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Volumn 171, Issue 8, 2014, Pages 1907-1916

Autophagy and mitophagy in the myocardium: Therapeutic potential and concerns

Author keywords

autophagy; BNIP3; heart; mitochondria; mitophagy; Parkin

Indexed keywords

AMINO ACID; BAFILOMYCIN A1; FATTY ACID; PARKIN; PROTEIN BNIP3; UBIQUITIN PROTEIN LIGASE E3; ANTHRACYCLINE; BNIP3 PROTEIN, HUMAN; BNIP3L PROTEIN, HUMAN; MEMBRANE PROTEIN; ONCOPROTEIN; TUMOR SUPPRESSOR PROTEIN;

EID: 84897469489     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12477     Document Type: Review
Times cited : (65)

References (81)
  • 1
    • 77951920370 scopus 로고    scopus 로고
    • The cardiac mitochondrion: Nexus of stress
    • Baines CP, (2010). The cardiac mitochondrion: nexus of stress. Annu Rev Physiol 72: 61-80.
    • (2010) Annu Rev Physiol , vol.72 , pp. 61-80
    • Baines, C.P.1
  • 2
    • 34248581851 scopus 로고    scopus 로고
    • ER-phagy: Selective autophagy of the endoplasmic reticulum
    • Bernales S, Schuck S, Walter P, (2007). ER-phagy: selective autophagy of the endoplasmic reticulum. Autophagy 3: 285-287.
    • (2007) Autophagy , vol.3 , pp. 285-287
    • Bernales, S.1    Schuck, S.2    Walter, P.3
  • 3
    • 79959344616 scopus 로고    scopus 로고
    • PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function
    • Billia F, Hauck L, Konecny F, Rao V, Shen J, Mak TW, (2011). PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proc Natl Acad Sci U S A 108: 9572-9577.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 9572-9577
    • Billia, F.1    Hauck, L.2    Konecny, F.3    Rao, V.4    Shen, J.5    Mak, T.W.6
  • 4
  • 5
    • 84880753942 scopus 로고    scopus 로고
    • Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy
    • Cao DJ, Jiang N, Blagg A, Johnstone JL, Gondalia R, Oh M, et al. (2013). Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy. J Am Heart Assoc 2: e000016.
    • (2013) J Am Heart Assoc , vol.2
    • Cao, D.J.1    Jiang, N.2    Blagg, A.3    Johnstone, J.L.4    Gondalia, R.5    Oh, M.6
  • 6
    • 84876531457 scopus 로고    scopus 로고
    • PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria
    • Chen Y, Dorn GW, 2nd, (2013). PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 340: 471-475.
    • (2013) Science , vol.340 , pp. 471-475
    • Chen, Y.1    Dorn II, G.W.2
  • 7
    • 77952683069 scopus 로고    scopus 로고
    • Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy
    • Chen Y, Lewis W, Diwan A, Cheng EH, Matkovich SJ, Dorn GW, 2nd, (2010). Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy. Proc Natl Acad Sci U S A 107: 9035-9042.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 9035-9042
    • Chen, Y.1    Lewis, W.2    Diwan, A.3    Cheng, E.H.4    Matkovich, S.J.5    Dorn II, G.W.6
  • 8
    • 84877628647 scopus 로고    scopus 로고
    • Autophagy in human health and disease
    • Choi AM, Ryter SW, Levine B, (2013). Autophagy in human health and disease. N Engl J Med 368: 1845-1846.
    • (2013) N Engl J Med , vol.368 , pp. 1845-1846
    • Choi, A.M.1    Ryter, S.W.2    Levine, B.3
  • 9
    • 3042562282 scopus 로고    scopus 로고
    • Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells
    • Daido S, Kanzawa T, Yamamoto A, Takeuchi H, Kondo Y, Kondo S, (2004). Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res 64: 4286-4293.
