Nonnatural protein-protein interaction-pair design by key residues grafting

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 13, 2007, Pages 5330-5335

  Liu, Sen ^a,b   Liu, Shiyong ^a,b   Zhu, Xiaolei ^a   Liang, Huanhuan ^a   Cao, Aoneng ^a   Chang, Zhijie ^c   Lai, Luhua ^a,b  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c Tsinghua University   (China)

Author keywords

De novo design of protein protein interaction pair; Erythropoietin; Functional site grafting; Key residue at interface

Indexed keywords

ERYTHROPOIETIN RECEPTOR; MUTANT PROTEIN; PHOSPHOLIPASE C; PLECKSTRIN; SCAFFOLD PROTEIN; PROTEIN;

ALGORITHM; ARTICLE; BINDING AFFINITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DATA BANK; PROTEIN PROTEIN INTERACTION; WILD TYPE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; IC 50; KINETICS; MUTATION; PROTEIN CONFORMATION; PROTEIN DATABASE; PROTEIN SECONDARY STRUCTURE; RAT; SURFACE PLASMON RESONANCE; WESTERN BLOTTING;

RATTUS;

ALGORITHMS; ANIMALS; BLOTTING, WESTERN; DATABASES, PROTEIN; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, SECONDARY; PROTEINS; RATS; SURFACE PLASMON RESONANCE;

EID: 34248335852     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0606198104     Document Type: Article

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