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Volumn 20, Issue 2, 2014, Pages 134-140

4-1BB chimeric antigen receptors

Author keywords

4 1BB (CD137, TNFRSF9); CD3 chimeric antigen receptors (CARs); costimulatory signals; T cell receptor (TCR) signals

Indexed keywords

CD137 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; TNFRSF9 PROTEIN, HUMAN;

EID: 84897566595     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0000000000000028     Document Type: Review
Times cited : (47)

References (71)
  • 1
    • 0032531091 scopus 로고    scopus 로고
    • Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product
    • Finney HM, Lawson AD, Bebbington CR, et al. Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J Immunol. 1998;161:2791-2797.
    • (1998) J Immunol , vol.161 , pp. 2791-2797
    • Finney, H.M.1    Lawson, A.D.2    Bebbington, C.R.3
  • 2
    • 0035251532 scopus 로고    scopus 로고
    • Functional expression of chimeric receptor genes in human T cells
    • Eshhar Z, Waks T, Bendavid A, et al. Functional expression of chimeric receptor genes in human T cells. J ImmunolMethods. 2001;248:67-76.
    • (2001) J ImmunolMethods , vol.248 , pp. 67-76
    • Eshhar, Z.1    Waks, T.2    Bendavid, A.3
  • 3
    • 0035576250 scopus 로고    scopus 로고
    • Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule
    • Hombach A, Wieczarkowiecz A, Marquardt T, et al. Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule. J Immunol. 2001;167:6123-6131.
    • (2001) J Immunol. , vol.167 , pp. 6123-6131
    • Hombach, A.1    Wieczarkowiecz, A.2    Marquardt, T.3
  • 4
    • 0035889157 scopus 로고    scopus 로고
    • Integrated src kinase and costimulatory activity enhances signal transduction through singlechain chimeric receptors in T lymphocytes
    • Geiger TL, Nguyen P, Leitenberg D, et al. Integrated src kinase and costimulatory activity enhances signal transduction through singlechain chimeric receptors in T lymphocytes. Blood. 2001;98:2364-2371.
    • (2001) Blood , vol.98 , pp. 2364-2371
    • Geiger, T.L.1    Nguyen, P.2    Leitenberg, D.3
  • 5
    • 0036137615 scopus 로고    scopus 로고
    • Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor
    • Maher J, Brentjens RJ, Gunset G, et al. Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor. NatBiotechnol. 2002;20:70-75.
    • (2002) NatBiotechnol , vol.20 , pp. 70-75
    • Maher, J.1    Brentjens, R.J.2    Gunset, G.3
  • 6
    • 0036839589 scopus 로고    scopus 로고
    • Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors
    • Haynes NM, Trapani JA, Teng MW, et al. Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood. 2002;100:3155-3163.
    • (2002) Blood , vol.100 , pp. 3155-3163
    • Haynes, N.M.1    Trapani, J.A.2    Teng, M.W.3
  • 7
    • 84876005284 scopus 로고    scopus 로고
    • CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
    • Brentjens RJ, Davila ML, Riviere I, et al. CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med. 2013;5:177ra138.
    • (2013) Sci Transl Med. , vol.5
    • Brentjens, R.J.1    Davila, M.L.2    Riviere, I.3
  • 8
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor- modified T cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, Kalos M, et al. Chimeric antigen receptor- modified T cells in chronic lymphoid leukemia. N Engl J Med. 2011;365: 725-733.
    • (2011) N Engl J Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3
  • 9
    • 80051775476 scopus 로고    scopus 로고
    • T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced Leukemia
    • Kalos M, Levine BL, Porter DL, et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced Leukemia. Sci Transl Med. 2011;3:95ra73.
    • (2011) Sci Transl Med. , vol.3
    • Kalos, M.1    Levine, B.L.2    Porter, D.L.3
  • 10
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor- modified T cells for acute lymphoid leukemia
    • Grupp SA, Kalos M, Barrett D, et al. Chimeric antigen receptor- modified T cells for acute lymphoid leukemia. N Engl J Med. 2013;368: 1509-1518.
    • (2013) N Engl J Med , vol.368 , pp. 1509-1518
    • Grupp, S.A.1    Kalos, M.2    Barrett, D.3
  • 11
    • 0023221529 scopus 로고
    • Isolation and initial characterization of multiple species of T-lymphocyte subset cDNA clones
    • Kwon BS, Kim GS, Prystowsky MB, et al. Isolation and initial characterization of multiple species of T-lymphocyte subset cDNA clones. Proc Natl Acad Sci U S A. 1987;84:2896-2900.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 2896-2900
    • Kwon, B.S.1    Kim, G.S.2    Prystowsky, M.B.3
  • 12
    • 0344247505 scopus 로고
    • CDNA sequences of two inducible T-cell genes
    • Kwon BS, Weissman SM. cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci U S A. 1989;86:1963-1967.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 1963-1967
    • Kwon, B.S.1    Weissman, S.M.2
  • 13
    • 0027133102 scopus 로고
    • A receptor induced by lymphocyte activation (ILA): A new member of the human nerve-growth-factor/ tumor-necrosis-factor receptor family
    • Schwarz H, Tuckwell J, Lotz M. A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/ tumor-necrosis-factor receptor family. Gene. 1993;134:295-298.
    • (1993) Gene. , vol.134 , pp. 295-298
    • Schwarz, H.1    Tuckwell, J.2    Lotz, M.3
  • 14
    • 0028899550 scopus 로고
    • ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages
    • Schwarz H, Valbracht J, Tuckwell J, et al. ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages. Blood. 1995;85: 1043-1052.
    • (1995) Blood , vol.85 , pp. 1043-1052
    • Schwarz, H.1    Valbracht, J.2    Tuckwell, J.3
  • 15
    • 84880021335 scopus 로고    scopus 로고
    • 4-1BB signal stimulates the activation, expansion, and effector functions of gammadelta T cells in mice and humans
    • Lee SJ, Kim YH, Hwang SH, et al. 4-1BB signal stimulates the activation, expansion, and effector functions of gammadelta T cells in mice and humans. Eur J Immunol. 2013;43:1839-1848.
    • (2013) Eur J Immunol , vol.43 , pp. 1839-1848
    • Lee, S.J.1    Kim, Y.H.2    Hwang, S.H.3
  • 16
    • 0032535119 scopus 로고    scopus 로고
    • NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies
    • Melero I, Johnston JV, Shufford WW, et al. NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell Immunol. 1998;190: 167-172.
    • (1998) Cell Immunol , vol.190 , pp. 167-172
    • Melero, I.1    Johnston, J.V.2    Shufford, W.W.3
  • 17
    • 76249092199 scopus 로고    scopus 로고
    • CD137 promotes proliferation and survival of human B cells
    • Zhang X, Voskens CJ, Sallin M, et al. CD137 promotes proliferation and survival of human B cells. J Immunol. 2010;184:787-795.
    • (2010) J Immunol , vol.184 , pp. 787-795
    • Zhang, X.1    Voskens, C.J.2    Sallin, M.3
  • 18
    • 0036569392 scopus 로고    scopus 로고
    • Cutting edge: Expression of functional CD137 receptor by dendritic cells
    • Wilcox RA, Chapoval AI, Gorski KS, et al. Cutting edge: expression of functional CD137 receptor by dendritic cells. J Immunol. 2002;168: 4262-4267.
    • (2002) J Immunol , vol.168 , pp. 4262-4267
    • Wilcox, R.A.1    Chapoval, A.I.2    Gorski, K.S.3
  • 19
    • 33846784977 scopus 로고    scopus 로고
    • CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity
    • Drenkard D, Becke FM, Langstein J, et al. CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity. FASEB J. 2007;21:456-463.
    • (2007) FASEB J , vol.21 , pp. 456-463
    • Drenkard, D.1    Becke, F.M.2    Langstein, J.3
  • 20
    • 0030732028 scopus 로고    scopus 로고
    • Differentiation-dependent and stimulus-specific expression of ILA, the human 4-1BB-homologue, in cells of mesenchymal origin
    • von Kempis J, Schwarz H, Lotz M. Differentiation-dependent and stimulus-specific expression of ILA, the human 4-1BB-homologue, in cells of mesenchymal origin. Osteoarthritis Cartilage. 1997;5:394-406.