    • (2004) Cancer Res , vol.64 , pp. 4286-4293
    • Daido, S.1    Kanzawa, T.2    Yamamoto, A.3    Takeuchi, H.4    Kondo, Y.5    Kondo, S.6
  • 10
    • 34948816749 scopus 로고    scopus 로고
    • Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice
    • Diwan A, Krenz M, Syed FM, Wansapura J, Ren X, Koesters AG, et al. (2007). Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice. J Clin Invest 117: 2825-2833.
    • (2007) J Clin Invest , vol.117 , pp. 2825-2833
    • Diwan, A.1    Krenz, M.2    Syed, F.M.3    Wansapura, J.4    Ren, X.5    Koesters, A.G.6
  • 11
    • 38349184844 scopus 로고    scopus 로고
    • Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation
    • Diwan A, Wansapura J, Syed FM, Matkovich SJ, Lorenz JN, Dorn GW, 2nd, (2008). Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation. Circulation 117: 396-404.
    • (2008) Circulation , vol.117 , pp. 396-404
    • Diwan, A.1    Wansapura, J.2    Syed, F.M.3    Matkovich, S.J.4    Lorenz, J.N.5    Dorn II, G.W.6
  • 12
    • 77955514158 scopus 로고    scopus 로고
    • Mitochondrial pruning by Nix and BNip3: An essential function for cardiac-expressed death factors
    • Dorn GW, 2nd, (2010). Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factors. J Cardiovasc Transl Res 3: 374-383.
    • (2010) J Cardiovasc Transl Res , vol.3 , pp. 374-383
    • Dorn II, G.W.1
  • 13
    • 78649463381 scopus 로고    scopus 로고
    • Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
    • Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, Taanman JW, (2010). Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet 19: 4861-4870.
    • (2010) Hum Mol Genet , vol.19 , pp. 4861-4870
    • Gegg, M.E.1    Cooper, J.M.2    Chau, K.Y.3    Rojo, M.4    Schapira, A.H.5    Taanman, J.W.6
  • 15
    • 84864015441 scopus 로고    scopus 로고
    • BNip3 regulates mitochondrial function and lipid metabolism in the liver
    • Glick D, Zhang W, Beaton M, Marsboom G, Gruber M, Simon MC, et al. (2012). BNip3 regulates mitochondrial function and lipid metabolism in the liver. Mol Cell Biol 32: 2570-2584.
    • (2012) Mol Cell Biol , vol.32 , pp. 2570-2584
    • Glick, D.1    Zhang, W.2    Beaton, M.3    Marsboom, G.4    Gruber, M.5    Simon, M.C.6
  • 17
    • 33749570745 scopus 로고    scopus 로고
    • Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes
    • Hamacher-Brady A, Brady NR, Gottlieb RA, (2006). Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem 281: 29776-29787.
    • (2006) J Biol Chem , vol.281 , pp. 29776-29787
    • Hamacher-Brady, A.1    Brady, N.R.2    Gottlieb, R.A.3
  • 19
    • 84861733247 scopus 로고    scopus 로고
    • Microtubule-associated protein 1 light chain 3 (LC3) interacts with BNIP3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy
    • Hanna RA, Quinsay MN, Orogo AM, Giang K, Rikka S, Gustafsson AB, (2012). Microtubule-associated protein 1 light chain 3 (LC3) interacts with BNIP3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy. J Biol Chem 287: 19094-19104.
    • (2012) J Biol Chem , vol.287 , pp. 19094-19104
    • Hanna, R.A.1    Quinsay, M.N.2    Orogo, A.M.3    Giang, K.4    Rikka, S.5    Gustafsson, A.B.6
  • 20
    • 79956126271 scopus 로고    scopus 로고
    • Oxidative stress stimulates autophagic flux during ischemia/reperfusion
    • Hariharan N, Zhai P, Sadoshima J, (2011). Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid Redox Signal 14: 2179-2190.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 2179-2190
    • Hariharan, N.1    Zhai, P.2    Sadoshima, J.3
  • 21
    • 84872043533 scopus 로고    scopus 로고
    • Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart
    • Hariharan N, Ikeda Y, Hong C, Alcendor RR, Usui S, Gao S, et al. (2013). Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart. Plos ONE 8: e51632.
