease. J Neurosc 2011; 31(17): 6587-6594.
    • (2011) J Neurosc , vol.31 , Issue.17 , pp. 6587-6594
    • McClean, P.L.1    Parthsarathy, V.2    Faivre, E.3    Holscher, C.4
  • 65
    • 0027406191 scopus 로고
    • Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the multiple risk factor intervention trial
    • Stamler J, Vaccaro O, Neaton JD, Wentworth D. Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the multiple risk factor intervention trial. Diabetes Care 1993; 16: 434-44.
    • (1993) Diabetes Care , vol.16 , pp. 434-444
    • Stamler, J.1    Vaccaro, O.2    Neaton, J.D.3    Wentworth, D.4
  • 66
    • 84856235572 scopus 로고    scopus 로고
    • Impairment of the ABCA1 and SR-BI-mediated cholesterol efflux pathways and HDL anti-inflammatory activity in Alzheimer's disease
    • Khalil A, Berrougui H, Pawelec G, Fulop T. Impairment of the ABCA1 and SR-BI-mediated cholesterol efflux pathways and HDL anti-inflammatory activity in Alzheimer's disease. Mech Ageing Dev 2012; 133(1): 20-9.
    • (2012) Mech Ageing Dev , vol.133 , Issue.1 , pp. 20-29
    • Khalil, A.1    Berrougui, H.2    Pawelec, G.3    Fulop, T.4
  • 68
    • 61649094721 scopus 로고    scopus 로고
    • Higher total cholesterol, cognitive decline, and dementia
    • Panza F, Solfrizzi V, D'Introno A, et al. Higher total cholesterol, cognitive decline, and dementia. Neurobiol Aging 2009; 30: 546-8.
    • (2009) Neurobiol Aging , vol.30 , pp. 546-548
    • Panza, F.1    Solfrizzi, V.2    D'introno, A.3
  • 69
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3- hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
    • Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G. Decreased prevalence of Alzheimer disease associated with 3- hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol 2000; 57: 1439-43.
    • (2000) Arch Neurol , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruosseau, P.3    Celesia, G.G.4    Siegel, G.5
  • 70
    • 0035160066 scopus 로고    scopus 로고
    • A cholesterollowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease
    • Refolo LM, Pappolla MA, LaFrancois J, et al. A cholesterollowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis 2001; 8: 890-9.
    • (2001) Neurobiol Dis , vol.8 , pp. 890-899
    • Refolo, L.M.1    Pappolla, M.A.2    Lafrancois, J.3
  • 71
    • 0033611310 scopus 로고    scopus 로고
    • Reduced coronary events in simvastatin-treated patients with coronary heart disease and diabetes or impaired fasting glucose levels: Subgroup analyses in the Scandinavian Simvastatin Survival Study
    • Haffner SM, Alexander CM, Cook TJ, et al. Reduced coronary events in simvastatin-treated patients with coronary heart disease and diabetes or impaired fasting glucose levels: subgroup analyses in the Scandinavian Simvastatin Survival Study. Arch Intern Med 1999; 159:2661-7.
    • (1999) Arch Intern Med , vol.159 , pp. 2661-2667
    • Haffner, S.M.1    Alexander, C.M.2    Cook, T.J.3
  • 72
    • 0032497945 scopus 로고    scopus 로고
    • Cardiovascular events and their reduction with pravastatin in diabetic and glucoseintolerant myocardial infarction survivors with average cholesterol levels: Subgroup analysis in the cholesterol and recurrent events (CARE) trial: The CARE Investigators
    • Goldberg RB, Mellies MJ, Sacks FM, et al. Cardiovascular events and their reduction with pravastatin in diabetic and glucoseintolerant myocardial infarction survivors with average cholesterol levels: subgroup analysis in the cholesterol and recurrent events (CARE) trial: the CARE Investigators. Circulation 1998; 98: 2513-9.
    • (1998) Circulation , vol.98 , pp. 2513-2519
    • Goldberg, R.B.1    Mellies, M.J.2    Sacks, F.M.3
  • 73
    • 10744228379 scopus 로고    scopus 로고
    • Secondary prevention of cardiovascular events with long-term pravastatin in patients with diabetes or impaired fasting glucose
    • LIPID Study Group
    • Keech A, Colquhoun D, Best J. LIPID Study Group. Secondary prevention of cardiovascular events with long-term pravastatin in patients with diabetes or impaired fasting glucose. Diabetes Care 2003; 26(10): 2713-21.
