Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 20, 2010, Pages 9035-9042

  Chen, Yun ^a   Lewis, William ^c   Diwan, Abhinav ^a   Cheng, Emily H Y ^b   Matkovich, Scot J ^a   Dorn II, Gerald W ^a  

^a Center for Pharmacogenomics   (United States)

^b Division of Oncology   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Heart failure; Mitochondrial permeability transition pore

Indexed keywords

CASPASE; CYCLOPHILIN D; CYCLOSPORIN A; CYTOCHROME C; LIPOCORTIN 5; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN BAK; PROTEIN BAX; PROTEIN BNIP3; PROTEIN NIX; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CARDIOMYOPATHY; CELL DEATH; CONTROLLED STUDY; DISEASE COURSE; DRUG MECHANISM; EMBRYO; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CARDIOMYOPATHIES; CASPASES; CYCLOPHILINS; ENDOPLASMIC RETICULUM; IN SITU NICK-END LABELING; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE PROTEINS; MICE; MICE, MUTANT STRAINS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NECROSIS; SIGNAL TRANSDUCTION;

MUS;

EID: 77952683069     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914013107     Document Type: Article

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