    • (2013) Plos ONE , vol.8
    • Hariharan, N.1    Ikeda, Y.2    Hong, C.3    Alcendor, R.R.4    Usui, S.5    Gao, S.6
  • 23
    • 84863393597 scopus 로고    scopus 로고
    • Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
    • He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, et al. (2012). Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature 481: 511-515.
    • (2012) Nature , vol.481 , pp. 511-515
    • He, C.1    Bassik, M.C.2    Moresi, V.3    Sun, K.4    Wei, Y.5    Zou, Z.6
  • 25
    • 84882425828 scopus 로고    scopus 로고
    • Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart
    • Hoshino A, Mita Y, Okawa Y, Ariyoshi M, Iwai-Kanai E, Ueyama T, et al. (2013). Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart. Nat Commun 4: 2308.
    • (2013) Nat Commun , vol.4 , pp. 2308
    • Hoshino, A.1    Mita, Y.2    Okawa, Y.3    Ariyoshi, M.4    Iwai-Kanai, E.5    Ueyama, T.6
  • 26
    • 33645221489 scopus 로고    scopus 로고
    • Excess peroxisomes are degraded by autophagic machinery in mammals
    • Iwata J, Ezaki J, Komatsu M, Yokota S, Ueno T, Tanida I, et al. (2006). Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem 281: 4035-4041.
    • (2006) J Biol Chem , vol.281 , pp. 4035-4041
    • Iwata, J.1    Ezaki, J.2    Komatsu, M.3    Yokota, S.4    Ueno, T.5    Tanida, I.6
  • 27
    • 84885626734 scopus 로고    scopus 로고
    • Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state
    • Jamart C, Naslain D, Gilson H, Francaux M, (2013). Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state. Am J Physiol Endocrinol Metab 305: E964-E974.
    • (2013) Am J Physiol Endocrinol Metab , vol.305
    • Jamart, C.1    Naslain, D.2    Gilson, H.3    Francaux, M.4
  • 28
    • 78649685455 scopus 로고    scopus 로고
    • Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
    • Jin SM, Lazarou M, Wang C, Kane LA, Narendra DP, Youle RJ, (2010). Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol 191: 933-942.
    • (2010) J Cell Biol , vol.191 , pp. 933-942
    • Jin, S.M.1    Lazarou, M.2    Wang, C.3    Kane, L.A.4    Narendra, D.P.5    Youle, R.J.6
  • 29
    • 65649120436 scopus 로고    scopus 로고
    • Functional significance and morphological characterization of starvation-induced autophagy in the adult heart
    • Kanamori H, Takemura G, Maruyama R, Goto K, Tsujimoto A, Ogino A, et al. (2009). Functional significance and morphological characterization of starvation-induced autophagy in the adult heart. Am J Pathol 174: 1705-1714.
    • (2009) Am J Pathol , vol.174 , pp. 1705-1714
    • Kanamori, H.1    Takemura, G.2    Maruyama, R.3    Goto, K.4    Tsujimoto, A.5    Ogino, A.6
  • 31
    • 84869452725 scopus 로고    scopus 로고
    • Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes
    • Kawaguchi T, Takemura G, Kanamori H, Takeyama T, Watanabe T, Morishita K, et al. (2012). Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes. Cardiovasc Res 96: 456-465.
    • (2012) Cardiovasc Res , vol.96 , pp. 456-465
    • Kawaguchi, T.1    Takemura, G.2    Kanamori, H.3    Takeyama, T.4    Watanabe, T.5    Morishita, K.6
  • 32
    • 0035032723 scopus 로고    scopus 로고
    • Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network
    • Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T, (2001). Beclin- phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2: 330-335.