    • (1997) Osteoarthritis Cartilage , vol.5 , pp. 394-406
    • Von Kempis, J.1    Schwarz, H.2    Lotz, M.3
  • 21
    • 84862739640 scopus 로고    scopus 로고
    • Immunotherapy of cancer with 4-1BB
    • Vinay DS, Kwon BS. Immunotherapy of cancer with 4-1BB. Mol Cancer Ther. 2012;11:1062-1070.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1062-1070
    • Vinay, D.S.1    Kwon, B.S.2
  • 22
    • 0032101119 scopus 로고    scopus 로고
    • CD28-independent, TRAF2- dependent costimulation of resting T cells by 4-1BB ligand
    • Saoulli K, Lee SY, Cannons JL, et al. CD28-independent, TRAF2- dependent costimulation of resting T cells by 4-1BB ligand. J Exp Med. 1998;187:1849-1862.
    • (1998) J Exp Med , vol.187 , pp. 1849-1862
    • Saoulli, K.1    Lee, S.Y.2    Cannons, J.L.3
  • 23
    • 17644389199 scopus 로고    scopus 로고
    • TNF/TNFR family members in costimulation of T cell responses
    • Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol. 2005;23:23-68.
    • (2005) Annu Rev Immunol , vol.23 , pp. 23-68
    • Watts, T.H.1
  • 25
    • 84877055329 scopus 로고    scopus 로고
    • Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells
    • Sabbagh L, Andreeva D, Laramee GD, et al. Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells. J Leukoc Biol. 2013;93:713-721.
    • (2013) J Leukoc Biol , vol.93 , pp. 713-721
    • Sabbagh, L.1    Andreeva, D.2    Laramee, G.D.3
  • 26
    • 0030845586 scopus 로고    scopus 로고
    • 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
    • Shuford WW, Klussman K, Tritchler DD, et al. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J ExpMed. 1997;186: 47-55.
    • (1997) J ExpMed , vol.186 , pp. 47-55
    • Shuford, W.W.1    Klussman, K.2    Tritchler, D.D.3
  • 27
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • Melero I, Shuford WW, Newby SA, et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med. 1997;3:682-685.
    • (1997) Nat Med , vol.3 , pp. 682-685
    • Melero, I.1    Shuford, W.W.2    Newby, S.A.3
  • 28
    • 0031906785 scopus 로고    scopus 로고
    • Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: Synergy with the CD28 co-stimulatory pathway
    • Melero I, Bach N, Hellstrom KE, et al. Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway. Eur J Immunol. 1998;28:1116-1121.
    • (1998) Eur J Immunol , vol.28 , pp. 1116-1121
    • Melero, I.1    Bach, N.2    Hellstrom, K.E.3
  • 29
    • 0033137063 scopus 로고    scopus 로고
    • Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal
    • Takahashi C, Mittler RS, Vella AT. Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. J Immunol. 1999;162:5037-5040.
    • (1999) J Immunol , vol.162 , pp. 5037-5040
    • Takahashi, C.1    Mittler, R.S.2    Vella, A.T.3
  • 30
    • 0032754036 scopus 로고    scopus 로고
    • Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
    • DeBenedette MA, Wen T, Bachmann MF, et al. Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. J Immunol. 1999;163:4833-4841.
    • (1999) J Immunol , vol.163 , pp. 4833-4841
    • Debenedette, M.A.1    Wen, T.2    Bachmann, M.F.3
  • 31
    • 0036083989 scopus 로고    scopus 로고
    • T cell activation with systemic agonistic antibody versus local 4-1BB ligand gene delivery combined with interleukin-12 eradicate liver metastases of breast cancer
    • Martinet O, Divino CM, Zang Y, et al. T cell activation with systemic agonistic antibody versus local 4-1BB ligand gene delivery combined with interleukin-12 eradicate liver metastases of breast cancer. Gene Ther. 2002;9:786-792.