    • (2003) Diabetes Care , vol.26 , Issue.10 , pp. 2713-2721
    • Keech, A.1    Colquhoun, D.2    Best, J.3
  • 74
    • 0035936527 scopus 로고    scopus 로고
    • Pravastatin and the development of diabetes mellitus. Evidence for a protective treatment effect in the West of Scotland Coronary Prevention study
    • Freeman DJ, Norrie J, Sattar N, et al. Pravastatin and the development of diabetes mellitus. Evidence for a protective treatment effect in the West of Scotland Coronary Prevention study. Circulation 2001; 103(3): 357-62.
    • (2001) Circulation , vol.103 , Issue.3 , pp. 357-362
    • Freeman, D.J.1    Norrie, J.2    Sattar, N.3
  • 75
    • 0037230328 scopus 로고    scopus 로고
    • Outsourcing in the brain: Do neurons depend on cholesterol delivery by astrocytes?
    • Pfrieger FW. Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes? BioEssays 2003; 25: 72-8.
    • (2003) BioEssays , vol.25 , pp. 72-78
    • Pfrieger, F.W.1
  • 76
    • 0035430622 scopus 로고    scopus 로고
    • Essential role for cholesterol in synaptic plasticity and neuronal degeneration
    • Koudinov AR, Koudinova NV. Essential role for cholesterol in synaptic plasticity and neuronal degeneration. FASEB J 2001; 15: 1858-60.
    • (2001) FASEB J , vol.15 , pp. 1858-1860
    • Koudinov, A.R.1    Koudinova, N.V.2
  • 77
    • 14844321855 scopus 로고    scopus 로고
    • Cholesterol homeostasis failure as a unifying cause of synaptic degeneration
    • Koudinov AR, Koudinova NV. Cholesterol homeostasis failure as a unifying cause of synaptic degeneration. J Neurol Sci 2005; 229- 30: 233-40.
    • J Neurol Sci 2005; 229- , vol.30 , pp. 233-240
    • Koudinov, A.R.1    Koudinova, N.V.2
  • 78
    • 80155191187 scopus 로고    scopus 로고
    • Statins: The role in the treatment and prevention of Alzheimer's neurodegeneration
    • Pac-Soo C, Lloyd DG, Vizcaychipi MP, Ma D. Statins: the role in the treatment and prevention of Alzheimer's neurodegeneration. J Alzheimers Dis 2011; 27(1): 1-10.
    • (2011) J Alzheimers Dis , vol.27 , Issue.1 , pp. 1-10
    • Pac-Soo, C.1    Lloyd, D.G.2    Vizcaychipi, M.P.3    Ma, D.4
  • 79
    • 34249825804 scopus 로고    scopus 로고
    • Effect of HMG-CoA Reductase Inhibitors on [beta]-Amyloid Peptide Levels: Implications for Alzheimer's Disease
    • Höglund K, Blennow K. Effect of HMG-CoA Reductase Inhibitors on [beta]-Amyloid Peptide Levels: Implications for Alzheimer's Disease. CNS Drugs 2007; 21(6): 449-62.
    • (2007) CNS Drugs , vol.21 , Issue.6 , pp. 449-462
    • Höglund, K.1    Blennow, K.2
  • 80
    • 0035826909 scopus 로고    scopus 로고
    • Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the _-secretase ADAM 10
    • Kojro E, Gimpl G, Lammich S, Marz W, Fahrenholz F. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the _-secretase ADAM 10. Proc Natl Acad Sci USA. 2001; 98(10): 5815-5820.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.10 , pp. 5815-5820
    • Kojro, E.1    Gimpl, G.2    Lammich, S.3    Marz, W.4    Fahrenholz, F.5
  • 81
    • 19944432452 scopus 로고    scopus 로고
    • Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex
    • Johnson-Anuna LN, Eckert GP, Keller JH, et al. Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex. J Pharmacol Exp Ther 2005; 312(2): 786-93.
    • (2005) J Pharmacol Exp Ther , vol.312 , Issue.2 , pp. 786-793
    • Johnson-Anuna, L.N.1    Eckert, G.P.2    Keller, J.H.3
  • 82
    • 34547315810 scopus 로고    scopus 로고
    • Alzheimer's disease: Cholesterol, membrane rafts, isoprenoids and statins
    • Reid PC, Urano Y, Kodama T, Hamakubo T. Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins. J Cell Mol Med 2007; 11: 383-92.