    • (2001) EMBO Rep , vol.2 , pp. 330-335
    • Kihara, A.1    Kabeya, Y.2    Ohsumi, Y.3    Yoshimori, T.4
  • 33
    • 60849099049 scopus 로고    scopus 로고
    • A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
    • Kirkin V, Lamark T, Sou YS, Bjorkoy G, Nunn JL, Bruun JA, et al. (2009). A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell 33: 505-516.
    • (2009) Mol Cell , vol.33 , pp. 505-516
    • Kirkin, V.1    Lamark, T.2    Sou, Y.S.3    Bjorkoy, G.4    Nunn, J.L.5    Bruun, J.A.6
  • 34
    • 80051813164 scopus 로고    scopus 로고
    • Eating the strangers within: Host control of intracellular bacteria via xenophagy
    • Knodler LA, Celli J, (2011). Eating the strangers within: host control of intracellular bacteria via xenophagy. Cell Microbiol 13: 1319-1327.
    • (2011) Cell Microbiol , vol.13 , pp. 1319-1327
    • Knodler, L.A.1    Celli, J.2
  • 35
    • 21044455137 scopus 로고    scopus 로고
    • Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    • Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, et al. (2005). Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169: 425-434.
    • (2005) J Cell Biol , vol.169 , pp. 425-434
    • Komatsu, M.1    Waguri, S.2    Ueno, T.3    Iwata, J.4    Murata, S.5    Tanida, I.6
  • 36
    • 34547471625 scopus 로고    scopus 로고
    • Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak
    • Kubli DA, Ycaza JE, Gustafsson AB, (2007). Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak. Biochem J 405: 407-415.
    • (2007) Biochem J , vol.405 , pp. 407-415
    • Kubli, D.A.1    Ycaza, J.E.2    Gustafsson, A.B.3
  • 37
    • 84872283780 scopus 로고    scopus 로고
    • Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction
    • Kubli DA, Zhang X, Lee Y, Hanna RA, Quinsay MN, Nguyen CK, et al. (2013). Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction. J Biol Chem 288: 915-926.
    • (2013) J Biol Chem , vol.288 , pp. 915-926
    • Kubli, D.A.1    Zhang, X.2    Lee, Y.3    Hanna, R.A.4    Quinsay, M.N.5    Nguyen, C.K.6
  • 38
    • 11144245626 scopus 로고    scopus 로고
    • The role of autophagy during the early neonatal starvation period
    • Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, et al. (2004). The role of autophagy during the early neonatal starvation period. Nature 432: 1032-1036.
    • (2004) Nature , vol.432 , pp. 1032-1036
    • Kuma, A.1    Hatano, M.2    Matsui, M.3    Yamamoto, A.4    Nakaya, H.5    Yoshimori, T.6
  • 39
  • 40
    • 84885145785 scopus 로고    scopus 로고
    • Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance
    • Lira VA, Okutsu M, Zhang M, Greene NP, Laker RC, Breen DS, et al. (2013). Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. FASEB J 27: 4184-4193.
    • (2013) FASEB J , vol.27 , pp. 4184-4193
    • Lira, V.A.1    Okutsu, M.2    Zhang, M.3    Greene, N.P.4    Laker, R.C.5    Breen, D.S.6
  • 41
    • 64149124827 scopus 로고    scopus 로고
    • Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure
    • Lu L, Wu W, Yan J, Li X, Yu H, Yu X, (2009). Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure. Int J Cardiol 134: 82-90.
    • (2009) Int J Cardiol , vol.134 , pp. 82-90
    • Lu, L.1    Wu, W.2    Yan, J.3    Li, X.4    Yu, H.5    Yu, X.6
  • 43
    • 84859151396 scopus 로고    scopus 로고
    • Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death
    • Ma X, Godar RJ, Liu H, Diwan A, (2012a). Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death. Autophagy 8: 297-309.