    • (2002) Gene Ther. , vol.9 , pp. 786-792
    • Martinet, O.1    Divino, C.M.2    Zang, Y.3
  • 32
    • 0037096878 scopus 로고    scopus 로고
    • Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells
    • May KF Jr, Chen L, Zheng P, et al. Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells. Cancer Res. 2002;62: 3459-3465.
    • (2002) Cancer Res , vol.62 , pp. 3459-3465
    • May Jr., K.F.1    Chen, L.2    Zheng, P.3
  • 33
    • 0037094139 scopus 로고    scopus 로고
    • 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function
    • Wen T, Bukczynski J, Watts TH. 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. J Immunol. 2002;168:4897-4906.
    • (2002) J Immunol , vol.168 , pp. 4897-4906
    • Wen, T.1    Bukczynski, J.2    Watts, T.H.3
  • 34
    • 0036800027 scopus 로고    scopus 로고
    • 4-1BB co-stimulation enhances human CD8(+) T cell priming by augmenting the proliferation and survival of effector CD8(+) T cells
    • Laderach D, Movassagh M, Johnson A, et al. 4-1BB co-stimulation enhances human CD8(+) T cell priming by augmenting the proliferation and survival of effector CD8(+) T cells. Int Immunol. 2002;14: 1155-1167.
    • (2002) Int Immunol , vol.14 , pp. 1155-1167
    • Laderach, D.1    Movassagh, M.2    Johnson, A.3
  • 35
    • 79953041310 scopus 로고    scopus 로고
    • Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function
    • Hernandez-Chacon JA, Li Y, Wu RC, et al. Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function. J Immunother. 2011;34:236-250.
    • (2011) J Immunother , vol.34 , pp. 236-250
    • Hernandez-Chacon, J.A.1    Li, Y.2    Wu, R.C.3
  • 36
    • 0034074135 scopus 로고    scopus 로고
    • Monoclonal antibodies directed against the T-cell activation molecule CD137 (interleukin-A or 4-1BB) block human lymphocyte-mediated suppression of tumor xenografts in severe combined immunodeficient mice
    • Sabel MS, Conway TF, Chen FA, et al. Monoclonal antibodies directed against the T-cell activation molecule CD137 (interleukin-A or 4-1BB) block human lymphocyte-mediated suppression of tumor xenografts in severe combined immunodeficient mice. J Immunother. 2000;23:362-368.
    • (2000) J Immunother , vol.23 , pp. 362-368
    • Sabel, M.S.1    Conway, T.F.2    Chen, F.A.3
  • 37
    • 0035266427 scopus 로고    scopus 로고
    • Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation
    • Kim JA, Averbook BJ, Chambers K, et al. Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation. Cancer Res. 2001;61:2031-2037.
    • (2001) Cancer Res , vol.61 , pp. 2031-2037
    • Kim, J.A.1    Averbook, B.J.2    Chambers, K.3
  • 38
    • 0037090337 scopus 로고    scopus 로고
    • Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection
    • Bertram EM, Lau P, Watts TH. Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection. J Immunol. 2002;168: 3777-3785.
    • (2002) J Immunol , vol.168 , pp. 3777-3785
    • Bertram, E.M.1    Lau, P.2    Watts, T.H.3
  • 39
    • 84885668507 scopus 로고    scopus 로고
    • Enhanced antitumor activity mediated by human 4-1BB-engineered T cells
    • Daniel-Meshulam I, Horovitz-Fried M, Cohen CJ. Enhanced antitumor activity mediated by human 4-1BB-engineered T cells. Int J Cancer. 2013;133:2903-2913.
    • (2013) Int J Cancer , vol.133 , pp. 2903-2913
    • Daniel-Meshulam, I.1    Horovitz-Fried, M.2    Cohen, C.J.3
  • 40
    • 84874889330 scopus 로고    scopus 로고
    • Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination
    • Melero I, Grimaldi AM, Perez-Gracia JL, et al. Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination. Clin Cancer Res. 2013;19:997-1008.
