An improved Protein G with higher affinity for human/rabbit IgG Fc domains exploiting a computationally designed polar network

Protein Engineering, Design and Selection

Volumn 27, Issue 4, 2014, Pages 127-134

  Jha, Ramesh K ^a   Gaiotto, Tiziano ^a   Bradbury, Andrew R M ^a   Strauss, Charlie E M ^a  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

Computational protein design; Fc domain; Immunoglobulin G; Polar interaction; Protein G

Indexed keywords

ANTIBODIES; BINDING ENERGY; BIOTECHNOLOGY; HYDROGEN BONDS;

COMPUTATIONAL PROTEIN DESIGN; FC DOMAIN; IMMUNOGLOBULIN G; POLAR INTERACTIONS; PROTEIN G;

YEAST;

IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; MUTANT PROTEIN; PROTEIN G; RECOMBINANT PROTEIN; BACTERIAL PROTEIN; IGG FC-BINDING PROTEIN, STREPTOCOCCUS;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; RABBIT; ANIMAL; CHEMISTRY; COMPUTER SIMULATION; GENETICS; HUMAN; METABOLISM; MOLECULAR DOCKING; MOUSE; MUTATION; PROCEDURES; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE; RAT;

ANIMALS; BACTERIAL PROTEINS; COMPUTER SIMULATION; HUMANS; HYDROGEN BONDING; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; MICE; MOLECULAR DOCKING SIMULATION; MUTATION; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RABBITS; RATS; RECOMBINANT PROTEINS;

EID: 84897426257     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzu005     Document Type: Article

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