    • (2012) Autophagy , vol.8 , pp. 297-309
    • Ma, X.1    Godar, R.J.2    Liu, H.3    Diwan, A.4
  • 44
    • 84863192578 scopus 로고    scopus 로고
    • Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury
    • Ma X, Liu H, Foyil SR, Godar RJ, Weinheimer CJ, Hill JA, et al. (2012b). Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury. Circulation 125: 3170-3181.
    • (2012) Circulation , vol.125 , pp. 3170-3181
    • Ma, X.1    Liu, H.2    Foyil, S.R.3    Godar, R.J.4    Weinheimer, C.J.5    Hill, J.A.6
  • 45
    • 34250894388 scopus 로고    scopus 로고
    • BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)
    • Maiuri MC, Criollo A, Tasdemir E, Vicencio JM, Tajeddine N, Hickman JA, et al. (2007a). BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 3: 374-376.
    • (2007) Autophagy , vol.3 , pp. 374-376
    • Maiuri, M.C.1    Criollo, A.2    Tasdemir, E.3    Vicencio, J.M.4    Tajeddine, N.5    Hickman, J.A.6
  • 46
    • 34248998801 scopus 로고    scopus 로고
    • Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
    • Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P, et al. (2007b). Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J 26: 2527-2539.
    • (2007) EMBO J , vol.26 , pp. 2527-2539
    • Maiuri, M.C.1    Le Toumelin, G.2    Criollo, A.3    Rain, J.C.4    Gautier, F.5    Juin, P.6
  • 47
    • 34147168105 scopus 로고    scopus 로고
    • Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy
    • Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, et al. (2007). Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res 100: 914-922.
    • (2007) Circ Res , vol.100 , pp. 914-922
    • Matsui, Y.1    Takagi, H.2    Qu, X.3    Abdellatif, M.4    Sakoda, H.5    Asano, T.6
  • 49
    • 34249714158 scopus 로고    scopus 로고
    • The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
    • Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, et al. (2007). The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 13: 619-624.
    • (2007) Nat Med , vol.13 , pp. 619-624
    • Nakai, A.1    Yamaguchi, O.2    Takeda, T.3    Higuchi, Y.4    Hikoso, S.5    Taniike, M.6
  • 50
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra D, Tanaka A, Suen DF, Youle RJ, (2008). Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183: 795-803.
    • (2008) J Cell Biol , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 51
    • 78649300971 scopus 로고    scopus 로고
    • P62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
    • Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ, (2010a). p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 6: 1090-1106.
    • (2010) Autophagy , vol.6 , pp. 1090-1106
    • Narendra, D.1    Kane, L.A.2    Hauser, D.N.3    Fearnley, I.M.4    Youle, R.J.5
  • 53
    • 17044440789 scopus 로고    scopus 로고
    • Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease)
    • Nishino I, Fu J, Tanji K, Yamada T, Shimojo S, Koori T, et al. (2000). Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). Nature 406: 906-910.
    • (2000) Nature , vol.406 , pp. 906-910
    • Nishino, I.1    Fu, J.2    Tanji, K.3    Yamada, T.4    Shimojo, S.5    Koori, T.6
  • 54
  • 55
    • 34548259958 scopus 로고    scopus 로고
    • P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, et al. (2007). p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 282: 24131-24145.
    • (2007) J Biol Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3    Brech, A.4    Bruun, J.A.5    Outzen, H.6
  • 56
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, et al. (2005). Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122: 927-939.
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3    Garuti, R.4    Liang, X.H.5    Mizushima, N.6
  • 57
    • 77955844260 scopus 로고    scopus 로고
    • The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway
    • Poole AC, Thomas RE, Yu S, Vincow ES, Pallanck L, (2010). The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. Plos ONE 5: e10054.
    • (2010) Plos ONE , vol.5
    • Poole, A.C.1    Thomas, R.E.2    Yu, S.3    Vincow, E.S.4    Pallanck, L.5
  • 58
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, et al. (2003). Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 112: 1809-1820.