    • (2013) Clin Cancer Res , vol.19 , pp. 997-1008
    • Melero, I.1    Grimaldi, A.M.2    Perez-Gracia, J.L.3
  • 41
    • 0036909587 scopus 로고    scopus 로고
    • Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses
    • Taraban VY, Rowley TF, O'Brien L, et al. Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses. Eur J Immunol. 2002;32:3617-3627.
    • (2002) Eur J Immunol , vol.32 , pp. 3617-3627
    • Taraban, V.Y.1    Rowley, T.F.2    O'Brien, L.3
  • 42
    • 0037331857 scopus 로고    scopus 로고
    • Costimulation of human CD28- T cells by 4-1BB ligand
    • Bukczynski J, Wen T, Watts TH. Costimulation of human CD28- T cells by 4-1BB ligand. Eur J Immunol. 2003;33:446-454.
    • (2003) Eur J Immunol , vol.33 , pp. 446-454
    • Bukczynski, J.1    Wen, T.2    Watts, T.H.3
  • 43
    • 0030041637 scopus 로고    scopus 로고
    • Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors
    • Li Y, Hellstrom KE, Newby SA, Chen L. Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors. J ExpMed. 1996;183:639-644.
    • (1996) J ExpMed , vol.183 , pp. 639-644
    • Li, Y.1    Hellstrom, K.E.2    Newby, S.A.3    Chen, L.4
  • 44
    • 36248951128 scopus 로고    scopus 로고
    • Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells
    • Habib-Agahi M, Phan TT, Searle PF. Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells. Int Immunol. 2007;19:1383-1394.
    • (2007) Int Immunol , vol.19 , pp. 1383-1394
    • Habib-Agahi, M.1    Phan, T.T.2    Searle, P.F.3
  • 45
    • 42349097028 scopus 로고    scopus 로고
    • 4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy
    • Zhang H, Snyder KM, Suhoski MM, et al. 4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy. J Immunol. 2007;179:4910-4918.
    • (2007) J Immunol , vol.179 , pp. 4910-4918
    • Zhang, H.1    Snyder, K.M.2    Suhoski, M.M.3
  • 46
    • 18644383814 scopus 로고    scopus 로고
    • Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemia
    • Furtner M, Straub RH, Kruger S, et al. Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemia. Leukemia. 2005;19: 883-885.
    • (2005) Leukemia , vol.19 , pp. 883-885
    • Furtner, M.1    Straub, R.H.2    Kruger, S.3
  • 47
    • 49449108720 scopus 로고    scopus 로고
    • Characterisation of soluble murine CD137 and its association with systemic lupus
    • Shao Z, Sun F, Koh DR, et al. Characterisation of soluble murine CD137 and its association with systemic lupus. Mol Immunol. 2008;45: 3990-3999.
    • (2008) Mol Immunol , vol.45 , pp. 3990-3999
    • Shao, Z.1    Sun, F.2    Koh, D.R.3
  • 48
    • 84872532787 scopus 로고    scopus 로고
    • Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression
    • Ho WT, Pang WL, Chong SM, et al. Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression. Cancer Res. 2013;73:652-661.
    • (2013) Cancer Res , vol.73 , pp. 652-661
    • Ho, W.T.1    Pang, W.L.2    Chong, S.M.3
  • 49
    • 0344157387 scopus 로고    scopus 로고
    • Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma
    • Nicholson IC, Lenton KA, Little DJ, et al. Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma. Mol Immunol. 1997;34:1157-1165.
    • (1997) Mol Immunol , vol.34 , pp. 1157-1165
    • Nicholson, I.C.1    Lenton, K.A.2    Little, D.J.3
  • 50
    • 3042551216 scopus 로고    scopus 로고
    • Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
    • Imai C, Mihara K, Andreansky M, et al. Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia. 2004;18:676-684.
    • (2004) Leukemia , vol.18 , pp. 676-684
    • Imai, C.1    Mihara, K.2    Andreansky, M.3
  • 51
    • 33846136138 scopus 로고    scopus 로고
    • Synthetic messenger RNA as a tool for gene therapy
    • Rabinovich PM, Komarovskaya ME, Ye ZJ, et al. Synthetic messenger RNA as a tool for gene therapy. Hum Gene Ther. 2006;17:1027-1035.