    • (2007) J Cell Mol Med , vol.11 , pp. 383-392
    • Reid, P.C.1    Urano, Y.2    Kodama, T.3    Hamakubo, T.4
  • 83
    • 77953280950 scopus 로고    scopus 로고
    • Membrane rafts in Alzheimer's disease beta-amyloid production
    • Vetrivel KS, Thinakaran G. Membrane rafts in Alzheimer's disease beta-amyloid production. Biochim Biophys Acta 2010; 1801: 860-7.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 860-867
    • Vetrivel, K.S.1    Thinakaran, G.2
  • 84
    • 67449132348 scopus 로고    scopus 로고
    • Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface
    • Guardia-Laguarta C, Coma M, Pera M, et al. Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface. J Neurochem 2009; 110: 220-30.
    • (2009) J Neurochem , vol.110 , pp. 220-230
    • Guardia-Laguarta, C.1    Coma, M.2    Pera, M.3
  • 85
    • 40349102241 scopus 로고    scopus 로고
    • Active gamma-secretase is localized to detergent-resistant membranes in human brain
    • Hur JW, Behbahani H, Aoki H, et al. Active gamma-secretase is localized to detergent-resistant membranes in human brain. FEBS J 2008; 275: 1174-87.
    • (2008) FEBS J , vol.275 , pp. 1174-1187
    • Hur, J.W.1    Behbahani, H.2    Aoki, H.3
  • 86
    • 0141482022 scopus 로고    scopus 로고
    • Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein
    • Cordy JM, Hussain I, Dingwall C, Hooper NM, Turner AJ. Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci USA 2003; 100: 11735-40.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11735-11740
    • Cordy, J.M.1    Hussain, I.2    Dingwall, C.3    Hooper, N.M.4    Turner, A.J.5
  • 87
    • 84864089648 scopus 로고    scopus 로고
    • Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in a mouse model of Alzheimer's disease
    • (In press)
    • Kurata T, Miyazaki K, Kozuki M, et al. Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in a mouse model of Alzheimer's disease. Neurol Res 2012. (In press)
    • (2012) Neurol Res
    • Kurata, T.1    Miyazaki, K.2    Kozuki, M.3
  • 88
    • 77952583554 scopus 로고    scopus 로고
    • Cholesterol and statins in Alzheimer's disease: Current controversies
    • Fonseca AC, Resende R, Oliveira CR, Pereira CM. Cholesterol and statins in Alzheimer's disease: current controversies. Exp Neurol 2010; 223(2): 282-93.
    • (2010) Exp Neurol , vol.223 , Issue.2 , pp. 282-293
    • Fonseca, A.C.1    Resende, R.2    Oliveira, C.R.3    Pereira, C.M.4
  • 89
    • 83055186684 scopus 로고    scopus 로고
    • Alzheimer disease: Statins in the treatment of Alzheimer disease
    • Oct 18, doi: 10.1038/nrneurol.2011.165
    • Sparks DL. Alzheimer disease: Statins in the treatment of Alzheimer disease. Nat Rev Neurol. 2011 Oct 18; 7(12): 662-3. doi: 10.1038/nrneurol.2011.165.
    • (2011) Nat Rev Neurol , vol.7 , Issue.12 , pp. 662-663
    • Sparks, D.L.1
  • 90
    • 80053336026 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease
    • Sano M, Bell KL, Galasko D, et al. A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease. Neurology 2011; 77(6): 556-63.
    • (2011) Neurology , vol.77 , Issue.6 , pp. 556-563
    • Sano, M.1    Bell, K.L.2    Galasko, D.3
  • 91
    • 74049099554 scopus 로고    scopus 로고
    • The relationship between Alzheimer's disease and Diabetes: Type 3 Diabetes?
    • Kroner Z. The relationship between Alzheimer's disease and Diabetes: Type 3 Diabetes? Altern Med Rev 2009; 14(4): 373-380.
    • (2009) Altern Med Rev , vol.14 , Issue.4 , pp. 373-380
    • Kroner, Z.1
  • 92
    • 70449732132 scopus 로고    scopus 로고
    • Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus
    • Valente T, Gella A, Fernandez-Busquets X, Unzeta M, Durany N. Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus. Neurobiol Dis 2010; 37(1): 67-76.