    • (2003) J Clin Invest , vol.112 , pp. 1809-1820
    • Qu, X.1    Yu, J.2    Bhagat, G.3    Furuya, N.4    Hibshoosh, H.5    Troxel, A.6
  • 59
    • 77957683915 scopus 로고    scopus 로고
    • Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore
    • Quinsay MN, Thomas RL, Lee Y, Gustafsson AB, (2010). Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore. Autophagy 6: 17-24.
    • (2010) Autophagy , vol.6 , pp. 17-24
    • Quinsay, M.N.1    Thomas, R.L.2    Lee, Y.3    Gustafsson, A.B.4
  • 60
    • 77955131007 scopus 로고    scopus 로고
    • Plasma membrane contributes to the formation of pre-autophagosomal structures
    • Ravikumar B, Moreau K, Jahreiss L, Puri C, Rubinsztein DC, (2010). Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat Cell Biol 12: 747-757.
    • (2010) Nat Cell Biol , vol.12 , pp. 747-757
    • Ravikumar, B.1    Moreau, K.2    Jahreiss, L.3    Puri, C.4    Rubinsztein, D.C.5
  • 61
    • 0037047647 scopus 로고    scopus 로고
    • Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes
    • Regula KM, Ens K, Kirshenbaum LA, (2002). Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes. Circ Res 91: 226-231.
    • (2002) Circ Res , vol.91 , pp. 226-231
    • Regula, K.M.1    Ens, K.2    Kirshenbaum, L.A.3
  • 64
    • 67650219052 scopus 로고    scopus 로고
    • Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy
    • Schwarten M, Mohrluder J, Ma P, Stoldt M, Thielmann Y, Stangler T, et al. (2009). Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy. Autophagy 5: 690-698.
    • (2009) Autophagy , vol.5 , pp. 690-698
    • Schwarten, M.1    Mohrluder, J.2    Ma, P.3    Stoldt, M.4    Thielmann, Y.5    Stangler, T.6
  • 66
    • 77949478474 scopus 로고    scopus 로고
    • Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
    • Sha D, Chin LS, Li L, (2010). Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet 19: 352-363.
    • (2010) Hum Mol Genet , vol.19 , pp. 352-363
    • Sha, D.1    Chin, L.S.2    Li, L.3
  • 67
    • 77955398958 scopus 로고    scopus 로고
    • Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
    • Suen DF, Narendra DP, Tanaka A, Manfredi G, Youle RJ, (2010). Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proc Natl Acad Sci U S A 107: 11835-11840.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 11835-11840
    • Suen, D.F.1    Narendra, D.P.2    Tanaka, A.3    Manfredi, G.4    Youle, R.J.5
  • 68
    • 84884371619 scopus 로고    scopus 로고
    • Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways
    • Sun M, Ouzounian M, de Couto G, Chen M, Yan R, Fukuoka M, et al. (2013). Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways. J Am Heart Assoc 2: e000191.
    • (2013) J Am Heart Assoc , vol.2
    • Sun, M.1    Ouzounian, M.2    De Couto, G.3    Chen, M.4    Yan, R.5    Fukuoka, M.6
  • 69
    • 19244384656 scopus 로고    scopus 로고
    • Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice
    • Tanaka Y, Guhde G, Suter A, Eskelinen EL, Hartmann D, Lullmann-Rauch R, et al. (2000). Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 406: 902-906.
    • (2000) Nature , vol.406 , pp. 902-906
    • Tanaka, Y.1    Guhde, G.2    Suter, A.3    Eskelinen, E.L.4    Hartmann, D.5    Lullmann-Rauch, R.6
  • 70
    • 47749105267 scopus 로고    scopus 로고
    • Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy
    • Tannous P, Zhu H, Nemchenko A, Berry JM, Johnstone JL, Shelton JM, et al. (2008). Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation 117: 3070-3078.
    • (2008) Circulation , vol.117 , pp. 3070-3078
    • Tannous, P.1    Zhu, H.2    Nemchenko, A.3    Berry, J.M.4    Johnstone, J.L.5    Shelton, J.M.6
  • 71
    • 84879138938 scopus 로고    scopus 로고
    • Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure
    • Thomas RL, Roberts DJ, Kubli DA, Lee Y, Quinsay MN, Owens JB, et al. (2013). Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure. Genes Dev 27: 1365-1377.