    • (2006) Hum Gene Ther. , vol.17 , pp. 1027-1035
    • Rabinovich, P.M.1    Komarovskaya, M.E.2    Ye, Z.J.3
  • 52
    • 76749149456 scopus 로고    scopus 로고
    • Expression of chimeric antigen receptors in natural killer cells with a regulatory-compliant non-viral method
    • Li L, Liu LN, Feller S, et al. Expression of chimeric antigen receptors in natural killer cells with a regulatory-compliant non-viral method. Cancer Gene Ther. 2010;17:147-154.
    • (2010) Cancer Gene Ther , vol.17 , pp. 147-154
    • Li, L.1    Liu, L.N.2    Feller, S.3
  • 53
    • 84863915982 scopus 로고    scopus 로고
    • A clinically adaptable method to enhance the cytotoxicity of natural killer cells against B-cell malignancies
    • Shimasaki N, Fujisaki H, Cho D, et al. A clinically adaptable method to enhance the cytotoxicity of natural killer cells against B-cell malignancies. Cytotherapy. 2012;14:830-840.
    • (2012) Cytotherapy. , vol.14 , pp. 830-840
    • Shimasaki, N.1    Fujisaki, H.2    Cho, D.3
  • 54
    • 62549097817 scopus 로고    scopus 로고
    • Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
    • Carpenito C,MiloneMC, Hassan R, et al. Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains. Proc Natl Acad Sci U S A. 2009;106:3360-3365.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , pp. 3360-3365
    • Cmilonemc, C.1    Hassan, R.2
  • 55
    • 70350726110 scopus 로고    scopus 로고
    • Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo
    • Milone MC, Fish JD, Carpenito C, et al. Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. Mol Ther. 2009;17: 1453-1464.
    • (2009) Mol Ther , vol.17 , pp. 1453-1464
    • Milone, M.C.1    Fish, J.D.2    Carpenito, C.3
  • 56
    • 74949124101 scopus 로고    scopus 로고
    • 4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies
    • Tammana S, Huang X, Wong M, et al. 4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies. Hum Gene Ther. 2010;21:75-86.
    • (2010) Hum Gene Ther , vol.21 , pp. 75-86
    • Tammana, S.1    Huang, X.2    Wong, M.3
  • 57
    • 76349087378 scopus 로고    scopus 로고
    • Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/ AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication
    • Zhong XS, Matsushita M, Plotkin J, et al. Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/ AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication. Mol Ther. 2010;18:413-420.
    • (2010) Mol Ther , vol.18 , pp. 413-420
    • Zhong, X.S.1    Matsushita, M.2    Plotkin, J.3
  • 58
    • 79959914449 scopus 로고    scopus 로고
    • In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB)
    • Song DG, Ye Q, Carpenito C, et al. In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB). Cancer Res. 2011;71: 4617-4627.
    • (2011) Cancer Res , vol.71 , pp. 4617-4627
    • Song, D.G.1    Ye, Q.2    Carpenito, C.3
  • 59
    • 0347994955 scopus 로고    scopus 로고
    • Activation of resting human primary T cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain
    • Finney HM, Akbar AN, Lawson AD. Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J Immunol. 2004;172:104-113.
    • (2004) J Immunol , vol.172 , pp. 104-113
    • Finney, H.M.1    Akbar, A.N.2    Lawson, A.D.3
  • 60
    • 84856071702 scopus 로고    scopus 로고
    • CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo
    • Song DG, Ye Q, Poussin M, et al. CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo. Blood. 2012;119:696-706.
    • (2012) Blood , vol.119 , pp. 696-706
    • Song, D.G.1    Ye, Q.2    Poussin, M.3
  • 61
    • 34548485103 scopus 로고    scopus 로고
    • Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains
    • Wang J, Jensen M, Lin Y, et al. Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains. Hum Gene Ther. 2007;18: 712-725.
    • (2007) Hum Gene Ther , vol.18 , pp. 712-725
    • Wang, J.1    Jensen, M.2    Lin, Y.3
  • 62
    • 76749120309 scopus 로고    scopus 로고
    • A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity
    • Zhao Y, Wang QJ, Yang S, et al. A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity. J Immunol. 2009;183: 5563-5574.