    • (2010) Neurobiol Dis , vol.37 , Issue.1 , pp. 67-76
    • Valente, T.1    Gella, A.2    Fernandez-Busquets, X.3    Unzeta, M.4    Durany, N.5
  • 94
    • 67649695176 scopus 로고    scopus 로고
    • Involvement of toxic AGEs (TAGE) in the pathogenesis of diabetic vascular complications and Alzheimer's Disease
    • Masayoshi T, Sho-ichi Y. Involvement of toxic AGEs (TAGE) in the pathogenesis of diabetic vascular complications and Alzheimer's Disease. J Alzheim Dis 2009; 16: 845-858.
    • (2009) J Alzheim Dis , vol.16 , pp. 845-858
    • Masayoshi, T.1    Sho-Ichi, Y.2
  • 95
    • 77956989586 scopus 로고    scopus 로고
    • Advanced glycation end products as biomarkers and gerontotoxins - A basis to explore methylglyoxallowering agents for Alzheimer's disease?
    • Krautwald M, Münch G. Advanced glycation end products as biomarkers and gerontotoxins - A basis to explore methylglyoxallowering agents for Alzheimer's disease? Exper Gerontol 2010; 45: 744-751.
    • (2010) Exper Gerontol , vol.45 , pp. 744-751
    • Krautwald, M.1    Münch, G.2
  • 96
    • 0030604239 scopus 로고    scopus 로고
    • Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain
    • Takedo A, Yasuda T, Miyata T, et al. Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain. Neurosci Lett 1996; 221: 17-20.
    • (1996) Neurosci Lett , vol.221 , pp. 17-20
    • Takedo, A.1    Yasuda, T.2    Miyata, T.3
  • 97
    • 79954585505 scopus 로고    scopus 로고
    • Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease
    • Srikanth V, Maczurek A, Phan T, et al. Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease. Neurobiology of Aging 2011; 32: 763-777.
    • (2011) Neurobiology of Aging , vol.32 , pp. 763-777
    • Srikanth, V.1    Maczurek, A.2    Phan, T.3
  • 98
    • 0042207369 scopus 로고    scopus 로고
    • Cunningham Influence of advanced glycation end-products and AGE-inhibitors on nucleation- dependent polymerization of β-amyloid peptide
    • Munch G, Mayer S, Michaelis J, et al. Cunningham Influence of advanced glycation end-products and AGE-inhibitors on nucleation- dependent polymerization of β-amyloid peptide. Biochimica et Biophysica Acta 1997; 1360: 17-29.
    • (1997) Iochimica Et Biophysica Acta , vol.1360 , pp. 17-29
    • Munch, G.1    Mayer, S.2    Michaelis, J.3
  • 99
    • 80053309989 scopus 로고    scopus 로고
    • Inhibition of advanced glycation end products by aminoguanidine restores mast cell numbers and reactivity in alloxan-diabetic rats
    • Carvalho VF, Florim LT, Barreto E, et al. Inhibition of advanced glycation end products by aminoguanidine restores mast cell numbers and reactivity in alloxan-diabetic rats. European Journal of Pharmacology 2011; 669: 143-148.
    • (2011) European Journal of Pharmacology , vol.669 , pp. 143-148
    • Carvalho, V.F.1    Florim, L.T.2    Barreto, E.3
  • 100
    • 0028453652 scopus 로고
    • Lilly Lecture 1993. Glycation and diabetic complications
    • Brownlee M. Lilly Lecture 1993. Glycation and diabetic complications. Diabetes 1994; 43: 836-841.
    • (1994) Diabetes , vol.43 , pp. 836-841
    • Brownlee, M.1
  • 102
    • 32944462931 scopus 로고    scopus 로고
    • The role of reactive α-dicarbonyls in AGE/ALE formation and implication in diabetic complications
    • Iacovella G, Alderson N, Thorpe S, Baynes J. The role of reactive α-dicarbonyls in AGE/ALE formation and implication in diabetic complications. SCJMM 2004; 5: 73-101.
    • (2004) SCJMM , vol.5 , pp. 73-101
    • Iacovella, G.1    Alderson, N.2    Thorpe, S.3    Baynes, J.4
  • 103
    • 33645733382 scopus 로고    scopus 로고
    • Tenilsetam prevents early diabetic retinopathy without correcting pericyte loss
    • Hoffmann J, Alt A, Lin J, et al. Tenilsetam prevents early diabetic retinopathy without correcting pericyte loss. Thromb Haemost 2006; 95(4): 689-95.
    • (2006) Thromb Haemost , vol.95 , Issue.4 , pp. 689-695
    • Hoffmann, J.1    Alt, A.2    Lin, J.3


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