    • (2013) Genes Dev , vol.27 , pp. 1365-1377
    • Thomas, R.L.1    Roberts, D.J.2    Kubli, D.A.3    Lee, Y.4    Quinsay, M.N.5    Owens, J.B.6
  • 72
    • 38549110110 scopus 로고    scopus 로고
    • Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
    • Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, et al. (2008). Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 27: 433-446.
    • (2008) EMBO J , vol.27 , pp. 433-446
    • Twig, G.1    Elorza, A.2    Molina, A.J.3    Mohamed, H.4    Wikstrom, J.D.5    Walzer, G.6
  • 73
    • 0033942613 scopus 로고    scopus 로고
    • BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore
    • Vande VC, Cizeau J, Dubik D, Alimonti J, Brown T, Israels S, et al. (2000). BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol 20: 5454-5468.
    • (2000) Mol Cell Biol , vol.20 , pp. 5454-5468
    • Vande, V.C.1    Cizeau, J.2    Dubik, D.3    Alimonti, J.4    Brown, T.5    Israels, S.6
  • 74
    • 81055140895 scopus 로고    scopus 로고
    • PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility
    • Wang X, Winter D, Ashrafi G, Schlehe J, Wong YL, Selkoe D, et al. (2011). PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 147: 893-906.
    • (2011) Cell , vol.147 , pp. 893-906
    • Wang, X.1    Winter, D.2    Ashrafi, G.3    Schlehe, J.4    Wong, Y.L.5    Selkoe, D.6
  • 75
    • 65649118917 scopus 로고    scopus 로고
    • Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
    • Xiong H, Wang D, Chen L, Choo YS, Ma H, Tang C, et al. (2009). Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest 119: 650-660.
    • (2009) J Clin Invest , vol.119 , pp. 650-660
    • Xiong, H.1    Wang, D.2    Chen, L.3    Choo, Y.S.4    Ma, H.5    Tang, C.6
  • 76
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue Z, Jin S, Yang C, Levine AJ, Heintz N, (2003). Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 100: 15077-15082.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 77
    • 0036061644 scopus 로고    scopus 로고
    • Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy
    • Yussman MG, Toyokawa T, Odley A, Lynch RA, Wu G, Colbert MC, et al. (2002). Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nat Med 8: 725-730.
    • (2002) Nat Med , vol.8 , pp. 725-730
    • Yussman, M.G.1    Toyokawa, T.2    Odley, A.3    Lynch, R.A.4    Wu, G.5    Colbert, M.C.6
  • 78
    • 32244442749 scopus 로고    scopus 로고
    • Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
    • Zeng X, Overmeyer JH, Maltese WA, (2006). Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J Cell Sci 119: 259-270.
    • (2006) J Cell Sci , vol.119 , pp. 259-270
    • Zeng, X.1    Overmeyer, J.H.2    Maltese, W.A.3
  • 79
    • 43649104579 scopus 로고    scopus 로고
    • Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
    • Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, et al. (2008). Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 283: 10892-10903.
    • (2008) J Biol Chem , vol.283 , pp. 10892-10903
    • Zhang, H.1    Bosch-Marce, M.2    Shimoda, L.A.3    Tan, Y.S.4    Baek, J.H.5    Wesley, J.B.6
  • 81
    • 84872291490 scopus 로고    scopus 로고
    • Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis
    • Zhu Y, Massen S, Terenzio M, Lang V, Chen-Lindner S, Eils R, et al. (2013). Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem 288: 1099-1113.
    • (2013) J Biol Chem , vol.288 , pp. 1099-1113
    • Zhu, Y.1    Massen, S.2    Terenzio, M.3    Lang, V.4    Chen-Lindner, S.5    Eils, R.6


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