    • (2009) J Immunol. , vol.183 , pp. 5563-5574
    • Zhao, Y.1    Wang, Q.J.2    Yang, S.3
  • 63
    • 84897540957 scopus 로고    scopus 로고
    • T lymphocytes expressing a CD16 signaling receptor exert antibody-dependent cancer cell killing
    • Kudo K, Imai C, Lorenzini P, et al. T lymphocytes expressing a CD16 signaling receptor exert antibody-dependent cancer cell killing. Cancer Res. 2013.
    • Cancer Res. , vol.2013
    • Kudo, K.1    Imai, C.2    Lorenzini, P.3
  • 64
    • 34548129970 scopus 로고    scopus 로고
    • Enhancement of the anti-leukemic activity of cytokine induced killer cells with an anti-CD19 chimeric receptor delivering a 4-1BB-zeta activating signal
    • Marin V, Kakuda H, Dander E, et al. Enhancement of the anti-leukemic activity of cytokine induced killer cells with an anti-CD19 chimeric receptor delivering a 4-1BB-zeta activating signal. Exp Hematol. 2007;35:1388-1397.
    • (2007) Exp Hematol , vol.35 , pp. 1388-1397
    • Marin, V.1    Kakuda, H.2    Dander, E.3
  • 65
    • 22044456688 scopus 로고    scopus 로고
    • Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells
    • Imai C, Iwamoto S, Campana D. Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells. Blood. 2005;106:376-383.
    • (2005) Blood , vol.106 , pp. 376-383
    • Imai, C.1    Iwamoto, S.2    Campana, D.3
  • 66
    • 78549253550 scopus 로고    scopus 로고
    • Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor
    • Zhao Y, Moon E, Carpenito C, et al. Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor. Cancer Res. 2010;70:9053-9061.
    • (2010) Cancer Res , vol.70 , pp. 9053-9061
    • Zhao, Y.1    Moon, E.2    Carpenito, C.3
  • 67
    • 79960403269 scopus 로고    scopus 로고
    • Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor
    • Moon EK, Carpenito C, Sun J, et al. Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor. Clin Cancer Res. 2011;17:4719-4730.
    • (2011) Clin Cancer Res , vol.17 , pp. 4719-4730
    • Moon, E.K.1    Carpenito, C.2    Sun, J.3
  • 68
    • 68449088813 scopus 로고    scopus 로고
    • Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor
    • Kochenderfer JN, Feldman SA, Zhao Y, et al. Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor. J Immunother. 2009;32:689-702.
    • (2009) J Immunother , vol.32 , pp. 689-702
    • Kochenderfer, J.N.1    Feldman, S.A.2    Zhao, Y.3
  • 69
    • 84874027123 scopus 로고    scopus 로고
    • Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
    • Haso W, Lee DW, Shah NN, et al. Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Blood. 2013;121: 1165-1174.
    • (2013) Blood , vol.121 , pp. 1165-1174
    • Haso, W.1    Lee, D.W.2    Shah, N.N.3
  • 70
    • 84879480191 scopus 로고    scopus 로고
    • Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1- specific chimeric antigen receptor T cells
    • Hudecek M, Lupo-Stanghellini MT, Kosasih PL, et al. Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1- specific chimeric antigen receptor T cells. Clin Cancer Res. 2013;19: 3153-3164.
    • (2013) Clin Cancer Res , vol.19 , pp. 3153-3164
    • Hudecek, M.1    Lupo-Stanghellini, M.T.2    Kosasih, P.L.3
  • 71
    • 44449162630 scopus 로고    scopus 로고
    • Retargeting of human T cells to tumorassociatedMUC1: The evolution of a chimeric antigen receptor
    • Wilkie S, Picco G, Foster J, et al. Retargeting of human T cells to tumorassociatedMUC1: the evolution of a chimeric antigen receptor. J Immunol. 2008;180:4901-4909.
    • (2008) J Immunol , vol.180 , pp. 4901-4909
    • Wilkie, S.1    Picco, G.2    Foster, J.3


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