Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation

Cancer Research

Volumn 61, Issue 5, 2001, Pages 2031-2037

  Kim, Julian A ^a   Averbook, Bruce J ^b   Chambers, Kathleen ^a   Rothchild, Kevin ^a   Kjaergaard, Jorgen ^a   Shu, Suyu ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b METROHEALTH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 4 1BB; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CROSS LINKING; CYTOTOXIC T LYMPHOCYTE; DRUG EFFECT; EFFECTOR CELL; IMMUNE RESPONSE; LUNG METASTASIS; LYMPH NODE METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TUMOR IMMUNITY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, CD; ANTIGENS, CD137; BRAIN NEOPLASMS; EPITOPES; FEMALE; LUNG NEOPLASMS; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, SCID; NEOPLASMS, EXPERIMENTAL; PHENOTYPE; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES;

EID: 0035266427     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
2. ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages
3. Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses
4. Monoclonal antibodies against the 4-1BB T-cell activation molecule can eradicate established tumors
5. Specificity and longevity of antitumor immune responses induced by B7-transfected tumors
6. Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells
7. Costimulation of tumor-reactive CD4+ and CD8+ T lymphocytes by B7, a natural ligand for CD28, can be used to treat established mouse melanoma
8. Specific adoptive immunotherapy mediated by tumor-draining lymph node cells sequentially activated with anti-CD3 and IL-2
9. Adoptive immunotherapy of newly induced murine sarcomas
10. Murine colon adenocarcinomas: Methods of selective culture in vitro
11. The selection and characterization of an invasive variant of the B16 melanoma
12. Studies of the chemotherapy of experimental brain tumors: Development of an experimental model
13. Adoptive immunotherapy of murine intracerebral tumors with anti-CD3/interleukin-2 activated tumor-draining lymph node cells
14. Accurate identification of experimental pulmonary metastases
15. Activation by anti-CD3 of tumor-draining lymph node cells for specific adoptive immunotherapy
16. Generation of T-cells reactive to the poorly immunogenic B16-BL6 melanoma with efficacy in the treatment of spontaneous metastases
17. Adoptive immunotherapy mediated by anti-TCR/IL-2-activated tumor-draining lymph node cells
18. In vitro differentiation of T cells capable of mediating the regression of established syngeneic tumors in mice
19. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification of in vivo cytotoxic T cell responses
20. Cellular interactions and the role of interleukin 2 in the expression and induction of immunity against a syngeneic murine sarcoma
21. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells
22. Regulation of 4-1BB expression by cell-cell interactions and cytokines, interleukin-2, and interleukin-4
23. Inducible T cell antigen 4-1BB: An analysis of expression and function
24. Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: Synergy with the CD28 co-stimulatory pathway
25. Defining the synergistic effects of irradiation and T cell immunotherapy for murine intracranial tumors
26. Adoptive immunotherapy of microscopic and advanced visceral metastases with in vitro sensitized lymphoid cells from mice bearing progressive tumors
27. Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T-cell blasts
28. Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth
29. Generation of therapeutic T lymphocytes from tumor-bearing mice by in vitro sensitization
30. Antigen-driven long-term cultured T cells proliferate in vivo, distribute widely, mediate specific tumor therapy, and persist long-term as functional memory T cells
31. Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal
32. Analysis of 4-1BB ligand-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza